17 results about "Eupolyphaga sinensis" patented technology

The invention discloses a characteristic peptide fragment for identifying male and female ground beetles and a detection method of the characteristic peptide fragment, and the characteristic peptide fragment with the sequence of Glu-Met-Ser-Trp-Ile-Ala-Asp-Thr-Tyr-Ala-Lys, the sequence of Ile-Val-Pro-Ile-Val-Glu-Pro-Asp-Gly-Asp-His-Asp-Leu-Asp-Glu-Leu-Leu-Gly-Arg and the sequence of the characteristic peptide fragment with the sequence of Glu-Met-Ser-Trp-Ile-Asp-Thy-Lys, the sequence of the characteristic peptide fragment with the sequence of Ile-Val-Pro-Ile-Val-Glu The characteristic peptide fragments have high specificity and can be used for identifying drugs containing male ground beeltle medicinal materials. According to the method for detecting the characteristic peptide fragment of the male ground beeltle, the optimal enzymolysis condition, the chromatographic condition and the mass spectrum condition are screened out through a large number of experiments, the whole method is easy to operate and accurate in judgment, quality control over ground beeltle drugs is facilitated, and the method has important significance on quality control over the drugs containing the ground beeltle.

This invention relates to the field of traditional Chinese medicine technology, and more particularly to the application of a traditional Chinese medicine composition in the preparation of drugs for the prevention and treatment of lung injury. The traditional Chinese medicine composition includes Astragalus membranaceus, Eupolyphaga sinensis, Morus alba root bark, Fritillaria cirrhosa, Perilla frutescens seed, Lepidium apetalum seed, Prunus armeniaca seed, Pheretima aspergillum, Ephedra sinica, and Clematis chinensis. Experiments show that this traditional Chinese medicine composition can significantly reduce the level of the inflammatory factor TNF-α, decrease the lung index, and alleviate pathological damage to lung tissue, and can be used for the prevention and treatment of lung injury.

This invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and its application, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition for treating chronic atrophic gastritis provided by this invention is made from the following raw materials in parts by weight: 15-25 parts of Salvia miltiorrhiza, 8-16 parts of Curcuma zedoaria (processed with vinegar), 2-6 parts of Eupolyphaga sinensis, 10-20 parts of Codonopsis pilosula, 8-16 parts of Dendrobium nobile (dried), 5-15 parts of Pinellia ternata (processed), 1-5 parts of Evodia rutaecarpa (processed), and 1-5 parts of Coptis chinensis. It has the effects of promoting blood circulation and removing blood stasis, strengthening the spleen and replenishing qi, nourishing yin and benefiting the stomach, inhibiting bacteria and inflammation, and regulating immunity. It is suitable for chronic atrophic gastritis, especially those with gastric blood stasis combined with stomach yin deficiency or spleen and stomach weakness. It can significantly repair the gastric mucosa and reverse atrophic intestinal metaplasia, and is safe and reliable, providing a new traditional Chinese medicine treatment for chronic atrophic gastritis.

The invention discloses an external nursing cream containing white muscardine silkworm and gentiana macrophylla and a preparation method thereof, the nursing cream takes white muscardine silkworm and gentiana macrophylla as main raw materials, the main raw materials are extracted by ethanol with the concentration of 20-99%, and the ethanol can be edible wine, health care medicinal liquor or medical ethanol; and the finished product is mild for external use after being blended by a matrix, and the irritation is controllable. Auxiliary materials such as artificial musk, ground beeltle, mirabilite, myrrh and angelica sinensis can be selectively added, and the ointment is prepared by extracting, concentrating and adding an external matrix. The invention has the advantages of simple and mild formula, flexible and simple process, easily available raw materials and wide application range, and is suitable for daily external skin care.

The invention discloses a traditional Chinese medicine composition for soothing channels and activating collaterals. The traditional Chinese medicine composition comprises the following components: 2-4 parts of asiatic toddalia root, 1-3 parts of raw pinellia ternate, 1-3 parts of monkshood, 1-3 parts of radix aconiti agrestis, 1-3 parts of radix aconiti carmichaeli, 3-5 parts of safflower, 3-5 parts of asarum, 3-5 parts of angelica sinensis, 3-5 parts of ligusticum wallichii, 1-3 parts of croton root, 3-5 parts of pepper, 3-5 parts of ground beeltle, 5-7 parts of pseudo-ginseng root, 3-5 parts of radix clematidis, 3-5 parts of sappan wood, 2-4 parts of cortex dictamni, 2-4 parts of radix angelicae pubescentis, 2-4 parts of honeycomb and 2-4 parts of frankincense. , 3-5 parts of pomegranate rind, 1-3 parts of hippocampus, 1-3 parts of centipede and 1-3 parts of dragon's blood. The traditional Chinese medicine composition for relaxing the channels and activating the collaterals has the effects of relaxing the channels and activating the collaterals, dispelling wind and eliminating dampness, and relieving swelling and pain, can effectively relieve swelling and pain caused by traumatic injury, blood stasis, joint dysfunction and the like, can be used for treating diseases such as traumatic injury, rheumatic arthralgia and the like after a fracture operation, also has a certain curative effect on stroke, is sprayed or smeared on an affected part, and has no toxic or side effect. A preservative film can be used for covering, so that the pesticide effect is greatly improved.

This invention belongs to the field of biotechnology, specifically relating to the acetylcholine receptor of the root-knot nematode *Eupolyphaga sinensis*. unc38 Genes, their dsRNAs, and applications. To provide novel target genes for the control of *Eriocheir sinensis* root-knot nematode, this invention is based on the *Eriocheir sinensis* acetylcholine receptor... unc38 Gene SEQ ID NO:1 was used to design and synthesize gene fragment SEQ ID NO:5 and the corresponding dsRNA. The synthesized dsRNA was used to soak second-instar root-knot nematodes. unc38 Gene expression levels were downregulated, resulting in a mortality rate of 68.9% at 60 hours, and complete death of nematodes at 120 hours. Immersion unc38 The dsRNA-infected second-instar larvae of the bean root-knot nematode significantly reduced the infectivity of tomato roots. After 30 days of inoculation, the number of root knots decreased significantly by about 57%, and the number of females, the number of egg masses, the number of eggs in each egg mass, and reproductive factors were all significantly reduced.

This invention relates to the field of traditional Chinese medicine preparations, and discloses a Tongli capsule and its preparation process, comprising the following raw materials: Eupolyphaga sinensis, processed Arisaema heterophyllum, vinegar-processed frankincense, vinegar-processed myrrh, dragon bone, Angelica dahurica, Lysimachia christinae, safflower, Notopterygium incisum, Angelica sinensis, Saposhnikovia divaricata, Cimicifuga foetida, Ligusticum chuanxiong, and Acorus tatarinowii; wherein, the raw materials are dried, pulverized, mixed, and then filled into capsule shells to form capsules. This Tongli capsule, using a total of fourteen traditional Chinese medicines as raw materials, follows the treatment principles of traditional Chinese medicine of dispelling wind and dampness, relaxing muscles and tendons, and promoting blood circulation and removing blood stasis. It has significant efficacy for late-stage fractures and joint dislocations, joint pain, synovitis, and other diseases caused by wind-cold-dampness obstructing the meridians. Furthermore, the capsule dosage form, with its uniform fine powder contents, makes it convenient to take, provides accurate dosage, has high bioavailability, and improves patient compliance. Compared to decoctions, capsules do not require decocting, making them easier to carry and store; compared to pills and powders, capsules can mask unpleasant odors of the medicine, and disintegrate rapidly, resulting in faster onset of action.

This invention provides a pharmaceutical composition for promoting fracture healing, its preparation method, and its application. The composition, by weight, comprises 25-50 parts of an active core component, 8-25 parts of an osteogenic synergistic bioactive component, 3-15 parts of a bone-targeting transdermal penetration enhancer, and 5-15 parts of a moisturizing dispersant. The active core component is based on bone-healing traditional Chinese medicines such as calcined natural copper nanoparticles and Eupolyphaga sinensis polypeptides. The osteogenic synergistic component is based on collagen peptides of specific molecular weights and graded sodium hyaluronate. The bone-targeting transdermal penetration enhancer is a compound of eugenol and limonene. This invention utilizes a three-dimensional synergistic formulation structure and a phase-separated low-temperature preparation process, overcoming the shortcomings of traditional topical medications, such as poor transdermal targeting, weak efficacy, easy inactivation, and low safety. It can achieve targeted enrichment at fracture ends, synergistically promoting fracture healing throughout its entire life cycle, and simultaneously repairing bone and soft tissue. It is suitable for promoting the repair of various fractures and possesses extremely high clinical value and promising prospects for widespread application.

The invention relates to the technical field of medicines, in particular to medicinal liquor for diminishing inflammation, relieving pain and activating blood. Comprising the following components: safflower, lycopodium clavatum, rhizoma smilacis glabrae, radices sileris, radix cyathulae, fructus gardeniae praeparatus, garden balsam stem, radix clematidis, radix paeoniae rubra, rheum officinale, polygonum cuspidatum, Chinese starjasmine stem, caulis spatholobi, salvia miltiorrhiza, sargentgloryvine stem, rhizoma dioscoreae nipponicae, kadsura pepper stem, honeysuckle stem, glabrous sarcandra herb 60, angelica sinensis, madder, berba aristolochiae mollissimae, tripterygium wilfordii, loose knot, schizonepeta, tripterygium wilfordii, cortex albiziae, radix angelicae pubescentis, salvia chinensis, cynanchum paniculatum, notopterygium root, homalomena occulta, fructus liquidambaris The medicinal liquor is prepared from herba taraxaci, semen brassicae, cortex erythrinae, eupolyphaga, folium artemisiae argyi, rhizoma corydalis and Baijiu of 52 degrees or above. The medicinal liquor for diminishing inflammation, relieving pain and activating blood has the advantages of quick response, good analgesic effect and convenience in use. The traditional Chinese medicine has a good treatment effect on cervical spondylosis, scapulohumeral periarthritis, synovitis, lumbar muscle degeneration, lumbar disc herniation, hyperostosis, rheumatism ostalgia, traumatic injuries and other diseases, and takes effect quickly.

The invention relates to a traditional Chinese medicine composition for treating lymphadenitis, a traditional Chinese medicine preparation, a preparation method and application. The composition is prepared from the following components in parts by weight: 1-3 parts of zaocys dhumnade, 2-5 parts of long-noded pit viper, 20-60 parts of centipede, 2-7 parts of scorpion and 3-8 parts of ground beetle. The traditional Chinese medicine composition provided by the invention is simple in medication and proper in compatibility, and the whole prescription has the effects of promoting menstruation and dredging collaterals, dispelling wind-evil phlegm toxin, eliminating bloating, dispersing phlegm stagnation, resolving phlegm toxin, breaking symptoms and eliminating abdominal mass, soothing liver-qi stagnation and effectively dredging liver meridian stagnation, and has an antibacterial effect.

This invention discloses a pharmaceutical composition for treating uterine fibroids, its preparation method, and its application, relating to the field of traditional Chinese medicine technology. The drug of this invention has the effects of softening and dispersing masses, breaking up lumps and eliminating masses, detoxifying and relieving pain, moistening dryness and promoting blood circulation, and regulating qi and dispersing blood stasis. It is composed of the following traditional Chinese medicine raw materials: *Deer antler cap*, *Da Jiu Jia*, fennel, *Spatholobus suberectus*, *Xue Tong*, *Evodia rutaecarpa*, *Aconite*, *Angelica sinensis*, *Ligusticum chuanxiong*, *Cyperus rotundus*, *Saussurea costus*, *Smilax china*, peach kernel, safflower, leech, earthworm, *Eupolyphaga sinensis*, cinnamon twig, and *Achyranthes bidentata*. The dosage form of the drug for treating uterine fibroids is a powder. Patients take 20-30 grams of the drug orally three times a day, mixed with 15-20 grams of honey in 275 ml of drinking water. The application refers to the use of the above-mentioned pharmaceutical composition and preparation in the preparation of drugs for treating or preventing uterine fibroids. The traditional Chinese medicine composition provided by this invention has significant efficacy in treating uterine fibroids, is non-toxic, has no side effects, has a reasonable formula, is simple to prepare, and has a low cost.

This invention discloses a formula and manufacturing method for an old black plaster. The old black plaster formula mainly consists of the following components in parts by weight: Clematis chinensis 1, Gentiana macrophylla 1, Clematis armandii 1, Curcuma longa 2, Alpinia officinarum 1, Eupolyphaga sinensis 0.5, Angelica dahurica 0.6, Cinnamomum cassia 1, natural copper 1, Lycopodium clavatum 0.8, Spatholobus suberectus 1, Boswellia carterii 1, Commiphora myrrha 1, Beeswax 1, Rosa rugosa 1, Gastrodia elata 1, Gardenia jasminoides 1, Drynaria fortunei 2, Angelica pubescens 1.5, Taxillus chinensis 1, Achyranthes bidentata 1.1, and Piper kadsura 0.8. This invention also provides a manufacturing method for the old black plaster, including steps such as crushing and mixing, vacuum frying, refining oil until it forms beads when dripped, adding cinnabar to form a plaster, removing heat toxicity, and spreading. This invention's formula targets the pathogenesis of qi stagnation and blood stasis caused by wind-cold-dampness obstructing the meridians, resulting in pain due to obstruction. It has comprehensive effects of dispelling wind, dispersing cold, removing dampness, promoting blood circulation, resolving stasis, unblocking meridians, strengthening tendons, and relieving pain, with significant therapeutic effects.

The invention discloses a pharmaceutical composition for prolonging life and preserving health. The traditional Chinese medicine composition comprises the following components: prepared rehmannia root, polygonum multiflorum, herba epimedii, male silkworm moth, schisandra chinensis, tribulus terrestris, dried ginger, angelica sinensis, bighead atractylodes rhizome, liquorice, cistanche, rhizoma cibotii, pseudo-ginseng, winter wheat, dendrobe, pericarpium citri reticulatae, glossy privet fruit, poria cocos, eucommia ulmoides, ligusticum chuanxiong hort, rhizoma alismatis, cudweed, lily, tendril-leaved fritillary bulb, rhizoma anemarrhenae, spina date seed, coix seed, medicated leaven, astragalus membranaceus, morinda officinalis, endothelium corneum gigeriae galli, musk, raspberry, codonopsis pilosula, phellinus igniarius, gecko, scorpion and ground beetle. A femtosecond wall breaking technology is combined with an ancient processing method, and medicated leaven is used for double fermentation, so that the medicine effect is improved by 8-10 times; the antioxidant capacity of the body can be improved, free radicals, immune functions and nerve protection functions are eliminated, and senescence is delayed; the medicine can treat old and chronic diseases. The preparation forms comprise decoction, oral liquid, pills and medicinal liquor. The composition can significantly improve the activity of antioxidant enzymes such as SOD, CAT and the like, reduce the MDA content and improve the cognitive and athletic ability.

This invention discloses a traditional Chinese medicine composition and its preparation for rheumatic arthralgia. The composition consists of nine herbs: *Hedyotis diffusa*, earthworm, *Eupolyphaga sinensis*, centipede, silkworm, scorpion, dung beetle, *Sinomenium acutum*, and *Zaocys dhumnades*. The composition exerts its efficacy through specific weight ratios, and is particularly suitable for treating joint pain and deformities caused by rheumatoid arthritis and osteoarthritis. The key to this invention lies in the heavy use of multiple insect-derived medicinal materials, which can penetrate deep into the meridians and collaterals, exerting a powerful effect of dispelling wind, clearing the meridians, relieving dampness and pain, and breaking up blood stasis and dissipating nodules in stubborn rheumatic arthralgia. Simultaneously, specific processing techniques are specified for the key insect-derived medicinal materials, such as wine-processing, salt-processing, roasting, and wheat bran-frying, to reduce toxicity, enhance efficacy, and ensure medication safety. The traditional Chinese medicine composition of this invention can be further prepared into various modern dosage forms such as powders, granules, and capsules, facilitating patient administration and clinical application.

The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 0.5 part of radix saposhnikoviae, 0.5 part of dandelion, 0.5 part of honeysuckle flower, 0.5 part of prepared kusnezoff monkshood root, 0.5 part of radix angelicae pubescentis, 0.5 part of angelica sinensis, 0.5 part of rheum officinale, 0.5 part of lindera aggregata, 0.5 part of radix sophorae flavescentis, 0.5 part of radix paeoniae rubra, 0.5 part of radix angelicae, 0.5 part of ground beeltle, 0.5 part of radix euphorbiae lantu, 0.5 part of gallnut, 0.5 part of asarum, 0.5 part of edible tulip, 0.5 part of oyster, 0.5 part of pollen typhae, 0.5 part of notopterygium root, 0.5 part of rhizoma bletillae and 0.5 part of ligusticum wallichii. The traditional Chinese medicine composition disclosed by the invention can be prepared into ointment after being decocted and taken according to the weight ratio, has the functions of relieving pain, stopping bleeding, promoting blood circulation, removing blood stasis, diminishing swelling, removing stasis and the like, and is good in fracture treatment effect, rapid in healing and high in cure rate.

This invention relates to the field of traditional Chinese medicine (TCM) technology, and particularly to the application of TCM compositions in the preparation of drugs for the prevention and treatment of asthma. The TCM composition includes Astragalus membranaceus, Eupolyphaga sinensis, Morus alba root bark, Fritillaria cirrhosa, Perilla frutescens seed, Lepidium apetalum seed, Prunus armeniaca seed, Pheretima aspergillum, Ephedra sinica, and Clematis chinensis. Experiments show that the TCM composition provided by this invention can effectively improve airway hyperresponsiveness, reduce lung resistance, and enhance dynamic lung compliance in asthma model animals. Simultaneously, it can significantly reduce the content of pro-inflammatory factors IL-4 and IL-13 in the bronchoalveolar lavage fluid of asthma models, alleviate airway inflammation, and relieve asthma pathological symptoms. It can stably exert its effect in preventing and treating asthma, and its efficacy is stable and its safety is good. It can be further developed into a drug for the prevention and treatment of asthma and has good clinical application prospects.

The invention discloses a dressing bag for dredging collaterals, relaxing tendons and ironing bones. Comprising phryma leptostachya, lycopodium clavatum, radix clematidis, caulis spatholobi, kadsura pepper stem, caulis sinomenii, Chinese starjasmine stem, photinia serrulata, tinospora sinensis merr, honeysuckle stem, ramulus mori, dryopteris pubescens, angelica sinensis, safflower, peach kernel, radix paeoniae rubra, hematoxylon, herba lycopi, artemisia anomala, prepared frankincense, prepared myrrh, pseudo-ginseng, ground beeltle, rhizoma bletillae, muskmelon seed, rhizoma drynariae, eucommia ulmoides, teasel root, radix cyathulae, cortex acanthopanacis, rhizoma cibotii, obscured homalomena rhizome, cassia twig, rhizoma zingiberis, folium artemisiae argyi, radix saposhnikoviae, notopterygium root and radix angelicae pubescentis. The preparation method comprises the following steps: decocting the medicinal materials except the borneol in the rice wine or yellow rice wine of 35-38 degrees, stirring and dissolving with the borneol to form a mixture, filtering the liquid in the mixture to obtain decoction dregs, packaging the decoction dregs to form the outer medicine bag, and heating the outer medicine bag to apply on the affected part firstly and then performing hot compress. According to the traditional Chinese medicine composition, the effects of warming and smoothing qi and blood are achieved, so that the effects of promoting blood circulation to remove blood stasis, relieving pain, promoting reunion of fractured tendons and bones, promoting tissue regeneration and meat growth and repairing soft tissues of the traditional Chinese medicine composition are accelerated.