Pharmaceutical composition for promoting fracture healing and preparation method and application thereof

By combining an active core component and a bone-targeted transdermal penetration enhancer, the problem of unclear effective ingredients and low transdermal absorption efficiency of topical medications is solved, achieving effective promotion of fracture healing for complex fracture types, and is suitable for elderly patients.

CN122163771APending Publication Date: 2026-06-09GUANGDONG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE HAINAN HOSPITAL
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Patent Information

Application Number
CN202610364199.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-24
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing topical medications for promoting fracture healing have problems such as unclear active ingredients, low transdermal absorption efficiency, insufficient local drug concentration, limited effectiveness for complex fracture types, and inapplicability to traditional dosage forms, making them particularly unsuitable for elderly patients.

Method used

Compositions of active core components, osteogenic synergistic bioactive components, and bone-targeting transdermal penetration enhancers, including acetic acid-calcined nano-natural copper powder, specific extracts, and bioactive peptides, are prepared into topical plasters, gels, or poultices through a stepwise pre-dispersion and pre-mixing process to improve local drug concentration and targeting.

Benefits of technology

It significantly promotes fracture healing, especially for complex fracture types, increases local drug concentration and transdermal absorption efficiency, reduces systemic side effects, and is suitable for different fracture sites and elderly patients.

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Abstract

The invention provides a pharmaceutical composition for promoting fracture healing as well as a preparation method and application thereof, and the composition comprises the following components in parts by weight: 25-50 parts of an active core component, 8-25 parts of an osteogenesis synergistic bioactive component, 3-15 parts of a bone targeting transdermal penetration enhancer, 5-15 parts of a moisturizing dispersant and the like, wherein the active core component takes vinegar calcined nano native copper, ground beeltle polypeptide and other bone setting traditional Chinese medicines as cores, the osteogenesis synergistic component takes specific molecular weight collagen peptide and graded sodium hyaluronate as cores, and the bone targeting transdermal penetration enhancer is a compound of eugenol and limonene. The three-dimensional synergistic composition framework is matched with a split-phase low-temperature preparation process, the pain points of poor transdermal targeting property, weak drug effect, easy activity inactivation and low safety of traditional externally applied drugs are solved, targeted enrichment of fracture broken ends can be realized, multi-target synergistic promotion of fracture complete-cycle healing and synchronous repair of bones and soft tissues can be realized, and the traditional Chinese medicine composition is suitable for promotion of repair treatment of various fractures and has wide application prospects. The clinical value and the popularization prospect are extremely high.
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