10 results about "Sinomenium" patented technology

The application discloses a soil conditioner for improving quality and yield of continuous cropping tomatoes, and raw materials of the soil conditioner include earthworm manure powder, sinomenium acutum powder, fallopia multiflora, limestone powder, humic acid, active adsorbent, composite microorganism, carboxymethyl hydroxyethyl cellulose, acrylamide, crosslinking agent, photoinitiator, catalyst and iron salt. The application also discloses a preparation method of the soil conditioner for improving quality and yield of continuous cropping tomatoes. The application adopts the compounding of the loaded microorganism and the earthworm manure powder, can quickly increase soil water stable aggregates, improve soil physical structure, enhance soil fertility, and has extremely remarkable effect of improving soil, and in combination with the sinomenium acutum and the fallopia multiflora, can not only show the inhibiting effect on fusarium oxysporum in the soil continuously cropped for 5-10 years, but also can continuously enhance soil enzyme activity.

The invention discloses a caulis sinomenii methyltransferase and an application of the caulis sinomenii methyltransferase in synthesis of sinomenine. The amino acid sequence of the caulis sinomenii methyltransferase is as shown in SEQ ID NO: 2. According to the invention, a new methyltransferase SaOMT3 is identified from a medicinal plant caulis sinomenii for the first time, and it is found that the methyltransferase participates in biosynthesis of sinomenine. Functional identification on SaOMT3 can greatly promote the research on the biosynthesis path of sinomenine, provide sufficient raw material guarantee for the creation of new sinomenine drugs, and also provide reference for the research of other medicinal plants. Meanwhile, the caulis sinomenii methyltransferase SaOMT3 disclosed by the invention is good in substrate specificity, high in catalytic efficiency and very high in application value.

This invention discloses a topical anti-inflammatory traditional Chinese medicine composition and its application, as well as an anti-inflammatory gel patch and its preparation method, belonging to the field of traditional Chinese medicine technology. The topical anti-inflammatory traditional Chinese medicine composition, by weight, comprises the following components: 30-120 parts of *Sinomenium acutum* and 0.35-1.4 parts of *Ilex cornuta* oil. The combination of the active components *Sinomenium acutum* and *Ilex cornuta* oil achieves a synergistic effect, ensuring the efficacy of the active ingredients. Pharmacological studies have shown that the topical anti-inflammatory traditional Chinese medicine composition of this invention exhibits significant therapeutic effects in alleviating biomarkers related to osteoarthritis, frozen shoulder, soft tissue injury, and muscle pain, which is of great significance for improving patients' quality of life.

The invention discloses a traditional Chinese medicine composition for treating arthralgia. The traditional Chinese medicine composition is prepared from honeysuckle stem, Chinese starjasmine stem, caulis sinomenii, kadsura pepper stem, tinospora sinensis merr, radix puerariae, cassia twig, angelica sinensis, radix paeoniae rubra, ligusticum wallichii, notopterygium root, radix angelicae pubescentis, peach kernel, safflower carthamus, radix clematidis, galangal, asarum, cinnamon leaf, radix cynanchi auriculati and radix zanthoxyli. Therefore, the invention further develops a traditional Chinese medicine preparation of the dredging ointment for treating arthralgia, and establishes a corresponding preparation method. According to the traditional Chinese medicine composition disclosed by the invention, the medicinal materials such as the five vines, the notopterygium root, the radix angelicae pubescentis, the peach kernel and the safflower are matched, so that a compound syndrome type of wind-cold-dampness-blood stasis and deep meridian blockage is accurately covered, and is not limited to mild wind-cold arthralgia or pure dampness arthralgia; the application mode of the incense applying method is flexible and convenient, the application position can be adjusted according to the affected part, and the incense applying device has adaptability to various severe arthralgia syndromes such as rheumatic arthritis. Meanwhile, the traditional Chinese medicine composition is simple in preparation process and convenient and safe to use, meets the requirement of long-term conditioning of patients with severe arthralgia syndromes, and overcomes the defects that in the prior art, the use threshold is high, and insistence at home is inconvenient.

This invention discloses a traditional Chinese medicine composition and its preparation for rheumatic arthralgia. The composition consists of nine herbs: *Hedyotis diffusa*, earthworm, *Eupolyphaga sinensis*, centipede, silkworm, scorpion, dung beetle, *Sinomenium acutum*, and *Zaocys dhumnades*. The composition exerts its efficacy through specific weight ratios, and is particularly suitable for treating joint pain and deformities caused by rheumatoid arthritis and osteoarthritis. The key to this invention lies in the heavy use of multiple insect-derived medicinal materials, which can penetrate deep into the meridians and collaterals, exerting a powerful effect of dispelling wind, clearing the meridians, relieving dampness and pain, and breaking up blood stasis and dissipating nodules in stubborn rheumatic arthralgia. Simultaneously, specific processing techniques are specified for the key insect-derived medicinal materials, such as wine-processing, salt-processing, roasting, and wheat bran-frying, to reduce toxicity, enhance efficacy, and ensure medication safety. The traditional Chinese medicine composition of this invention can be further prepared into various modern dosage forms such as powders, granules, and capsules, facilitating patient administration and clinical application.

This invention belongs to the field of pharmaceutical testing technology, specifically relating to PCR primer pairs and probes for identifying adulteration of *Sinomenium acutum* in *Radix Sophorae Flavescentis* and their applications. The sequences of the PCR primer pairs are shown in SEQ ID NO: 2 and SEQ ID NO: 3, and the sequence of the probe is shown in SEQ ID NO: 1. The method for identifying adulteration of *Sinomenium acutum* in *Radix Sophorae Flavescentis* constructed based on the PCR primer pairs and probes provided by this invention has strong specificity for *Sinomenium acutum*, can distinguish it from common easily confused varieties, such as *Sinomenium acutum*, and has a reasonably set detection threshold limit, making it suitable for qualitative or quantitative detection of *Sinomenium acutum* in medicinal materials, processed medicinal slices, and compound preparations.

The invention discloses a caulis sinomenii gel plaster as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine preparations. The caulis sinomenii gel plaster comprises a backing layer, a medicine storage layer and a release layer, and the medicine storage layer is prepared from the following components in parts by weight: 3-12 parts of caulis sinomenii and 5-15 parts of a gel matrix. The caulis sinomenii gel plaster disclosed by the invention has a remarkable curative effect by improving the prescription of the active ingredients and the gel matrix. The preparation method comprises the following steps: extracting caulis sinomenii with an ethanol water solution, concentrating and drying to obtain an extract, preparing the caulis sinomenii extract into the gel plaster, and the pharmacodynamic test result shows that the gel plaster has a remarkable curative effect, is dose-dependent, and has the characteristics of high initial adhesion and good application comfort.

The invention discloses a formula and a preparation method of rheumatoid arthritis traditional Chinese medicine granules for improving joint swelling and pain. The granules are prepared from twelve traditional Chinese medicines including caulis sinomenii, tripterygium wilfordii (prepared), radix paeoniae alba, astragalus membranaceus, angelica sinensis, caulis spatholobi, radix clematidis, gentiana macrophylla, radix stephaniae tetrandrae, rhizoma smilacis glabrae, liquorice and rhizoma corydalis according to specific compatibility of monarch, minister, assistant and guide in parts by weight. The preparation method adopts a graded extraction process, and comprises the following steps: decocting partial medicinal materials with water, performing ethanol reflux extraction on partial medicinal materials, independently extracting astragalus membranaceus, combining and concentrating, and mixing and granulating with liquorice fine powder. The granules are scientific in formula and reasonable in process, the obtained granules are stable in quality and convenient to take, experiments prove that the granules have remarkable anti-inflammatory, detumescence, analgesia and immune regulation effects, and the granules are suitable for improving and treating symptoms such as joint swelling and pain, morning stiffness and limited activity caused by rheumatoid arthritis.

This invention belongs to the field of traditional Chinese medicine analysis, specifically relating to a method for studying the active components of the *Sinomenium acutum*-*Paeonia lactiflora* pair. This invention, for the first time, uses UHPLC-Q Exactive Focus MS combined with molecular network technology to systematically analyze the non-volatile components of the *Sinomenium acutum*-*Paeonia lactiflora* pair. Through high-resolution mass spectrometry data acquisition, molecular network construction, and database comparison, a total of 138 chemical components were identified, including 81 alkaloids, 21 monoterpenes, 22 tannins, 5 flavonoids, and 9 other compounds. Furthermore, new components generated after co-decoction of *Sinomenium acutum*-*Paeonia lactiflora* pair were analyzed and identified, providing a new method for further research on the mechanism of action and efficacy of the *Sinomenium acutum*-*Paeonia lactiflora* pair.

This invention provides an Aspergillus flavus strain, its application in extracting zephyranthesin from plant materials, and a method for extracting zephyranthesin from Dioscorea bulbifera. The Aspergillus flavus strain is KS1105. The application of the Aspergillus flavus strain in extracting zephyranthesin from plant materials involves using the strain to ferment and break down the cell walls of plant materials containing zephyranthesin. A method for extracting zephyranthesin from Dioscorea bulbifera includes the following steps: pulverizing Dioscorea bulbifera and mixing it with water; inoculating the mixture with the Aspergillus flavus strain for fermentation and cell wall breaking to obtain broken-wall Dioscorea bulbifera; soaking the broken-wall Dioscorea bulbifera in an alkaline aqueous solution, filtering and washing with water until neutral, and then drying for later use; and extracting the material treated in step S3 with an extractant to obtain a zephyranthesin extract. The Aspergillus flavus strain increases the zephyranthesin extraction rate by 2.48 times compared to before cell wall breaking, reduces the amount of organic solvent used, lowers energy consumption, is environmentally friendly, and has low industrialization costs.