9 results about "Sinomenine" patented technology

This invention belongs to the field of traditional Chinese medicine preparation analysis, specifically disclosing a one-test-multiple-evaluation method for determining the content of seven components in Jinteng Qingbi granules and its application. Using sinomenine as an internal standard, a one-test-multiple-evaluation method is used to establish relative correction factors between sinomenine and gallic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, and isochlorogenic acid C in Jinteng Qingbi granules. The contents of gallic acid, neochlorogenic acid, sinomenine, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, and isochlorogenic acid C in Jinteng Qingbi granules are calculated using these correction factors. This invention's method is highly practical, simple to operate, cost-effective, and provides accurate and reliable test results, overcoming the shortcomings of existing methods for quality testing of Jinteng Qingbi granules and providing a new approach for quality control and intrinsic quality evaluation of Jinteng Qingbi granules.

The invention belongs to the technical field of traditional Chinese medicine separation and purification, and discloses a method for separating caulis sinomenii alkaloid by a microfiltration-ultrafiltration-nanofiltration-electrodialysis integrated membrane technology. An ultrafiltration membrane electrodialysis device is adopted, the ultrafiltration membrane electrodialysis device comprises an anode plate, a cathode plate and a membrane stack arranged between the anode plate and the cathode plate, and the membrane stack is formed by connecting n groups of electrodialysis units in series, the device sequentially comprises an anode, an anode chamber, [a cation exchange membrane, an acid chamber, an anion exchange membrane, a feeding chamber, an ultrafiltration membrane and a product chamber] n, a cation exchange membrane, a cathode chamber and a cathode from the anode to the cathode. According to the method, the maximum recovery rate of sinomenine hydrochloride can reach 84.1%, the recovery rate of magnoflorine can reach 68.2%, the method is a simple and efficient multi-membrane integrated separation method with low energy consumption and small pollution, and a new thought is provided for separation and purification in the field of traditional Chinese medicine alkaloids.

The invention belongs to the technical field of medicines, and discloses application of a compound M1 shown as a formula (I) and pharmacodynamically acceptable salt thereof in preparation of medicines for preventing, relieving and / or treating autoimmune demyelination diseases. On a mouse experimental autoimmune encephalomyelitis model, the compound M1 shows a good treatment effect, can effectively prevent and treat pathological changes and disease progression of diseases, relieve the severity of the diseases and inhibit LPS-stimulated microglial BV2 cells from releasing inflammatory mediators, and provides a new drug and a new structure for clinical treatment.

The invention provides a eutectic compound of rosmarinic acid and sinomenine as well as a preparation method and application of the eutectic compound, and belongs to the technical field of analgesic drugs. The eutectic compound of rosmarinic acid and sinomenine provided by the invention comprises a crystal form A or a crystal form G. Compared with a mixture of rosmarinic acid and sinomenine, the eutectic compound of rosmarinic acid and sinomenine provided by the invention has a better analgesic effect, can be absorbed quickly and completely, and can stay in vivo for a longer time.

The extraction method of effective components of traditional Chinese medicine composition for treating knee osteoarthritis based on entropy weight method and response surface method belongs to the technical field of traditional Chinese medicine extraction, establishes the content determination method of index components in the composition, i.e., sinomenine, magnoflorine, paeonol glycoside, paeoniflorin and dioscin, and carries out methodology investigation; the comprehensive score of index component content is calculated by the entropy weight method as an evaluation index, the influence factors are ethanol concentration, solid-liquid ratio and soaking time, the experiment is designed by applying the response surface method, the index weight is determined by the comprehensive weighting theory of evaluation index, the comprehensive score is calculated, the multiple quadratic regression model of comprehensive score and investigation factors is established, the variance analysis is carried out, the optimal process is predicted and verified, and the optimized extraction process parameters of Jiantongkang are determined. The extraction condition optimization research of index components of the composition based on the entropy weight method and the response surface method is strong in pertinence, simple in operation, high in accuracy, scientific and reasonable in process, and is suitable for the content determination of medicinal material effective components.

The application provides a composite antibacterial biological preparation for preventing and treating tobacco brown spot, and a preparation method and application thereof, and belongs to the technical field of tobacco disease prevention and treatment.The composite antibacterial biological preparation comprises the following components in parts by weight: Chinese herbal medicine fermentation liquor 50-110 parts, active ingredient 8-25 parts, and auxiliary agent 1.5-3.8 parts; the active ingredient is a mixture of 5-amino levulinic acid hydrochloride and sinomenine and limonene at a mass ratio of 5-10:0.01-0.03:0.15-0.78.The application realizes effective prevention and treatment of tobacco brown spot through synergistic effect of multiple components, and the components are natural, easy to degrade, strong in rainwater erosion resistance, free of pesticide residues and environmentally friendly.

This invention belongs to the field of pharmaceutical technology and discloses sinomenine derivatives and their application in the treatment of glioma. Specifically, it discloses a sinomenine derivative represented by Formula I, its synthesis method, and its application in the treatment of glioma. This invention provides a new method for the structural modification of sinomenine, and some compounds can effectively inhibit the proliferation of glioma cells, showing potential as anti-glioma drugs.

The invention discloses sinomenine hydrochloride solid lipid nanoparticles, gel, a preparation method and application, by exploring the preparation method of the sinomenine hydrochloride solid lipid nanoparticles HA-SH-SLNs, when the mass ratio of sinomenine hydrochloride to soya bean lecithin to hyaluronic acid modified targeting molecule DSPE-PEG-HA to poloxamer Pluronic F-68 is (0.3-0.7): (1-4): (0.0125-0.1): (1-4), the gel can be used for preparing the sinomenine hydrochloride solid lipid nanoparticles HA-SH-SLNs. The sinomenine hydrochloride solid lipid nanoparticles which are uniform in particle size, high in encapsulation efficiency, high in drug loading capacity and stable in quality are obtained, and the preparation method of the sinomenine hydrochloride solid lipid nanoparticle gel is further researched. The obtained sinomenine hydrochloride solid lipid nanoparticle gel HA-SH-SLNs-Gel is good in stability and small in hemolysis rate, the in-vivo residence time is longer than that of sinomenine hydrochloride solid lipid nanoparticles, the drug release period is delayed, and better articular cavity injection administration is facilitated.

This invention belongs to the field of pharmaceutical technology and discloses sinomenine derivatives and their application in the treatment of glioma. Specifically, it discloses a sinomenine derivative represented by Formula I, its synthesis method, and its application in the treatment of glioma. This invention provides a new method for the structural modification of sinomenine, and some compounds can effectively inhibit the proliferation of glioma cells, showing potential as anti-glioma drugs.