893 results about "Safflowers" patented technology

The invention relates to the technical field of traditional Chinese medicine, in particular to a Mongolian medicine tea drink for relieving respiratory system abnormality and a preparation method and application thereof.The Mongolian medicine tea drink is prepared from rhododendron micranthum, pomegranate, amomum cardamomum, long pepper, cinnamon, safflower, agilawood, clove, myristica fragrans, fructus choerospondiatis, bistort rhizome, liquorice, tabasheer, radix aucklandiae, white raisin and crabs. The processed products of the Mongolian medicine components are weighed according to the formula dosage, then ground into coarse powder and bagged to prepare tea bags. The Mongolian medicine tea drink provided by the invention has the effects of moving Heli, relieving cough, reducing phlegm and diminishing swelling; the traditional Chinese medicine composition can be used for treating the symptoms such as' Bada dry Hiri 'dizziness, asthma, chronic bronchitis, indigestion disease, edema, edema and water tympanites.

The invention provides a traditional Chinese medicine gel patch for treating gouty arthritis and a preparation method thereof. The traditional Chinese medicine gel patch for treating gouty arthritis comprises at least a gel layer loaded with traditional Chinese medicine extracts; the traditional Chinese medicine extracts comprise the following raw materials: coix seed, phellodendron amurense, clematis root, radix scutellariae, atractylodes lancea, radix ophiopogonis, radix scutellariae, acer scutellariae, radix scutellariae, radix aconiti kusnezoffii, radix strychnii, frankincense, myrrh, angelica sinensis, safflower, cyathula root, radix paeoniae rubra, radix smilacis gracile, radix striatae, eucalyptus glomeratae, sophora flavescens, andrographis paniculatae, radix lobeliae, rhizoma coptidis, radix scutellariae, cassia twig, zanthoxylum bungeanum, and borneol; and a matrix of the gel layer comprises the following raw materials in parts by weight: silk fibroin, polyvinyl pyrrolidone, azido-polyethylene glycol-carboxylic acid, 1-ethynylcyclopropylcarboxylic acid, 2,5-dicarboxylic acid-3,4-ethylenedioxythiophene, and glycerol. The traditional Chinese medicine gel plaster of the present invention can achieve good therapeutic effects through percutaneous absorption.

The invention discloses a traditional Chinese medicine composition for soothing liver-qi stagnation, softening hard mass and dissolving phlegm and a preparation method thereof, and particularly relates to the technical field of traditional Chinese medicines. Comprising the following components: roasted rhizoma atractylodis macrocephalae, angelica sinensis, cortex moutan, peach kernels, raw oyster shells, rhizoma sparganii, radix curcumae, spina gleditsiae, rhizoma acori graminei, rhizoma bolbostemmae, immature bitter oranges, selfheal, roses, lindera aggregata leaves, prepared arisaema consanguineum schott, fructus liquidambaris, orange peels, feverfew, hawksbill flowers, paeonia ostii flowers, exocarpium citri rubrum, mulberries, fructus lycii, flos caryophylli, fingered citron, rosemary, jasmine flowers, saffron, mulberry leaves, dandelions, gorse, kumquats, radix fici simplicissimae, purple perilla and mint. The traditional Chinese medicine composition has multiple effects of soothing the liver, promoting the circulation of qi, softening hardness to dissipate stagnation, tonifying the spleen, reducing phlegm, activating blood and clearing heat, gives consideration to overall conditioning and target treatment, and contains medicinal and edible components, so that the safety is improved. According to the preparation method, the processes of segmented decoction, vacuum low-temperature concentration, high-pressure homogenization and pasteurization are adopted, so that sufficient extraction and retention of effective components are ensured, and the curative effects of soothing liver-qi stagnation, softening hard mass and dissolving phlegm are remarkably improved.

The invention discloses a traditional Chinese medicine composition for preventing / treating systemic lupus erythematosus and application thereof.The traditional Chinese medicine composition is reasonably combined according to etiology and pathogenesis of systemic lupus erythematosus, pseudo-ginseng, ginseng, glossy privet fruit and syngnathus serve as monarch drugs, and the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, nourishing the liver and tonifying the kidney and directly tonifying yin deficiency of the liver and the kidney; salvia miltiorrhiza, safflower, peach kernel, American ginseng, codonopsis pilosula, prepared rhizome of rehmannia, wolfberry, mulberry and panax japonicus are taken as ministerial drugs and are matched to assist the monarch drugs and clear stasis heat, cornu cervi pantotrichum, herba epimedii, hippocampus, pericarpium citri reticulatae, polygonum multiflorum, angelica sinensis, radix paeoniae alba, rhizoma polygonati and dog kidney are taken as adjuvant and conductant drugs and assist the monarch and ministerial drugs to harmonize yin and yang, all the drugs are matched and have a synergistic effect, and the effects of nourishing kidney and replenishing essence, reinforcing qi and nourishing yin, promoting blood circulation to remove meridian obstruction, warming yang and removing stasis can be achieved. The traditional Chinese medicine can treat both symptoms and root causes, and can effectively treat systemic lupus erythematosus.

The invention discloses a traditional Chinese medicine composition for treating skin diseases and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-12 parts of radix notoginseng, 8-15 parts of radix salviae miltiorrhizae, 10-20 parts of rhizoma chuanxiong, 8-15 parts of rhizoma curcumae longae, 15-35 parts of radix angelicae sinensis, 3-8 parts of sandalwood, 3-8 parts of fructus aurantii immaturus, 40-60 parts of ramulus cinnamomi, 8-15 parts of rhizoma corydalis, 8-15 parts of rhizoma curcumae, 2-5 parts of flos carthami, 5-12 parts of radix puerariae, 8-15 parts of radix rehmanniae, 3-8 parts of pericarpium citri reticulatae and 8-15 parts of spica prunellae. The traditional Chinese medicine composition is prepared from 3-8 parts of radix trichosanthis, 15-35 parts of tribulus terrestris, 15-35 parts of cicada slough, 5-12 parts of stiff silkworm and 8-15 parts of rhizoma drynariae. According to a multi-target collaborative mechanism, network pharmacology proves that 12 pathological pathways such as IL-17A and the like can be regulated and controlled, and the TNF-alpha inhibition rate is 89% and the barrier repair speed is increased by 2.3 times through key component combination. According to a transdermal synergistic technology, the specific surface area of the medicine reaches 8.5 m < 2 > / g through superfine grinding, a Franz test shows that the penetration amount of tanshinone is increased by 3.7 times, and the onset time is shortened to 8.3 minutes. Dual scar regulation and control: the thickness of scars in 12 weeks is reduced by half through TGF-beta3 up-regulation and alpha-SMA inhibition, and the collagen order degree is improved by 3.2 times.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine micro-powder capsule based on functions of promoting blood circulation to remove blood stasis, dispelling wind and eliminating dampness and activating meridians to stop pain. 0.8%-1.2% of scorpion; 0.8%-1.2% of Chinese polyphaga; 0.8%-1.2% of safflower carthamus; 0.8%-1.2% of peach kernels; 0.8%-1.2% of zaocys dhumnade; 0.8% to 1.2% of frankincense; 0.8%-1.2% of ligusticum wallichii; 0.8%-1.2% of cortex moutan; 0.8% to 1.2% of myrrh; 0.8%-1.2% of notopterygium root; 0.8%-1.2% of radix angelicae pubescentis; 0.8%-1.2% of fructus lycii; 0.8%-1.2% of centipede; 15%-25% of a functional auxiliary material: 3%-5% of a nano dispersion carrier; and 3%-5% of an inclusion compound. By adopting a beta-cyclodextrin inclusion technology, volatile oil and a humid and hot environment can be effectively isolated, the stability of the volatile oil can be enhanced, by taking ligustrazine as an example, under an accelerated test condition, the retention rate of the ligustrazine in 6 months is up to 89.5%, and compared with a non-inclusion condition, the retention rate is improved, the degradation rate is reduced by 3.1 times, and the stability of the core component for promoting blood circulation to remove blood stasis in the storage and use process is ensured.

The invention provides a safflower pigment extraction method. The safflower pigment extraction method comprises the following steps: preparing a safflower decoction; adding whey protein into the safflower boiling liquid, and uniformly stirring; standing for layering, removing supernatant liquid, and then regulating and controlling the pH value of the mixed liquid; selective separation of carthamin yellow and haematochrome is realized through pH control; wherein yellow pigment mud is obtained under the alkaline condition, and red pigment mud is obtained under the acidic condition; the obtained yellow pigment mud and the obtained red pigment mud are subjected to vacuum drying and then ground, and the drying temperature is 30-40 DEG C. According to the safflower pigment extraction method provided by the invention, the selective separation of safflower yellow / red pigment is realized by regulating the pH value, and the limitation of single pigment extraction is broken through; and the weather resistance of the product is effectively improved through low-temperature grinding and a color fixing agent compounding and coating process. The invention further provides application of the safflower pigment.

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition for treating cervical spondylotic radiculopathy and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 40 parts of radix puerariae, 5 to 25 parts of cassia twig, 20 to 40 parts of ramulus mori, 5 to 25 parts of notopterygium root, 20 to 40 parts of radix astragali seu hedysari, 20 to 40 parts of radix salviae miltiorrhizae, 5 to 25 parts of rhizoma chuanxiong, 5 to 25 parts of radix angelicae sinensis, 20 to 40 parts of radix paeoniae alba, 5 to 25 parts of radix clematidis, 5 to 20 parts of radix notoginseng, 2 to 10 parts of flos carthami, 5 to 25 parts of fructus chaenomelis lagenariae, 5 to 25 parts of earthworm, 20 to 40 parts of caulis spatholobi and 5 to 25 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition disclosed by the invention is precise and reasonable in formula, standard and feasible in preparation process, free of any hormone, preservative and additive, and high in safety as natural raw materials are selected.

The invention discloses a pharmaceutical composition for preventing and treating chronic atrophic gastritis. The pharmaceutical composition is prepared from the following raw materials in the following weight ratio: 14-18 parts of peach kernel, 10-14 parts of Chuanxiong rhizome, 8-12 parts of Panax notoginseng, 6-10 parts of safflower, 20-28 parts of kelp, 10-14 parts of selfheal, 15-25 parts of codonopsis pilosula, 10-14 parts of atractylodes macrocephala, 12-16 parts of fructus aurantii, 8-12 parts of amomum villosum, 12-16 parts of bupleurum, 10-18 parts of citron, and 5-10 parts of fucoidan. The pharmaceutical composition is used to treat chronic atrophic gastritis of gastric collateral blood stasis type by promoting blood circulation and removing blood stasis, unblocking meridians and relieving pain, eliminating phlegm, softening and dispersing nodules, invigorating qi and promoting qi circulation, and soothing the liver and harmonizing the stomach. The invention also discloses a preparation method of the pharmaceutical composition.

The invention discloses a camellia chekiangoleosa improved variety breeding method and a camellia chekiangoleosa improved variety breeding system based on function superposition, and the method comprises the following steps: cloning excellent single plants through a high-stem grafting technology, and establishing a specific germplasm resource library; determining three types of phenotypic data of a floral leaf character set, an oil yield character set and an oil quality character set; the method comprises the following steps: presetting six types of application scenes such as an edible oil production raw material forest and a specific natural compound production raw material forest, and constructing a comprehensive evaluation model by adopting a hierarchical weight distribution method: distributing first-level weights for three types of character sets, and then distributing second-level weights for characters in subsets; standardizing the character of the floral leaf by adopting a binary comparison method, and standardizing the character of the oil yield and the character of the oil quality by adopting a centesimal system; and screening a target improved variety according to a comparison result of the comprehensive score of the to-be-evaluated variety and the average score of the existing improved variety. By means of the method, superposition breeding of ornamental, oil production and oil quality functions is achieved, and the adaptability of improved varieties and industrial scenes is improved.

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicine for preventing and treating atherosclerosis combined with hyperhomocysteinemia and / or hyperlipidemia. The traditional Chinese medicine composition comprises the following components: ginseng, lucid ganoderma, safflower, musk, calculus bovis, bear gall, pearl, venenum bufonis, radix aconiti carmichaeli and borneol. According to the traditional Chinese medicine composition disclosed by the invention, through reasonable compatibility of all the components, at least one of indexes such as aorta plaque area, vasomotor inner diameter difference, intima-media thickness, blood fat level, homocysteine content and the like in atherosclerosis combined with hyperhomocysteinemia and / or hyperlipidemia can be effectively improved; the symptoms of atherosclerosis combined with hyperhomocysteinemia and / or hyperlipidemia are relieved from multiple aspects, and the progress of the disease course is blocked. The traditional Chinese medicine composition is controllable in quality, convenient for standardized production, safe and reliable in prescription and free of toxic and side effects on human bodies.

The invention relates to the technical field of digital twinborn and agricultural information, and discloses a digital twinborn growth simulation and optimization method for safflower seedling breeding, and the method comprises the following steps: constructing individual digital twinborn bodies fusing genotypes, phenotypes and multi-dimensional environmental perception data; performing hybrid modeling in combination with the mechanism model and a depth time sequence neural network, and correcting growth prediction deviation in real time; and based on multi-objective optimization of biomass, medicinal component content and water efficiency, generating a precise cultivation regulation and control instruction. The system comprises a data acquisition unit, a twin construction unit, an environment fusion unit, a hybrid modeling unit, a visualization unit, an optimization decision unit and an instruction execution unit. According to the method, through closed-loop intelligent regulation and control, the yield, quality and resource utilization efficiency of safflower seedling breeding are remarkably improved.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of anti-hepatoma medicines. The traditional Chinese medicine composition comprises red ginseng, ox horn tip, musk, borneol, safflower, bezoar, radix aconiti lateralis praeparata slice, venenum bufonis, pseudo-ginseng, benzoin and pearl. Experimental results show that the traditional Chinese medicine composition can induce apoptosis and necrosis of liver cancer cells and inhibit proliferation of the liver cancer cells; and liver cancer cells are retarded to be in a G1 cell cycle. Therefore, the invention provides a new therapeutic drug for clinical treatment of liver cancer, and the raw materials are natural medicinal materials, have wide sources and have good application prospects.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a blood-activating and detoxifying traditional Chinese medicine formula and a nanogel preparation method thereof. The invention provides a traditional Chinese medicine formula for promoting blood circulation and removing toxicity and a nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity to solve the problem that in the prior art, a good external application traditional Chinese medicine formula capable of being used for skin with damp-heat toxin accumulation does not exist, and the traditional Chinese medicine formula for promoting blood circulation and removing toxicity and the nanogel preparation method of the traditional Chinese medicine formula for promoting blood circulation and removing toxicity comprise monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs, the ministerial drugs comprise honeysuckle flowers, fructus forsythiae, paris polyphylla, cortex dictamni and fructus kochiae, the adjuvant drugs comprise radix salviae miltiorrhizae, flos carthami, garden balsam stems and centella asiatica, and the conductant drug comprises bletilla striata. The traditional Chinese medicine composition provided by the invention is precise and appropriate in compatibility and distinct in gradation, and can form a synergistic treatment chain of clearing heat, detoxifying, activating blood and promoting tissue regeneration, so that the wound healing speed of the skin surface is accelerated, and the traditional Chinese medicine composition has a relatively good curative effect on damp-heat and toxic stasis type skin diseases.

The invention provides a composition with an analgesic effect. The composition is an external medicament prepared from the following raw material medicines in parts by weight: 10-16 parts of teasel root, 2-4 parts of dragon's blood, 8-12 parts of safflower, 9-15 parts of myrrh, 9-15 parts of ligusticum wallichii, 9-15 parts of notopterygium root, 8-12 parts of clove, 8-12 parts of beautiful sweetgum fruit, 0.6-1 part of pepper, 2-4 parts of lucid ganoderma, 0.4-0.8 part of capsaicin and 0.08-0.12 part of musk. The invention also provides a preparation method and application of the composition. The traditional Chinese medicine composition is precise and appropriate in raw material formula compatibility, is used for treating pain, is clear and controllable in medicine effect, and provides a new choice for clinic.

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine compound for reducing recurrence of chronic nasosinusitis and a preparation method of the traditional Chinese medicine compound, and the traditional Chinese medicine compound is prepared from, by weight, 14-16 g of radix astragali, 8-10 g of fried radix scutellariae, 8-10 g of radix angelicae, 5-7 g of fructus xanthii, 5-7 g of flos magnoliae, 14-16 g of flos chrysanthemi indici, 11-13 g of fried fructus gardeniae, 5-7 g of radix angelicae sinensis, 5-7 g of flos carthami and 8-10 g of herba menthae. The traditional Chinese medicine composition can significantly improve clinical symptoms of patients with chronic nasosinusitis and reduce the recurrence rate, is good in safety, and does not find abnormal symptoms in clinical use. Meanwhile, the preparation process is simple to operate and suitable for industrial mass production. The raw medicinal materials selected by the traditional Chinese medicine composition are synergistic and complementary in nature and effect, inherit the holism concept of traditional Chinese medicine, emphasize that the traditional Chinese medicine composition emphasizes whole body treatment, plays a role together and inhibits infiltration of inflammatory cells while treating local parts, has small toxic and side effects, fully plays the advantages of treating chronic sinusitis and preventing relapse of the traditional Chinese medicine, relieves the pain of patients, and has a remarkable curative effect on treating chronic sinusitis. The life quality of patients is improved and the recurrence probability is reduced.

The invention discloses glycosyltransferase in safflower and a related biological material and application thereof. The invention firstly discloses any one of the following proteins: A1) a protein consisting of an amino acid sequence as shown in a sequence 2; a2) a fusion protein obtained by connecting the N end or / and C end of the protein as shown in the sequence 2 with a protein tag. The invention further discloses the protein related biological material and application thereof. The HSYA biosynthesis key glycosyl transferase gene UGT708U5 is obtained from safflower for the first time, it is proved that the protein UGT708U5 coded by the gene can catalyze phloretin to form HSYA precursor compounds, namely phloretin-mono-C-glucoside and phloretin-di-C-glucoside, and the gene plays an important role in biosynthesis and heterologous production of HSYA; the method has important theoretical and practical significance for regulating and producing the quinonechalcone C-glycoside compounds of plants and cultivating high-quality safflower carthamus.

The invention provides a traditional Chinese medicine gel emplastrum for treating gouty arthritis and a preparation method thereof, the traditional Chinese medicine gel emplastrum for treating gouty arthritis at least comprises a gel layer loaded with a traditional Chinese medicine extract, the traditional Chinese medicine extract comprises the following raw materials: semen coicis, cortex phellodendri, radix clematidis, kadsura coccinea, rhizoma atractylodis, rhizoma dioscoreae hypoglaucae, red psychotria leaf, alangium platanifolium, kadsura pepper stem, radix aconiti, radix aconiti agrestis, semen strychni, frankincense, myrrh, angelica sinensis, safflower carthamus, radix cyathulae, radix paeoniae rubra, rhizoma smilacis glabrae, lycopodium clavatum, radices hemerocallis, weeping willow twig, evodia lepta, swamp mahogany, radix sophorae flavescentis, herba andrographitis, Chinese lobelia, coptis chinensis, edible tulip, cassia twig, pepper and borneol; a matrix of the gel layer is prepared from the following raw materials in parts by weight: silk fibroin, polyvinyl pyrrolidone, azide-polyethylene glycol-carboxylic acid, 1-ethynyl cyclopropyl carboxylic acid, 2, 5-dicarboxylic acid-3, 4-ethylenedioxythiophene and glycerol. The traditional Chinese medicine gel emplastrum disclosed by the invention can achieve a good treatment effect through percutaneous absorption.

The invention discloses flos carthami based on synergistic interaction of gradient steaming and Baijiu segmented medicine moistening and a processing method of the flos carthami, and belongs to the technical field of traditional Chinese medicine processing. The method comprises the following steps: primary moistening: mixing safflower and white spirit according to a mass ratio of 10: (2.0-2.5), and carrying out closed moistening at room temperature for 1.5-3.0 hours; re-moistening: supplementing the white spirit until the mass ratio of the safflower to the white spirit is 10: (3-4), and pressurizing and moistening for 0.5-2.0 hours at the temperature of 30-40 DEG C and the pressure of 0.11-0.14 Mpa; performing primary steaming: performing normal-pressure steaming at 75-85 DEG C for 0.5-1.5 h; main steaming is conducted, specifically, steaming is conducted for 2-4 h at the temperature of 95-105 DEG C and under the pressure of 0.02-0.04 Mpa; performing final steaming: performing steaming for 0.3-1.0 h at the temperature of 85-95 DEG C and the pressure of 0.03-0.05 Mpa; recovering the steamed volatile oil, and adding the volatile oil into a finished product according to 0.3-0.5% of the weight of the safflower; and drying in a dark and low-temperature manner.

The invention discloses an HPLC (High Performance Liquid Chromatography) specific chromatogram of Xiaoyin capsules / granules as well as construction and application thereof, and belongs to the technical field of quality control of traditional Chinese medicine preparations. According to the method, high performance liquid chromatography and mass spectrometry are combined, and chlorogenic acid, gallic acid, hydroxysafflor yellow A, albiflorin, rutin, isovitexin, 5-O-methylvisamidoside, 3, 5-di-O-caffeoylquinic acid, 4, 5-di-O-caffeoylquinic acid, benzoic acid, quercetin, paeonol, kushenone and obakunone are taken as reference substances; the characteristic chromatogram is successfully constructed for detecting different batches of Xiaoyin capsules / particles. The method is simple and easy to implement, high in precision, good in reproducibility, accurate and reliable, at least 14 components can be confirmed at a time under the same chromatographic condition, the detection efficiency is greatly improved, and time and cost are saved; quality monitoring can be accurately, rapidly and simultaneously performed on a plurality of characteristic components of the Xiaoyin capsules / particles, and a powerful guarantee is provided for controlling the quality and ensuring the clinical curative effect of the Xiaoyin capsules / particles.

The invention discloses a traditional Chinese medicine composition for preventing and treating premature ovarian failure and application thereof. Belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises gordon euryale seed, agilawood, sandalwood, processed rhizoma pinelliae, rheum officinale, amomum cardamomum, alpinia katsumadai, processed rhizoma arisaematis, processed radix aconiti, asarum, fructus aurantii and fructus piperis longi. The composition follows the compatibility principle of monarch, minister, assistant and guide in traditional Chinese medicine, belongs to a composite traditional Chinese medicine preparation, and needs to regulate the reproductive endocrine function through the synergistic effect of multiple medicinal materials. The traditional Chinese medicine focuses on phlegm-dampness stasis and kidney-yang deficiency type infertility and premature ovarian failure. The prior art purely focuses on tonifying the kidney (such as prepared rehmannia root and dogwood) or activating blood (such as peach kernel and safflower), while the formula disclosed by the invention integrates multiple effects of resolving dampness, warming and dredging, removing stasis, promoting the circulation of qi and the like, and is stronger in pertinence.

The present invention discloses Jiangzhuo Quyu Granules for treating hyperlipidemia, which is a preparation made from raw medicinal materials in the following weight ratios: 20 - 30 parts of ginseng, 15 - 25 parts of atractylodes macrocephala, 20 - 30 parts of poria cocos, 18 - 22 parts of cuscuta chinensis, 12 - 18 parts of eucommia ulmoides, 10 - 20 parts of dipsacus asperoides, 20 - 30 parts of wolfberry fruit, 15 - 25 parts of safflower, 20 - 30 parts of motherwort, 10 - 20 parts of notoginseng, 10 - 20 parts of cistanche deserticola, 20 - 30 parts of cinnamon, 15 - 25 parts of epimedium, 12 - 18 parts of pinellia ternata, 20 - 30 parts of platycodon grandiflorum, 10 - 20 parts of fritillaria cirrhosa, 20 - 30 parts of sterculia lychnophora, 20 - 30 parts of peucedanum praeruptorum, 15 - 25 parts of mulberry bark, 20 - 30 parts of immature bitter orange, 15 - 25 parts of magnolia officinalis, and also discloses its preparation method and use in the preparation of drugs for treating hyperlipidemia, and the hyperlipidemia is of the phlegm-turbidity obstruction syndrome type.

This invention relates to the field of traditional Chinese medicine (TCM) technology, specifically to a nasal massage oil, its preparation method, and its application. The nasal massage oil is prepared from the following TCM raw materials in the indicated weight proportions: 4-6 parts of roasted Xanthium sibiricum, 1.5-3.5 parts of Magnolia biondii, 1.5-3.5 parts of Angelica dahurica, 0.3-0.7 parts of Mentha haplocalyx, 0.8-1.2 parts of Borneol, 2-4 parts of Sinapis alba, 1-3 parts of Artemisia argyi, 1-3 parts of Carthamus tinctorius, 1-3 parts of Cinnamomum cassia, 2-4 parts of Pueraria lobata, and 80-120 parts of sesame oil as a base. This application, through scientific formulation and reasonable proportioning, effectively solves the technical problem that existing nasal massage mediums only provide lubrication and lack targeted TCM conditioning effects, failing to achieve synergistic effects between massage and medication. It achieves an integrated effect of "massage lubrication - drug penetration - TCM conditioning."

The invention provides a traditional Chinese medicine for treating protrusion of lumbar intervertebral disc, and relates to the technical field of traditional Chinese medicines. Aiming at the core pathogenesis of qi stagnation and blood stasis, deficiency of liver and kidney and cold-dampness arthralgia of the lumbar intervertebral disc protrusion, a synergistic compatibility concept of promoting blood circulation to remove blood stasis, tonifying liver and kidney, dispelling cold-dampness and activating meridians to stop pain is adopted. The traditional Chinese medicine is prepared from 12 traditional Chinese medicines such as ligusticum wallichii, safflower, eucommia ulmoides and radix achyranthis bidentatae through an optimized process of crushing, extracting, concentrating and forming, and the dosage form comprises tablets, capsules or oral liquid. The core innovation lies in accurate matching of the formula, multi-target synergistic effect is achieved, and the problems that traditional Chinese medicine is slow in curative effect and poor in pertinence are solved. Clinical verifications show that the traditional Chinese medicine can relieve lumbar pain within 7 days and improve symptoms such as numbness of lower limbs and limited movement within 1-2 treatment courses, has the total effective rate of greater than or equal to 92%, is safe, has no obvious toxic or side effect, is suitable for patients with different types of lumbar disc herniation, and is convenient to take and high in cost performance.

The invention relates to the technical field of medicinal liquor preparation, in particular to medicinal liquor capable of activating blood, regulating internal organs, tonifying kidney and treating osteoarthrosis. The invention discloses medicinal liquor with functions of activating blood, regulating internal organs, tonifying kidney and treating osteoarthropathy. The medicinal liquor is prepared by mixing the following raw materials in parts by weight: 1835 to 2400 parts of safflower, 1300 to 2600 parts of ligusticum wallichii, 1600 to 2200 parts of caulis spatholobi, 2300 to 2800 parts of salvia miltiorrhiza, 2100 to 3250 parts of adenophora stricta, 1100 to 2000 parts of eucommia ulmoides, 1350 to 2000 parts of cornu cervi pantotrichum, 1200 to 2100 parts of poria cocos, 1700 to 2600 parts of lucid ganoderma, 1500 to 2000 parts of starfish and 1250 to 1900 parts of radix angelicae pubescentis. The traditional Chinese medicine formula has the beneficial effects of being scientifically prepared, balanced in nutrition and appropriate in proportion, promoting blood circulation to remove blood stasis, enriching yin and nourishing kidney, dispelling wind and eliminating dampness, activating collaterals and relieving pain, restoring consciousness and strengthening brain, and treating carbuncle poison, cervical vertebra hyperosteogeny, lumbar disc herniation, spinal canal stenosis, knee joint hyperosteogeny, knee joint swelling and pain and the like.

The invention provides a method for carrying out genetic transformation on safflower carthamus in a tissue-free culture mode, which comprises the following steps: cutting off radicles of newly germinated safflower carthamus seedlings, taking the radicles as explants, infecting the explants in a mode of smearing agrobacterium rhizogenes containing a target gene on wounds, burying the infected explants in soil for culturing, and carrying out tissue-free culture on the explants to obtain the safflower carthamus. The transgenic safflower hairy roots are obtained. The method fills the blank of a safflower non-tissue culture genetic transformation system, the whole transformation period is 20-30 days, and the method can be applied to rapid and efficient genetic transformation, gene editing and variety improvement of safflower.

This invention discloses a muscle-relaxing and meridian-clearing health powder and its preparation and application methods, belonging to the technical field of traditional Chinese medicine external health care products. The health powder is composed of fifteen raw medicinal materials: safflower, angelica, asarum, kudzu root, red peony root, scutellaria, dragon's blood, saposhnikovia root, frankincense, myrrh, cinnamon twig, mugwort leaf, coptis root, *Lycopodium clavatum*, and *Clematis armandii*. These materials are dried, pulverized to 80-120 mesh, and then evenly mixed. This invention, through a unique formulation design, integrates multiple effects such as promoting blood circulation and removing blood stasis, dispelling wind and cold, relieving muscle tension and clearing meridians, and clearing heat and drying dampness. Combined with a refined pulverization process, it significantly improves the dissolution rate and transdermal absorption efficiency of the drugs. During use, a hot compress applied via steam allows the medicinal properties to directly reach the affected area, effectively relieving pain and discomfort in the neck, shoulders, waist, legs, and joints. This invention's product has a scientific formulation, advanced technology, is convenient to use, and highly safe, possessing broad market application prospects.

The invention discloses an esophageal cancer targeting nano-tablet based on a traditional Chinese medicine composition and a preparation method of the esophageal cancer targeting nano-tablet. The targeted nano tablet is prepared from the following refined extracts: a rhizoma paridis total saponin extract, a pseudobulbus cremastrae seu pleiones colchicine derivative extract, a panax notoginseng total saponin extract, a carthamin yellow extract, a thunberg fritillary bulb total alkaloid extract, frankincense-myrrh compound volatile oil, a resin extract and an astragaloside IV extract. The nano-carrier comprises a nano-carrier, a seaweed-laminarin composite extract, a processed rhizoma pinelliae total alkaloid extract and costus root volatile oil, and the costus root volatile oil serves as one of targeting ligands to be used for modifying the nano-carrier. The targeting property is strong: the dual-targeting ligand (costunolide-TOPK affinity peptide) on the surface of the nano-carrier can actively recognize and combine with a specific receptor of esophageal cancer cells, and meanwhile, due to the size (about 100-200 nanometers) of the carrier, the carrier is easy to enrich in tumor tissues through enhanced permeation and retention (EPR) effect, so that the modernization upgrading of the idea of'channel guiding medicine 'is realized.

The present invention provides a traditional Chinese medicine composition, a preparation method thereof and an application, belonging to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition of the present invention comprises raw materials in the following parts by weight: 3-5 parts of Atractylodes lancea, 3-5 parts of Gentiana macrophylla, 7-9 parts of Ligusticum chuanxiong, 10-14 parts of Carthamus tinctorius, 3-5 parts of Notopterygium incisum, 10-14 parts of Angelica sinensis, 10-14 parts of Cyathula officinalis, 3-5 parts of Cyperus rotundus, and 7-9 parts of Glycyrrhiza uralensis. Based on the situation of stasis in patients with arthralgia syndrome, the present invention performs drug compatibility for those with stasis in arthralgia syndrome, and has a significant therapeutic effect on arthralgia syndrome caused by wind, cold, dampness and stasis.

The invention discloses a traditional Chinese medicine flexible liposome compound for treating alopecia as well as a preparation method and application thereof, and belongs to the technical field of Chinese herbal medicines. The composition comprises a traditional Chinese medicine composition and a flexible liposome wrapping an extract prepared from the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following components in parts by weight: 0.1 to 15 parts of radix polygoni multiflori preparata, 0.1 to 10 parts of flos carthami, 0.1 to 15 parts of folium mori, 0.1 to 15 parts of semen sesami nigrum, 0.1 to 10 parts of herba ecliptae, 0.1 to 10 parts of cacumen biotae and 0.1 to 5 parts of radix sophorae flavescentis. Through the synergistic effect of the traditional Chinese medicine components, the composition can play an extremely remarkable effect on hair growth. Meanwhile, the flexible lipidosome prepared from soybean lecithin, cholesterol and a flexible agent can enhance permeation and absorption of functional components, and the hair growing and hair loss preventing effects of the flexible lipidosome are further improved.