75 results about "Safflower yellow" patented technology

The invention discloses a quality detection method related to a Ruyi Zhenbao preparation. The method comprises a qualitative identification method for banksia rose, dalbergia wood, clove, long pepper, safflower, cassia seeds and gallic acid and a content determination method for safflower yellow A in safflower, piperine in long pepper and cholic acid in bezoar. According to tests and research, when a sample is tested by using the identification method in the quality detection method provided in the invention, spots appear at positions on a chromatogram of the tested sample corresponding to positions where spots with same colors appear on a chromatogram of a contrast sample; negative controls produce no interference; the identification method is simple, feasible and remarkably characteristic. When the content determination method in the invention is used for determining the content of hydroxysafflower yellow A, piperine and cholic acid in the Ruyi Zhenbao preparation, it is proved thata good linear relation is obtained, that accuracy of tests of a recovery rate is high, that very good repeatability and stability are achieved and that accurate and strict control of quality of the the Ruyi Zhenbao preparation can be realized.

The invention belongs to the field of natural medicine extraction, and particularly relates to a separation and purification method for safflower yellow, which is used for obtaining solid matters with total safflower yellow content more than 96%. The separation and purification method for safflower yellow utilizes safflowers as raw materials and utilizes water as dissolve for extracting, and extractives are separated and purified by means of LX-68 type macro-porous absorption resin, so that the total safflower yellow content and hydroxy safflower yellow A content contained in the solid matters are more than 96% and more than 16% respectively, and the separation and purification method for safflower yellow is simple and convenient in operation, and low in reagent consumption and pollution.

A sustained-release nepafenac eye-drops preparation includes nepafenac, safflower yellow, polycarbophil, polysorbate and accessories in the weight ratio of 1:1:0.5-2:0.05-0.2:0.102-1.5 or 0.502-5.5, and further comprises water for injection, wherein the mass fraction of nepafenac is 0.1%-1%. The sustained-release nepafenac eye-drops preparation can also include nepafenac, safflower yellow, polycarbophil, polysorbate, anhydrous lanolin, liquid paraffin and yellow vaseline in the weight ratio of 1:1:0.5-2:0.05-0.2:8-15:2-10:75-95. The invention has the advantages of good intraocular penetration, high intraocular bioavailability, strong penetration, strong targeting effect, and little toxic and side effect.

The invention relates to a preparation method of safflower yellow B and the application thereof. The safflower is extracted after immersion and diacolation in polar solvent and is then treated with refinement and separation by a method of combining chromatographic column and alcohol precipitation so as to obtain the safflower yellow B of the invention. The preparation method for the safflower yellow B of the invention can improve the yield of the safflower yellow B and is applicable to commercial production. In addition, the safflower yellow B obtained after separation can be used for preventing and curing cardiovascular and cerebrovascular diseases.

The invention discloses a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Through a stability test, a pharmacodynamic screening and verification test and a toxicological test, the composition is determined to comprise the following components of (by weight parts): salvianolic acid A 1-10 and safflower yellow 1-30, preferably salvianolic acid A 1-5 and safflower yellow 20-30, or salvianolic acid A 6-10 and safflower yellow 1-19. The invention also discloses a detection method and an application of the pharmaceutical composition and the preparations thereof. The pharmacological experiment shows that the pharmaceutical composition has good pharmacological effect.

A method for extracting and purifying dehydrated safflower yellow B in safflower belongs to the technical field of plant extracting methods and comprises the following steps: 1), extracting safflower water extract by means of warm immersion; 2), pretreating macroporous adsorbent resin; 3), adsorbing with the macroporous resin; 4), eluting with the macroporous resin. The method of the invention has high extracting rate, the content of purified dehydrated safflower yellow B is 3-4 times as high as the not purified content, and basis is provided for the efficient extraction and purification of dehydrated safflower yellow B in safflower.

The invention relates to a dyeing method of Chinese cypress base paper, belonging to the technical field of tobaccos. The method comprises the following specific steps: an in-pulp dyeing method: preparing any natural plant pigment finished product of roselle calyx pigment, red cabbage pigment, black currant pigment, chrysanthema xanthin and safflower yellow into a water solution of which the concentration is 5%, uniformly stirring, then filtering with a sieve of 200-250 meshes, adding the natural plant pigment of which the mass is 3-5% relative to the oven-dried pulp into the Chinese cypress base paper pulp, and simultaneously adding thickening agent of which the mass is 10-20% relative to the oven-dried pulp into the Chinese cypress base paper pulp for dyeing; and a dip dyeing method: mixing cleaned mulberry (the fruit of a mulberry tree) or gardenia fruit (the fruit of a gardenia tree) and water according to the solid-to-liquid ratio of 1:8, boiling for 2-3 hours, then filtering with a sieve of 200-250 meshes, diluting the filtrate with water up to 5 times of the filtrate, adding arabogalactan which is 1-2% relative to the diluted filtrate, and then dipping the white Chinese cypress base paper for 30 seconds. The invention has the advantages of low cost and high safety of the Chinese cypress base paper.

The invention aims at providing a traditional Chinese medicine plant pigment and plant oil compound lipstick. The traditional Chinese medicine plant pigment and plant oil compound lipstick is preparedfrom the following components: 5 to 10g of a safflower yellow pigment, 5 to 10g of a mulberry red pigment, 3 to 10g of tomato lycopene, 5 to 15g of bee wax, 10 to 20ml of olive oil, 5 to 15ml of sweet almond oil, 10 to 20ml of grape seed oil, 1 to 5ml of limnanthes alba seed oil, 0.05 to 1ml of rose essential oil, 0.05 to 1ml of bergamot essential oil, 0.01 to 0.05ml of rhizoma nardostachyos essential oil, 0.01 to 0.05ml of rosemary essential oil and 1 to 5ml of oil-soluble vitamin E. The traditional Chinese medicine plant pigment and plant oil compound lipstick has the advantages of abundantraw materials and simple preparation method, can be used for protecting lip skin and reducing oxidization damages on the lip skin and can keep good moisturizing degree and absorption degree; and thetraditional Chinese medicine plant pigment and plant oil compound lipstick has a bright color and a good utilization effect, is a great innovation of the lipstick and has remarkable economic benefitsand social benefits.

A safflower dripping pill is a dripping pill which is prepared from a medicine extract prepared by taking traditional Chinese medicine safflower as a raw material and a medicinal carrier used as a substrate together and has the content of hydroxy safflower yellow A not lower than 25mg / g. The preparation method of the safflower dripping pill comprises the following steps: carrying out concentration and ethanol deposition on a safflower water extract, purifying by a macroporous adsorptive resin column after recovering ethanol, collecting eluent, concentrating, drying, obtaining a safflower medicine extract, mixing with substrate polyethylene glycol 4000, dripping into a coolant and preparing the dripping pill. The safflower dripping pill has an oral medicament form, has convenient administration, increases the administration safety of a patient, can be applied to the convalescent treatment of the patient with the cardiovascular disease after leaving the hospital, and meets different requirements of the patient for medicines at different periods. The invention quickens the dissolution and absorption of the medicine, enhances the bioavailability of the medicine, has high stability, ensures the quality of the medicine, is not easy to generate anaphylaxis in comparison with injection and has small side effect and safe and convenient use.

The invention provides a facial mask with an after-sun repair function and a preparation method of the facial mask. The facial mask with the after-sun repair function is prepared from the following components in percentage by weight: 0.5-1.5 % of safflower yellow, 0.1-0.8 % of hydrolyzed silk, 0.5-5 % of mycose, 0.5-2 % of allantoin, 2.9-15.5 % of a humectant, 1-5 % of a thickener, 0.5-1 % of a stabilizer, 0.5-2.5 % of an emulsifier, and the balance of water. The facial mask provided by the invention can effectively inhibit after-sun melanin formation and whiten the skin, also can improve the skin microcirculation and promote the after-sun skin repair.

A Chinese medicine for treating cardiovascular and cerebrovascular diseases, such as cerebral thrombosis, coronary heart disease, angina pectoris, vasculitis, myocardiac infarction and hyperlipemia, is prepared from safflower and hawthorn leaf, or their extracts (safflower yellow and hawthorn leaf flavone).

The invention discloses a quality detecting method for traditional Chinese medicine Qianliening preparation. In the method, the quality standard of the existing traditional Chinese medicine Qianliening preparation is improved, and thin layer chromatography of myrobalan, safflower, pennycress seeds and radix et rhizoma rubies is added. According to the invention, the content of gallic acid and the content of hydroxyl safflower yellow A are simultaneously measured under the same chromatographic condition by adopting high performance liquid chromatography through varying the detection wave length of an ultraviolet detector. The thin layer chromatography has obvious characteristic spots and strong specificity. The high performance liquid chromatography is simple and practicable, has better accuracy and precision and can effectively ensure the preparation quality.

The invention discloses a new usage of safflower yellow prepared through the extraction from traditional Chinese medicine safflowers during the preparation of a medicine for treating and / or preventing lung injury, in particular the invention discloses a new usage in the preparation of a medicine for treating and / or preventing acute lung injury cased by lung ischemia reperfusion injury, pulmonary embolism or inflammatory reaction which is the result of the action of inflammatory agent onto the lung. The invention also discloses a medicine made from the safflower yellow and a preparation of the medicine thereof.

The invention discloses a brewing method of a safflower yellow rice wine. The wine is prepared from raw materials of: yellow rice, rice, corn flour, corn maltose, dried orange peel, safflower and rice wine yeast. The brewing method comprises steps that: the materials are prepared; yellow rice and rice are washed and soaked; yellow rice and rice are mixed with corn flour, and the mixture is steamed; the mixture is cooled, rice wine yeast is mixed with the mixture, and the mixture is fermented; when fermentation is finished, cool water is added to the mixture, and the mixture is stirred and filtered; corn maltose is added to the filtrate, and secondary fermentation is carried out; when secondary fermentation is finished, dried orange peel and safflower are added to the mixture, and post-curing and aging are carried out; and the wine liquid is clarified, filled, sealed, and stored. With the method, safflower yellow rice wine which is hard to get deteriorated is produced. The wine can be supplied all year long, and can be stored for a long time without getting deteriorated.

The present invention relates to an extraction method and an application of a safflower yellow pigment. According to the present invention, safflower is subjected to water crude extraction, separation, filtration and ethanol precipitation, and the obtained substance is added to a polyamide column, and then is subjected to elution of impurities through acid washing, alkali solution elution and concentration drying to obtain the safflower yellow pigment, wherein the obtained safflower yellow pigment and an acceptable injection adjuvant are mixed and prepared into the injection according to the conventional injection preparation process, during polyamide column elution, an acid elution liquid is adopted to elute impurities, an alkali elution liquid is adopted to elute the safflower yellow pigment, is preferably an ethanol solution of ammonia, and the pH value of the ethanol solution is 9.50-10.50. The safflower yellow pigment prepared through the method has high safflower yellow pigment content.

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating cardiac and cerebral vascular diseases and its preparation process. The medicine composition is prepared with safflower 500-10000 weight portions and rhodiola root 250-3000 weight portions; or prepared with safflower yellow pigment 50 weight portions and rhodiola root extract. The medicine composition may be prepared into different pharmaceutically acceptable forms, preferably injection and orally taken preparation. The medicine composition is used in treating coronary heart disease, angina pecoris, myocardial infaction, ischemic cerebral vascular diseases, etc.

The invention aims to provide a sustained release tablet prepared from raw material of safflower yellow and a preparation method thereof. The sustained release tablet is characterized by being a gastric floating sustained release tablet and comprising components in a weight ratio of a medicament raw material to accessories equal to 30-50%:50-70%. The medicament raw material is safflower yellow, and the accessories comprise components in a weight ratio of hydroxypropyl methyl cellulose to carboxymethylcellulose sodium to ethyl cellulose to polyvinyl alcohol to vinylpyrrolidone equal to 35-55:4-8:1-3:3-5:1-3. According to the preparation technology, a secondary granulation and an internal and external accessory adding method are employed to mix the medicament raw material and the accessories; and 95% ethanol liquid of polyvinylpyrrolidone and 95% ethanol are used as adhesives respectively.

The invention relates to a preparation method for extracting hydroxysafflower yellow A from traditional Chinese medicine safflower. At present, there are only a few reports about safflower yellow, but no report on the preparation method and application of hydroxysafflower yellow A has been found. The method for extracting hydroxysafflower yellow A provided by the invention is purified by column chromatography with different fillers. The process is simple, the cost is low, and there is no environmental pollution. It is suitable for industrialization and large-scale production. The content of the extracted hydroxysafflower yellow A Above 90%, the yield is above 1%. The medicine made from hydroxysafflower yellow A has remarkable curative effect on the prevention and treatment of ischemic cerebrovascular diseases: cerebral ischemia, cerebral infarction, cerebral thrombosis and reducing blood viscosity.

The present invention provides a carthamus yellow dripping pills preparation. It contains carthamus yellow and at least one matrix selected from polyethylene glycol, gelatin, stearic acid, polyvinylpyrrolidone and glyceryl monostearate. The weight ratio of the carthamus yellow and the described matrix is 1-10:20-40. Said carthamus yellow dripping pills can be used for preventing and curing angiocardiopathy and cerebrovascular disease.

The invention relates to a content detection method for the Naoxintong capsule. The Naoxintong capsule comprises 66 parts of astragalus root, 27 parts of red peony root, 27 parts of root of red-rooted salvia, 27 parts of Chinese angelica, 27 parts of Szechuan lovage rhizome, 27 parts of peach kernel, 13 parts of safflower, 13 parts of prepared Frankincense, 13 parts of prepared myrrh, 20 parts of suberect spatholobus stem, 27 parts of twotooth achyranthes root, 20 parts of cassia twig, 27 parts of mulberry twig, 27 parts of earthworm, 13 parts of scorpion, and 27 parts of leech. The main chemical components, namely hydroxy safflower yellow A, paeoniflorin, ferulic acid, salvianolic acid B and ligustilide, in the Naoxintong capsule are simultaneously measured by the UPLC (ultra-performance liquid chromatography) technique. Single chromatographic analysis can be completed in 24 minutes. Chromatographic peaks of the main components are well separate, RSD (relative standard deviation) in both precision and receptiveness is smaller than 2.0%, and the quality of Naoxintong capsule can be controlled comprehensively.

The invention discloses momordica grosvenori drink. Raw materials of the momordica grosvenori drink include: momordica grosvenori, tippy tea, honeysuckle, smilax glabra, wild chrysanthemum flower, folium sennae, peach kernel, coptis chinensis, kudzu vine root, scutellaria baicalensis, dioscorea nipponica makino, radix sophorae tonkinensis, sophora flavescens, sculellaria barbata, apple vinegar, safflower yellow, nisin from streptococcus lactis, stevia sugar, honey, disodium glycyrrhizunate, tripotassium glycyrrhizunate, gingko flavonoid, vitamin B1, vitamin B2, valine, phenylalanine, glutamic acid, an iron element, a zinc element, a selenium element, a manganese element, polypropylene pyrrolidone, carboxymethyl cellulose, agar, potassium polyacrylate, potassium alginate, an American Dupont EEA2112AC phase compatibilizer, a food-grade 9701 antioxidant, guar gum, furfuryl alcohol methyl fumarate, dipotassium guanylate, L-alanine, glycine, dihydrojiasmone, ethyl vanillin, 3-methyl cyclopentadecanone and citronellal. The momordica grosvenori drink disclosed by the invention is full of nutrients, sour, sweet, refreshing and strong in tea fragrance and thus is novel drink.

The invention discloses a method for preparing a safflower extract through a eutectic solvent. The method comprises the steps of adding safflower powder into an aqueous solution of the eutectic solvent, performing ultrasonic extraction for 15-60 minutes at the temperature of 25-75 DEG C under the power of 50-200 W, performing centrifuging, and taking a supernatant to obtain the safflower extract.According to the efficient and green method for preparing the safflower extract through the eutectic solvent, main components in safflower can be simultaneously extracted efficiently, wherein the content of dehydrated safflower yellow B is 45.9% higher than that of an aqueous extract. The solvent dosage in the method is low, wherein extraction of 200 mg of a safflower medicinal material requires 1mL of the extraction solvent; the defects are effectively avoided that the extraction time required by other solvents is low and extracts are likely to go bad; therefore, the method is regarded as anovel extraction method suitable for Chinese medicine and other natural medicine.

The invention provides difficult-deteriorated sesame oil. The difficult-deteriorated sesame oil is prepared from the following ingredients in percentage by weight: 99.1% to 99.8% of sesame oil base oil, 0.014% to 0.018% of myricetin, 0.012% to 0.015% of safflower yellow, 0.056% to 0.065% of vitamin E, 0.033% to 0.037% of pumpkin vine extract and 0.021% to 0.025% of folium cortex eucommiae extract. According to the difficult-deteriorated sesame oil, by addition of natural and healthy oxidation resisting substances and fats and oils, the difficult-deteriorated sesame oil can be preserved for a long time and can achieve a health-care effect.

The invention discloses a mango tea vinegar beverage. The mango tea vinegar beverage is prepared from the following raw materials: mango, Liupu tea, motherwort herb, plantain herb, herba siegesbeckiae, radix bupleuri, salviae miltiorrhizae radix et rhizome, Chinese angelica, semen cassiae, folium apocyni veneti, ramulus uncariaecum uncis, herba taxilli, pineapple vinegar, sodium iodide, potassium hydroxypropyl methylcellulose, sodium polyacrylate, potassium alginate, a DuPont EEA2112AC compatilizer, a food-grade antioxidant BHA (Butylated Hydroxyanisole), carrageenan, safflower yellow, nisin, sucrose, sodium cyclamate, lactose, aspartyl-phenylalanine methyl ester, vitamin B4, vitamin B5, vitamin B6, cystine, proline, tyrosine, serine, a selenium element, a molybdenum element, a manganese element, a chromium element, caproyl-furfuryl fumarate, 51-disodium 5-inosinate, disodium succinate, L-alanine, nerol, myrcene, nonanal and eugenol. The beverage provided by the invention has abundant nutrients, is sour, sweet and tasty and has rich tea aroma; the beverage is a novel mango tea vinegar beverage and can lower blood pressure.

The invention discloses a method for improving functional characteristics of alpha-lactalbumin. The method for improving the functional characteristics of the alpha-lactalbumin comprises the followingsteps: taking alpha-lactalbumin as a raw material; and then, adding safflower yellow at different concentrations, and carrying out mixing by using a high-speed stirrer so as to adjust the pH value ofthe mixture system to 6.5, thereby obtaining an alpha-lactalbumin safflower-yellow complex. Thus, the purpose of improving functional characteristics of the alpha-lactalbumin is achieved. Being adopted, the method for improving the functional characteristics of the alpha-lactalbumin is capable of directly preparing a novel functional alpha-lactalbumin base material with excellent anti-oxidation activity; and thus, application range of the alpha-lactalbumin and the safflower yellow in the field of food industry is broadened.

The invention discloses a novel siraitia grosvenorii tea drink, which comprises the following raw materials: siraitia grosvenorii, Maojian tea, manyleaf paris rhizome, spreading hedyotis herb, herba violae, common andrographis herb, folium isatidis, coptis, root of kudzu vine, scutellaria baicalensis, dioscorea nipponica makino, bushy sophora, radix sophorae flavescentis, barbat skullcap, apple vinegar, safflower yellow, nisin, stevioside, honey, disodium glycyrrhizate, tripotassium glycyrrhizinate, ginkgo biloba extract, vitamin B1, vitamin B2, valine, phenylalanine, glutamic acid, iron element, zinc element, selenium element, manganese element, polypropylene pyrrolidones, carboxymethylcellulose potassium, agar, potassium polyacrylate, potassium alginate, America Dupont EEA2112 AC compatilizer, a food-grade 9701 antioxidant, guar gum, ethyl-furfuryl fumarate, dipotassium 5'-guanylate, L-alanine, glycine, dihydrojasmone, ethyl vanillin, muscone and citronellal. The novel siraitia grosvenorii tea drink has rich nutrients, is sour-sweet and tasty, has rich tea fragrance, and is a novel drink.

The invention discloses a drug combination containing total ginsenoside and safflower yellow and its preparation and application, and its characteristic: it is composed of the extracted and purified total ginsenoside and safflower yellow and made into various preparations having the effect of curing cardiovascular and cerebrovascular diseases and acceptable in pharmacy, such as solid preparation and injection. The pharmacological test result shows that it better overcomes the danger of hemorrhage caused by long-term safflower application and has remarkable effect on the bad reactions caused by safflower application, safer to apply and having better pharmacological effect and higher safety as compared with the similar drugs in the markets.

The invention relates to a danhong oral agent and relative production, wherein said agent comprises Danshen element and carthamus tinctorius yellow colour, while the content of Danshen is 2-4 times of carthamus tinctorius yellow colour; and said agent can be tablet, capsule, drop, etc. And the production comprises that: preparing carthamus tinctorius yellow colour and preparing final agent. Said method can obtain high purity drug, high utilization, and low side effect, to treat coronary disease, angina pectoris, etc.

The invention discloses a dendrobium officinale drink. The drink is prepared from the following raw materials: fresh dendrobium officinale strips, Baimao tea, hawthorn fruit, wrinkled gianthyssop herb, cassia twig, dahurian angelica root, katsumade galangal seed, peppermint, weeping forsythia capsule, white mulberry root-bark, common anemarrhena rhizome, sweet osmanthus flower, malt vinegar, polypropylene pyrrolidone, hydroxypropyl methyl cellulose sodium, potassium polyacrylate, sodium alginate, a DuPont EEA2112AC compatilizer, a food grade antioxidant potassium isoascorbate, xanthan gum, safflower yellow, nisin, maltose, starch sugar, acesulfame potassium, xylitol, vitamin E, vitamin K, vitamin PP, alanine, glutamic acid, asparaginic acid, glycine, iron, selenium, cobalt, zinc, propyl furfuryl fumarate, disodium 51-guanylate, disodium 51-ribonucleotide, glycine, carvone, dihydrojiasmone, isoamyl acetate and 2-hexenol. The drink can be used for effectively treating or alleviating halitosis symptoms.

The invention discloses novel pseudo-ginseng healthcare vinegar tea drink. The drink comprises the following raw materials: pseudo-ginseng, green tea, fructus forsythia, dandelion, herba violae, herba andrographitis, indigo naturalis, apple vinegar, potassium iodide, potassium alginate, agar, modified polyacrylate, a food-grade antioxidant MSK-NE150, xanthan gum, safflower yellow, nisin, a copper element, a manganese element, a cobalt element, alanine, isoleucine, cystine, proline, vitamin E, vitamin B1, vitamin B4, cane sugar, sodium cyclamate, dihydrojasmone, myrcene, nerol, methyl-furfuryl fumarate, L-alanine and disodium succinate. The novel pseudo-ginseng healthcare vinegar tea drink disclosed by the invention is rich in nutrition, sour and sweet and tasty, thick in tea fragrance, and is a novel traditional Chinese medicine pseudo-ginseng healthcare vinegar tea drink; and the novel pseudo-ginseng healthcare vinegar tea drink disclosed by the invention has the effects of clearing heat and removing toxin and has a remarkable function in treating symptoms of wind-induced heat.