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Preparation method of sydroxy carthamin a

A technology of hydroxysafflower and yellow pigment, which is applied to the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of the preparation method and application of hydroxysafflower yellow A that have not yet been found, and achieve low cost, The effect of simple process

Inactive Publication Date: 2006-11-15
YOUCARE PHARMA GROUP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are only a small amount of reports about safflower yellow, but no report on hydroxysafflower yellow A and its preparation method and application has been found.

Method used

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  • Preparation method of sydroxy carthamin a
  • Preparation method of sydroxy carthamin a
  • Preparation method of sydroxy carthamin a

Examples

Experimental program
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Effect test

Embodiment 1

[0035] Example 1: Preparation of hydroxysafflower yellow A by polyamide purification method

[0036] (1) Extraction: Weigh 20 kg of Chinese herbal medicine safflower, add 600 kg of water, and slowly stir and leach for 24 hours at 100°C, then filter, and then repeat the extraction of the filter residue twice according to the above conditions, then filter, combine the filtrate, and cool to room temperature to obtain extract A.

[0037] (2), separation: take the extract A, put it on a macroporous resin column with a column bed volume of 200L, and use deionized water at a rate of 10mL / cm 2 The flow rate of .min was eluted, and the collected eluents were combined and concentrated under reduced pressure at 100°C to a specific gravity of 1.8 to obtain concentrated solution B.

[0038] (3), pure precipitation: take the concentrated solution B, add methanol under continuous stirring to make the alcohol content reach 90%, at this time, an orange-yellow precipitate is separated out, sta...

Embodiment 2

[0042] Example 2 is the preparation of hydroxy safflower yellow A by the polyamide purification method, Example 3 is the preparation of hydroxy safflower yellow A by the macroporous resin purification method, and examples 4 and 5 are the preparation of hydroxy safflower yellow A by the silica gel purification method, Examples 6, 7, 8, 9, and 10 are for the preparation of hydroxysafflower yellow A by Sephadex gel purification. Drop into safflower drug dosage and be 20kg, concrete steps are with embodiment 1. The process conditions of each step are shown in the attached table. In the table, column packing A represents macroporous resin, B represents polyamide, C represents silica gel, D represents dextran gel; A represents methanol, B represents ethanol, and C represents acetone.

Embodiment 11

[0043] Example 11: Hydroxysafflower yellow A freeze-dried powder injection.

[0044] Hydroxysafflower Yellow A 25g

[0045] Mannitol 25g

[0046] Water for injection 400g

[0047] Weigh the dry powder of hydroxysafflower yellow A and mannitol respectively, add water for injection to dissolve and add water for injection to the full amount, stir well, filter aseptically, divide the filtrate into vials, 0.4mL per bottle, vacuum freeze-dry , press the stopper, seal the aluminum cap, and make 955 bottles of hydroxysafflower yellow A freeze-dried powder injection.

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Abstract

The invention relates to a preparation method for extracting hydroxysafflower yellow A from traditional Chinese medicine safflower. At present, there are only a few reports about safflower yellow, but no report on the preparation method and application of hydroxysafflower yellow A has been found. The method for extracting hydroxysafflower yellow A provided by the invention is purified by column chromatography with different fillers. The process is simple, the cost is low, and there is no environmental pollution. It is suitable for industrialization and large-scale production. The content of the extracted hydroxysafflower yellow A Above 90%, the yield is above 1%. The medicine made from hydroxysafflower yellow A has remarkable curative effect on the prevention and treatment of ischemic cerebrovascular diseases: cerebral ischemia, cerebral infarction, cerebral thrombosis and reducing blood viscosity.

Description

technical field [0001] The invention relates to a method for preparing hydroxysafflower yellow A from traditional Chinese medicine safflower. Background technique [0002] The traditional Chinese medicine safflower (the dried flower of Carthamus tinctorius L. in the genus Carthamus tinctorius L. of Compositae) has remarkable functions such as promoting blood circulation and removing blood stasis, stimulating menstruation and relieving pain. The extraction of active ingredients in safflower has attracted more and more attention from relevant people. In recent years, studies have confirmed that the active ingredients of safflower are mainly concentrated in the water-soluble yellow pigment part. Preliminary analysis shows that safflower yellow pigment is three water-soluble components. Mixture of: Hydroxysafflor yellow-A (Hydroxysafflor yellow-A), Safflor yellow-B, Safflower yellow-C. At present, there are only a few reports on safflower yellow, but...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/207C07H1/08
Inventor 李盛学
Owner YOUCARE PHARMA GROUP
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