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Safflower dripping pill and preparation method thereof

A technology of safflower and dripping pills, which is applied in the directions of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, can solve the problems of first-pass bioavailability of the liver and intestines, affecting the therapeutic effect, and long dissolution time, etc. Improved bioavailability, less allergic reaction, and no dust pollution

Inactive Publication Date: 2010-01-20
山西德元堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition, due to preparation technology and other reasons, the oral dosage forms of most drugs have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug. , also directly affects the therapeutic effect

Method used

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  • Safflower dripping pill and preparation method thereof
  • Safflower dripping pill and preparation method thereof
  • Safflower dripping pill and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 186g of safflower medicinal material, add 20 times the weight of water, extract at 80°C for 60 minutes, filter the extract, add 15 times the weight of water to the filter residue, extract at 80°C for 60 minutes, filter the extract, add 15 times the weight of the filter residue of water, extracted at 80°C for 60 minutes, and filtered. The three filtrates were combined, concentrated under reduced pressure to a relative density of 1.05 (80°C), and placed at room temperature. Add 90% ethanol to make the alcohol content reach 80%, let it stand at 4°C for 24 hours, filter to remove the precipitate, and recover the ethanol from the filtrate under reduced pressure at 60°C until it has no alcohol smell. After adding 10 times the volume of the concentrated solution to dilute, apply the treated DM-130 macroporous adsorption resin column, the mass ratio of the sample amount to the resin amount is 1:1, elute with water for 1 column volume, discard the washed Remove the liquid,...

Embodiment 2

[0028] Effects of Honghua Dropping Pills on Physiological Indexes of Myocardial Ischemia Rats

[0029] Get 50 male healthy rats, divide them into 5 groups at random (model group, safflower dropping pills low, middle and high groups, safflower injection group), model group is given normal saline by 1ml / 100g, safflower dropping pills low , medium and high dose groups were administered by intragastric administration at doses of 30mg / kg, 60mg / kg, and 120mg / kg (according to the amount of safflower extract in the safflower dripping pills, respectively equivalent to crude drug 390, 780, and 1560mg / kg), Each group was administered continuously for 7 days. 45 minutes after the last administration, 20% urethane was injected intraperitoneally at 1.2g / kg for anesthesia, the dorsal position was fixed, and the normal electrocardiogram was recorded. Hair removal and disinfection of the chest, longitudinal skin incision about 2 cm along the midline of the left clavicle, blunt separation of th...

Embodiment 3

[0038] Effects of Honghua Dropping Pills on Biochemical Indexes in Rats with Myocardial Ischemia

[0039] Get 60 male healthy rats and divide them into 6 groups at random (sham operation group, model group, safflower dropping pills low, middle and high groups, safflower injection group), and sham operation group and model group are administered with 1ml / 100g Physiological saline and safflower dropping pills group were given by intragastric administration at doses of 30mg / kg, 60mg / kg, and 120mg / kg (according to the amount of safflower extract in safflower dropping pills, respectively equivalent to crude drug 390, 780, and 1560mg / kg). 20% urethane 1.2g / kg was anesthetized by intraperitoneal injection 45min after the last administration, and the dorsal position was fixed. The chest was depilated and disinfected, and the skin was cut longitudinally about 2 cm along the midline of the left clavicle. The muscle layer was bluntly separated in the fourth or fifth intercostal space, th...

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Abstract

A safflower dripping pill is a dripping pill which is prepared from a medicine extract prepared by taking traditional Chinese medicine safflower as a raw material and a medicinal carrier used as a substrate together and has the content of hydroxy safflower yellow A not lower than 25mg / g. The preparation method of the safflower dripping pill comprises the following steps: carrying out concentration and ethanol deposition on a safflower water extract, purifying by a macroporous adsorptive resin column after recovering ethanol, collecting eluent, concentrating, drying, obtaining a safflower medicine extract, mixing with substrate polyethylene glycol 4000, dripping into a coolant and preparing the dripping pill. The safflower dripping pill has an oral medicament form, has convenient administration, increases the administration safety of a patient, can be applied to the convalescent treatment of the patient with the cardiovascular disease after leaving the hospital, and meets different requirements of the patient for medicines at different periods. The invention quickens the dissolution and absorption of the medicine, enhances the bioavailability of the medicine, has high stability, ensures the quality of the medicine, is not easy to generate anaphylaxis in comparison with injection and has small side effect and safe and convenient use.

Description

technical field [0001] The invention relates to a medicine for treating cardiovascular diseases, which has the functions of promoting blood circulation, removing blood stasis, replenishing qi and relieving pain, in particular a drop pill preparation prepared by using traditional Chinese medicine safflower. The invention also relates to a preparation method of the safflower dropping pills. technical background [0002] Safflower is the dried flower of Carthamus tinctorius L., a plant of Compositae. It is a commonly used traditional Chinese medicine for promoting blood circulation and removing blood stasis. It has been used as medicine for thousands of years. treat. [0003] Since the 1970s in my country, extensive research has been done on the chemical constituents of safflower. Most studies have proved that the main active ingredients of safflower exist in its water-soluble parts, and safflower yellow is its main physiologically active substance. In recent years, scholars...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/286A61K9/20A61P9/00
Inventor 彭建华程辉
Owner 山西德元堂药业有限公司
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