Use of Carthamus tinctorius yellow colour in preparing medicament for treating and/or preventing lung damnification

A technology for safflower yellow and lung injury, which is applied in the field of safflower yellow and can solve problems that have not been reported yet

Inactive Publication Date: 2008-12-24
BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, although the research reports on the pharmacological effects of safflower yellow have gradually increased, the research on safflower yellow in alleviating lung injury, especially acute lung injury, has not been reported yet.

Method used

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  • Use of Carthamus tinctorius yellow colour in preparing medicament for treating and/or preventing lung damnification
  • Use of Carthamus tinctorius yellow colour in preparing medicament for treating and/or preventing lung damnification
  • Use of Carthamus tinctorius yellow colour in preparing medicament for treating and/or preventing lung damnification

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Preparation of Crude Magenta Yellow Pigment by Macroporous Resin Column Chromatography

[0094] Experimental Materials

[0095] Safflower raw medicine was purchased from Urumqi Medicinal Materials Company of Xinjiang Uygur Autonomous Region, and its origin is Jimsar County, Xinjiang Uygur Autonomous Region. The authenticator, Professor Li Jiashi, Department of Pharmacognosy, School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, is the dried flower of Carthamustinctorius L., a safflower of Compositae. 95% sanitation alcohol is produced by Beijing Yuanhong Medicinal Alcohol Co., Ltd.; D-4020 type non-polar macroporous resin is a product of Tianjin Nankai University Chemical Factory; Porous resins such as D-3520, X-5, NKA-9, etc. Newly purchased macroporous resin is soaked in 5% NaOH solution for 2 hours, washed with water until neutral, then soaked in 5% HCl for 2 hours, washed with water until neutral, wet-packed, washed with 95% ethanol...

Embodiment 2

[0107] Preparation of Fine Safflower Yellow Pigment by Macroporous Resin-Gel Column Chromatography

[0108]The gel used in this experiment is Sephadex LH-20, which is a product of Pharmacia Company; in addition to Sephadex LH-20, Sephadex G-25 or Sephadex G-50 gel can also be used in the gel column chromatography experiment of the present invention. Take the safflower yellow crude product concentrate prepared by the aforementioned macroporous resin chromatography on a gel chromatography column with a diameter of 10 cm x a height of 70 cm, elute with distilled water to remove the brown impurities that flow out first, collect the yellow eluate, and store at 60 ° C. Concentrate under reduced pressure to obtain the fine product of safflower yellow pigment. The Analysis Results of Fine Safflower Yellow Pigment by HPLC

[0109] All the yellow fractions were collected by macroporous resin column chromatography and then purified by gel column chromatography. The obtained safflower ye...

Embodiment 3

[0111] Preparation of high-purity refined safflower yellow by macroporous resin-gel column chromatography

[0112] Get the D-4020 type non-polar macroporous resin chromatographic column with a diameter of 40 cm × a height of 120 cm on 4000 mL of crude drug / mL safflower water extract, wash with distilled water until the Molish reaction is negative, and then elute with 20% ethanol, in order to obtain The safflower yellow with higher purity can be obtained by analyzing each part of the effluent by HPLC when the safflower water extract is subjected to macroporous resin column chromatography, and then concentrating the effluents with more than 80% of the HSYA chromatographic peak area. Concentrate of crude safflower yellow pigment with high HSYA content. The concentrated safflower yellow crude product with high HSYA content is then applied to a gel chromatography column with a diameter of 10 cm x 70 cm in height, and the brown impurities that flow out first are eluted with distille...

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Abstract

The invention discloses a new usage of safflower yellow prepared through the extraction from traditional Chinese medicine safflowers during the preparation of a medicine for treating and / or preventing lung injury, in particular the invention discloses a new usage in the preparation of a medicine for treating and / or preventing acute lung injury cased by lung ischemia reperfusion injury, pulmonary embolism or inflammatory reaction which is the result of the action of inflammatory agent onto the lung. The invention also discloses a medicine made from the safflower yellow and a preparation of the medicine thereof.

Description

Technical field: [0001] The present invention relates to a new application of safflower yellow extracted and prepared from traditional Chinese medicine safflower, that is, a new application in the preparation of drugs for treating and / or preventing lung injury, especially acute lung injury, and a pharmaceutical composition composed of the above-mentioned safflower yellow. technical background: [0002] Lung injury is a common disease, and acute lung injury seriously affects human health. Excessive inflammatory responses in the body often lead to acute lung injury, the symptoms of which can be seen as respiratory insufficiency, increased pulmonary capillary permeability, pulmonary interstitial edema, decreased lung compliance, pulmonary congestion, hemorrhage around pulmonary vessels, and alveolar collapse, Phenomena such as alveolar epithelial necrosis and leukocyte infiltration [Edited by Long Cun, Extracorporeal Circulation, Beijing, People's Military Medical Publishing Ho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/351A61P11/00
Inventor 金鸣龚庆成臧宝霞杨璟王晓菲童静刘锋何美玲吴伟
Owner BEIJING INST OF HEART LUNG & BLOOD VESSEL DISEASES
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