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Composition of medication prepared from safflower and leaves of hawthorn

The technology of a composition and hawthorn leaves is applied in the field of medicine and achieves the effects of uniform and stable medicine quality, reducing the relative dosage of medicine, and alleviating reperfusion injury.

Inactive Publication Date: 2007-10-10
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, using the interaction between safflower or its extract and hawthorn leaf or its extract, the compatible prescription is used to treat cardiovascular and cerebrovascular diseases, and there is no report yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0119] Embodiment 1 Preparation of safflower yellow pigment

[0120] Take the dried safflower crude powder, and soak it with acid water with a pH of 3 for three times at 70°C, each time with 50 times the amount of acid water, for 1.5 hours each time. Combine the extracts, filter, collect the filtrate, let it cool, adjust the pH value to neutral, concentrate under reduced pressure to a relative density of 1.05-1.10, add ethanol until the alcohol concentration is 70%, refrigerate (below 10°C) for 24 hours, filter Had a good time. Dissolve the precipitate in water, add it to the processed macroporous adsorption resin HPD100 column chromatography (the ratio of medicinal material to resin is 1:10 (W / V)), first use deionized water at 1-2.5ml / cm 2 / min flow rate to elute two column bed volumes, and then use 60% ethanol at 1-2.5ml / cm 2 / min flow rate to elute five column bed volumes. The fraction eluted with 60% alcohol is concentrated under reduced pressure to a density of about 1...

Embodiment 2

[0129] Example 2 Preparation of total flavonoids from hawthorn leaves

[0130] Take hawthorn leaves, add 75% ethanol to reflux and extract three times, each time for 1.5 hours, combine the extracts, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, add an equal amount of water to dilute, and degrease with 1 / 2 amount of petroleum ether Finally, discard the petroleum ether liquid, and then extract it with ethyl acetate, recover the ethyl acetate under reduced pressure and concentrate to dryness, add an appropriate amount of water to dissolve it, and add it to the treated polyamide column (particle size: 30-60 For this purpose, use 95% ethanol to wet-pack the column, first elute with 3 times column volume of 95% ethanol, then use 3 times column volume of water to elute until there is no alcohol smell, standby), first use 2 times column volume of water Elution, discard the washing liquid, then elute with 3 times column volume o...

Embodiment 3

[0144] Example 3 Preparation of HS Composition Aqueous Injection

[0145] 1. Prescription:

[0146] Prescription 1:

[0147] Safflower yellow 53.25g (equivalent to 2.5kg of raw medicinal materials)

[0148] Hawthorn leaf total flavonoids 45.20g (equivalent to 2.0kg of raw medicinal materials)

[0149] Add water for injection to 2000ml

[0150] A total of 1000 sticks were prepared

[0151] Prescription 2:

[0152] Safflower yellow pigment 106.50g (equivalent to 5.0kg of raw material)

[0153]Hawthorn leaf total flavonoids 90.40g (equivalent to 4.0kg of raw medicinal materials)

[0154] Add water for injection to 5000ml

[0155] A total of 1000 sticks were prepared

[0156] 2. Preparation method:

[0157] 1) Dispose of the pipes and containers used for liquid preparation one day in advance, and rinse them with fresh water for injection before use.

[0158] 2) Weigh the prescribed amount of safflower yellow and total flavonoids of hawthorn leaves.

[0159] 3) Add saffl...

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PUM

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Abstract

A Chinese medicine for treating cardiovascular and cerebrovascular diseases, such as cerebral thrombosis, coronary heart disease, angina pectoris, vasculitis, myocardiac infarction and hyperlipemia, is prepared from safflower and hawthorn leaf, or their extracts (safflower yellow and hawthorn leaf flavone).

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition mainly made of safflower or its extract and hawthorn leaf or its extract for treating cardiovascular and cerebrovascular diseases, a preparation containing the pharmaceutical composition and its preparation method. 2. Background technology [0002] Cardiovascular and cerebrovascular diseases have always been known as the number one killer threatening human health, such as stroke, coronary heart disease, angina pectoris, etc. are one of the main causes of human death. In recent years, as our country gradually enters an aging society, people's living standards have improved, the pace of life has accelerated, and eating habits have developed towards high fever and high fat. Among the population, cardiovascular and cerebrovascular diseases such as heart disease and stroke have become threats to human health and One of the serious diseases of life. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/734A61P9/10A61K31/352A61K31/7048
Inventor 黄振华
Owner JIANGYIN TIANJIANG PHARMA
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