Antineoplastic medicine composition

A technology of anti-tumor drugs and compositions, applied in the field of medicine

Inactive Publication Date: 2007-08-08
JIANGSU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, the interaction of ginseng or its extracts, astragalus or its extracts, coix seed oil, cantharidin or its derivatives or analogs is used to prepare anti-tumor drugs, and there is no report yet

Method used

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  • Antineoplastic medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0135] Example 1 Preparation of Ginseng Polysaccharide

[0136] Ginseng polysaccharide preparation process:

[0137] Take ginseng, chop it, extract with 75% ethanol, reflux for 4 hours, filter, dry the medicine residue, add water and cook five times, combine the decoction, add 0.3% activated carbon, stir for 30 minutes, let stand overnight, filter Pass the filtrate through a resin column, collect the effluent, concentrate under reduced pressure, add ethanol to make the alcohol content reach 95%, refrigerate, filter, take the precipitate and wash with acetone, drain the acetone, take out the precipitate and dry at 60~80℃, and crush it. Got.

[0138] Ginseng polysaccharide identification test

[0139] (1) Take about 0.2g of this product, add 5ml of water to dissolve it, add 5 drops of alkaline copper tartrate test solution, heat it to produce a red precipitate, cool, filter, take the filtrate and add 1 drop of hydrochloric acid to make it acidic, and heat it in a water bath for 10 ...

Embodiment 2

[0148] Example 2 Preparation of ginseng total saponins

[0149] Preparation process of total ginseng saponins:

[0150] Take the ginseng medicinal materials, crush them into fine particles, extract twice with ethanol reflux, 3 hours each time, add 10 times the amount of alcohol each time, combine the extracts, refrigerate, filter, and recover the ethanol from the filtrate and concentrate it to a thick paste. Add water to an appropriate amount ( Make each 1ml equivalent to 1g of the original medicinal material), stir well, refrigerate, and filter. The filtrate is added to the processed macroporous resin column, first eluted with 2V~3V column volume of water, discarded the washing liquid, and then Elute with 3 times the column volume of 80% ethanol, collect the eluate, recover the ethanol and concentrate it under reduced pressure to a thick paste with a relative density of 1.30 to 1.35, and vacuum dry to obtain.

[0151] Identification of total saponins of ginseng

[0152] Take 0.5...

Embodiment 3

[0165] Example 3 Preparation of Astragalus Polysaccharide

[0166] Astragalus polysaccharide preparation process:

[0167] Take astragalus medicinal materials, add 7 times the amount of 70% ethanol to extract twice, 2 hours each time, discard the extract, take the medicinal residue and add water to extract twice, combine the extracts and concentrate until the ratio of the volume of the extract to the crude medicinal material is 1.05: 1. Add ethanol to precipitate to make the alcohol content reach 70%, filter to obtain the precipitate, wash the precipitate with 70% ethanol, then dissolve it with an appropriate amount of water, filter, the filtrate is over the macroporous resin, eluted with water, collect the washing liquid, and wash the liquid Concentrate to a ratio of 1:2.5 between the volume of the medicinal solution and the medicinal materials. Add ethanol to make the alcohol content reach 70% to obtain a precipitate. The precipitate is washed and dehydrated with 95% ethanol an...

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Abstract

The invention discloses an antineoplastic pharmaceutical composition, its preparing process and use, wherein the composition comprises the following raw materials (by weight portion), ginseng 200-20000 parts, astragalus root 200-40000 parts, coix seed oil 4000-100000 parts and / or cantharidin or derivative or analogues 0.02-5000 parts. The composition can also be prepared from ginseng extract, astragalus root extract, coix seed and / or cantharidin or derivative or analogues, and can be prepared into clinically and pharmaceutically acceptable dosage forms.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition mainly made from ginseng or its extract, astragalus or its extract, cantharidin or its derivative or analogue, and / or coix seed oil, and a preparation method thereof And uses. 2. Background technology [0002] Cancer is a type of disease that seriously threatens human life and health. According to statistics, there are about 1 million newly discovered cancer patients in my country each year, and about 6 million people are killed every year in the world, and 10 million people are placed on the verge of death. With the deteriorating human living environment, cancer occurs. The rate is increasing year by year. The World Health Organization predicts that cancer will become the "first killer" of mankind in the 21st century. At present, the treatment of cancer in modern medicine is mainly surgical treatment combined with radiotherapy and chemotherapy. Although...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8994A61K36/481A61P35/00A61K31/365A61K31/704A61K31/7048A61K31/715A61K35/64
Inventor 黄振华
Owner JIANGSU UNIV OF TECH
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