59results about How to "Strict quality control" patented technology

A process for extracting arasaponin from notoginseng and purifying it includes such steps as pulverizing the notoginseng, removing impurities, baking, percolating by the aqueous solution of alcohol, extracting by hot reflux, vacuum concentrating, adsorbing by macroreticular resin, eluting sequentially with water, ammonia water and alcohol solution, collecting the eluting liquid, concentrating, and drying. It can be made into tablet, capsule, or injection.

The invention provides a method for rapidly breeding seedlings by using bletilla striata tubers. According to the method, rapid breeding is realized by using bletilla striata tubers, and the technical route of synchronization of bud increase and rooting is adopted, complete plants can be formed after about 50 days, and a large number of complete plants can be obtained within 4-6 months, so that large-scale industrial seedling breeding of bletilla striata is realized. The method for rapidly breeding seedlings by using bletilla striata tubers is simple, and the seedling breeding cost is reduced greatly. By adopting the method, quick budding and high reproduction rate are realized, the method is simple, tissue culture equipment is not required to be added, the production cost is low, batch production is realized and the application value is high.

The invention discloses a method for tissue culture fast propagation of bletilla. The method specifically comprises the following steps of sterilization of an explant, sterile germination of bletilla seeds, observation of seed embryo form and seed coat breaking process, tissue culture fast propagation of bletilla, and determining of bletilla seed activity by a TTC (triphenyltetrazolium chloride) method. The method has the advantages that the method of obtaining bletilla seedlings is simple, and the seedling culture cost is greatly reduced; the germination is quick, the proliferation rate is high, the method is simple, the adding of tissue culture equipment is not needed, the production cost is low, the batched production is realized, and the application value is high.

The invention discloses ginseng Sini granules and a preparing method thereof. The ginseng Sini granules improve the dosage forms of ancient prescriptions 'ginseng Sini decoction'. The effective constituents of each Chinese medicine in the ancient prescriptions are extracted. The extraction process is combined with efficacy, thus the process is more reasonable. The efficacy trial indicates that the ginseng Sini granules have better treatment efficacy and more stringent quality control than ginseng Sini decoction. The invention has the advantages of small granules dosage, convenience in the taking and capability of long-term preservation.

This invention discloses a low molecular heparin by decomposing natural heparin with nitrous acid, with average molecular weight between 2100Da and 2700Da, and 90% of the total component between 1500Da and 5400Da. The low molecular heparin of this invention has a low activity of anti-IIa factor, and the activity ratio of anti-Xa factor/anti-IIa factor is over 20, which greatly decreases the bleeding-out possibility. This invention also discloses the method for making the low molecular heparin, comprising procedures of nitrous acid decomposition, sodium borohydride reduction, and ethanol precipitation, with high yield.

A composition for improving osteoporosis and increasing bone mineral density, a preparation method of the same and an application of the same in preparation of a health-caring product. The composition comprises an active ingredient and auxiliary materials and is characterized in that the active ingredient includes following components, by weight, 65-85 parts of a raw medicine in an extract of epimedium, 5-15 parts of glucosamine, 5-15 parts of chondroitin sulfate, 1.5-3.5 parts of collagen and a proper amount of vitamin D3; and the auxiliary materials include following components, by weight, 1.5-4.5 parts of an excipient and 0.2-1.5 parts of a lubricant. The composition is designed especially for middle-aged and elderly people and is strong in targeted performance. In the invention, the composition is prepared through integration of Chinese and western medicines, not only is traditional Chinese medicine guide theory inherited but also modern medicinal treatment methods are referenced. An experimental result proves that epimedium in the formula can increases the bone mineral density and the chondroitin sulfate, the glucosamine, the collagen and the vitamin D3 have an effect of improving the osteoporosis. The composition has excellent effects of increasing the bone mineral density and promoting absorption of calcium.

The invention discloses a quick propagation method for humulus scandens. The method comprises the following steps of: culturing tissues, such as stem section of the humulus scandens, on an LS culture medium; accurately cutting and taking the stem section with 1-2 axillary buds as an explant; disinfecting and then inoculating in an LS+6-BA 1.2mg/L+NAA 0.2mg/L culture medium for culturing; wherein the explant buds after being inoculated for about 6-8 days and grows into a plantlet with leaves after being inoculated for about 10 days; cutting off the plantlet and transferring to an LS+6-BA 0.5mg/L+IAA 0.4mg/L culture medium, so as to keep high-speed increasing and a propagation coefficient above 5; selecting LS+6-BA 0.5mg/L+IAA 0.4mg/L+NAA 0.5mg/L as a rooting culture medium, wherein the rooting rate is above 90% and the complete plant can be obtained only after about 25 days; and transplanting a test-tube plantlet into sandy soil, carefully keeping water and humidity, and establishing a set of high-frequency stable regeneration system after the transplanting survival rate is above 90% after transplanting for 1 month. The method provided by the invention has the advantages of excellent stability, convenience in operation, high propagation speed and low production cost, achieves industrial level, and the like.

Belonging to the field of nuclear technologies, the invention specifically relates to an iodine adsorber performance test method and device. The method includes: forming circulating air between the inlet and outlet of a test iodine adsorber, adopting a frequency adjustment fan to accurately adjust the flow of circulating air, controlling the humidity of the circulating air by a heat pump system to make the air humidity on the inlet side and outlet side of the iodine adsorber consistent, injecting a test source into the inlet side of the iodine adsorber, conducting sampling at the inlet and outlet of the iodine adsorber respectively to test the purification performance of the iodine adsorber. The method and the device provided by the invention combine air circulation, frequency adjustment technology, heat pump technology and other energy saving technologies, and reach the comprehensive benefits of environmental protection, energy saving, safety and high efficiency.

The invention provides a fast propagation technology for wild buckwheat rhizome. The method comprises the following steps: culturing tender tissues such as fresh tender shoots and stems of the wild buckwheat rhizome on an MS culture medium; inoculating the tender tissues on the culture medium consisting of 2 mg/L of (MS+2,4-D) and 0.5 mg/L of (6-BA), wherein the success rate of callus induction is over 98%; transferring to a differential medium consisting of 1.5 mg/L of (MS+ KT) and 1.5 mg/L (6-BA) for differential culture, wherein a large number of seedlings appear after 15 days; transferring about 1.5 to 3.5-cm seedlings to a hormone-free MS rooting medium, wherein roots appear after about 12 days and the rooting rate reaches 100%; opening the cover of the culture bottle to culture for three days, taking out the tissue culture seedlings of the wild buckwheat rhizome, cleaning the rooting medium, and transplanting the seedlings to a greenhouse and growing on special nutrient soil for tissue culture, wherein the survival rate reaches 98%; and after three months, transplanting the seedlings to fields for large-scale planting. The method of the invention has the advantages of high stability, simple operation, fast propagation, low production cost, reached industrial level and the like.

The invention relates to a method for testing the contents of gallic acid, salidroside, tyrosol and p-coumaric acid in Rhodiola rosea extracts. The method comprises the steps of respectively preparing a gallic acid reference sample solution, a salidroside reference sample solution, a tyrosol reference sample solution and a p-coumaric acid reference sample solution and preparing a Rhodiola rosea extract test solution; testing the content of the reference sample solutions with the chromatographic column of Phenomenex Luna C18 (4.6mm*250mm, 5mum), the moving phase of acetonitrile-0.3% glacial acetic acid, the column temperature of 40 DEG C, and the volume flow rate of 0.7mL.min-1 respectively at the wavelengths of 275nm and 308nm, recording the chromatogram map and calculating the contents of gallic acid, salidroside, tyrosol and p-coumaric acid in the Rhodiola rosea extract test solution.

The invention belongs to the technical field of Chinese patent drugs, relating to a quality control method for Xinnaojing tabelets as Chinese medicine preparation, which are prepared from Chinese herbal medicines as raw materials; the method comprises the following steps: with the microscopic characteristics of nacre mother of pearl and cinnabar set in the quality standard as contrasts, distinguishing whether the prescription of the Xinnaojing tabelets contains nacre mother of pearl and cinnabar with a microscope; with berberine hydrochloride, borneol and flos sophorae as contrasts, distinguishing whether the prescription of the Xinnaojing tabelets contains the distinguishing items of berberine hydrochloride, borneol and flos sophorae with thin layer chromatography; and with baicalin as a contract, detecting the content of baicalin in the medicine with high efficient liquid chromatography; therefore, the checking method and the quantitative index that the sample contains not less than 10.0mg of baicalin (C21H18O11) perfect the quality standard, and the amended quality standard improves the quality control of medicine.

The invention belongs to the technical field of Chinese patent medicine, relates to a quality control method of Yangrong Baicao Wan which is prepared from traditional Chinese medicine and used for treating irregular menses caused by hemophthisis, wherein the quality standard comprises the authentication items of dried orange peel and nutgrass galingale rhizome, the content of paeoniflorin (C23H28O11) in the medicine is measured by means of high efficiency liquid chromatography, the medicine of each gram comprises radix paeoniae alba of not less than 3.0 mg by means of quantitative indexes and inspection method based on the paeoniflorin (C23H28O11), so that the quality standard is relatively complete, the quality of the medicine is controlled strictly, and the improvement for the quality of the product is ensured.

A 'Zhengqi' tablet fingerprint detection method is provided. The method includes 1) preparation of a solution of a sample to be tested, 2) preparation of a contrast solution and 3) measurement. The invention further provides application of the 'Zhengqi' tablet fingerprint in 'Zhengqi' tablet component quality detection and a quality detection method thereof. The invention further provides a fingerprint screening method for a plurality of medicine materials in the 'Zhengqi' tablets. Through the 'Zhengqi' tablet fingerprint detection method and application, a high-performance liquid chromatogramfingerprint of the 'Zhengqi' tablets is established, chromatographic peaks of medicine materials in the 'Zhengqi' tablets are assigned and confirmed, effective monitoring can be performed from the source of each raw material, raw material quality is strictly controlled, and relatively stable contents of effective components in the components of the 'Zhengqi' tablets are ensured, thus ensuring safety and effectiveness of clinical medication.

The present invention provides: resins which can be used for various applications such as radical curable resin compositions, colorant-dispersed compositions, and photosensitive resin compositions; resin compositions; and means for producing the resins. Specifically, the present invention provides an α-allyloxymethylacrylic copolymer having in its main chain a structural unit represented by formula (1):

wherein R is a hydrogen atom or a C1-C30 organic group.

The invention discloses a method for establishing a Macaca fascicularis experimental autoimmune encephalomyelitis model and application thereof. According to a concrete technical scheme in the invention, the method comprises the following steps: preparing an emulsion (an MOG solution: CFA = 1: 1) from MOG 34-56 (100 mu g/ml); narcotizing Macaca fascicularis for experiments and injecting 1 ml of the prepared emulsion at 10 injection points; carrying out immunization injection of the emulsion (secondary immunization) according to the above-mentioned method and dose in 7 days after the primary immunization injection (primary immunization); carrying out clinical observation in one day after primary immunization and recording clinical scores; and determining pathogenic sites, degrees and the like by using an MRI iconographic method at pathogenic time nodes. The model established in the invention has an application value which cannot be achieved by other rodent models, has the characteristics of recurrence-alleviation type attacks, low cost, wide availability of Macaca fascicularis for experiments and the like compared with a Macaca rhesus model and has a wide application scope in fields related to multiple sclerosis diseases.

The invention discloses a method for establishing a non-human primate autoimmune cerebrospinal meningitis model and the application of the model. The specific technical scheme comprises the following steps; a machin is selected as the non-human primate experimental animals; MOG34-56(100Mug/ml) is prepared into an emulsion (MOG CFA=1; 1); after the experimental machin is anesthetized, the machin is intradermally injected with 1ml of prepared emulsion at 10 injection points; on the seventh day after the first injection, an MOG-CFA emulsion is prepared by use of the same method, and the second immune injection is performed at the same dosage and by use of the same method; the experimental autoimmune cerebrospinal meningitis model established by use of the method has the clinical characters of remission-relapse, and can be widely used to the related field of disseminated sclerosis diseases. Compared with the existing rhesus method and model, the method and the model also have the characteristics of short induction period, low cost, rich monkey resources and the like, and also have the application value which cannot be realized by rodent models.

The invention relates to a building method of a non-human primate dysmenorrheal model and a measuring principle of non-human primate dysmenorrheal pains. Combined induction of estrogen and oxytocin isutilized to build the non-human primate dysmenorrheal pain model, and a measurement device is utilized to measure the pains. When the device measures the pains, a medium loading unit is connected with a flexible expansion unit through a communication pipe, after the flexible expansion unit is put into the vagina of a primate, mediums are loaded according to a preset procedure to expand the expansion unit, a measuring monitoring unit is connected with the primate and a medium loading controlling unit separately, and by detecting the reaction of the primate to the pains and feeding the reactionback to the medium loading controlling unit, and recording loading data at the same time, the degree of the dysmenorrheal pains is quantitatively measured. As is shown by cases, the measuring methodis high in sensitivity and repeatability. The dysmenorrheal model and the measuring principle and method of the non-human primate dysmenorrheal pains have a wide application range in the relevant field of scientific research, teaching, products and technological development and the like, and can also provide experimental estimation for the development of new drugs for the dysmenorrheal pains.