Low molecular weight heparin and its preparation method

A low-molecular-weight heparin and average molecular weight technology, applied in the field of low-molecular-weight heparin and its preparation, can solve the problem of low bleeding and achieve the effect of improving the therapeutic index
CN1880344AInactive Publication Date: 2006-12-20上海复旦张江生物医药股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
上海复旦张江生物医药股份有限公司
Publication Date
2006-12-20
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention discloses a low molecular heparin by decomposing natural heparin with nitrous acid, with average molecular weight between 2100Da and 2700Da, and 90% of the total component between 1500Da and 5400Da. The low molecular heparin of this invention has a low activity of anti-IIa factor, and the activity ratio of anti-Xa factor / anti-IIa factor is over 20, which greatly decreases the bleeding-out possibility. This invention also discloses the method for making the low molecular heparin, comprising procedures of nitrous acid decomposition, sodium borohydride reduction, and ethanol precipitation, with high yield.
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Description

technical field

[0001] The invention relates to a heparin product and a preparation method thereof, in particular to a low molecular weight heparin and a preparation method thereof. Background technique

[0002] Thromboembolic disease is one of the serious threats faced by human beings at present. It has a relatively high morbidity and mortality and is a disease that seriously endangers human health, such as coronary heart disease, myocardial infarction, deep vein thrombosis (DVT), cerebral embolism, etc. , Pulmonary embolism (PE), etc. In addition, thrombosis is an important pathological process involved in the pathogenesis of many diseases, such as diabetic small vessel disease, glomerulonephritis, exacerbation of local lesions in severe burns, pregnancy-induced hypertension syndrome, retinal vein thrombosis, various Causes of disseminated intravascular coagulation, etc. Therefore, the prevention and treatment of thrombosis is of great significance to improve the quality...

Claims

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