41 results about "MS multiple sclerosis" patented technology

The invention relates to the field of medicinal chemistry, and particularly discloses a piperidine derivative as well as a pharmaceutical composition, application and a preparation method thereof. The piperidine derivative has the following general formula. The piperidine derivative can be effectively used for treating or preventing multiple sclerosis, and shows an unexpected synergistic effect in an animal model: the piperidine derivative not only can significantly improve neurological function impairment and promote recovery, but also can deeply reduce the levels of key proinflammatory cytokines IFN-gamma and IL-17 at the same time. The invention provides a novel small molecule candidate drug with central permeability, neuroprotection and comprehensive immune regulation functions for treatment of multiple sclerosis.

The invention discloses a tomography and targeted energy thermal therapy system and method based on an acousto-optic coupling functional film layer, and relates to the technical field of noninvasive medical diagnosis and treatment. The system comprises an intelligent processing carrier, an acousto-optic coupling function film layer, a scanning mechanism, an energy treatment module and a processing and temperature control module. The intelligent processing carrier at least comprises a 20Hz-20kHz audio unit, a pickup unit, an optical signal unit and a processor; the acousto-optic coupling functional film layer is of a single physical structure and is inseparable, acoustic frequency conversion focusing imaging and targeted warm delivery at 42-47 DEG C are achieved in the same physical area in a time-sharing mode, the acoustic processing layer achieves 1000-8000 frequency doubling through a multi-stage resonance microcavity array, and the echo signal-to-noise ratio is larger than or equal to 15 dB; the scanning mechanism comprises a plurality of modes such as rotation, translation, multi-device array, human body movement, local limb movement, human body bearing support device movement and the like; the energy forms cover all types of light, electromagnetism, radio frequency and the like capable of generating a warm effect, including but not limited to non-contact or contact energy delivery modes. The traditional Chinese medicine composition is suitable for tumors, infections, inflammations, and all lesions sensitive to temperature of 42-47 DEG C including nervous system lesions such as amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, multiple sclerosis and the like, is low in cost, free of radiation and easy to popularize, and has extremely high creativity and practical value.

The present disclosure provides, in one aspect, compounds, compositions, and methods for reducing and / or inhibiting the activity of p38gamma. In certain embodiments, the compounds, compositions, and methods of the disclosure are useful for promoting remyelination. In certain embodiments, the compounds, compositions, and methods of the disclosure are useful for treating, preventing, and / or ameliorating one or more diseases or disorders in a subject, including but not limited to multiple sclerosis (MS), inflammatory disease, and cancer.

The present disclosure provides methods of treating multiple sclerosis (MS) using Compound 1 represented by the following structure, or a pharmaceutically acceptable salt thereof, in combination with dihydroxymethyl fumarate (DRF).

The disclosure relates to the treatment, diagnosis and / or prevention of multiple sclerosis (MS) by using an immunodominant protein or peptide. More particular the invention relates to the field of antigen specific immunotherapies, such as the induction of tolerance.

The present disclosure provides methods of treating multiple sclerosis (MS) using Compound 1 represented by the following structure or a pharmaceutically acceptable salt thereof.

A DMA replication-associated protein (Rep) for multiple sclerosis (MS) is described, wherein (a) an increased amount of Rep protein or fragments thereof in a sample from a subject compared to an amount in a control sample or an increased amount of anti-Rep protein antibodies to antigen in a sample from a subject compared to an amount in a control sample is associated with a diagnosis of MS, wherein the Rep protein is an MSBI1 Rep or MSBI2 Rep.

The present disclosure relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based compounds. More particularly, the present disclosure provides a class of compounds that can inhibit and / or attenuate apoptosis via caspase 3 for the treatment of various degenerative disorders. Additionally, the present disclosure relates to methods for treating specific degenerative disorders such as amyotrophic lateral sclerosis (ALS), Huntington's disease, epilepsy, spinal cord injury, complication due to diabetes, multiple sclerosis (MS), muscular dystrophy (MD), Parkinson's disease (PD), irritable bowel syndrome (IBS) and Alzheimer's disease (AD) in a patient comprising administering to the patient an effective amount of a present compound.

The present disclosure includes, among other things, methods, kits, and systems for determining the status of MS in a subject. In various embodiments, the present disclosure relates to the use of one or more histone modifications, chromatin accessibility, binding of one or more transcription factors, and / or DNA methylation that are characteristic of the status of MS. In some embodiments, differential modifications and / or differential accessibility are detected and quantified, at one or more genomic loci of a biological sample, e.g., in cell-free DNA (cfDNA) from a liquid biopsy sample obtained or derived from a subject with MS. In various embodiments a determined status is useful, e.g., in selecting treatment for and / or treating MS.

The disclosure relates to the treatment, diagnosis and / or prevention of multiple sclerosis (MS) by using an immunodominant protein or peptide. More particular the invention relates to the field of antigen specific immunotherapies, such as the induction of tolerance.

The application discloses a cerebrospinal fluid low-abundance protein biomarker for multiple sclerosis diagnosis and application thereof, and belongs to the field of biomedical technology. The application obtains the MS cerebrospinal fluid biomarker with high specificity and sensitivity through high-throughput proteomics technology screening and strict clinical verification, and establishes a standardized detection method, thereby providing a new core biomarker PFKP protein for the diagnosis of MS, enriching the technical means for early diagnosis of MS, and having good market application prospect and social and economic benefits.

The present invention relates to the management of conditions other than multiple sclerosis in treatment of patients with Ofalimumab, and specifically provides methods of multiple sclerosis (MS) treatment that allow for the control of conditions other than MS, such as infections.

To provide a method for treating relapsing multiple sclerosis.SOLUTION: (R) - l - (l-acryloylpiperidin-3-yl) - 4-amino-3 - (4-phenoxyphenyl) - 1H - imidazo [4, 5-c] pyridin-2 (3H) - one to a subject in need thereof. Another aspect of the present disclosure is to provide methods of treating RMS comprising administering to a subject in need thereof BTK inhibitors, including (R) - l - (l-acryloylpiperidin-3-yl) - 4-amino-3 - (4-phenoxyphenyl) - imidazo [4, 5-c] pyridin-2 (LA) - one.SELECTED DRAWING: Figure 1

The present invention provides compositions and methods of using them for treating or ameliorating multiple sclerosis (MS) by administering a formulation comprising 40 mg of glatiramer acetate intramuscularly to the MS patient.

The present disclosure relates to treatment regimens for the treatment of multiple sclerosis (MS). These methods include subcutaneous administration of anti-CD20 antibodies and provide efficacy and safety with extended subcutaneous administration intervals.

The present disclosure is directed to isolated cell populations comprising stable regulatory T cells and methods of producing the same.

This application relates to the field of medicinal chemistry, specifically disclosing a piperidine derivative and its pharmaceutical composition, uses, and preparation method. The piperidine derivative has the following general formula: [Formula omitted]. This piperidine derivative can be effectively used to treat or prevent multiple sclerosis, exhibiting unexpected synergistic effects in animal models: it not only significantly improves neurological function impairment and promotes recovery, but also simultaneously and profoundly reduces the levels of key pro-inflammatory cytokines IFN-γ and IL-17. This invention provides a novel small molecule drug candidate for the treatment of multiple sclerosis that combines central penetration, neuroprotection, and comprehensive immunomodulation.

The present invention relates to methods for treating multiple sclerosis (MS) in a patient which in some cases involves subcutaneously administering an anti-CD20 antibody into the patient at a dose of about 920 mg. Compositions, formulations and articles of manufacture with instructions for such use are also included.

The present invention relates to a method for diagnosis of Multiple Sclerosis (MS) and a method for the prognosis of MS, wherein said methods comprise detecting an isoform of TAF1 in a biological sample. The present invention further relates to a method for the screening an active compound for treating and / or preventing multiple sclerosis.

A transmucosal delivery composition in form of a sublingual orally dispersible film comprising cladribine as active ingredient and comprising at least two hydrophilic polymers, wherein the at least two hydrophilic polymers represent at least 20% (w / w) of the total composition, wherein cladribine is contained in the composition as a cladribine-cyclodextrin complex. Said composition for use in the treatment of multiple sclerosis (MS), myasthenia gravis (MG), neuromyelitis optica spectrum disorders (NMOSD). A method for producing a transmucosal delivery composition in form of a sublingual orally dispersible film, wherein cladribine or cladribine-cyclodextrin complex is mixed with film-forming polymers by stirring with at least 100 rpm for at least 10 min at a temperature of at least 30° C.

The present application provides compounds of Formula (I) and related compositions and methods, including methods of therapy for treating nervous system diseases and disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), and methods for in vivo imaging of AMPA receptors or surrogates thereof in the brain. (I)

Provided herein are methods and immune biomarkers for identifying multiple sclerosis (MS) progression and treatment options. Materials and methods for prognosing, staging, and monitoring MS in a sample are also provided, including methods for determining a subject as at risk for developing MS. The methods include detecting at least one biomarker, such as CXCL13, CXCL10, CD27, NEFL, CCL4, and / or CCL3, in the cerebrospinal fluid (CSF) of a subject, and administering a pharmaceutically effective amount of a therapy (e.g., trebrutinib and potentially one or more additional therapies, e.g., an anti-CD20 therapy) to the subject.

The present application belongs to the field of medicine, and particularly relates to a novel compound for treating multiple sclerosis. Specifically, the present application provides a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the same, wherein the compound or the salt or the pharmaceutical composition comprising the same has the biological activity of inhibiting CD4 + The biological activity of T cells differentiating into Th17 cells can be used for preventing and / or treating autoimmune deficiency diseases related to Th17 cells, for example, multiple sclerosis (MS). The compound of the present application is novel in structure, excellent in biological activity, and can be used as an ideal candidate drug compound for treating MS.

Provided herein are methods and immune biomarkers for identifying progression and therapeutic selection of multiple sclerosis (MS). Also provided are materials and methods for prognosis, staging, and monitoring of MS in a sample, and including methods of determining that a subject is at risk of developing MS. The method comprises detecting at least one biomarker, such as CXCL13, CXCL10, CD27, NEFL, CCL4, and / or CCL3, in the cerebrospinal fluid (CSF) of the subject; and administering to the subject a pharmaceutically effective amount of a treatment (e.g., tobutinib and potentially one or more additional therapies, such as an anti-CD20 therapy).

The present disclosure includes, among other things, methods, kits, and systems for determining the status of MS in a subject. In various embodiments, the present disclosure relates to the use of one or more histone modifications, chromatin accessibility, binding of one or more transcription factors, and / or DNA methylation that are characteristic of the status of MS. In some embodiments, differential modifications and / or differential accessibility are detected and quantified, at one or more genomic loci of a biological sample, e.g., in cell-free DNA (cfDNA) from a liquid biopsy sample obtained or derived from a subject with MS. In various embodiments a determined status is useful, e.g., in selecting treatment for and / or treating MS.

NSIs with anti-inflammatory activity are provided, as are methods of using the NSIs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as multiple sclerosis (MS), Alzheimer's disease (AD), traumatic brain injury (TBI), Parkinson's disease (PD), acute myocardial infarction (AMI), heart failure, gout, rheumatoid arthritis, COVID- 19, diabetes, macular degeneration, or an autoimmune or autoinflammatory disease.

The present application belongs to the field of medicine, and particularly relates to a novel compound for treating multiple sclerosis. Specifically, the present application provides a compound as shown in formula (I) or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising the same, wherein the compound or the salt or the pharmaceutical composition comprising the same has the biological activity of inhibiting CD4 + The biological activity of T cells differentiating into Th17 cells can be used for preventing and / or treating autoimmune deficiency diseases related to Th17 cells, for example, multiple sclerosis (MS). The compound of the present application is novel in structure, excellent in biological activity, and can be used as an ideal candidate drug compound for treating MS.

The present invention relates to methods for treating multiple sclerosis (MS) in a patient which in some cases involves subcutaneously administering an anti-CD20 antibody into the patient at a dose of about 920 mg. Compositions, formulations and articles of manufacture with instructions for such use are also included.

A method of imaging a biological material having a component that exhibits an ultra-short transverse relaxation time after excitement by electromagnetic energy is disclosed. More specifically, balanced steady state free precession ultra-short echo time (bSSFP UTE) magnetic resonance imaging (MRI) is used in combination with 3D center-out trajectory data collection and image subtraction techniques, to yield accurate high spatial resolution images of a material component having an ultra-short transverse relaxation time. In an embodiment, the 3D center-out trajectory can be a 3D rosette k-space trajectory. The disclosed methods can be used to image, among other things, biological materials such as without limitation, cortical and trabecular bones, lung parenchyma, tendons, and ligaments. In a particular example, the disclosed methods are used to image the myelin bilayer in brain white matter, such as for example, to detect, treat, or monitor brain lesions in multiple sclerosis patients.

The present invention relates to methods for treating multiple sclerosis (MS) in a patient, and in some cases, the methods involve subcutaneously administering an anti-CD20 antibody to the patient at a dose of about 920 mg. Compositions, formulations, and articles with instructions for such uses are also included.