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Intelligent manufacturing method and system of terazosin hydrochloride capsules

A terazosin hydrochloride and intelligent manufacturing technology is applied in the field of intelligent manufacturing methods and systems of terazosin hydrochloride capsules, which can solve the problems of difficulty in detecting the purity of the main drug, inability to control the purity of the drug meticulously, etc. Content, guaranteed quality and yield, scientific and effective effect of quality control

Pending Publication Date: 2020-12-01
CHONGQING PHARSCIN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Among them, most of terazosin hydrochloride is based on tablets, and capsule preparations are less, because in the production process, it is difficult to detect the purity of the main drug when the drug is filled into the capsule, and in the intelligent manufacturing process The quality control system is also a macroscopic control of product quality. At present, the use of light inspection cannot carefully control the purity of drugs, especially the control of the purity of main drug components.

Method used

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  • Intelligent manufacturing method and system of terazosin hydrochloride capsules
  • Intelligent manufacturing method and system of terazosin hydrochloride capsules
  • Intelligent manufacturing method and system of terazosin hydrochloride capsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation method of embodiment 1 terazosin hydrochloride total mixture

[0063] formula

[0064] Main drug: Terazosin Hydrochloride Accessories: microcrystalline cellulose Magnesium stearate lactose Crospovidone

[0065] Predictive Model Establishment

[0066] Establish a predictive model for terazosin hydrochloride raw materials: 1) input the micrographs of standard terazosin hydrochloride raw materials into the matching subsystem for archiving as a subsequent comparison model. 2) Subsequent microphotography is performed on the extracted sample to obtain a micrograph of the sample. 3) The microphotograph of the sample is intelligently matched with the microphotograph of the archived standard model, and the matching parameters are the particle size and shape of the drug at the same fraction. 4) When the photo matching degree reaches 90% and above, the system can carry out the production operation of the next step of t...

Embodiment 2

[0072] Embodiment 2 produces the intelligent manufacturing system of terazosin hydrochloride capsule

[0073] The invention focuses on improving the quality management subsystem, and introduces a matching subsystem to control the purity of raw materials, thereby improving the quality of medicines. Intelligent manufacturing system of the present invention such as figure 1 Shown include:

[0074] The production subsystem is used to produce terazosin hydrochloride raw material.

[0075] Sampling the subsystem to extract the raw material sample of terazosin hydrochloride in the production subsystem.

[0076] The matching subsystem matches the sample microphotographs extracted by the sampling subsystem with the pre-judgment model graphics, including a microscopic camera for taking the sample microphotographs; a graphic matching module for intelligently analyzing the The degree of matching between the micrograph of the sample and the figure of the pre-judged model.

[0077] The ...

Embodiment 3

[0096] Embodiment 3 produces the intelligent manufacturing method of terazosin hydrochloride capsule

[0097] 1. Prediction model establishment

[0098] Establish the prediction model of terazosin hydrochloride raw material:

[0099] 1) Input the micrograph of the standard terazosin raw material into the matching subsystem for archiving as a follow-up comparison model.

[0100] 2) Subsequent photomicrographs of the extracted samples were taken to obtain microphotographs of the samples, and the resolution and magnification of the photos were consistent with those of the model pictures.

[0101] 3) Intelligent matching of sample microphotographs and archived standard model microphotographs.

[0102] 4) When the photo matching degree reaches 90% and above, the system can carry out the production operation of the next step of terazosin hydrochloride total mixture.

[0103] 2. Preparation of terazosin hydrochloride total mixture

[0104] After the matching is qualified, prepare...

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Abstract

The invention relates to the technical field of pharmacy, mainly discloses an intelligent manufacturing method and system of terazosin hydrochloride capsules. A model matching subsystem is establishedto perform similarity matching on main drug components, a quality management subsystem in an intelligent manufacturing system is emphatically optimized, and material yield calculation is introduced after a terazosin hydrochloride capsule aluminum-plastic step, so that whether a product meets the standard or not is judged. The main drug components of a product produced by the intelligent manufacturing system are guaranteed in a standardized manner, and the main drug components of capsules produced by the intelligent manufacturing system are higher in purity and more standard.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to an intelligent manufacturing method and system for terazosin hydrochloride capsules. Background technique [0002] With the rise of intelligent manufacturing, the manufacturing industry has ushered in a new round of reform and upgrading. With the rapid development of my country's pharmaceutical industry, its huge development potential and broad market space make it a sunrise industry with great market prospects. , has been positioned by the country and the government as a key area for the development of my country's strategic emerging industries. Its pharmaceutical companies are also upgrading to intelligent manufacturing, reducing dependence on labor and improving product quality and production efficiency by updating equipment, improving processes, and upgrading systems. [0003] Among them, most of terazosin hydrochloride is based on tablets, and capsule preparations are less,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/38A61K31/517G06K9/62G06Q10/06G06Q50/04
CPCA61K9/4866A61K31/517G06Q10/06395G06Q10/06313G06Q50/04G06F18/22Y02P90/30
Inventor 黄介周帮建陈劲王茂江新伟柏和贤叶兆军代宏东
Owner CHONGQING PHARSCIN PHARM CO LTD
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