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Composition for improving osteoporosis and increasing bone mineral density, preparation method of same and application of the same in preparation of health-caring product

A technology for increasing bone density and osteoporosis, applied to the preparation of health care products, a composition for increasing bone density, improving the field of osteoporosis, achieving the effects of increasing bone mass, protecting wear and tear, and preventing osteoarthritis

Inactive Publication Date: 2014-12-17
JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-term use of these drugs has obvious side effects, such as bisphosphonate side effects including esophageal irritation, hypocalcemia, kidney irritation symptoms or very rare osteonecrosis of the jaw, clinical data show that bisphosphonate treatment can also lead to atrial trembling

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] [U3] Epimedium extract 36, glucosamine hydrochloride 24, chondroitin sulfate sodium 24, collagen 6, vitamin D 3 Appropriate amount; auxiliary materials: dextrin 7, talcum powder 2.

[0070] Prepare as follows:

[0071] (1) Powder: Epimedium extract, glucosamine hydrochloride, and sodium chondroitin sulfate are crushed through a 60-mesh sieve and set aside;

[0072] (2) Mixing: Mix Epimedium extract, glucosamine hydrochloride, sodium chondroitin sulfate, collagen, and mix A; dextrin and talcum powder, and then add vitamin D 3 Mix B evenly; mix A and B evenly, and pass through a 40-mesh sieve;

[0073] (3) Granulation: Add the mixed raw and auxiliary materials into the granulator, and add an appropriate amount of 60% edible alcohol, and granulate with a 40-mesh screen to obtain wet granules;

[0074] (4) Drying and sizing: dry the prepared wet granules at a drying temperature of 40-50°C and a drying time of 2-3 hours until the moisture content of the granules is 3-5%, ...

Embodiment 2

[0077] The weight ratio of raw and auxiliary materials is Epimedium 76, Sodium Chondroitin Sulfate 8.5, Glucosamine Sulfate 8.5, Collagen 2, Vitamin D 3 Appropriate amount; excipients are dextrin 3.2, talcum powder 1.

[0078] (1) Extraction: decoct and extract Epimedium with 15 times the amount of water twice, each time for 1.5 hours, combine the extracts, concentrate under reduced pressure to an extract with a relative density of 1.2-1.3 (50°C), and vacuum dry (60 -80℃), to obtain the dry extract of Epimedium;

[0079] (2) Powder: dry epimedium extract, glucosamine sulfate, and sodium chondroitin sulfate are crushed through a 60-mesh sieve and set aside;

[0080] (3) Mixing: Mix Epimedium dry extract, glucosamine sulfate, sodium chondroitin sulfate, collagen, and mix A; dextrin and talcum powder, and then mix with vitamin D 3 Mix B evenly; mix A and B evenly, and pass through a 30-mesh sieve;

[0081] (4) Granulation: Add the mixed raw and auxiliary materials into the gr...

Embodiment 3

[0085] The weight ratio of raw and auxiliary materials is Epimedium 74, Sodium Chondroitin Sulfate 10, Glucosamine Hydrochloride 10, Collagen 2.5, Vitamin D 3 Appropriate amount; excipients are dextrin 3, talcum powder 0.7.

[0086] Prepare as follows:

[0087] (1) Extraction: decoct and extract Epimedium with 20 times the amount of water for 3 times, each time for 2 hours, combine the extracts, concentrate under reduced pressure to an extract with a relative density of 1.2-1.3 (50°C), and vacuum dry (60 -80℃), to obtain the dry extract of Epimedium;

[0088] (2) Powder: dry epimedium extract, glucosamine hydrochloride, and sodium chondroitin sulfate are crushed and passed through an 80-mesh sieve, and set aside;

[0089] (3) Mixing: Mix the dried epimedium extract, glucosamine hydrochloride, sodium chondroitin sulfate, and collagen A; mix dextrin and talcum powder, and then mix with vitamin D 3 Mix B evenly; mix A and B evenly, and pass through a 40-mesh sieve;

[0090] ...

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Abstract

A composition for improving osteoporosis and increasing bone mineral density, a preparation method of the same and an application of the same in preparation of a health-caring product. The composition comprises an active ingredient and auxiliary materials and is characterized in that the active ingredient includes following components, by weight, 65-85 parts of a raw medicine in an extract of epimedium, 5-15 parts of glucosamine, 5-15 parts of chondroitin sulfate, 1.5-3.5 parts of collagen and a proper amount of vitamin D3; and the auxiliary materials include following components, by weight, 1.5-4.5 parts of an excipient and 0.2-1.5 parts of a lubricant. The composition is designed especially for middle-aged and elderly people and is strong in targeted performance. In the invention, the composition is prepared through integration of Chinese and western medicines, not only is traditional Chinese medicine guide theory inherited but also modern medicinal treatment methods are referenced. An experimental result proves that epimedium in the formula can increases the bone mineral density and the chondroitin sulfate, the glucosamine, the collagen and the vitamin D3 have an effect of improving the osteoporosis. The composition has excellent effects of increasing the bone mineral density and promoting absorption of calcium.

Description

technical field [0001] The invention relates to a health care product and, in particular, to a composition for improving osteoporosis and increasing bone density, its preparation method and its application in the preparation of health care products. Background technique [0002] Osteoporosis (OP) is a disease with insidious occurrence and development, and has become a bone health problem of worldwide concern. With the aging of society, the incidence of osteoporosis is on the rise, which directly threatens the health and quality of life of the elderly. Therefore, it is very important to improve the prevention and treatment of osteoporosis. WHO statistics show that there are more than 200 million osteoporosis patients in the world, more than 75 million in the United States, Western Europe and Japan, and 90 million in my country. Its incidence rate has jumped to the seventh place among various common diseases in the world. Osteoporosis (OP) is clearly a worldwide and growing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A61K38/39A61P19/10A61P19/08A61K31/7008A61K31/737A61K36/296A61K31/593A23L29/30A23L33/105A23L33/155A23L33/17
CPCA23L29/30A23P10/30A23V2002/00
Inventor 夏月殷书梅林新艳黄张磊虞阳谢红兵
Owner JIANGSU KANGYUAN SUNSHINE PHARMA CO LTD
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