118results about How to "Good biomechanical properties" patented technology

Compositions, methods of production and use, and kits for an osteochondral graft involving both articular cartilage and underlying bone are provided.

The invention discloses a porous medical tantalum implant material and a preparation method and application thereof. The porous medical tantalum implant material is prepared through the steps of reducing a tantalum metal compound into tantalum metal powder and uniformly depositing the tantalum metal powder on the surface of a graphite carbon skeleton to form a tantalum coating according to the chemical vapor deposition method, wherein the tantalum metal compound is one of tantalum pentachloride and tantalum fluoride; the porosity of the graphite carbon skeleton is greater than 70% and the aperture is 200-600 microns; the tantalum coating is 40-60 microns in thickness. The porous medical tantalum implant material is high in porosity and uniform in pore size, adopts an interconnected porous structure, has few dead pore spaces, is similar to a human cancellous bone, can promote bone ingrowth, and can be applied to repairing injured bones at multiple parts of a body and bone defects after osteonecrosis.

The invention relates to a degradable magnesium alloy implanting material for bone fixation and a preparing method of the degradable magnesium alloy implanting material. The implanting material is prepared from, by mass percent, 0.5-4% of Mg, 0.5-4% of Ag and the balance Y. The preparing method of the implanting material comprises the steps of ingot casting metallurgy, extruding, rolling and heat treatment. The prepared implanting material meets the requirement of plates, rods and profiles, wherein the plates, the rods and the profiles serve in biological fluid environments. By means of alloy materials, the good comprehensive mechanical performance needed by bone fixing materials is ensured, the beneficial effects of being capable of inhibiting bacteria, resistant to corrosion, free of cytotoxicity, good in biological mechanical property and the like are achieved, and the alloy materials can be degraded under the biological fluid environments. The implanting material can serve as bone nails or marrow nails or bone fraction plates or other various devices to be used under the medical conditions, and the comprehensive performance is good; and especially, the implanting material has both the biomechanical property and the biodegradable performance at the same time, and the typical defect of existing metal materials of a titanium alloy or stainless steel or high polymer materials in application of the department of orthopaedics is overcome.

The invention discloses a reductively biodegradable type honeycomb polyurethane support, and a preparation method and application thereof. The preparation method comprises: taking 2,2'-dithiodiethanol as an initiator, employing a ring-opening polymerization method to synthesize double-hydroxy-terminated polycaprolactone containing disulfide bonds; reacting with diisocyanate containing a disulfide bond to form polyester type polyurethane containing disulfide bonds; then dipping a biological template wisteria sinensis with a sodium chloride solution and calcining to obtain a negative template porous sodium chloride of wisteria sinensis; and finally immersing the negative template porous sodium chloride of wisteria sinensis with a waterless organic solution of the polyester type polyurethane containing disulfide bonds, drying and removing the negative template to obtain the honeycomb polyurethane support, wherein the molecular structural formula of the polyurethane is shown in the description. The reductively biodegradable type honeycomb polyurethane support has the advantages of simple technology, easy batch preparation, and strong biodegradation controllability; and the honeycomb structure is beneficial to transportation of substances inside or outside the support, the support can be used as a porous support for tissue regeneration repair, and belongs to a tissue engineering support material with excellent comprehensive performances.

The invention discloses a repair material of a multi-component amino acid polymer for tissues and a preparation method thereof. The repair material is obtained from the polymerization of caprolactam with at least 5 kinds of other amino acids, wherein, the mole ratio of the caprolactam is 40 percent to 90 percent and the remaining parts are other amino acids with a mole ratio larger than or equal to 0.5 percent for a single kind amino acid. Under the protection of inert gases, the varied raw amino acids are heated and melted and then undergo pre-polymerization reaction and polymerization reaction in sequence at 210 DEG C to 220 DEG C and 230 DEG C and 250 DEG C respectively, thus the repair material is prepared. Other amino acids are selected from glycine, alanine, leucine, isoleucine, valine, threonine, serine, phenylalanine, tyrosine, tryptophan, praline, hydroxyproline, lysine and arginine. The material contains no catalyzer or other assistants, has good biological safety and compatibility, as well as good and controllable mechanical property and degradation speed, and can be singly used for repairing and reconstructing human tissues or can be used for repairing and reconstructing human tissues after being formed into a composite material.

The invention relates to the technical field of medical artificial bone transplantation materials. At present, bone transplantation is widely distributed in multiple fields such as orthomorphia, oral cavity, craniofacial region and the like. But all preparation methods of artificial bone transplantation materials have the problems that the manufacture period is long, the yield is low, and prepared artificial bone transplantation materials do not have precise anatomical morphology same to that of natural bone, and the like. The invention aims at providing a nanometer artificial bone scaffold possessing good bioactivity and excellent mechanical properties and a structure similar to that of natural bone. A selective laser sintering technology is employed, poly-epsilon-caprolactone and hydroxylapatite are taken as raw materials, and layer-by-layer sintering is performed according to a designed model and set parameters, and finally the artificial bone scaffold with the structure similar to that of natural bone is obtained. The artificial bone scaffold has outstanding biocompatibility, cells have relatively high propagation rate on the artificial bone scaffold, and the scaffold keeps good biomechanical properties.

The invention relates to a 3D-printed porous tantalum metal bone plate. The 3D-printed porous tantalum metal bone plate is characterized in that tantalum metal powder is taken as a base material, andthe bone-imitating trabecular bone plate having bone induction property and produced by 3D printing has an interconnecting-pore structure fit for bone growth. The production method includes: under argon production, using medical grade spherical tantalum powder as a raw material to produce the porous bone plate by 3D printing; removing excess metal powder adhering to the surface of the bone plate through sandblasting; removing residual stress through heat treatment to make the surface of the bone plate smooth. By the arrangement, the porous bone plate with the bone induction property can form excellent bone integration with bone tissue so as to achieve permanent fixation in biology.

The invention relates to a polymethyl methacrylate bone cement and a preparation method thereof. Concretely, the bone cement comprises a solid component and a liquid component. The solid component comprises a solid component A including polymethyl methacrylate, a methyl methacrylate-styrene segmented copolymer, a contrast agent, and an initiator; and a solid component B including mineralized collagen. The liquid component includes methyl methacrylate, a stabilizer and an accelerating agent. Through control of the molecular weight and ratio of the components, it is ensured that the obtained PMMA bone cement doesn't release a large amount of heat during application, thereby preventing damage to the surrounding bone tissue. The bone cement is suitable in viscosity and has random plasticity. Through addition of mineralized collagen which is excellent in osteogenic activity, the mechanical property and biocompatibility of bone cement are improved, and the bone cement is excellent in osseointegration capability and low in elastic modulus.

The invention relates to a tissue engineering stent based on low-temperature rapid modeling and a preparation method thereof. The preparation method comprises the following steps: mixing a polylactic acid-glycolic acid copolymer and an organic solvent in a mass ratio of 1: 6 to 1: 8 to prepare a PLGA (polylactic acid-glycolic acid) solution, and adding sodium chloride granules to obtain a printing slurry, wherein the mass ratio of the sodium chloride granules to the PLGA is 1: 2 to 2: 1; setting the fiber diameter to be 200-300 microns, setting the fiber spacing to be 300-350 microns, printing out a stent body containing the sodium chloride granules at a speed of 3-6mm/s, and removing the organic solvent and the sodium chloride to obtain the tissue engineering stent based on the low-temperature rapid modeling. According to the invention, through addition of an excipient, low-temperature printing of a PLGA material is achieved, and the defect of a too large or too small aperture size caused by high-temperature fused printing of a PLGA stent is overcome; the prepared PLGA stent is moderate in aperture size, can easily store cells, and has good biomechanical properties.

A composition for improving osteoporosis and increasing bone mineral density, a preparation method of the same and an application of the same in preparation of a health-caring product. The composition comprises an active ingredient and auxiliary materials and is characterized in that the active ingredient includes following components, by weight, 65-85 parts of a raw medicine in an extract of epimedium, 5-15 parts of glucosamine, 5-15 parts of chondroitin sulfate, 1.5-3.5 parts of collagen and a proper amount of vitamin D3; and the auxiliary materials include following components, by weight, 1.5-4.5 parts of an excipient and 0.2-1.5 parts of a lubricant. The composition is designed especially for middle-aged and elderly people and is strong in targeted performance. In the invention, the composition is prepared through integration of Chinese and western medicines, not only is traditional Chinese medicine guide theory inherited but also modern medicinal treatment methods are referenced. An experimental result proves that epimedium in the formula can increases the bone mineral density and the chondroitin sulfate, the glucosamine, the collagen and the vitamin D3 have an effect of improving the osteoporosis. The composition has excellent effects of increasing the bone mineral density and promoting absorption of calcium.

The invention relates to the technical field of the medical artificial bone grafting material. At present, no documents available report a nanometer artificial bone framework with a transverse gradient hole structure which is the same as a natural bone. The invention aims to provide a nanometer artificial bone framework which has good bioactivity, excellent mechanical property and the transverse gradient hole structure which is the same as a natural bone. The preparation method comprises the steps of: dissolving hydroxyapatite (HA) in a salt (NaCl) solvent to prepare a HA sol; then dissolving polycaprolactone (PCL) slowly in the HA sol; then heating and removing the solvent at a higher temperature; and finally casting layer by layer to a special mould to prepare a HA/PCL composite material. In the invention, the artificial bone framework which is similar to the structure of the natural bone and has the transverse gradient hole structure is obtained and the cells on the prepared artificial bone framework have higher reproduction rate and the framework has good biomechanical properties.

The invention relates to a bone cement stirrer comprising a control cabinet, a stirring shaft as well as an injector sleeve and a stirring device. The control cabinet is internally provided with a motor, the stirring shaft is fixedly connected with a rotating shaft of the motor, the injector sleeve is provided with a Ruhr joint at the front end and a top end opening blind nut at the rear end, thestirring device is arranged in the injector sleeve, the rear end of the stirring device is dismountably connected with the end part of the stirring shaft, and the injector sleeve is connected with a vacuumizing device through the Ruhr joint at the front end. The bone cement stirrer of the invention finishes stirring bone cement under vacuum condition, enables the bone cement to reach favorable properties through uniform stirring and ensures that the stirred bone cement has favorable biomechanical performance so as to achieve more ideal filling effect.

The invention provides a preparation method for artificial cartilage. According to the method, a non water-soluble organic macromolecule material is prepared into a three-dimensional network-shaped porous support through 3D printing; meanwhile, a PVA solution is mechanically mixed with nano-hydroxyapatite powder, and an HA-PVA composite solution is obtained; then the HA-PVA composite solution is used for performing mold reversing on the three-dimensional network-shaped porous support, after the HA-PVA composite solution is made to permeate into the three-dimensional network-shaped porous support, the HA-PVA composite solution permeating into the three-dimensional network-shaped porous support is placed into an artificial cartilage mold, and an artificial cartilage/porous support composite body is obtained through a repeated freezing and thawing method; and the porous support of the obtained the artificial cartilage/porous support composite body is selectively dissolved through a solvent, and the artificial cartilage is obtained. The prepared artificial cartilage is good in biocompatibility, the biomechanical performance is close to that of cartilage, the porosity rate is high, regular through large holes and a small communicating hole system are achieved, and bone cells can grow to enters the cartilage and are perfectly combined with the artificial cartilage.

The invention discloses a dual-phase magnetic nano-composite scaffold material. The dual-phase magnetic nano-composite scaffold material is prepared by compositing a cartilago phase with a bone phase,wherein the cartilago phase contains polylactic acid and a natural polymer compound; and the bone phase contains polylactic acid, nano-hydroxyapatite and magnetic nanoparticles. The invention furtherdiscloses a preparation method of the dual-phase magnetic nano-composite scaffold material. The three-dimensional dual-phase magnetic nano-composite scaffold material is prepared from polylactic acid, the natural polymer compound, nano-hydroxyapatite and the magnetic nano particles by virtue of a low-temperature rapid forming technique and is integrated with the advantages of the four materials,is capable of promoting the adhesion and proliferation of cells, reducing the toxicity of degradation products and improving the biomechanical properties based on good osteoconduction and biocompatibility and is relatively beneficial to the adhesion growth and vascularization of solid cells, and the speed and effect of the coalescence between artificial cartilages transplanted at bone defect partsof a joint cartilage and a subchondral bone and the bones are greatly increased and improved.

The invention relates to a PLGA three-dimensional nerve conduit and a preparation method thereof. The PLGA three-dimensional nerve conduit comprises a laminin coating and an orientation yarn core layer. The preparation method comprises the steps that a polylactide acid-glycolic acid copolymer (PLGA) is dissolved into a solvent, and the materials are mixed to be uniform to obtain a spinning solution; single-spray-head electrostatic spinning is conducted to obtain the PLGA three-dimensional nerve conduit containing the orientation yarn core layer, the PLGA three-dimensional nerve conduit is bonded with laminin through covalent bonds, and then the PLGA three-dimensional nerve conduit which is provided with the laminin coating and contains the orientation yarn core layer is obtained. The three-dimensional nerve conduit which is provided with the laminin coating and filled with orientation yarn has the good mechanical property, biological activity and degradation property; protein in the coating can promote nerve cell adhesion and nerve axon regeneration, and meanwhile, the yarn in the core layer can induce nerve cells to grow in a crawling mode in the yarn orientation direction, so that regeneration and reconstruction of three-dimensional nerve tissue are promoted, and important application can be achieved in peripheral nerve tissue repair and regeneration.

The invention relates to the technical field of biomedical tissue engineering, in particular to a novel bone tissue engineering scaffold and a preparation method thereof. The bone scaffold comprises abone material and an exosome-loaded fibrin gel compound, the bone material is provided with holes, and the gel compound is distributed in the holes. The invention researches a bone material which ishighly similar to a natural bone matrix and has osteogenesis and vascularization activities. The porous decellularized tissue engineering scaffold is closer to a normal bone, has good biomechanical properties, is suitable for bone defect repair of a load bearing area, and maximally retains inherent components of the scaffold. According to the method, cell components with most antigens in tissues can be effectively removed, the immunological rejection reaction of grafts is reduced, the approximate morphological structure of the tissues can be maintained, and most tissue matrix components and bioactive factors are retained.

The invention discloses a composite bioactivity functional coating, in particular a composite bioactivity functional coating positioned on a metal base body. The composite bioactivity functional coating comprises a first titanium metal coating positioned on the metal base body, a tantalum metal coating positioned on the first titanium metal coating and a hydroxyapatite or beta-TCP (tricalcium phosphate) bioactivity coating positioned on the tantalum metal coating.

The invention relates to a tissue tissue-engineered cartilage graftimplant and a preparation method thereof and belongs to the technical field of induced differentiation carried out on bone marrow mesenchymal stem cells (BMSCs) by utilizing a bioactive inducing factor to form a cartilage cell chondroblast composite scaffold material and so as to construct a tissue tissue-engineered cartilage by utilizing a biological activity inducing factor in biomedicine tissue engineering. The tissue tissue-engineered cartilage graftimplant is prepared by adopting the method comprising the following steps: (1) preparing a Nano-HA/PLLA (hyaluronic aciddroxyapatite/poly left L-lactic acid) cartilage scaffold material; (2) carrying out coculture on BMSCs and the Nano-HA/PLLA cartilage scaffold material, and carrying out induced differentiation on BMSCs to form cartilage cells by adopting a cartilage formation inducing solution, so that the tissue tissue-engineered cartilage graftimplant is obtained. The tissue tissue-engineered cartilage graftimplant improves flexibility and biodegradability of the cartilage scaffold material, improves biomechanical property and is more beneficial to adhesion, growth and vascularization of bone cells; an animal experiment proves that the tissue tissue-engineered cartilage graftimplant has a good cartilage defect repairing function.

Stent strut and surface geometries are provided for enhancing surface coating applications while providing highly beneficial biomechanical properties. A low-profile, flexible, expandable, elongated, stent assembly is provided and defined by a structure of connected circumferential arrays of webs or bends, the webs or bends and their connections having limited degrees of curvature that help avoid interference during various surface-modifying and surface-enhancing processes.

The invention discloses a porous decellularized tissue engineering cartilage support, which is prepared through a decellularized method after tissue engineering cartilage materials are subjected to punching treatment, so as to achieve three-dimensional porosity, higher biomechanical property and biocompatibility. The tissue engineering cartilage support is applicable to defect repair of cartilages in loaded parts, and can become a major breakthrough in defect repair of cartilages in tissue engineering.

The invention discloses a bionic bone joint based on curved surface 3D printing and a preparation method thereof. The multilayer bionic joint is formed by an inner layer, a middle layer and an outer layer which are in close contact in sequence, wherein the inner layer is a porous tantalum metal support, the middle layer is a solid biological ceramic support, the outer layer is a solid gelatin/ sodium alginate composite hydrogel support, the inner layer, the middle layer and the outer layer are all of an arc-shaped shell structure, the radian of the arc-shaped shell is 120-240 degrees, and a cell loading cavity formed by continuous or discontinuous edges formed by protruding outwards from the surface of the outer layer and grooves formed between the edges is formed in the surface of the outer layer. The multilayer bionic joint is large in arc surface radian and suitable for repairing large-area osteochondral joint defects, and the repairing area can be larger than 1/2 of the area of thewhole joint. Cells are inoculated into the cell loading cavity, so that the adhesion rate of the cells is increased, and the problem that the surface of the outer layer of the bionic joint is smooth,so that the inoculated cells are not prone to adhesion is solved.