30 results about "Epsilon-Aminocaproic Acid" patented technology

The present invention relates to a bone-repairing composite polymer material containing a ceramic ingredient and a preparation method thereof. The bone-repairing composite polymer material is composed of the calcium phosphate ceramic ingredient and a polybasic amino acid polymer ingredient, wherein, the mass ratio of the calcium phosphate ceramic ingredient is between 5 percent and 30 percent, and the rest is the polybasic amino acid polymer ingredient. Epsilon-aminocaproic acid is polymerized with at least two other types of amine acids to form the polybasic amino acid polymer ingredient, wherein, the mole ratio of the epsilon-aminocaproic acid in the polybasic amino acid polymer ingredient is between 50 percent and 90 percent, and the rest is the other amine acids including aminoacetic acid, lactamic acid, phenylalanine, lysine and proline. Under the protection of a inert gas, the materials, the amine acids and the calcium phosphate, are sufficiently and uniformly dispersed into water and then heated, so that various forms of waters can be removed from the materials, and finally, the materials are polymerized in two steps, respectively under a temperature between 200 DEG C and 220 DEG C and a temperature between 230 DEG C and 250 DEG C. The bone-repairing composite polymer material, which has excellent mechanical property, bioactivity, biocompatibility and controllable degradation property, can be perfectly combined with the interface of the bone tissue, and moreover, the degradation product is non-toxic and non-irritant.

The present invention relates to a solid composition useful for tissue gluing, tissue sealing and haemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N/cm, density of 1-10 mg/cm3, chamber diameter of more than 0.75 mm and less than 4 mm and/or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin. The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibres. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and/or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, epsi-aminocaproic acid or alpha2-antiplasmin,

The invention discloses a process for preparing Quinclorac artificial semiantigen, artificial antigen, specific antibody and use thereof, wherein the preparation comprises, subjecting the dichloroquine (3,7-dichlorine-8-quinoline carboxylic acid) to sulfoxide chlorinated acylation, reacting with reanal and aminocaproic acid, thus obtaining semiantigen 4-(3,7-dichlorine-8-quinolineformyl) reanal or 6-(3,7-dichlorine-8-quinolineformyl) aminocaproic acid (QB or QC).

The invention relates to an injection moldable bone repair composite material and a preparation method and a using method thereof. The composite material is a powder material consisting of a copolymer of multiple amino acids and a sulfate component of calcium, the sulfate component of the calcium accounts for 60-95% of total weight of the component material, and the balance is the copolymer of the multiple amino acids. The sulfate component of the calcium comprises alpha-hemihydrated calcium sulfate which accounts for 15%-60% of the total weight of the composite material and the balance of other sulfates of the calcium. The copolymer of the multiple amino acids is formed by polymerizing epsilon-aminocaproic acid and at least two types of other amino acids, and the molar ratio of each amino acid in the other amino acids is not less than 1% of the total weight of the amino acids. When in preparation, an intermediate parent body is obtained by in-situ polymerization and composition of other sulfates of the calcium and the amino acid monomers under inert gas protection and heating, and the composite material is prepared by smashing and then being composed with the alpha-hemihydrated calcium sulfate. The composite material powder is mixed with curing liquid, and then the composite material can be used by injection. The composite material can be fast molded after the injection and has the strength which is equivalent to that of cancellous bone, good biocompatibility and adjustable degradation speed, thereby being applicable to fixation and repair of clinical orthopedic complicated and irregular traumas.

The invention relates to a composite material containing microelement for hard tissue repair and reconstruction and a preparation method thereof. The composite material further contains at least one of three microelements of strontium, zinc and copper acceptable in human body with the calcium mole ratio of 0.01-0.5% in ceramic component of calcium phosphate in the ceramic component containing the calcium phosphate and the substrate material of multi-amino acid polymer, wherein the mass ratio of the ceramic component of calcium phosphate is 30-65%, and the balance of multi-amino acid polymer polymerized by epsilon-aminocaproic acid and other amino acids. The process for preparing the calcium phosphate ceramic comprises the following steps of: adding microelement, then mixing the amino acid components evenly, removing water of various forms in the mixture at a temperature lower than or equal to 200 DEG C under the protection of inert gas, then composing in situ polymerization under the condition of 210-250 DEG C and pH of 6.5-7.5. The composite material is a bionic biomedical and tissue engineering material which has controllable degradation speed, good bioactivity and compatibility and overcomes deficiencies and problems of similar repair materials at present.

A hemostatic composition comprises calcium alginate, a chitosan, epsilon-aminocaproic acid, an acid selected from aminomethylbenzoic acid and tranexamic acid, and tannin. The method of making the hemostatic composition comprises mixing one or more polysaccharide bases, tannin, a fibrinolytic inhibitor, colloidal silver and a solvent to form a mixture, and drying the mixture at a temperature between 25° C. and 80° C. until residual moisture content is approximately 15 to 20%.

A hemostatic textile material to stop bleeding comprising a dialdehyde cellulose (DAC) carrier wherein the degree of oxidation of the dialdehyde cellulose varies from about 1.5% to 12%; and a blood coagulation factor selected from the group consisting of chitosan and gelatin; the blood coagulation factor being chemically immobilized thereon; and further optionally comprising a bacteriolytic agent selected from the group consisting of a lysozyme enzyme, silver nitrate, and chlorhexidine; and further optionally comprising a selected component that prevents hemolysis, the component selected from the group consisting of tranexamic acid or ε-aminocaproic acid chemically immobilized thereon.

The invention discloses a preparing method for a bioglass/amino acid polymer composite. The preparing method comprises the following steps that epsilon-aminocaproic acid and other alpha-amino acid are taken and added with water, the mixture is dehydrated at 150-160 DEG C and then heated to 200-220 DEG C to be reacted for 2-3 h under the protection of nitrogen, the mixture is then heated to 230-235 DEG C to be reacted for 1-2 h, and an amino acid polymer is generated; then, bioglass is added, the mixture is evenly mixed and cooled, and the bioglass/amino acid polymer composite is obtained. The composite prepared through the method can have enough mechanical strength in the initial stage, can also be quickly degraded in the later stage and can meet the requirements for the mechanical strength and the degradation property at the same time; in addition, the method is easy and convenient to implement, simple in operation, convenient to control, safe, environmentally friendly, low in energy consumption, short in cycle, high in production efficiency and suitable for industrial application.

The present invention relates to the controllable degradation, filling-type complex bone implant of multivariant amino acid polymer-organic calcium/phosphorus salts, as well as to the preparative method thereof. The complex bone implant is consisted of multivariant amino acid polymers and medically acceptable organic calcium/phosphorus salts, while the content of organic calcium/phosphorus salts is 20-90% based on the total mass of composite material; the multivariant amino acid polymer is polymerized by ε-aminocaproic acid and at least two other amino acids, in which the molar content of ε-aminocaproic acid is at least 50% of the total molar quantity of amino acid polymers, while the amounts of other amino acids are at least 0.5% of the total molar quantity of amino acid polymers.

The invention discloses a traditional Chinese medicine capable of alleviating asthenopia and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 16-22 parts of vaccinium vitis-idaea lutein, 10-20 parts of all-grass of silybum marianum, 10-15 parts of zinc oxide, 10-15 parts of copper oxide, 17-23 parts of blueberries, 9-14 parts of flos buddlejae, 3-5 parts of licorice root,10-20 parts of semen cassiae, 13-27 parts of flos chrysanthemi indici, 3-5 parts of epsilon-aminocaproic acid, 3-5 parts of potassium L-aspartate, 4-6 parts of rose flowers, 5-7 parts of nostoc commune, 4-8 parts of fructus kochiae, and 5-7 parts of succus aloes folii siccatus. For the traditional Chinese medicine, through the reasonable mixing of the active ingredients, the traditional Chinese medicine has multiple efficacies of treating pseudomyopia, preventing and treating xerophthalmus, and protecting and brightening the eyes, and also can improve or alleviate the asthenopia symptoms including visual impairment, eye fatigue, photaesthesia, ache, lacrimation, foreign body sensation, ocular dryness, ophthalmospasm, and the like, and meanwhile, the traditional Chinese medical ingredients contained in the traditional Chinese medicine can directly participate in the tissue metabolism of eyes, and have the efficacy of removing liver-fire for improving eyesight.

The wound dressing for first aid is one support matter made of biocompatible synthetic material and sprayed with additive containing calcium ion, animal thrombase, aminocaproic acid, antibiotic resisting secondary infection, analgetic, and fibrous primordial cell growth factor or epithelial cell growth factor. The present invention controls hemorrhage through activating bodyí»s blood coagulation mechanism and inhibiting fibrin dissolution, and can inhibit massive haemorrhage of both artery and vein effectively in short time. The present invention has no any foreign human protein and thus has no hematogenic virus contamination and excellent safety.

A high-performance asphalt pavement repair material, which is made of the following raw materials in parts by weight: 25-35 parts of petroleum asphalt, 3-7 parts of micaceous iron oxide, 6-11 parts of butanol, and 7-9 parts of aluminum stearate , 2-4 parts of accelerator, 12-16 parts of rubber particles, 3-5 parts of hexaaminocaproic acid, 6-8 parts of polyvinyl alcohol, 0.4-1.2 parts of sodium aluminate, 0.5-1.2 parts of disodium octaborate tetrahydrate , 5-8 parts of fluorite powder, 4-8 parts of film-forming aids, 6-13 parts of acrylate, 5-7 parts of p-phenylenediamine, 4-8 parts of triethanolamine, 5-9 parts of sodium silicate, and 4 parts of sulfur ‑8 parts, polyamide 2‑4 parts. The beneficial effects of the present invention are: the high-performance asphalt pavement repair material of the present invention has very good viscosity and anti-aging properties, excellent repair performance, improves the anti-cracking ability of the material under low temperature conditions, and provides relatively high-demand road pavement. good guarantee.

The invention discloses an aminocaproic acid medicine composition and pharmaceutical application thereof. The aminocaproic acid medicine composition contains aminocaproic acid and a natural product compound (I) which is separated from dried folium sennae and is of a novel structure. Only common deep-scald protection effects can be realized when the aminocaproic acid and the natural product compound (I) are individually used, but deep-scald protection effects can be obviously improved when the aminocaproic acid and the natural product compound (I) are used with each other, and accordingly the aminocaproic acid medicine composition can be developed to obtain deep-scald protection medicines. Compared with the prior art, the aminocaproic acid medicine composition and the pharmaceutical application have the advantages of outstanding substantial characteristics and obvious advancement.