Wound dressing for first aid

A first-aid patch and trauma technology, applied in the field of medicine, can solve the problems of expensive human fibrinogen, limited application, solution wash-out, etc., and achieve the effect of controlling secondary infection, good safety, and easy operation

Active Publication Date: 2006-05-17
YANG LING ANDIYUAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main disadvantage is that during the preparation of the solution, more bleeding may occur, the solution is washed away by a large amount of bleeding, and does not stay in the wound long enough to achieve a hemostatic effect
Despite some progress in the composition and manipulation of prothrombin, these hemostatic shortcomings limit its application in hemostasis
Another major disadvantage of using "fibrin glue" is that it includes human plasminogen, a protein purified from human blood that is likely to be contaminated with highly dangerous HIV and blood-borne viruses such as hepatitis virus, so the US FDA Clinical use of plasminogen has been banned
In addition to safety concerns, human fibrinogen isolated from human plasma is also very expensive

Method used

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  • Wound dressing for first aid
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The sheet-like PVA sponge is used as the substrate of the sheet;

[0035] Spray 10mg / ml gelatin solution on the base sheet with a large-hole sprayer, and air-dry at room temperature; the amount of gelatin can be determined according to the application occasion of the sheet. Typically, gelatin is flowable and dispersed in a phosphate solution to a final concentration of at least 2 mg / cm 2 , usually 1mg / cm 2 to 50mg / cm 2 , the most commonly used is 2mg / cm 2 to about 10mg / cm 2 .

[0036] Spray the calcium alginate solution onto the substrate and dry it by air drying;

[0037] Spray the covalently bound bovine thrombin solution with a concentration of 10 activity units / ml onto the substrate with a small-hole sprayer, and dry it in a vacuum oven for 2 hours to a final concentration of 2 activity units / cm 2 ;

[0038] Spray the 6-aminocaproic acid solution with a concentration of 10 mg / ml on the substrate with a fine small-hole sprayer, and the final concentration is 1...

Embodiment 2

[0047] The sheet-like PVA sponge is used as the substrate of the sheet, the calcium ion additive is calcium chloride, the animal thrombin is covalently bonded bovine thrombin, and the aminocaproic acid is 8-aminocaproic acid. First spray 15 mg / ml gelatin solution on the substrate, then spray calcium chloride solution, thrombin solution with a concentration of 10 activity units / ml and 8-aminocaproic acid solution with a concentration of 20 mg / ml.

[0048] Animal hemostatic test and effect are the same as in Example 1.

Embodiment 3

[0050] The sheet-like PVA sponge is used as the substrate of the sheet, the calcium ion additive is calcium alginate, the animal thrombin is covalently bonded bovine thrombin, and the aminocaproic acid is 6-aminocaproic acid. After the solution of the above materials is sprayed on the substrate, broad-spectrum antibiotics, morphine and fibroblast growth factor are sprayed. Animal hemostatic test and effect are the same as in Example 1.

[0051] The size and shape of the first-aid trauma patch of the present invention can be determined according to specific uses, and can be spherical, conical, cubic or cylindrical, so that it is used for special parts of the body, and square sheet is commonly used. The present invention can also adhere the above-mentioned calcium ion additive, animal thrombin and aminocaproic acid to the synthetic polymer or natural fiber bandage.

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PUM

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Abstract

The wound dressing for first aid is one support matter made of biocompatible synthetic material and sprayed with additive containing calcium ion, animal thrombase, aminocaproic acid, antibiotic resisting secondary infection, analgetic, and fibrous primordial cell growth factor or epithelial cell growth factor. The present invention controls hemorrhage through activating bodyí»s blood coagulation mechanism and inhibiting fibrin dissolution, and can inhibit massive haemorrhage of both artery and vein effectively in short time. The present invention has no any foreign human protein and thus has no hematogenic virus contamination and excellent safety.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a wound first-aid patch mainly used for rescuing trauma wounded outside a hospital. Background technique [0002] Although many current technological advances have improved the management of the injured in the hospital, the treatment of the injured before hospitalization still remains at the level of traditional methods, such as the treatment of patients with traumatic bleeding is limited to bandaging, immobilization and high posture The mechanical hemostasis method, the hemostatic material for traumatic bleeding is also mainly mechanical hemostatic products. At present, about 20% of the casualties caused by war or traffic accidents die from massive blood loss; for patients with hemophilia, or patients using anticoagulants, such as patients after cardiac surgery, rapid massive bleeding The problem could be more serious. [0003] A good topical wound treatment product for combat casualti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44A61K9/70A61K38/43A61P17/02
Inventor 刘宇卉张世伟楚雍烈朱彤
Owner YANG LING ANDIYUAN BIOTECHNOLOGY CO LTD
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