Tissue renovation material of polymer form and preparation method thereof

Abstract

The present invention relates to a tissue-repairing material in the form of a polymer and a preparation method thereof. Epsilon-aminocaproic acid is polymerized with at least two other types of amine acids to form the tissue-repairing material shown in the formula, wherein, the mole ratio of the Epsilon-aminocaproic acid is 50 percent to 90 percent, and the rest is the other amine acids includingaminoacetic acid, lactamic acid, phenylalanine, lysine and proline. After being sufficiently and uniformly dispersed into water, the materials, amine acids, are heated to less than or equal to 200 DEG C, so that various forms of water can be removed from the materials; the materials are then pre-polymerized under the temperature between 200 DEG C and 220 DEG C and polymerized under the temperature between 220 DEG C and 250 DEG C; and the preparation process is conducted and fulfilled under the protection of an inert gas. The tissue-repairing material has ideal mechanical property, biological activity and controllable degradation property, and the degradation product of the tissue-repairing material is non-toxic and non-irritant. The tissue-repairing material can be widely used for the reparation and reconstruction of the tissues of the human body.

Description

technical field The present invention relates to a tissue repairing material in the form of a polymer in the medical field and a preparation method thereof, more specifically a tissue repairing material polymerized from polyamino acids and a preparation method thereof. Background technique Synthetic polymer materials play an important role in biomedicine such as medical hoses, syringe snares, valves, urinary catheters, catheters, heart valves, etc., and have been widely used in the treatment of human hard tissue injuries and diseases in recent years. Repaired and rebuilt with excellent performance. For example, polyether ether ketone (PEEK) is considered to be a hard tissue replacement material with good biomechanical compatibility, and is widely used in the fields of spinal repair and correction; ultra-high molecular weight polyethylene (UHMWPE) has a wide range of uses in artificial joints. Currently used medical polymer materials can be divided into two types: non-degra...

AI Technical Summary

Problems solved by technology

The main problems of the natural polymer materials currently used are low strength and rejection

Synthetic controllable degradable polymer materials (such as polylactic acid, etc.), whose degradation rate in the body cannot be controlled, the degradation process and mechanical properties cannot be matched, and the degradation products cause side effects such as irritation and inflammation to the tissue; while the controllable degradation of aliphatic polyester The strength of the series of materials is low, which cannot meet the repair and reconstruction of bearing parts

Among the synthetic polymer materials, although polyamide (PA) has the same amide bond-N-C=O as protein, the research results show that the commonly used synthetic polyamide PA-66 cannot be degraded by esterase, but can only be degraded by papain. , trypsin and chymotrypsin, and the degree of degradation is very low; the degradation of PA-6 is also very difficult