35 results about "Glycylglycine" patented technology

The invention relates to the field of polypeptide synthesis, and specifically relates to a preparation method of terlipressin through combination of solid and liquid. According to the preparation method, Boc-Gly-OH and glycylglycine are subjected to liquid phase synthesis so as to obtain a peptide fragment (Boc-Gly-Gly-Gly-OH); at the same time, solid phase synthesis is performed to obtain a cyclic peptide segment (H-c[Cys-Tyr(OtBu)-Phe-Gln(Trt)-Asn(Trt)-Cys]-Pro-Lys(Boc)-Gly-amino resin); finally the peptide fragment and cyclic peptide segment are coupled to prepare terlipressin resin; and then the terlipressin resin is cracked, purified, and freeze-dried to obtain terlipressin. The provided technology reduces the generation of impurity peptides, improves the purity and yield of coarse peptide, simplifies the operation steps, further reduces the production cost, and can be easily applied to large scale enlarged production.

The invention discloses anti-allergy face cream, and belongs to the technical field of daily chemicals. A method for preparing the anti-allergy face cream includes mixing sesame oil, natural surfactants and water with one another to obtain first mixtures and shearing the first mixtures at the high speed; sequentially adding ficus carica extract, cactaceae juice, glycylglycine, natural thickeners,honey, borneolum syntheticum, vegetable alkaloid, inositol, caffeine, carbomer and modified sepiolite into the first mixtures, stirring and mixing the ficus carica extract, the cactaceae juice, the glycylglycine, the natural thickeners, the honey, the borneolum syntheticum, the vegetable alkaloid, the inositol, the caffeine, the carbomer, the modified sepiolite and the first mixtures with one another and then carrying out high-pressure homogenization treatment, sterilization, discharging and filling to obtain the anti-allergy face cream. Ficus carica and water are smashed, pulped and filteredand then are mixed and boiled with natrii sulfas, and then cooling crystallization, filtering and drying are carried out to obtain the ficus carica extract; the natural surfactants comprise tea saponin, lecithin and lanolin; the natural thickeners comprise peach gum, xanthan gum and fucoidan. The anti-allergy face cream has the advantage that excellent anti-allergy effects can be realized by the anti-allergy face cream.

The invention relates to a joint detection reagent for bacterial vaginosis, which comprises a sialidase activity detection reagent and a praline aminopeptidase activity detection reagent, wherein the sialidase activity detection reagent consists of the following substances: 0.5-2.5g/l enzyme substrate A, 30-60g/l carbohydrate and 1-2g/l citric acid; the enzyme substrate A is 5-bromine-4-chlorine-3-indol-N-acetyl-alpha-sialic acid glycosides, nitrobenzene-N-acetyl-alpha-sialic acid glycosides or naphthol-N-acetyl-alpha-sialic acid glycosides; the praline aminopeptidase activity detection reagent consists of the following substances: 2-5g/l enzyme substrate B, 0.1-0.3mol/l Tris-hydrochloric acid buffer solution and 10-20g/l N-glycylglycine; and the enzyme substrate B is L-proline-paranitroaniline, L-proline-alpha-naphthylamine or L-proline-beta-naphthylamine. The reagent is used conveniently, special devices such as a microscope and the like are not required in detection, the detection speed is high, the sensitivity and the specificity are high, BV detection miss caused by merely detecting the activity of one enzyme is effectively avoided, and the reagent is popularized easily.

[Problem] To provide a keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit whereby the regrowth of a keratotic plug can be effectively inhibited without causing skin irritation. [Solution] A keratotic plug regrowth inhibition agent, characterized in containing: (a) a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof; (b) a specific surfactant (for example, fatty acid soap, higher alkyl sulfate ester salt, polyoxyalkylene phytosterol, or the like); and (c) a specific skin irritation mitigation agent (for example, POE/POP dimethyl ether, tranexamic acid, pantothenyl ethyl ether, trimethyl glycine, glycylglycine, or the like). A keratotic plug regrowth inhibition method, in which a skin cleanser including a POE fatty acid ester is applied to the skin and thereafter a keratotic plug regrowth inhibition agent including a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof is applied to the skin; also, a keratotic plug regrowth inhibition kit comprising the skin cleanser and keratotic plug regrowth inhibition agent.

The invention relates to the technical field of cosmetics, and in particular to a composition (cool-fermex) and a cosmetic for controlling oil and balancing moisture. The composition provided by the invention consists ofis prepared from citrus paradisi extract, kapok extract, glucosylglycerol, matmarine factors and glycylglycine for compounding, the formedprepared composition can have a good effect in controlling skin oil content, increasing skin moisture content and inhibiting skin moisture loss. In the composition, none of the components is dispensable, the components are cooperated with oneanother to produce a synergistic effect, and under an appropriate proportion, the composition achieves the best efficacy.

The invention discloses a kit for determining glycylproline dipeptide aminopeptidase. The kit comprises a liquid reagent R1 and a liquid reagent R2 which are mutually independent. The reagent R1 comprises a 120-310 mmol/L Tris buffer solution, 3.0-14.0 g/L glycylglycine and 0.6-1.5 g/L sodium azide. The solvent of the reagent R1 is purified water. The reagent R2 comprises 110-300 mmol/L glycyl-L-proline nitroaniline, 15-65 ml/L ethanediol, 3-12 g/L bovine serum albumin and 0.6-1.5 g/L sodium azide. The solvent of the reagent R2 is purified water. The kit has the advantages of high accuracy and the like.

The invention provides facial mask liquid capable of controlling oil and contracting pores. The facial mask liquid capable of controlling oil and contracting pores is prepared from the following raw materials in parts by weight of 1-2 parts of glycylglycine, 1-3 parts of nicotinamide, 2-5 parts of okra polysaccharide, 1-3 parts of a radix rhodiolae extract, 1-5 parts of a camellia extract, 2-4 parts of a purslane herb extract, 0.1-0.5 part of barosma betulina flavonoid, 2-5 parts of a traditional Chinese medicine bacteriostasis extract, 0.01-1 part of polyglutamic acid, 0.05-2.5 parts of sodium lactate, 0.05-7.5 parts of sodium pyrrolidone carboxylate, 0.05-5 parts of betaine, 0.1-2 parts of hydroxyethyl urea, 0.01-5 parts of a thickening agent, 0.01-0.5 part of ethylenediaminetetraaceticacid disodium salt, 2-20 parts of polyalcohol and 50-100 parts of deionized water. The facial mask liquid disclosed by the invention are purely natural in raw material components, does not have irritant chemical addition components, has the effects of enhancing cell tolerance and protecting cell membranes, has the function of strengthening skin natural barriers and has the effect of protecting theskin.

The invention discloses a kit for detection of liver function glycyl-proline dipeptidyl aminopeptidase and a preparation method. The kit includes a reagent A and a reagent B, wherein the reagent A comprises, by weight, 20-25 parts of a buffer solution, 16-19 parts of glycylglycine, 14-18 parts of sodium azide, 8-12 parts of a stabilizing agent, and 30-35 parts of deionized water; the reagent B includes, by weight, 21-25 parts of glycyl-proline p-nitroaniline p-toluenesulfonic acid, 15-19 parts of sodium azide, 19-23 parts of a buffer solution, 11-15 parts of a stabilizing agent, 22-26 parts of ethylene glycol, 6-9 parts of a surfactant, and 31-34 parts of deionized water; the buffer solution includes, by weight, 15-20 parts of trihydroxymethyl aminomethane, 20-25 parts of deionized water, and 18-22 parts of hydrochloric acid. A preparation method includes the steps of: mixing the trihydroxymethyl aminomethane and the deionized water. The kit has excellent stability and can improve precision and accuracy of detection and satisfy a strict demand. The kit is enlarged in use range, has simple preparation method and is convenient to use, and is low in cost.

Provided is a water-in-oil type preparation for hiding pores, said preparation containing glycylglycine, which has a parakeratosis inhibiting action, in a stable state, and having having both an outstanding pore hiding effect and good usability. The preparation contains; (a) 0.001 to 20 mass % of glycylglycine, (b) 0.5 to 2.5 mass % of a crosslinked polyether modified organopolysiloxane polymer, (c) a powder and (d) 6 to 10 mass % ethanol, wherein the (c) powder is titanium dioxide or a composite powder with titanium dioxide as the core having an average particle diameter of 0.2 to 0.5 mu m, which may be hydrophobilized, and is included at a proportion of 0.5 to 1.5 mass% relative to the entire mass of the preparation.

The invention discloses pore shrinking essence and a preparation method thereof, and belongs to the technical field of essence. The pore shrinking essence is prepared from the following raw materialsin parts by weight: 2 to 4 parts of tea polyphenol extract, 2 to 4 parts of propolis extract, 1 to 3 parts of glycylglycine, 0.5 to 1 part of protease, 0.5 to 1 part of aminopeptidase, 1 to 2 parts ofchamomile extract, 1 to 2 parts of liquorice root extract, 1 to 3 parts of yeast polypeptide, 2 to 4 parts of fucus serratus extract, 1 to 3 parts of oliopeptide-20, 0.5 to 1 part of carbomer, 0.6 to2 parts of aminomethyl propanol, 3 to 6 parts of propanediol, 3 to 6 parts of 1,3-butanediol, 0.5 to 1 part of PEG (Polyethylene Glycol)-40 hydrogenated castor oil, 0.5 to 1 part of blumea balsamifera oil, 0.5 to 1 part of caprylin, 0.1 to 0.2 part of methyl hydroxybenzoate, 0.1 to 0.2 part of allantoin, 0.02 to 0.1 part of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.03 to 0.1 part of sodium hyaluronate and 70 to 100 parts of deionized water. Glycylglycine contains a component capable of inhibiting the adverse effect of unsaturated fatty acid, and is not only capable of shrinking anoutward spreading structure of pores, but also capable of improving the skin state surrounding the pores; the tea polyphenol is a water-soluble substance, and has the effects of cleaning the grease onthe face, astringing the pores, removing acne, diminishing inflammation and sterilizing.

The invention discloses a plant breathable water-saving anti-transpiration agent, and belongs to the technical field of forestry planting. Acid catalysis aldolization is adopted for manufacturing a mytilopsis protein polymer, the phenolic hydroxyl group can be partially slowly oxidized into quinone, plant pores are not blocked, absorption of oxygen and exhaust of carbon dioxide for plants are obstructed, and the water-saving anti-transpiration effect is improved; ultrasonic dispersion is performed on serpentine, agglomeration among ingredients is reduced, the good adsorption effect is achieved, the composite auxiliary ingredients can slow down metabolism, and the anti-transpiration effect is achieved; by adding glycylglycine, the percutaneous water evaporation amount can be lowered, the good anti-transpiration effect is achieved, the effect of improving the lead pore state is achieved, normal breathing and ventilation can be ensured, and the water-saving and anti-transpiration effectsare synthesized. The problems that an existing common plant anti-transpiration agent is likely to block plant pores, absorption of oxygen and exhaust of carbon dioxide for plants are obstructed, and the plant growth and metabolism are not facilitated are solved.

The invention discloses an easy-to-fit eye pad and belongs to the technical field of biological materials. The easy-to-fit eye pad is prepared by sequentially weighing, by weight, 50-80 parts of modified bacterial cellulose, 10-18 parts of essential oil mixture, 8-10 parts of mixed enzyme solution, 2-6 parts of Carbomer, 10-15 parts of glycylglycine, 3-8 parts of emulsifier and 10-18 parts of traditional Chinese medicine extracts, mixing Carbomer with the traditional Chinese medicine extracts, regulating pH of mixture of Carbomer and the traditional Chinese medicine extracts to be 6.8-7.4 to obtain pre-processed traditional Chinese medicine extracts, mixing the modified bacterial cellulose with the pre-processed traditional Chinese medicine extracts, sequentially adding the essential oil mixture, mixed enzyme solution, glycylglycine and emulsifier with stirring and mixing to obtain base feed liquid, transferring the base feed liquid in a mold, freezing at the temperature of -20-12 DEGC for 30-40 minutes, unfreezing at the room temperature for 40-50 minutes, repeating the freezing and unfreezing process five or six times, and stripping to obtain the easy-to-fit eye pad.

The invention discloses a preparation method of N-[3-(2-furyl) acryloyl]-L-phenylalanyl-glycyl-glycine (FAPGG), and belongs to the technical field of organic synthesis. The preparation method comprises the following steps of: (1) letting thionyl chloride react with glycylglycine in ethanol to obtain glycylglycine ethyl ester hydrochloride; (2) dissolving N-[3-(2-furyl) acryloyl]-L-phenylalanine and glycylglycine ethyl ester hydrochloride into dichloromethane, and reacting under the conditions of organic alkali and a condensing agent to obtain N-[3-(2-furyl) acryloyl]-L-phenylalanyl-glycyl-glycine ethyl ester; and (3) dissolving N-[3-(2-furyl) acryloyl]-L-phenylalanyl-glycyl-glycine ethyl ester in an organic solvent, and hydrolyzing under an alkaline condition to obtain the FAPGG. FAPGG isan important substrate for determining the activity of angiotensin converting enzyme, and can be used for diagnosing hypertension, diseases in lung, kidney, liver and thyroid and other diseases. The synthetic method disclosed by the invention is short in route, simple in process and repeatable, and the obtained product is high in purity, high in yield and suitable for industrial production and hasimportant economic and social benefits.