35 results about "Glycylglycine" patented technology

There is provided a hair dye composition which is excellent in the dyeing (or bleaching) power against damaged hair, fragile and weakened hair or naturally fine and soft hair, and can impart bounce, body and volume to the hair.A hair dye composition containing the following components (a) and (b) and having a pH from 2 to 12 at the time of use:(a) 0.1 to 20% by mass of an aromatic sulfone compound represented by formula (1) shown below: wherein R's are identical or different, and each of them represents a hydrogen atom or a monovalent hydrocarbon group, or adjacent two R's are joined to form a saturated or unsaturated bivalent hydrocarbon group; when X is an oxygen atom, Y represents a hydrogen atom, and when X is a nitrogen atom, Y represents a carbonyl group that is bonded to X; and Z+ represents a monovalent cation; and(b) 0.01 to 5% by mass of at least one selected from glycylglycine, glycylglycylglycine and salts thereof.

By selecting one or more deodorizing agents from among glycine, cysteine and glycylglycine, and incorporating the selected deodorizing agent(s) and a surfactant, the toxicity of the surfactant to men and beasts is controlled without inhibiting the antibacterial actions that the surfactant has inherently. Glycine, cysteine, and glycylglycine each have a strong deodorizing action. The invention causes antibacterial deodorants to further have a deodorizing action by using such deodorizing agents. Moreover, the invention increases the permeating ability, thereby enhancing both the antibacterial action and the deodorizing action by subjecting water to treatment for fragmenting a cluster of the water and then adding the resulting active water as a diluent, or by preparing the diluent by incorporating alcohol with the active water.

A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.

The invention relates to the field of polypeptide synthesis, and specifically relates to a preparation method of terlipressin through combination of solid and liquid. According to the preparation method, Boc-Gly-OH and glycylglycine are subjected to liquid phase synthesis so as to obtain a peptide fragment (Boc-Gly-Gly-Gly-OH); at the same time, solid phase synthesis is performed to obtain a cyclic peptide segment (H-c[Cys-Tyr(OtBu)-Phe-Gln(Trt)-Asn(Trt)-Cys]-Pro-Lys(Boc)-Gly-amino resin); finally the peptide fragment and cyclic peptide segment are coupled to prepare terlipressin resin; and then the terlipressin resin is cracked, purified, and freeze-dried to obtain terlipressin. The provided technology reduces the generation of impurity peptides, improves the purity and yield of coarse peptide, simplifies the operation steps, further reduces the production cost, and can be easily applied to large scale enlarged production.

The invention discloses anti-allergy face cream, and belongs to the technical field of daily chemicals. A method for preparing the anti-allergy face cream includes mixing sesame oil, natural surfactants and water with one another to obtain first mixtures and shearing the first mixtures at the high speed; sequentially adding ficus carica extract, cactaceae juice, glycylglycine, natural thickeners,honey, borneolum syntheticum, vegetable alkaloid, inositol, caffeine, carbomer and modified sepiolite into the first mixtures, stirring and mixing the ficus carica extract, the cactaceae juice, the glycylglycine, the natural thickeners, the honey, the borneolum syntheticum, the vegetable alkaloid, the inositol, the caffeine, the carbomer, the modified sepiolite and the first mixtures with one another and then carrying out high-pressure homogenization treatment, sterilization, discharging and filling to obtain the anti-allergy face cream. Ficus carica and water are smashed, pulped and filteredand then are mixed and boiled with natrii sulfas, and then cooling crystallization, filtering and drying are carried out to obtain the ficus carica extract; the natural surfactants comprise tea saponin, lecithin and lanolin; the natural thickeners comprise peach gum, xanthan gum and fucoidan. The anti-allergy face cream has the advantage that excellent anti-allergy effects can be realized by the anti-allergy face cream.

The invention relates to a joint detection reagent for bacterial vaginosis, which comprises a sialidase activity detection reagent and a praline aminopeptidase activity detection reagent, wherein the sialidase activity detection reagent consists of the following substances: 0.5-2.5g / l enzyme substrate A, 30-60g / l carbohydrate and 1-2g / l citric acid; the enzyme substrate A is 5-bromine-4-chlorine-3-indol-N-acetyl-alpha-sialic acid glycosides, nitrobenzene-N-acetyl-alpha-sialic acid glycosides or naphthol-N-acetyl-alpha-sialic acid glycosides; the praline aminopeptidase activity detection reagent consists of the following substances: 2-5g / l enzyme substrate B, 0.1-0.3mol / l Tris-hydrochloric acid buffer solution and 10-20g / l N-glycylglycine; and the enzyme substrate B is L-proline-paranitroaniline, L-proline-alpha-naphthylamine or L-proline-beta-naphthylamine. The reagent is used conveniently, special devices such as a microscope and the like are not required in detection, the detection speed is high, the sensitivity and the specificity are high, BV detection miss caused by merely detecting the activity of one enzyme is effectively avoided, and the reagent is popularized easily.

[Problem] To provide a keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit whereby the regrowth of a keratotic plug can be effectively inhibited without causing skin irritation. [Solution] A keratotic plug regrowth inhibition agent, characterized in containing: (a) a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof; (b) a specific surfactant (for example, fatty acid soap, higher alkyl sulfate ester salt, polyoxyalkylene phytosterol, or the like); and (c) a specific skin irritation mitigation agent (for example, POE / POP dimethyl ether, tranexamic acid, pantothenyl ethyl ether, trimethyl glycine, glycylglycine, or the like). A keratotic plug regrowth inhibition method, in which a skin cleanser including a POE fatty acid ester is applied to the skin and thereafter a keratotic plug regrowth inhibition agent including a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof is applied to the skin; also, a keratotic plug regrowth inhibition kit comprising the skin cleanser and keratotic plug regrowth inhibition agent.

The invention relates to the technical field of cosmetics, and in particular to a composition (cool-fermex) and a cosmetic for controlling oil and balancing moisture. The composition provided by the invention consists ofis prepared from citrus paradisi extract, kapok extract, glucosylglycerol, matmarine factors and glycylglycine for compounding, the formedprepared composition can have a good effect in controlling skin oil content, increasing skin moisture content and inhibiting skin moisture loss. In the composition, none of the components is dispensable, the components are cooperated with oneanother to produce a synergistic effect, and under an appropriate proportion, the composition achieves the best efficacy.

A composition of a long-acting enzyme comprises the enzyme in a formulation comprising a buffer and an additive selected from the group consisting of tranexamic acid, ε-aminocaproic acid, and analogs of L-lysine other than tranexamic acid and ε-aminocaproic acid, combinations thereof, and mixtures thereof. The composition can further comprise another additive selected from the group consisting of L-lysine, L-arginine, L-ornithine (or its pharmaceutically acceptable salts; e.g., L-ornithine hydrochloride), γ-aminobutyric acid, 5-aminovaleric acid, 7-aminoheptanoic acid, glycylglycine, triglycine, N-α-acetyl-L-arginine, betaine, sarcosine, gelatin, HSA, streptokinase, tPA, uPA, non-ionic surfactants, glycerin, D-sorbitol, combinations thereof, and mixtures thereof. A method for prolonging the activity of an autodegradable enzyme comprises storing the enzyme after manufacture at a low pH, and reconstituting the acidified enzyme before use with a solution containing at least one of such additives. The method is useful to provide enzyme for wide use, which otherwise would lose activity upon long storage. In one embodiment the method is applicable to provide enzyme for inducing controlled posterior vitreous detachment.

The invention discloses a seminal plasma gamma-L-glutamyl transpeptidase activity quantitative detecting reagent kit, which comprises a reagent R1 and a reagent R2; the reagent R1 comprises the following ingredients: 100 to 200 mmol / L trihydroxymethyl aminomethane buffer with pH value of 8.0 to 8.3, 90 to 110mmol / L glycylglycine and 0.01%to 0.1% antiseptic; and the reagent R2 comprises the following ingredients: 100 to 200mmol / L trihydroxymethyl aminomethane buffer with pH value of 8.0 to 8.3, 0.5 to 3.0mmol / L substrate and 0.01% to 0.1% antiseptic. The two liquid reagents can be directly used without being frozen at the temperature of minus 20 DEG C, the type and the consumption of the reagent can be remarkably reduced, and the sample is free from being diluted for more than 200 times; the substrate has good specificity and good appetency to the enzyme, so the reaction speed is fast; and the reagent kit is matched with an automatic biochemical instrument to use, so the procedures can be implified, the reagent can be saved, the manual error can be reduced, automatic and large-scale detection can be realized, the detection result is more accurate and more reliable, and the detection efficiency can be greatly improved.

The invention discloses a kit for determining glycylproline dipeptide aminopeptidase. The kit comprises a liquid reagent R1 and a liquid reagent R2 which are mutually independent. The reagent R1 comprises a 120-310 mmol / L Tris buffer solution, 3.0-14.0 g / L glycylglycine and 0.6-1.5 g / L sodium azide. The solvent of the reagent R1 is purified water. The reagent R2 comprises 110-300 mmol / L glycyl-L-proline nitroaniline, 15-65 ml / L ethanediol, 3-12 g / L bovine serum albumin and 0.6-1.5 g / L sodium azide. The solvent of the reagent R2 is purified water. The kit has the advantages of high accuracy and the like.

The invention provides facial mask liquid capable of controlling oil and contracting pores. The facial mask liquid capable of controlling oil and contracting pores is prepared from the following raw materials in parts by weight of 1-2 parts of glycylglycine, 1-3 parts of nicotinamide, 2-5 parts of okra polysaccharide, 1-3 parts of a radix rhodiolae extract, 1-5 parts of a camellia extract, 2-4 parts of a purslane herb extract, 0.1-0.5 part of barosma betulina flavonoid, 2-5 parts of a traditional Chinese medicine bacteriostasis extract, 0.01-1 part of polyglutamic acid, 0.05-2.5 parts of sodium lactate, 0.05-7.5 parts of sodium pyrrolidone carboxylate, 0.05-5 parts of betaine, 0.1-2 parts of hydroxyethyl urea, 0.01-5 parts of a thickening agent, 0.01-0.5 part of ethylenediaminetetraaceticacid disodium salt, 2-20 parts of polyalcohol and 50-100 parts of deionized water. The facial mask liquid disclosed by the invention are purely natural in raw material components, does not have irritant chemical addition components, has the effects of enhancing cell tolerance and protecting cell membranes, has the function of strengthening skin natural barriers and has the effect of protecting theskin.

The invention discloses a kit for detection of liver function glycyl-proline dipeptidyl aminopeptidase and a preparation method. The kit includes a reagent A and a reagent B, wherein the reagent A comprises, by weight, 20-25 parts of a buffer solution, 16-19 parts of glycylglycine, 14-18 parts of sodium azide, 8-12 parts of a stabilizing agent, and 30-35 parts of deionized water; the reagent B includes, by weight, 21-25 parts of glycyl-proline p-nitroaniline p-toluenesulfonic acid, 15-19 parts of sodium azide, 19-23 parts of a buffer solution, 11-15 parts of a stabilizing agent, 22-26 parts of ethylene glycol, 6-9 parts of a surfactant, and 31-34 parts of deionized water; the buffer solution includes, by weight, 15-20 parts of trihydroxymethyl aminomethane, 20-25 parts of deionized water, and 18-22 parts of hydrochloric acid. A preparation method includes the steps of: mixing the trihydroxymethyl aminomethane and the deionized water. The kit has excellent stability and can improve precision and accuracy of detection and satisfy a strict demand. The kit is enlarged in use range, has simple preparation method and is convenient to use, and is low in cost.

The invention belongs to the field of biological detection, and particularly relates to a firefly luciferase activity determination method. The method includes the following steps that mixed liquid containing ATP, Mn2+, Ca2+, fluorescein, aminolevulinic glycylglycine and phosphate is prepared; the PH value is adjusted; the mixed liquid is precooled to 4 DEG C; biotinylation luciferase is incubated in the mixed liquid; the ATP is added, the mixture is put into a detection instrument, and the intensity of a fluorescence signal is determined. By means of the determination method, high throughput screening and using of the luciferase are facilitated.

Provided is a water-in-oil type preparation for hiding pores, said preparation containing glycylglycine, which has a parakeratosis inhibiting action, in a stable state, and having having both an outstanding pore hiding effect and good usability. The preparation contains; (a) 0.001 to 20 mass % of glycylglycine, (b) 0.5 to 2.5 mass % of a crosslinked polyether modified organopolysiloxane polymer, (c) a powder and (d) 6 to 10 mass % ethanol, wherein the (c) powder is titanium dioxide or a composite powder with titanium dioxide as the core having an average particle diameter of 0.2 to 0.5 mu m, which may be hydrophobilized, and is included at a proportion of 0.5 to 1.5 mass% relative to the entire mass of the preparation.

Provided is a salty taste enhancer that is capable of maintaining the flavor balance inherent in a food and enhancing salty taste despite a reduction in salt content. The salty taste enhancer effectively enhances salty taste by adding to a food or beverage having salty taste at least one selected from the group consisting of prolylglycine, glycylglycine, glycylproline and hydroxyprolylglycine, or a gelatin degradation product containing the dipeptide.

The invention provides a sequential synthesis method of tetra-glycylglycine. The method includes steps: 1, producing glycylglycine after condensating and ring opening of glycine; 2, producing tri-glycylglycine after activated ester condensation of glycylglycine and N-protected glycine and deprotection; and 3, producing tetra-glycylglycine after activated ester condensation of tri-glycylglycine and N-protected glycine and deprotection.

The invention discloses pore shrinking essence and a preparation method thereof, and belongs to the technical field of essence. The pore shrinking essence is prepared from the following raw materialsin parts by weight: 2 to 4 parts of tea polyphenol extract, 2 to 4 parts of propolis extract, 1 to 3 parts of glycylglycine, 0.5 to 1 part of protease, 0.5 to 1 part of aminopeptidase, 1 to 2 parts ofchamomile extract, 1 to 2 parts of liquorice root extract, 1 to 3 parts of yeast polypeptide, 2 to 4 parts of fucus serratus extract, 1 to 3 parts of oliopeptide-20, 0.5 to 1 part of carbomer, 0.6 to2 parts of aminomethyl propanol, 3 to 6 parts of propanediol, 3 to 6 parts of 1,3-butanediol, 0.5 to 1 part of PEG (Polyethylene Glycol)-40 hydrogenated castor oil, 0.5 to 1 part of blumea balsamifera oil, 0.5 to 1 part of caprylin, 0.1 to 0.2 part of methyl hydroxybenzoate, 0.1 to 0.2 part of allantoin, 0.02 to 0.1 part of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.03 to 0.1 part of sodium hyaluronate and 70 to 100 parts of deionized water. Glycylglycine contains a component capable of inhibiting the adverse effect of unsaturated fatty acid, and is not only capable of shrinking anoutward spreading structure of pores, but also capable of improving the skin state surrounding the pores; the tea polyphenol is a water-soluble substance, and has the effects of cleaning the grease onthe face, astringing the pores, removing acne, diminishing inflammation and sterilizing.

The invention relates to a biological detection reagent and in particular relates to a stable serum gamma-glutamyl transferase reagent having strong anti-jamming capacity and a detection method of the serum gamma-glutamyl transferase reagent, belonging to the technical field of the clinical in-vitro detection. Reagent R1 contains a buffer solution, glycylglycine, BSA (Bull Serum Albumin), trehalose, APG (alkyl glycoside) and preservative; reagent R2 contains a buffer solution, L-gamma-glutamyl-3-carboxyl-4-nitranilide, BSA, trehalose, APG and preservative; a PIPES (piperazine-1,4-Piperazinediethanesulfonic acid) buffer solution is adopted, and stabilizers (BSA and trehalose) are added, so that the stability of the reagent is improved greatly; and a novel surface active agent-alkyl glycoside is adopted, so that the measurement performance is remarkably improved and the stability and the anti-jamming capability of the reagent are enhanced.

The invention relates to the field of biological detection, and in particular relates to a method for detecting activity of luciferase in a sample. The method comprises the step of incubating biotinylated luciferase in a mixed solution containing ATP, Mg<2+>, Ca<2+>, luciferin, amino acetyl glycylglycine and phosphate to generate optical signals. In the process of detecting the luciferase, the optical signal intensity is high, and the duration is long, so that the high-throughput screening and use of the luciferase are facilitated.

The invention discloses a plant breathable water-saving anti-transpiration agent, and belongs to the technical field of forestry planting. Acid catalysis aldolization is adopted for manufacturing a mytilopsis protein polymer, the phenolic hydroxyl group can be partially slowly oxidized into quinone, plant pores are not blocked, absorption of oxygen and exhaust of carbon dioxide for plants are obstructed, and the water-saving anti-transpiration effect is improved; ultrasonic dispersion is performed on serpentine, agglomeration among ingredients is reduced, the good adsorption effect is achieved, the composite auxiliary ingredients can slow down metabolism, and the anti-transpiration effect is achieved; by adding glycylglycine, the percutaneous water evaporation amount can be lowered, the good anti-transpiration effect is achieved, the effect of improving the lead pore state is achieved, normal breathing and ventilation can be ensured, and the water-saving and anti-transpiration effectsare synthesized. The problems that an existing common plant anti-transpiration agent is likely to block plant pores, absorption of oxygen and exhaust of carbon dioxide for plants are obstructed, and the plant growth and metabolism are not facilitated are solved.

The invention provides a sodium lauroyl sarcosine-glycylglycine compound and a composite oil displacement agent. The chemical structural formula of the sodium lauroyl sarcosine-glycylglycine compoundis shown in the description. The sodium lauroyl sarcosine-glycylglycine composite oil displacement agent including the sodium lauroyl sarcosine-glycylglycine compound obtained through the reaction ofsodium lauroyl sarcosine and glycylglycine is provided. The compounding of the composite oil displacement agent and oil production function bacteria can be well realized, so that a microbial-chemicalcomposite oil displacement agent can be formed. The microbial-chemical composite oil displacement agent has the efficacy of microorganisms to degrade crude oil and reduce the viscosity of the crude oil, and also has the effects of chemical flooding to emulsify the crude oil and reduce the viscosity of the crude oil; and through the mode of biological carrying, the swept volume and dispersion efficiency of a chemical oil displacement agent in oil layers can be expanded, so that the synergistic reaction efficiency of the microorganisms and the chemical agent can be effectively enhanced, and thepurpose of 1+1>2 can be realized.

By selecting one or more deodorizing agents from among glycine, cysteine and glycylglycine, and incorporating the selected deodorizing agent(s) and a surfactant, the toxicity of the surfactant to men and beasts is controlled without inhibiting the antibacterial actions that the surfactant has inherently. Glycine, cysteine, and glycylglycine each have a strong deodorizing action. The invention causes antibacterial deodorants to further have a deodorizing action by using such deodorizing agents. Moreover, the invention increases the permeating ability, thereby enhancing both the antibacterial action and the deodorizing action by subjecting water to treatment for fragmenting a cluster of the water and then adding the resulting active water as a diluent, or by preparing the diluent by incorporating alcohol to the active water.

The invention discloses an easy-to-fit eye pad and belongs to the technical field of biological materials. The easy-to-fit eye pad is prepared by sequentially weighing, by weight, 50-80 parts of modified bacterial cellulose, 10-18 parts of essential oil mixture, 8-10 parts of mixed enzyme solution, 2-6 parts of Carbomer, 10-15 parts of glycylglycine, 3-8 parts of emulsifier and 10-18 parts of traditional Chinese medicine extracts, mixing Carbomer with the traditional Chinese medicine extracts, regulating pH of mixture of Carbomer and the traditional Chinese medicine extracts to be 6.8-7.4 to obtain pre-processed traditional Chinese medicine extracts, mixing the modified bacterial cellulose with the pre-processed traditional Chinese medicine extracts, sequentially adding the essential oil mixture, mixed enzyme solution, glycylglycine and emulsifier with stirring and mixing to obtain base feed liquid, transferring the base feed liquid in a mold, freezing at the temperature of -20-12 DEGC for 30-40 minutes, unfreezing at the room temperature for 40-50 minutes, repeating the freezing and unfreezing process five or six times, and stripping to obtain the easy-to-fit eye pad.

The invention discloses a preparation method of N-[3-(2-furyl) acryloyl]-L-phenylalanyl-glycyl-glycine (FAPGG), and belongs to the technical field of organic synthesis. The preparation method comprises the following steps of: (1) letting thionyl chloride react with glycylglycine in ethanol to obtain glycylglycine ethyl ester hydrochloride; (2) dissolving N-[3-(2-furyl) acryloyl]-L-phenylalanine and glycylglycine ethyl ester hydrochloride into dichloromethane, and reacting under the conditions of organic alkali and a condensing agent to obtain N-[3-(2-furyl) acryloyl]-L-phenylalanyl-glycyl-glycine ethyl ester; and (3) dissolving N-[3-(2-furyl) acryloyl]-L-phenylalanyl-glycyl-glycine ethyl ester in an organic solvent, and hydrolyzing under an alkaline condition to obtain the FAPGG. FAPGG isan important substrate for determining the activity of angiotensin converting enzyme, and can be used for diagnosing hypertension, diseases in lung, kidney, liver and thyroid and other diseases. The synthetic method disclosed by the invention is short in route, simple in process and repeatable, and the obtained product is high in purity, high in yield and suitable for industrial production and hasimportant economic and social benefits.

The invention discloses a polyamide reverse osmosis composite membrane having renewable chlorine resistance and a preparation method thereof, wherein the preparation method comprises the steps: (1) a polyamide reverse osmosis original membrane having the surface with carboxyl is soaked in a catalyst and is subjected to surface activation; and (2) the membrane obtained after surface activation is soaked in a solution containing a graft material and is subjected to surface grafting, wherein the catalyst contains 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, and the graft material is at least one of glycylglycine, glutamine and tyrosine. According to the preparation method, the surface of the polyamide reverse osmosis original membrane is introduced with aliphatic amide small molecules with the tail end being carboxyl, amide N-H in a structure is used as an sacrificial-layer functional group for preferentially undergoing a reaction with active chlorine, a body polyamide layer is protected, the chlorine resistance of the polyamide reverse osmosis composite membrane is strengthened, and at the same time, the chlorine resistance can be regenerated through reduction.

The invention discloses a glycyl proline dipeptidylaminopeptidase determining reagent kit, and relates to the technical field of biologic detection. The glycyl proline dipeptidylaminopeptidase determining reagent kit comprises a reagent R1 and a reagent R2 which are mutually independent, wherein the reagent R1 comprises the following ingredients by corresponding content of 5-10g / L trihydroxymethylaminomethane, 5-10g / L glycylglycine and 0.1-0.5g / L sodium azide, and the reagent R2 comprises the following ingredients by corresponding content of 10-20g / L glycyl proline para-nitroaniline tosylate,20-80ml / L ethanediol, 2-8g / L bovine serum albumin and 0.1-0.5g / L sodium azide. In an implementation process, the addition proportion of mannitol to mannan to glucosamine in the reagent R2 is (1-5) to(1-2) to 1, besides, the volume ratio of the reagent R1 to the reagent R2 is controlled to be (5-10) to 1, stability and accuracy of the reagents are reinforced, the capacity of resisting disturbanceof the reagents is increased, and further promotion and use of the reagents in the market can be facilitated.

A hair dye composition containing the following components (a) and (b) and having a pH from 2 to 12 at the time of use: (a) 0.1 to 20% by mass of an aromatic sulfone compound represented by the formula (1) shown below:Wherein R's, Y, X− and Z+ are defined in the claims and in the disclosure. (b) 0.01 to 5% by mass of at least one component selected from glycylglycine, glycylglycylglycine and salts thereof.

The invention relates to a cis-nitenpyram analogue containing glycylglycine, a general formula of a structure of the analogue is: simultaneously the invention also provides a preparation method of cis-nitenpyram analogue containing glycylglycine, and provides an application of the analogue in the agricultural insecticidal field, the cis-nitenpyram analogue containing glycylglycine can be prepared into pesticide dosage types such emulsions, aqueous suspensions or emulsions in water. According to the invention, the cis-nitenpyram analogue containing glycylglycine shown in the general formula (I) has high activity and low toxicity, is safe to people and animals and promotes the growth of crops. In addition, the cis-nitenpyram analogue of the invention uses a microwave heating method which greatly shortens the required time of the reaction.

[Problem] To provide a keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit whereby the regrowth of a keratotic plug can be effectively inhibited without causing skin irritation. [Solution] A keratotic plug regrowth inhibition agent, characterized in containing: (a) a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof; (b) a specific surfactant (for example, fatty acid soap, higher alkyl sulfate ester salt, polyoxyalkylene phytosterol, or the like); and (c) a specific skin irritation mitigation agent (for example, POE / POP dimethyl ether, tranexamic acid, pantothenyl ethyl ether, trimethyl glycine, glycylglycine, or the like). A keratotic plug regrowth inhibition method, in which a skin cleanser including a POE fatty acid ester is applied to the skin and thereafter a keratotic plug regrowth inhibition agent including a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof is applied to the skin; also, a keratotic plug regrowth inhibition kit comprising the skin cleanser and keratotic plug regrowth inhibition agent.