The invention discloses a two-stage ultrasonic vibration atomizer, which comprises a liquid conveying pipeline, a bolt, a rear cover plate, a piezoelectric ceramic plate, an electrode sheet, an amplitude transformer, a first-stage atomizing spray head and a second-stage atomizing radiation surface, wherein the rear cover plate, the piezoelectric ceramic plate and the electrode sheet are pressed by the connection between the amplitude transformer and the thread at the front end of the bolt, so as to form a second-stage ultrasonic atomizing vibrator; the first-stage atomizing spray head is connected with the front end of the amplitude transformer; and the second-stage atomizing radiation surface is clamped between the front end of the amplitude transformer and the rear end of the first-stage atomizing spray head. According to the invention, the vibrator part adopts a sandwich transducer structure, and has high power capability; the first-stage atomizing is realized by the micro-spraying holes on the first-stage atomizing spray head; the second-stage atomizing is realized by ultrasonic vibration; and through two-stage atomizing, the two-stage ultrasonic vibration atomizer has the advantages of small gas atomizing grains and the like, and can be applied to the fields of cooling of mechanical processing and cutting heat, air moistening, medical treatment, dedusting, deodorizing, weaving, printing and dyeing, tobacco, flowers, papermaking, electronics, spray-coating, chemical industry, granulating, fungus culturing, fruit storage and the like.