154results about How to "Reduce the difficulty of synthesis" patented technology

The invention relates to a process for preparing ordered porous silicon oxide single sheet material with large scale and no fracture, wherein the conventional sol-gal process is improved by introducing inert medium liquid as shape protecting agent, and solvent volatilization is realized at high temperature.

The invention relates to a perfluoropolyether group-containing silane compound represented by a formula (1): Rf-X1-X2-NQkT2-k(1), and a preparation method therefor. The invention also relates to a perfluoropolyether group-containing silane compound shown in the description, and a preparation method therefor. The invention also relates to a perfluoropolyether group-containing silane compound represented by a formula (3) shown in the description, and a preparation method therefor. The perfluoropolyether group-containing silane compound can be used for a surface treatment agent so that the glassand other base materials processed by the surface treatment agent are excellent in anti-pollution, anti-fingerprint, scrape-resistant and wear-resistant performances, and the preparation methods for the compounds are simple in process, and are easy to operate and implement.

The invention belongs to the field of polypeptide synthesis, and relates to a solid-phase synthesis method of ziconotide by a segment process. The method aims to solve the technical problems of long synthesis period and low crude peptide purity in the existing preparation method, and the technical problems of complex operation, low total yield and the like in the disulfide-bond formation process. The technical scheme is as follows: the method comprises the following steps: synthesizing four segment peptides [19-25]A, [12-18]B, [6-11]C and [1-5]D of ziconotide by a solid-phase process; sequentially connecting the all-protected peptide fragments B, C and D to the peptide resin A, and cracking to obtain a ziconotide linear peptide; and finally, carrying out liquid-phase one-step oxidization, which has the advantages of mild conditions, simplified operation, easy after-treatment and environment friendliness, to obtain the ziconotide. The technical scheme can greatly shorten the synthesis period, lower the synthesis and purification difficulty and the production cost, and enhance the purity of the linear peptide and the total yield of the product. The method is beneficial to industrial large-scale production.

The invention relates to a fluorescent microsphere marker and a preparation method thereof. The invention aims to provide a fluorescent microsphere marker. Compared with the traditional fluorescent marker, the fluorescent microsphere marker disclosed by the invention has the advantages of higher fluorescence intensity and higher stability, is easier to mark and is simpler to prepare. The technical scheme of the fluorescent microsphere marker is to provide the fluorescent microsphere marker. The fluorescent microsphere marker comprises a carrier, wherein the carrier is a microsphere polymerized by a styrene monomer, and the microsphere is connected with a fluorescence complex. The fluorescent microsphere marker disclosed by the invention has the beneficial effects that the preparation method is simpler and easier because the microsphere polymerized by the styrene monomer is used as the carrier. The microsphere disclosed by the invention not only can be used for marking the rare earth fluorescence complex but also can be used for marking common fluorescence substance, such as FITC (fluorescein isothiocyanate), the microsphere with various fluorescence properties can be manufactured, and the requirement of multiple detection can be satisfied.

A process for synthesizing mesoporous silicon oxide as molecular sieve features that an ultrasonic system is used and the non-ionic surfactant is used as structure guide agent to effectively and quickly synthesize 2-D and 3-D mesoporous silicon oxide. Its advantages are high sequential pore channel structure, and greater specific surface area and porous volume.

The invention relates to a preparation method for a transparent mesoporous silicon dioxide gel monolith material which pertains to the technical field of inorganic porous material, in particular to an ordered mesoporous silicon dioxide gel monolith material with large size, no crackle and optical transparent and the technical proposal of the simple, highly efficient, rapid and convenient preparation method. The method is characterized in that direct conversion of sol, gel, aging and drying can be realized at high temperature by adjusting synthesis ratio without any special protective means or complicated operation procedures. The method has short synthesis period and simple operation steps and is easy to control. The material produced by the method has an ordered hexagonal phase mesoporous structure with 2nm to 10nm of aperture, 0.2cm<3>/g to 0.8cm<3>/g of pore volume, 450m<2>/g to 850m<2>/g of specific area and 2.2nm of wall thickness, and the wall thickness of the structure is larger than the aperture, thereby having wide application value in the research aspect of novel optical units, electrical units and magnetic units.

The invention relates to a rapid preparation method of a transparent mesoporous silica gel monolith, which belongs to the technical field of the inorganic porous material, in particular to a technical scheme of a simple, efficient, rapid and convenient preparation method of a large-sized, crack-free and optically transparent ordered mesoporous silica gel monolith. The preparation method is characterized in that the direction conversion of gel melting, condensation, aging and drying can be realized at a high temperature through adjusting a synthesis ratio without special protection means and complex operating procedures. Moreover, the method has the advantages of short synthesis period, simple operating steps and easy control. The material prepared in the method has an ordered two-dimensional and hexagonal-phase mesoporous structure, the pore size is 2.0-7.0nm, the pore volume is 0.5-0.8 cm3/g, and the specific surface area is 500-1000m2/g. Therefore, the material has extensive application value in research and development of optical, electrical and magnetic devices.

The invention discloses a video synthesis method, device and equipment and a storage medium, and relates to the field of video processing. The method comprises the steps of obtaining a text; acquiringan audio corresponding to the text, and processing the audio to obtain n mouth shape identifiers corresponding to the phoneme sequence in the audio and mouth shape time point information of each mouth shape identifier, n being a positive integer; obtaining a standardized mouth shape sequence frame and a video containing an anchor image, wherein the standardized mouth shape sequence frame comprises mouth shape video frames corresponding to n mouth shape identifiers; and according to the mouth shape time point information of each mouth shape identifier, performing synthesis processing on the mouth shape video frames corresponding to the n mouth shape identifiers and the video containing the live streamer image to obtain a live streamer video. The live streamer video can be synthesized onlyby providing the text without pre-training a machine learning model for synthesizing the video, so that the video synthesis difficulty is reduced, and the video synthesis efficiency is improved.

The invention relates to an image encoding method, an image decoding method, an encoding device and a decoding device. The method comprises the following steps: carrying out one-stage or multi-stage decomposition on an original image through a wavelet transformation function to obtain wavelet transformation coefficients corresponding to pixel data of a plurality of sub-images and the levels of thesub-images; determining an effective value of the wavelet transform coefficient according to the wavelet transform coefficient and the level of the sub-image corresponding to the wavelet transform coefficient; determining a coded DNA sequence of the wavelet transform coefficient according to a corresponding relation between the DNA base sequence and numbers and the effective numerical value; andaccording to the level of the sub-image, connecting the coded DNA sequence of the wavelet transform coefficient, and determining the coded DNA sequence of the original image. The image compression ratio is high, the digital representation can comprise a binary system number or more, the probability that four basic bases continuously appear can be reduced, and therefore the DNA synthesis difficultyis reduced.

The invention relates to a carbon-based compounded ferric cyanamide material and a preparation method thereof. The carbon-based compounded ferric cyanamide material comprises ferric cyanamide and carbon compounded with the ferric cyanamide. According to the material, the ferric cyanamide is compounded with the carbon, so that the problem that the volume of ferric cyanamide is increased can be effectively solved, meanwhile due to compounding of the two materials, the reaction activity of a battery can be further improved, the battery can be relatively stable in structure, and the multiplying power and the circulation performance of the battery can be improved.

The present invention provides a hairpin-like adaptor, a construct and a method for characterizing a double-stranded target polynucleotide. The hairpin-like adaptor comprises a first single strand and a second single strand which are respectively connected with a template strand and a complementary strand of the double-strand target polynucleotide, and the first single strand and the second single strand form at least one double-strand nucleic acid region which is used for enabling the complementary strand to be close to a transmembrane pore after the template strand passes through the transmembrane pore. Also provided are a construct comprising the hairpin-like adapter, as well as a method, a kit, and the like for characterizing double-stranded target polynucleotides. The characterization method disclosed by the invention has many advantages, such as balancing the translocation speed of the template strand and the complementary strand of the target polynucleotide, improving the sequencing accuracy and the like.

The invention relates to the technical field of information processing, in particular to an image storage method, an image reading method, an image storage device and an image reading device. The method comprises the following steps of carrying out wavelet transformation on an original image to obtain the wavelet transformation coefficients corresponding to multiple levels of sub-images; obtaininga target wavelet transformation coefficient corresponding to the sub-image with the level greater than or equal to a preset value; and encoding the target wavelet transformation coefficient into a DNA sequence according to a preset corresponding relationship between the DNA base sequence and the wavelet transformation coefficient. According to the importance of the levels and types of the sub-images to image reconstruction and the data volume of the sub-images, the target wavelet transformation coefficients corresponding to the sub-images meeting the requirements are selected for DNA coding,so that the coded data volume can be effectively compressed, the high-definition decoding can be guaranteed, and the efficient storage of the image data is achieved.

The invention discloses a DNA storage encoding and decoding method based on a hybrid model. The method comprises the following steps: inputting original data to perform binary conversion, and performing Huffman encoding compression; dividing the file into a plurality of columns, and adding an address code to the column head; storing the DNA in a quaternion and binary model for hybrid coding, and modifying an initial model code; adding an error correction code to the model code by adopting RS coding, and then performing RS coding error correction on the DNA sequence; repeating the above steps until all sequences are coded and corrected; sorting all the sequences according to file codes and coding numbers, and adding four columns of error correction sequences to every 123 columns by utilizing RS codes; according to the method, a traditional DNA storage quaternary model and a binary model are subjected to hybrid encoding, and the encoding potential reaches 1.75; compared with a quaternarymodel, the GC percentage can be better controlled, and compared with a binary model, the storage capacity is greatly improved.

The invention relates to a novel strategy for preparing aspartic acid-arginine derivate [Asp-Arg(X)] units, and a product obtained thereby. The novel strategy is especially applicable to a polypeptide sequence which can promote the subsidiary reaction of asparaginimide in the synthesis process of arginine or arginine derivates. The method comprises a strategy for optimizing polypeptide synthesis conditions based on a fragment condensation method. In such strategy, the polypeptide sequence is divided into two fragments at Asp-Arg(X), and the two fragments are respectively synthesized, wherein one fragment containing the Asp residue is synthesized on 2-chlorotrityl chloride resin (CTC resin) extremely sensitive to acid, and the fully-protected fragment (both the N terminals and side chains are protected) obtained by preparation is coupled onto an amino group of the Arg(X) of the other fragment, thus finishing the synthesis of the whole sequence. The coarse peptide obtained by cutting ispurified by the conventional high performance liquid chromatography, thus ultimately obtaining the pure target polypeptide product. The method effectively suppresses the promotion effect of alkaline guanidyl side chains of Arg(X) on the subsidiary reaction of asparaginimide, and greatly improves the synthesis success rate of the polypeptide and the purity of the final product.

The invention relates to a fondaparinux sodium pentasaccharide intermediate in the technical field of chemical preparation and a preparation method thereof, particularly to a preparation method of the fondaparinux sodium pentasaccharide intermediate, and comprises a trisaccharide intermediate of fondaparinux sodium and preparation method thereof. The invention designs a novel synthetic route to prepare the fondaparinux sodium pentasaccharide intermediate. The route has mild reactions, good reaction selectivity, strong controllability and low operation difficulty, and is beneficial to achievement of industrial production. The route has a low cost so that the method can meet requirements of large-scale industrial production.

The invention relates to a preparation method of polybutadiene with greatly adjustable microstructure content and crystallinity. MoCl5.n-BuOH is adopted as the main catalyst, AlEt3 is taken as the cocatalyst, and toluene is employed as the solvent. The method provided by the invention has great scientific value and practical significance for development of Mo catalyzed polybutadiene and its copolymer in China, and lays a theoretical foundation for industrial production of polybutadiene. The obtained polymers with different structural unit varieties and microstructure content can be used as rubber materials of high performance "green" tires, and the tires prepared therefrom have good safety, comfortableness, fuel economy, durability and other characteristics. Also the method expands the application of polybutadiene in plastics, paint, adhesives, functional polymers and other fields.

The invention discloses preparation and application of a chiral resolution additive used for conveniently modifying magnetic nanoparticles. The additive is triblock copolymer with an A-r-dopa-r-beta-CD general structure, wherein A is a protonation or deprotonation unit, dopa represents a dopamine functional group, beta-CD represents beta-cyclodextrin, and r represents random distribution. The polymer additive can be directly attached to the surface of the magnetic nanoparticles through one-step ligand exchange reaction, an adoption process is quick and convenient, and adsorption stability is higher; a hydrophilic beta-cyclodextrin unit in the polymer additive can assist the magnetic nanoparticles in realizing a monodisperse state in a water environment, the magnetic nanoparticles can own a larger specific surface area, and contact with a raceme can be more sufficient; the synthetic process of the polymer additive only contains two steps, synthetic difficulty is lower, and requirements on a synthetic condition are not harsh.

The invention provides amido bond symmetrical molecular tweezers-containing series of porphyrin compounds and a preparation method thereof. The structural formulas of the porphyrin compounds are as follows: the molecular formulas of the series of compounds are C96H74N10O2, C96H70N10O2Zn2, C96H70N10O2Cl2Mn2, C96H70N10O2Cu2, C96H70N10O2Ni2 and C96H70N10O2Co2 sequentially. Porphyrin free base P is obtained through condensation reaction between bimolecular 5-p-aminophenyl-10,15,20-triphenylporphyrin and adipic acid; the synthesized porphyrin free base P is reacted with MnCl2.4H2O, ZnCl2, CuCl2, NiCl2.6H2O and CoCl2.6H2O to form corresponding porphyrin compounds. The synthesized series of porphyrin compounds are molecular tweezers compounds with specific cavity sizes, and can be further developed into sensitive materials for detecting benzene.

The present invention discloses a red light organic electrophosphorescence material metal iridium coordination compound having a structural formula represented by a formula (P), wherein R is methyl. The preparation method comprises that: a Suzuki coupling reaction is performed to obtain a ring metal ligand, the ring metal ligand and iridium trichloride trihydrate are subjected to a polymerization reaction in a 2-ethoxyethanol and water mixed solvent to obtain a chloro-bridge dimer, and the chloro-bridge dimer and 2,2,6,6-tetramethyl-3,5-heptanedione are subjected to a coordination reaction to obtain the red light organic electrophosphorescence material metal iridium coordination compound. The present invention further provides an organic electroluminescent device containing the metal iridium coordination compound. According to the present invention, 2,2,6,6-tetramethyl-3,5-heptanedione is added to the ring metal ligand as the auxiliary ligand so as to increase the steric hindrance effect of the metal iridium coordination compound, such that the direction effect between the metal atoms is reduced, the self-quenching phenomenon of the triplet state excitons is reduced, and the luminescence efficiency of the organic electroluminescent device is increased.

The invention relates to a fluorene ring group-containing non-condensed ring organic small molecular material and a preparation method and an application thereof. 2, 7-di(4, 4, 5, 5-tetramethyl-1, 3-dioxo-2-borane)-9, 9-dioctyl fluorene is used as a central core unit, and a thiophene unit is introduced to enhance [pi] conjugation of a molecular main chain, on this basis, benzothiadiazole is introduced to increase the electron deficiency capacity of the obtained molecule, thiophene units are connected to the two sides to expand conjugation and finally reduce the energy band gap of the molecule, side chains on thiophene can improve the solubility of the molecule, and fluorine-containing cyanoindanone units are connected to the two ends to form effective charge transfer in the whole molecule.