9results about How to "Good reaction selectivity" patented technology

The invention relates to a catalyst for preparing anisole through phenol methanol etherification as well as a preparation method and application of the catalyst. The catalyst takes aluminum phosphate as a carrier and is doped with zirconium oxide; on the basis of the mole number of Al, the mole ratio of P to Al is (0.05-2): 1, and the mole ratio of Zr to Al is (0.08-0.20): 1. Dropwise adding the aluminum-zirconium mixed aqueous solution into the phosphorus source aqueous solution, stirring, standing and washing to obtain a solid sample; and drying and roasting the solid sample to obtain the aluminum phosphate catalyst. Under the action of the catalyst, phenol and methanol are catalyzed to generate anisole. Compared with the prior art, the phenol conversion rate is greater than or equal to 50%, the anisole selectivity is greater than or equal to 85%, highly toxic dimethyl sulfate and a large amount of alkali are not needed, the process is green, the cost is low, separation is simple, and the method is suitable for large-scale industrial production of anisole.

The application discloses a pyridine-yne-benzene-yne diaromatic yne precursor, which is the first aromatic yne precursor capable of continuously generating pyridine-yne-benzene-yne. The diaromatic yne precursor can be compatible with multiple substituted alkyl, aryl, silicon, alkoxy, halogen and other functional groups. The diaromatic yne precursor can have a high-selectivity nucleophilic reaction with oxygen, nitrogen, sulfur and other nucleophilic reagents to quickly construct carbon-heteroatom bonds, and can have a [4+2] cycloaddition reaction with diene to quickly construct double carbon-carbon bonds, so that the diaromatic yne precursor can be used for efficiently and quickly preparing multiple substituted pyridine, benzene ring and other derivatives, and has a wide application prospect.

This invention discloses a phosphonothiolated binaphthol derivative and its synthetic method. Using readily available binaphthioonium salts as starting materials, secondary phosphine oxides as coupling agents, and a base as a promoter, a series of phosphonothiolated binaphthol derivatives are generated. This invention features simple raw material preparation, very mild synthetic reaction conditions, convenient experimental operation, high reaction efficiency, and diverse functional groups.

The invention discloses a preparation method and application of a zinc monatomic doped oxygen material, and relates to the technical field of catalytic materials.The preparation method comprises the steps that zinc salt and 2-methylimidazole react in an organic solvent, and a zeolite imidazate framework material is obtained through ultrasonic treatment, self-assembly, centrifugal washing and drying; performing primary pyrolysis on the framework material in an inert atmosphere, and performing acid pickling, washing and drying to obtain a zinc monatomic material; and performing alkali treatment on the zinc monatomic material and an alkaline substance, performing secondary pyrolysis in an inert atmosphere after drying, and performing acid pickling, washing and drying again to obtain the zinc monatomic doped oxygen material. The zinc monatomic doped oxygen material comprises a carbon carrier and zinc monatomic active sites dispersed on the carbon carrier. The material can be used for electrocatalytic preparation of hydrogen peroxide in a two-electron oxygen reduction reaction, and has a good application prospect.

The invention discloses a preparation method of 4 '; the novel preparation process comprises the following steps: under the protection of inert gas, dissolving a chiral ligand and a metal salt in an organic solvent, stirring the mixture for 30 minutes to 1 hour at room temperature, adding a solution of a compound II into a catalyst solution, stirring for 15-30 minutes at a low temperature of-40 DEG C, adding a compound I, an activating agent and an alkali reagent, stirring for 15-30 minutes at a low temperature of-40 DEG C, and reacting for 1-2 hours to obtain a compound I; and continuously stirring at-40 DEG C to react for 6-8 hours, monitoring the proceeding of the reaction by HPLC (High Performance Liquid Chromatography), and separating a product after the reaction is completed to obtain a compound III. The method has the beneficial effects that the operation is simple, the reaction steps can be effectively reduced, the reaction route is short, the raw materials are easy to obtain, the reaction time is short, and the production cost and the labor cost can be effectively reduced; the product yield is high, the reaction selectivity is good, the product purity is high, the reaction product yield is high, the selectivity is good, the target product can be obtained at a high yield, and meanwhile, the post-treatment difficulty of the product is reduced.

The application belongs to the technical field of medicine, chemical industry and related chemistry, and discloses a preparation method of difluoromethyl arene compound based on palladium catalytic decarbonylation coupling. The method uses aryl boronic acid as a raw material, uses N, N-disubstituted difluoroacetamide compound as a difluoromethylation reagent, and prepares difluoromethyl arene compound under the catalysis of palladium, so that the green and efficient synthesis is realized. The method has the advantages of easy preparation and storage of the difluoromethylation reagent, high reaction selectivity, good functional group compatibility, wide substrate application range, environmental friendliness and the like. Since the difluoromethyl arene compound is an important functional molecular skeleton structure, the compound has very wide application in the fields of fine chemical industry and pharmacy, so that the application has great application value and social and economic benefits.

The invention discloses a high-conversion-rate process and system for continuously synthesizing bis (diethylamino) silane by a gas phase method, and belongs to the technical field of fine chemical engineering and advanced material preparation. The process takes dichlorosilane and diethylamine as raw materials, and comprises the following steps: carrying out system inerting pretreatment; accurately metering the raw materials according to a specific molar ratio of (1: (4.0-5.0)), gasifying and mixing; the mixed gas is subjected to a continuous gas-phase reaction at 60-70 DEG C (preferably 65 DEG C), and solid byproducts are suspended through enhanced heat transfer and stirring; continuously discharging the reaction slurry through liquid level control, and removing solids through two-stage online filtration (containing nanoscale fine filtration); and finally, continuously rectifying the filtrate under reduced pressure to obtain a high-purity product. According to the method, solvent pollution is thoroughly eliminated, the bottlenecks of easy blockage and difficult continuity of a gas phase method are overcome through precise temperature control and an online solid removal technology, and the conversion rate gt of dichlorosilane is realized; the product purity is gt; 99.9% stable continuous production is achieved, and the high-end semiconductor process requirements are met.

The invention provides a polyene rigid spiro compound as well as a preparation method and application thereof. The preparation method comprises the following steps: dispersing an androstenedione dipolymer in ethanol, firstly adding sodium borohydride to carry out a regioselective reduction reaction, then adding water to carry out quenching after the reaction is finished, then adding diluted hydrochloric acid to carry out an elimination reaction, and finally carrying out concentration, extraction and organic phase merging, and concentration and purification again to obtain the polyene rigid spiro compound. A novel conjugated diene structure is successfully introduced by carrying out selective reduction and acid-promoted specific elimination on specific keto-carbonyl groups of the conjugated diene, and the conjugated diene shows remarkable proliferation inhibition activity on colorectal cancer, cervical cancer, liver cancer and breast cancer cell strains.

The invention discloses a preparation method of 1, 4-dimethylnaphthalene. According to the method, 1-methylnaphthalene is used as a raw material, a specific amount of beta-cyclodextrin is added in a chloromethylation reaction step to serve as a selective accelerant, beta-cyclodextrin and a naphthalene ring of 1-methylnaphthalene are subjected to subject-object clathration through a hydrophobic cavity of beta-cyclodextrin, the 4-site of the naphthalene ring is specifically exposed and activated, and the 1-methylnaphthalene is prepared. Therefore, the 1-chloromethyl-4-methylnaphthalene intermediate is efficiently and highly selectively generated. The intermediate is subjected to a reduction reaction, and is finally rectified to obtain high-purity 1, 4-dimethylnaphthalene. According to the present invention, through the directional guiding effect of the beta-cyclodextrin, the regioselectivity of the reaction is fundamentally improved, the isomer by-product is significantly reduced, the post-treatment process is simplified, the product purity and the total yield are high, the conditions are mild, and the method is suitable for industrial production.