The invention discloses an electrochemical method of deuterated
silane. The method comprises the following steps: in a protective
atmosphere, mixing substituted
silane, an
electrolyte, a
nickel catalyst, a ligand and
deuterium water in a
solvent, carrying out an electrochemical deuterization reaction under a
constant current condition, and carrying out post-treatment to prepare the deuterated
silane compound. The method takes
deuterium water as a
deuterium source, and is green, economical, cheap and easy to obtain; a catalytic amount of
nickel and silane form a
silicon-
nickel intermediate, so that the polarity of
silicon is reversed, and the generation of a silane self-
coupling product and a
silanol byproduct is effectively avoided; the electrochemical synthesis method has the characteristics of mild
reaction conditions, cleanness, greenness and simplicity in reaction operation. The electrochemical synthesis method provided by the invention realizes successful preparation of the
natural product post-modified deuterated silane, and has important significance in the aspects of
drug development and deuterated compound research; the electrochemical synthesis method disclosed by the invention can
resist high current to prepare the ten-
gram-grade deuterated silane, and has a wide industrial application prospect. In addition, the deuterated silane synthetic product can be used as a
silicon deuteration
reagent, the practicability of the deuterated silane synthetic product in unsaturated bond reduction reaction is proved, and the deuterated silane synthetic product has a wide development prospect.