2results about How to "Short synthesis cycle" patented technology

This invention relates to the field of flame retardant preparation technology, and more particularly to a method for preparing an environmentally friendly and highly efficient flame-retardant polyolefin cable sheath material. The invention uses compounds containing primary amino and amide bonds and compounds containing phenyl and phosphoryl chloride groups as raw materials. The reaction is carried out at room temperature for 0.5-1 h, then heated to 45 °C for 3-4 h, and then to 65 °C for 5-6 h. Through a condensation reaction, a phosphoramide macromolecular flame retardant containing phenyl and amide bonds is obtained, with a yield as high as 80.5-95.6%. This flame retardant is added to polyolefin cable sheath material at a mass ratio of 25%, then compounded and extruded to obtain a halogen-free flame-retardant polyolefin cable sheath material. The flame retardant molecule prepared by this invention simultaneously contains phosphorus and nitrogen flame-retardant elements and amide bonds forming a char skeleton. During combustion, it can exert a phosphorus-nitrogen synergistic flame-retardant effect and promote the catalytic char formation of the matrix, which can significantly reduce the heat and toxic gas release of polyolefin cable sheath material during combustion, thereby providing protection for the lives of people in fire scenes.

The invention provides a rapamycin derivative with better anticancer activity and a preparation method of the rapamycin derivative. The tumor cell proliferation inhibition activity of the rapamycin derivative provided by the invention is obviously superior to that of a parent compound rapamycin and a clinical drug temsirolimus. The method for synthesizing the rapamycin derivative through lipase catalysis has the advantages of being mild in condition, high in selectivity and wide in substrate application range, solves the technical problems that in traditional chemical synthesis, hydroxyl needs to be protected / deprotected, the steps are tedious and the selectivity is poor, and provides an efficient and green synthesis path for large-scale preparation of the novel rapamycin derivative.