Preparation and application of chiral resolution additive used for conveniently modifying magnetic nanoparticles

A technology of magnetic nano ions and additives, applied in the direction of nanotechnology, nanotechnology, nanotechnology, etc. for materials and surface science, can solve the problems of limited coating ability, difficult control of uniformity, and difference in movement speed, etc., to achieve The synthesis conditions are not harsh, the adsorption process is fast and simple, and the adsorption stability is high.

Inactive Publication Date: 2017-05-31
FOSHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of this method are: the coating ability is limited, and it may not be possible to completely prevent the agglomeration or oxidation of nanoparticles; it is not easy to control the size distribution of magnetic micro-nano materials, and it is not easy to control the distribution of the number of magnetic nanoparticles in each micro / nano particle material as uniformly as possible. This will lead to differences in the movement speed of micro / nanoparticles during the magnetic attraction process, which may lead to incomplete magnetic attraction enrichment process; since the encapsulation process involves multiple magnetic nanoparticles, it may lead to a decrease in the specific surface area of ​​the magnetic nanoparticles. reduction of

Method used

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  • Preparation and application of chiral resolution additive used for conveniently modifying magnetic nanoparticles
  • Preparation and application of chiral resolution additive used for conveniently modifying magnetic nanoparticles
  • Preparation and application of chiral resolution additive used for conveniently modifying magnetic nanoparticles

Examples

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Embodiment 1

[0042] A preparation of a chiral separation polymer additive for modifying magnetic nano ions, comprising the following steps:

[0043] (1) In terms of parts by mass, dissolve 5.3 parts of itaconic acid into 100 parts of N,N-dimethylformamide, and then add 1% of azo Diisobutyronitrile, at 60°C, in an atmosphere of inert gas bubbling, heat under reflux for 10h, spin evaporate the solution after the reaction to 1 / 4 of the original volume, and then directly add the concentrated solution dropwise to 80 parts of petroleum ether , stand still for 30 minutes, pour off the liquid part, and leave the remaining solid for 60 minutes in a ventilated state, and vacuum-dry at 60° C. to obtain the main chain of the polymer additive.

[0044] (2) In terms of molar parts, take the polymer additive main chain containing 1000 parts of itaconic acid units, dissolve it in 5000 parts of N,N-dimethylformamide, add 300 parts of EDC·HCl and 300 parts of NHS of NHS, bubbled with inert gas to deoxygena...

Embodiment 2

[0047] A preparation of a chiral separation polymer additive for modifying magnetic nano ions, comprising the following steps:

[0048] (1) In terms of parts by mass, dissolve 7 parts of itaconic acid into 100 parts of N,N-dimethylacetamide, and then add 1% of azo Diisobutyronitrile, at 60°C, in an atmosphere of inert gas bubbling, heating under reflux for 9 hours, rotary steaming and concentrating the reacted solution to 1 / 4 of the original volume, and then directly adding the concentrated solution dropwise to 80 parts of petroleum ether , stand still for 30 minutes, pour off the liquid part, and leave the remaining solid for 60 minutes in a ventilated state, and vacuum-dry at 60° C. to obtain the main chain of the polymer additive.

[0049] (2) In terms of molar parts, take the polymer additive main chain containing 1000 parts of itaconic acid units, dissolve it in 6000 parts of N,N-dimethylformamide, add 300 parts of EDC·HCl and 250 parts of NHS of NHS, pass through an ine...

Embodiment 3

[0052] A preparation of a chiral separation polymer additive for modifying magnetic nano ions, comprising the following steps:

[0053] (1) In parts by mass, dissolve 9 parts of itaconic acid into 100 parts of chloroform, then add 1% azobisisobutyronitrile relative to protonable or deprotonable unit equivalents, in At 60°C, in an inert gas bubbling atmosphere, heat under reflux for 8 hours, spin evaporate and concentrate the reacted solution to 1 / 4 of the original volume, then directly add the concentrated solution dropwise to 80 parts of petroleum ether, let stand for 40 minutes, pour The liquid part was removed, and the remaining solid was left to stand for 70 minutes in a ventilated state, and vacuum-dried at 60° C. to obtain the main chain of the polymer additive.

[0054] (2) In terms of molar parts, take the polymer additive main chain containing 1,000 parts of itaconic acid units, dissolve it in 8,000 parts of N,N-dimethylformamide, add 400 parts of EDC·HCl and 200 part...

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Abstract

The invention discloses preparation and application of a chiral resolution additive used for conveniently modifying magnetic nanoparticles. The additive is triblock copolymer with an A-r-dopa-r-beta-CD general structure, wherein A is a protonation or deprotonation unit, dopa represents a dopamine functional group, beta-CD represents beta-cyclodextrin, and r represents random distribution. The polymer additive can be directly attached to the surface of the magnetic nanoparticles through one-step ligand exchange reaction, an adoption process is quick and convenient, and adsorption stability is higher; a hydrophilic beta-cyclodextrin unit in the polymer additive can assist the magnetic nanoparticles in realizing a monodisperse state in a water environment, the magnetic nanoparticles can own a larger specific surface area, and contact with a raceme can be more sufficient; the synthetic process of the polymer additive only contains two steps, synthetic difficulty is lower, and requirements on a synthetic condition are not harsh.

Description

technical field [0001] The invention belongs to the field of chiral resolution functional polymers, in particular to the preparation and application of a chiral resolution additive for conveniently modifying magnetic nanoparticles. Background technique [0002] Two compounds with the same chemical composition but different spatial configurations are called enantiomers. The difference in physical properties between the two is very small, but there may be great differences in their absorption, transport, and metabolism in vivo. Therefore, the construction of a simple and efficient enantiomer separation method has always been a research hotspot in the academic community. Magnetic solid-phase extraction technology has the advantages of simple separation operation, large surface adsorption area, and mild separation conditions, so it is one of the very valuable methods in the field of chiral separation. How to modify the surface of magnetic nanoparticles prepared by conventional ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/02C08F122/02C08F120/06C08F120/04B01J20/26B01J20/29B01J20/30B82Y25/00B82Y30/00
CPCB01J20/264B01J20/29B82Y25/00B82Y30/00C08F120/04C08F120/06C08F122/02C08G81/02
Inventor 苗磊杨俊杰董富欣袁晓华王平
Owner FOSHAN UNIVERSITY
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