Keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit

A technology of inhibitors and horn plugs, applied in the field of horn plug regeneration inhibitors, can solve problems such as irritation, rough skin feeling, and difficulty in actually feeling, and achieve the effect of inhibiting horn plug regeneration

Active Publication Date: 2014-06-11
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reality is that it is difficult to actually feel the effect. There are products on the market that claim to shrink pores, such as astringent lotion, but there are no products that claim to make it difficult for horn plugs to regenerate.
Also, organic acids can cause skin roughness and sensory irritation when used alone, and are often difficult to use as cosmetics

Method used

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  • Keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit
  • Keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit
  • Keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] (Example 1: comparison of the inhibition effect of horn plug regeneration by human experiment)

[0080] 1. Sample

[0081] Formulations 1 and 2 shown below were used. Preparation 1 is a comparative preparation containing (a) component and (c) component. Formulation 2 is a sample in which POE (30) phytosterol was added to Formulation 1, and is a formulation of the product of the present invention containing (a) component, (b) component, and (c) component.

[0082] (Preparation 1: Comparative product preparation. pH4.1)

[0083]

[0084]

[0085] 2. Evaluation test method

[0086]Four males aged 30 to 50, whose horn plugs were conspicuous, were subjected to a regeneration inhibition test of horn plugs. A frame paper was pasted on an appropriate area of ​​the tip of the nose, and the horn plug was observed with a video microscope (VMS, (Video microscope), "KEYENCE VHX-100"). After dropping a few drops of an adhesive ("Aron Alpha A"; Sankyo) onto a glass slide (M...

Embodiment 2

[0095] (Example 2: Effects of Angle Plug Regeneration Inhibitor on Skin Condition)

[0096] 1. Sample

[0097] Formulation 3 shown below (=formulation in which panthenyl ethyl ether was added to the above formulation 2. Formulation of the present invention) was used.

[0098] (Preparation 3: preparation of the present invention. pH4.1)

[0099]

[0100]

[0101] 2. Evaluation test method

[0102] Five male subjects were tested, and the above preparation 3 was continuously used, and the nose and cheeks were applied on half of the face for 3 weeks, and the changes in skin conditions were compared with those on the non-applied side. For the alar of the coated side and the non-coated side, the amount of sebum and the water content of the stratum corneum were measured and compared by a multi-probe instrument MP5 (Courage+khazaka company) before continuous use and after 3 weeks of continuous use. Table 3 shows the results of the amount of sebum, figure 1 In represents the...

Embodiment 4

[0107] (Embodiment 4: comparison of the inhibition effect of horn plug regeneration by human experiment)

[0108] 1. Sample

[0109] Formulation 2 described in Example 1 (=formulation of the product according to the invention) and formulations 4, 5 described below were used.

[0110] Preparation 4 is a preparation obtained by removing tranexamic acid and POE(14)·POP(7) dimethyl ether from preparation 2, increasing glycerin and potassium hydroxide, and adding xylitol. ) component, (b) the comparative preparation of the component.

[0111] Preparation 5 is a preparation in which tranexamic acid is removed from preparation 2, and potassium hydroxide is increased, and L-serine, trimethylglycine, and Hypericum extract are added. The product preparation of the component b) and (c) component of the present invention.

[0112] (Preparation 4: Comparative product preparation. pH4.2)

[0113]

[0114]

[0115] 2. Evaluation test method

[0116] Four males aged 30 to 50, whose...

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PUM

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Abstract

[Problem] To provide a keratotic plug regrowth inhibition agent, keratotic plug regrowth inhibition method, and keratotic plug regrowth inhibition kit whereby the regrowth of a keratotic plug can be effectively inhibited without causing skin irritation. [Solution] A keratotic plug regrowth inhibition agent, characterized in containing: (a) a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof; (b) a specific surfactant (for example, fatty acid soap, higher alkyl sulfate ester salt, polyoxyalkylene phytosterol, or the like); and (c) a specific skin irritation mitigation agent (for example, POE/POP dimethyl ether, tranexamic acid, pantothenyl ethyl ether, trimethyl glycine, glycylglycine, or the like). A keratotic plug regrowth inhibition method, in which a skin cleanser including a POE fatty acid ester is applied to the skin and thereafter a keratotic plug regrowth inhibition agent including a specific acid (for example, lactic acid, succinic acid, citric acid, or the like) or a salt thereof is applied to the skin; also, a keratotic plug regrowth inhibition kit comprising the skin cleanser and keratotic plug regrowth inhibition agent.

Description

technical field [0001] The invention relates to an inhibitor of horn plug regeneration, a method for inhibiting horn plug regeneration and a kit for inhibiting horn plug regeneration. More specifically, it relates to a horn plug regeneration inhibitor capable of effectively suppressing horn plug regeneration without causing skin roughness, a horn plug regeneration suppressing method, and a horn plug regeneration suppressing kit. Background technique [0002] Horn plug troubles are the top items among women's skin troubles. The horn plug is a mixture of sebum and exfoliated horny layer that clogs the pores (see Non-Patent Document 1), and as it grows, the pores become clogged white pimples, or if it further contains fine hair and dirt The pores become clogged with small black pimples, and no matter what kind of skin it is, it will appear in a state of conspicuous pimples, which is not good in appearance or feel, so it is not recommended. It is also said to cause skin troubl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/365A61K8/36A61K8/368A61K8/39A61K8/44A61K8/49A61K8/67A61K8/86A61K8/97A61Q19/00A61Q19/10
CPCA61K8/673A61K8/361A61Q19/10A61K8/44A61K8/86A61K8/416A61Q19/00A61K8/42A61K8/463A61K8/365A61P17/00
Inventor 麦仓茂饭田年以小野隆之末继胜
Owner SHISEIDO CO LTD
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