The invention belongs to the technical field of daily cosmetics, and discloses a moisturizing lotion with a slow-release efficacy and a preparation method of the moisturizing lotion. According to the moisturizing lotion disclosed by the invention, a traditional moisturizer glycerinum, butanediol, a deep moisturizer sodium hyaluronate, betaine, oat peptide and a tremella extract are combined through the formula design, and are simultaneously wrapped by substances silkpatch with a micro network structure; the deep moisturizer is continuously conveyed to a horny layer and a corium layer of skin through the slow-release process of the micro network structure, so as to deeply repair a skin barrier; meanwhile, the traditional moisturizer is also continuously released to an epidermal layer of the skin; and the skin is moisturized by lastingly absorbing external water molecules, thus an effective moisturizing effect is provided.