Paeonol microemulsion preparation and preparation method thereof

A technology of paeonol and milk preparations, applied in the field of medicine, to achieve the effects of reducing the number of administrations, high biodegradability, and simple preparation methods

Inactive Publication Date: 2009-04-01
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Paeonol microemulsion preparation and preparation method thereof
  • Paeonol microemulsion preparation and preparation method thereof
  • Paeonol microemulsion preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1. manual drop method prepares paeonol microemulsion preparation, and component and weight percentage thereof are as follows:

[0026] Paeonol 1%

[0027] Lecithin (surfactant) 6%

[0028] APG (surfactant) 12%

[0029] Propylene glycol (co-surfactant) 9%

[0030] Isopropyl myristate (oil phase) 12%

[0031] Deionized water 60%

[0032] The preparation method is as follows:

[0033] Dissolve paeonol into isopropyl myristate according to the proportion, then add lecithin and APG to mix and fully dissolve to form the drug-containing inner phase. Add deionized water dropwise to the drug-containing inner phase while stirring at room temperature to Stir at a constant speed of 200r / min for 2h to form a clear and transparent paeonol microemulsion. Measure paeonol microemulsion particle size with Zetasizer Nano ZS90 measuring instrument, see the result figure 1 , the particle size range is 30-50nm, the particle size is uniform, and the appearance is clear, see ...

Embodiment 2

[0034] Example 2. Paeonol microemulsion preparation was prepared by sonication method, and the components and proportioning were the same as in Example 1.

[0035] Dissolve paeonol into isopropyl myristate, then add lecithin and APG to mix and fully dissolve to form the drug-containing inner phase, mix the drug-containing inner phase with deionized water, and finally use a probe ultrasonic instrument at a power of 250w Next, sonicate for 3 minutes to obtain paeonol microemulsion. Zetasizer Nano ZS90 was used to measure the particle size of paeonol microemulsion, the particle size range was 30-50nm, the particle size was uniform, and the appearance was clear.

Embodiment 3

[0036] Example 3. Paeonol microemulsion preparation was prepared by high-pressure homogenization method, and the components and proportioning were the same as in Example 1.

[0037] Dissolve paeonol into isopropyl myristate, then add lecithin and APG to mix and fully dissolve to form the drug-containing inner phase, mix the drug-containing inner phase with deionized water, and use a high-pressure homogenizer in the primary valve 60-70bar, the secondary valve is 600-700bar, homogenize the milk for 3 times to get paeonol microemulsion. Zetasizer Nano ZS90 was used to measure the particle size of paeonol microemulsion, the particle size range was 30-50nm, the particle size was uniform, and the appearance was clear.

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Abstract

The invention relates to the medical technical field, in particular to a paeonol micro-emulsion preparation and a preparation method thereof. The paeonol micro-emulsion preparation consists of components with the weight percentage as follows: 0.1 percent to 2 percent of paeonol, 10 percent to 25 percent of surfactant, 5 percent to 30 percent of cosurfactant, 5 percent to 15 percent of oil phase and 40 percent to 70 percent of deionized water. The mouse percutaneous experiment in vitro shows that the paeonol micro-emulsion prepared by the invention has obviously higher capacity of penetrating through the horny layer than the saturated aqueous solution of paeonol (p is less than 0.05), and the paeonol micro-emulsion can penetrate into the skin deeply to take curative effect within a short time and also has certain sustained and controlled release function. At the same time, the paeonol micro-emulsion improves the solubility of the paeonol obviously, increases the drug loading quantity of the preparation and reduces the drug administration times and the dosage. The paeonol micro-emulsion preparation has simple preparation method and uniform grain diameter of the preparation, has the advantages of being safe, stable and efficient and, can be used for preparing dermal medication preparation or cosmetic.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a paeonol microemulsion preparation and a preparation method thereof. Background technique [0002] Paeonol (Paeonol, Pae), also known as paeonol, is the main active ingredient of the root bark of Paeonia suffruticosa Andr. and the whole plant of Pycnostelma Paniculatum (Bunge) K.Schu of the Ranunculaceae plant. It has good antibacterial , anti-inflammatory, anti-allergic and antipyretic, analgesic and antihypertensive effects. Currently marketed dosage forms mainly include paeonol injection, paeonol tablet and paeonol ointment. Clinically, it is mainly used to treat rheumatic pain, stomach pain and other pains, eczema, allergic dermatitis, etc., and has good curative effect. Paeonol percutaneous administration is used for the treatment of eczema, allergic dermatitis, etc., which overcomes the shortcomings of traditional hormone drugs such as large side effects and easy recurren...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/12A61K47/24A61K47/34A61P29/00A61P31/04A61P9/12A61K47/10A61K47/14A61K47/26
Inventor 胡晋红韩盈刘继勇王玫徐建国
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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