2results about How to "Low hemolytic" patented technology

The application discloses an antibacterial peptide designed by a generative artificial intelligence framework and targeting gram-negative bacteria and an application thereof, and belongs to the fields of artificial intelligence and biotechnology. The application designs and successfully obtains a novel antibacterial peptide by a generative artificial intelligence framework, the antibacterial peptide targeting gram-negative bacteria and having good antibacterial activity. It is verified by experiments that the antibacterial peptide MTAMP003 has good bacteriostatic capacity on E. coli, S. typhimurium, P. aeruginosa and A. baumannii, exhibits low cytotoxicity on human gastric mucosa epithelium and low hemolyticity on rabbit red blood cells, and has good application prospect and research value.

The invention relates to the technical field of vaccine adjuvants and drug delivery, and discloses a 3D-MLA and QS-21 composite adjuvant as well as a preparation method and application of the 3D-MLA and QS-21 composite adjuvant. A saponin QS-21; polyethylene glycol sodium alginate; embedding particles with pH-sensitive calcium chloride; the preparation method of the vaccine antigen comprises the following steps: performing pegylation modification on sodium alginate; embedding calcium chloride with a pH sensitive polymer, and carrying out spray drying to prepare cross-linking agent particles; dissolving the synthetic monophosphoryl lipid A and saponin QS-21 to prepare a composite adjuvant solution; mixing the adjuvant solution with the pegylated sodium alginate solution to prepare a precursor preparation; and adding antigen and cross-linking agent particles into the precursor preparation, and uniformly mixing to obtain a final product. According to the invention, the composite adjuvant is delivered through the pH responsive in-situ gel, an immune reservoir is formed, and a powerful and lasting comprehensive immune response biased to the Th1 type is safely induced.