Garlicin and garlic oil cyclodextrin derivatives inclusion compound and method for making same
A cyclodextrin and derivative technology, applied in the field of medicine, can solve the problems of unstable chemical properties, low solubility of garlic oil, oxidative deterioration, etc., and achieve the effect of being beneficial to clinical application, improving water solubility and stability, and good dissolution.
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[0029] In the above preparation process, the liquid allicin or garlic oil cyclodextrin derivative inclusion compound can be dried at a temperature of 40-80° C. to obtain the solid allicin or garlic oil cyclodextrin derivative inclusion compound.
[0030] The preparation method of the inclusion compound of allicin and garlic oil cyclodextrin derivatives in the present invention can also be that the cyclodextrin derivatives are placed in a colloid mill, a ball mill or a mortar, and an appropriate amount of suitable solvent is added, and ground to make a paste According to the molecular molar ratio of allicin and cyclodextrin derivatives is 1:1-1000, the weight ratio of garlic oil and cyclodextrin derivatives is 1:8.6-8600, add allicin or garlic oil to the paste Grinding for 1-5 hours to obtain a uniform viscous paste, drying at 40-80°C to obtain solid allicin or garlic oil cyclodextrin derivative inclusion compound.
[0031] The preparation method of allicin and garlic oil cyclo...
Embodiment 1
[0038] Example 1: Preparation of liquid allicin or garlic oil hydroxypropyl-β-cyclodextrin derivative inclusion compound
[0039] (1) Weigh 26g of hydroxypropyl-β-cyclodextrin, pour it into 100mL of distilled water, and stir to dissolve;
[0040] (2) Another 1.5 g of allicin or garlic oil was weighed and poured into the above-mentioned hydroxypropyl-β-cyclodextrin solution;
[0041] (3) The mixed solution was stirred by magnetic stirring for 20 minutes. The stirring speed should be such that the liquid does not splash out. Observe the solution until it is clear, and then the liquid allicin or garlic oil hydroxypropyl-β-cyclodextrin inclusion compound is obtained.
Embodiment 2
[0042] Example 2: Preparation of solid allicin or garlic oil hydroxypropyl-β-cyclodextrin derivative inclusion compound
[0043] (1) Weigh 26g of hydroxypropyl-β-cyclodextrin, pour it into 100mL of distilled water, and stir to dissolve;
[0044] (2) Another 1.5 g of allicin or garlic oil was weighed and poured into the above-mentioned hydroxypropyl-β-cyclodextrin solution;
[0045] (3) The mixed solution is stirred for 20 minutes by magnetic stirring method, and the stirring speed is preferably such that the liquid does not splash out, and the solution is observed until it is clear, and the liquid allicin or garlic oil hydroxypropyl-β-cyclodextrin inclusion compound is obtained;
[0046] (4) concentrating the liquid allicin or garlic oil hydroxypropyl-β-cyclodextrin inclusion compound, and drying under reduced pressure to obtain solid allicin or garlic oil hydroxypropyl-β-cyclodextrin inclusion compound.
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