453 results about "Cyclodextrin derivative" patented technology

This invention is directed to compositions comprising a water-miscible organic solvent or solvent mixture and one or more cyclodextrin derivatives soluble in the organic water-miscible organic solvent or solvent mixture. In some embodiments, the composition comprises one or more compounds. The invention is further directed to capsules containing the compositions of the present invention and the administration of pharmaceutically active compounds or molecules to subjects. The invention also includes methods of enhancing the solubility of a compound comprising forming a complex or mixture of a compound with a hydroxybutenyl cyclodextrin and a water-miscible solvent.

The present invention relates to development of efficacious pharmaceutical compositions comprising an anti-angiogenic compound in a therapeutically effective amount complexed with or encapsulated in a cyclodextrin derivative.

A sulfoalkyl ether-alkyl ether cyclodextrin (SAE-AE-CD) derivative is provided. The SAE-AE-CD possesses advantages over known SAE-CD and AE-CD derivatives as well as over the parent cyclodextrin by being more water soluble and less membrane disturbing. The SAE-AE-CD includes at least one sulfoalkyl ether group and at least one alkyl ether group even though the degree of substitution for the functional groups can be different. The SAE functional group can be present in molar excess over the AE functional group and vice versa. The total degree of substitution of the cyclodextrin, with respect to both functional groups, can be varied such that a minority or a majority of the hydroxyl moieties of the CD are derivatized. The SAE-AE-CD derivative can be used to solubilize compounds with insufficient water solubility. In some cases, they also stabilize compounds in solution against degradation or to solubilize degradation products formed during degradation. In addition, SAE-AE-CD can also be used for other purposes such as osmotic agents, agents used to mask the taste of problematic drugs. Surprisingly, while AE-CDs are known to be toxic by being membrane disturbing, SAE-AE-CDs are less membrane disturbing and therefore have greater safety.

Disclosed herein are compositions comprising cyclodextrin derivatives and prednisolone and prodrugs thereof, and methods related thereto. The use of soluble polyanionic polymers such as hydroxypropylmethylcellulose and others in relation to these compositions is also disclosed. Delivery of these prednisolone-related compounds to the back of the eye via topical ophthalmic administration is also disclosed.

The present invention relates to butylbenzene phthalein cyclodextrin or cyclodextrin derivative clathrate, its preparation method and application. The described butylbenzene phthalein is mixed-rotatory butylbenzene phthalein and levo-butylbenzene phthalein. In order to raise water solubility of butylbenzene phthalein and develop solid dosage form and liquid dosage form required for clinical application said invention adopts cyclodextrin or cyclodextrin derivative to include the butylbenzene phthalein. Said clatherate contains butylbenzene phthalein and cyclodextrin or cyclodextrin derivative, the mole ratio of both them is 1:1-10. The cyclodextrin or cyclodextrin derivative optimally selects hydroxypropyl-beta-cyclodextrin. Said clathrate can be used for preparing various dosage forms of injection, oral preparation, tablet, capsule and others.

Disclosed herein are methods of delivering drugs or therapeutically active agents to the back of the eye via topical administration of compositions comprising cyclodextrin derivatives. Compositions related thereto are also disclosed herein.

The invention discloses a composition used in a scale-inhibition corrosion inhibitor, a scale-inhibition corrosion inhibitor, and an application thereof. The composition used in the scale-inhibition corrosion inhibitor comprises cyclodextrin and/or a cyclodextrin derivative, a carboxylic-acid-group-containing homopolymer, a sulfonic-acid-group-containing copolymer, and selectively hydroxycarboxylic acid with a weight ratio of 1:0.2-20:0.04-15:0.2-30:0-20. The scale-inhibition corrosion inhibitor provided by the invention is environment-friendly. According to the invention, the application of phosphorus-containing compound or non-renewable molybdate or tungstate is prevented, such that the scale-inhibition corrosion inhibitor is phosphorus-free and nitrogen-free. The scale-inhibition corrosion inhibitor has high tolerance to calcium and alkali, resistance to corrosion of high-concentration chloride ion and sulfate ion, and wide applicability to water quality. Therefore, technical condition is provided for operation of circulation water under high concentration multiple and for reducing sewage discharge. The scale-inhibition corrosion inhibitor provided by the invention has excellent scale inhibition and corrosion inhibition performances in circulation water system application. With the scale-inhibition corrosion inhibitor, a dose is low, scale-inhibition treatment process is simple and substantial effect is provided. The scale-inhibition corrosion inhibitor is suitable for popularization.

Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.

The invention discloses a crystallization controllable thermoplastic polyurethane material and a preparation method of the crystallization controllable thermoplastic polyurethane material. The thermoplastic polyurethane material comprises and is prepared from the following components: 1) a diisocyanate compound; 2) a hydroxyl and/or amido end capped macromolecular compound; 3) a diamine or diol cyclodextrin derivative; 4) a chain extender. The types and the use amounts of a main chain extender and an auxiliary chain extender in the chain extender are controlled, meanwhile, the cyclodextrin derivative is introduced, so that the crystallization characteristic of the thermoplastic polyurethane material is controlled, the controllable degree of crystallinity and the improved viscosity temperature sensitivity are obtained, and the shrinkage percentage of the material is also changed correspondingly. The obtained thermoplastic polyurethane material can be used in a rapid forming method in the fusing processing, like a fused deposition rapid forming method or a selective laser sintering method.

The present invention relates to a fuliconazole injection. Said injection includes the following components; (by wt%) fuliconazole 0.01-20%, cyclodextrin or cyclodextrin derivative 0%-60%, water-soluble excipient 0-75%, solubilizer 0%-20% and the rest is injection water. Its preparation method includes the following steps: mixing the above-mentioned raw materials, using active carbon to remove impurity and heat source, filtering, fine filtering, filling, sterilizing, checking and putting in storage.

The invention provides 6-deoxy-sulfones cyclodextrin derivatives, which have a structure in a formula (I). The preparation method comprises the following steps: taking 6-deoxy-thioether aminoacid cyclodextrin derivatives or 6-deoxy-thioether cyclodextrin derivatives as raw materials, and obtaining 6-deoxy-sulfoxide cyclodextrin derivatives through oxidation reaction 1; and furthering oxidizing to obtain the 6-deoxy-sulfones cyclodextrin derivatives, wherein the 6-deoxy-thioether aminoacid cyclodextrin derivatives are prepared by the following steps: performing halogenation on acetic acid containing R3 substituent to obtain double halides; performing condensation on the double halides and amino acid to obtain acid amides; adding a sulfur reagent to obtain a sulfur-containing compound; removing protecting groups to obtain a sulfhydryl compound; and performing condensation on the sulfhydryl compound and halogenated cyclodextrin. The compounds provided by the invention can be used for reversing the phenomenon of neuromuscular relaxation induced by human or animal muscular relaxants, have effects of reversing and antagonizing the muscular relaxation induced by the muscular relaxants, and can be applied to the preparation of medicaments for antagonizing the muscular relaxation.

The present invention is directed to pharmaceutical compositions comprising melphalan and a cyclodextrin derivative, and methods of making and using the same.

A smokeless oral tobacco product comprises a cyclodextrin or cyclodextrin derivative. Such a product can further comprise a flavourant complexed with the cyclodextrin or derivative thereof. Cyclodextrins or their derivative can be used in smokeless oral tobacco products to complex with molecules which arise or solubilize during use of the product and optionally to also release, e.g., flavour or aroma during use of the product.

A liquid preparation of meloxican is prepared from the meloxicam or its medical salt and water-soluble cyclodextrin derivative HP-beta-CD used as solubilizer and stabilizer, proportionally mixing, adding cosolvent, pH regulator and water for injection, heating and membrane filtering. It has long storage time at low temp.

The present invention is directed to pharmaceutical compositions comprising prasugrel and a cyclodextrin derivative, and methods of making and using the same.

The invention relates to a garlic oil cyclodextrin or cyclodextrin derivative inclusion compound, and a preparation method thereof. Garlic oil is an organic sulfide extracted from garlic and has the functions of resisting bacteria, diminishing inflammation, improving organism immunity, preventing and treating cardiovascular system diseases, and the like. Garlic oil has aroma and hot taste similar to fresh garlic, is integral in flavor, pure natural, safe and healthy, and is widely applied to salty food additives, health-care food, edible blend oil and the like, but as the garlic oil is unstable in properties, strong in volatility and acrimony and difficult to dissolve in water, the application of the garlic oil to food is greatly limited. The preparation method applies cyclodextrin and cyclodextrin derivatives to the inclusion of garlic oil so as to prepare the garlic oil cyclodextrin or cyclodextrin derivative inclusion compound, solves the problems that the garlic oil is low in water solubility, strong in acrimony and the like, and enables the garlic oil to be directly applied to food and health care products.

A cyclodextrin derivative for preventing and treating cardiovascular and cerebrovascular diseases, diabetes, liver injury, diseases in respiratory system, rheumatic and rheumatoid diseases, dermatopathy and tumor is disclosed. It is an artificial analogue enzyme with the activity of glutathion peroxidase.

The invention discloses a supermolecule corrosion inhibitor for copper and copper alloy and a high-speed mixing preparation method thereof, belonging to the technical field of metal corrosion and protection. The supermolecule corrosion inhibitor comprises the following components in parts by mass: 20-30 parts of a cyclodextrin derivative, 5-10 parts of an organic imidazole compound, 10-20 parts of an inducer and 40-600 parts of water, and is prepared by stirring at high speed. According to the supermolecule corrosion inhibitor for copper and copper alloy, the organic imidazole compound and cyclodextrin derivative are used for forming a subject-object supermolecule structure through weak interaction such as hydrophobic effect and hydrogen bond, so that the solubility and dispersibility of the organic imidazole compound in water are improved. The supermolecule corrosion inhibitor for copper and copper alloy has strong universality and good anti-corrosion effect, the use amount is less, when the chemical dosing concentration is 20-60mg/L, the corrosion rate of the copper and copper alloy can be controlled to be less than 0.005mm/a, effective components of the supermolecule corrosion inhibitor can be released uniformly, and the supermolecule corrosion inhibitor can work for a long period with chemical dosing once.