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457 results about "Cyclodextrin derivative" patented technology

Cyclodextrin and cyclodextrin derivatives are used in the pharmaceutical industry for drug formulation; Sporanox (Janssen) is an intravenous formulation of the antifungal itraconazole with hydroxypropyl-β-cyclodextrin for treatment of fungal infections.

Compositions comprising cyclodextrin derivatives

A stable composition for removing unwanted molecules from a surface comprises low-degree of substitution cyclodextrin derivatives. The compositions are suitable for capturing unwanted molecules from inanimate surfaces, including fabrics, including carpets, and household surfaces such as countertops, dishes, floors, garbage cans, ceilings, walls, carpet padding, air filters, and the like, and from animate surfaces, including skin, hair, and the like. The compositions can further comprise cyclodextrin-compatible and -incompatible materials, and other optional ingredients.
Owner:THE PROCTER & GAMBLE COMPANY

Cyclodextrin solubilizers for liquid and semi-solid formulations

This invention is directed to compositions comprising a water-miscible organic solvent or solvent mixture and one or more cyclodextrin derivatives soluble in the organic water-miscible organic solvent or solvent mixture. In some embodiments, the composition comprises one or more compounds. The invention is further directed to capsules containing the compositions of the present invention and the administration of pharmaceutically active compounds or molecules to subjects. The invention also includes methods of enhancing the solubility of a compound comprising forming a complex or mixture of a compound with a hydroxybutenyl cyclodextrin and a water-miscible solvent.
Owner:EASTMAN CHEM CO

Sulfoalkyl ether-alkyl ether cyclodextrin derivatives

A sulfoalkyl ether-alkyl ether cyclodextrin (SAE-AE-CD) derivative is provided. The SAE-AE-CD possesses advantages over known SAE-CD and AE-CD derivatives as well as over the parent cyclodextrin by being more water soluble and less membrane disturbing. The SAE-AE-CD includes at least one sulfoalkyl ether group and at least one alkyl ether group even though the degree of substitution for the functional groups can be different. The SAE functional group can be present in molar excess over the AE functional group and vice versa. The total degree of substitution of the cyclodextrin, with respect to both functional groups, can be varied such that a minority or a majority of the hydroxyl moieties of the CD are derivatized. The SAE-AE-CD derivative can be used to solubilize compounds with insufficient water solubility. In some cases, they also stabilize compounds in solution against degradation or to solubilize degradation products formed during degradation. In addition, SAE-AE-CD can also be used for other purposes such as osmotic agents, agents used to mask the taste of problematic drugs. Surprisingly, while AE-CDs are known to be toxic by being membrane disturbing, SAE-AE-CDs are less membrane disturbing and therefore have greater safety.
Owner:UNIVERSITY OF KANSAS

Barrier material comprising a thermoplastic and a compatible cyclodextrin derivative

A barrier film composition can comprise a thermoplastic web comprising a thermoplastic polymer and a dispersed cyclodextrin composition having substituents that compatibilize the cyclodextrin in the film. The thermoplastic / cyclodextrin film obtains substantial barrier properties from the interaction between the substituted cyclodextrin in the film material with a permeant. The substituents on the cyclodextrin molecule causes the cyclodextrin to be dispersible and stable in the film material resulting in an extrudable thermoplastic. Such materials can be used as a single layer film material, a multilayer film material which can be coated or uncoated and can be used in structural materials wherein the thermoplastic is of substantial thickness resulting in structural stiffness. The cooperation between the cyclodextrin and the thermoplastic polymer provides barrier properties to a web wherein a permeant can be complexed or entrapped by the cyclodextrin compound and held within the film preventing the permeant from passing through the film into the interior of a film, an enclosure or container. The permeant can comprise a variety of well known materials such as moisture, aliphatic or aromatic hydrocarbons, monomer materials, off flavors, toxic compounds etc.
Owner:CELLRESIN TECH

Sulfoalkyl ether-alkyl ether cyclodextrin derivatives

A sulfoalkyl ether-alkyl ether cyclodextrin (SAE-AE-CD) derivative is provided. The SAE-AE-CD possesses advantages over known SAE-CD and AE-CD derivatives as well as over the parent cyclodextrin by being more water soluble and less membrane disturbing. The SAE-AE-CD includes at least one sulfoalkyl ether group and at least one alkyl ether group even though the degree of substitution for the functional groups can be different. The SAE functional group can be present in molar excess over the AE functional group and vice versa. The total degree of substitution of the cyclodextrin, with respect to both functional groups, can be varied such that a minority or a majority of the hydroxyl moieties of the CD are derivatized. The SAE-AE-CD derivative can be used to solubilize compounds with insufficient water solubility. In some cases, they also stabilize compounds in solution against degradation or to solubilize degradation products formed during degradation. In addition, SAE-AE-CD can also be used for other purposes such as osmotic agents, agents used to mask the taste of problematic drugs. Surprisingly, while AE-CDs are known to be toxic by being membrane disturbing, SAE-AE-CDs are less membrane disturbing and therefore have greater safety.
Owner:UNIVERSITY OF KANSAS

Prednisolone compositions

Disclosed herein are compositions comprising cyclodextrin derivatives and prednisolone and prodrugs thereof, and methods related thereto. The use of soluble polyanionic polymers such as hydroxypropylmethylcellulose and others in relation to these compositions is also disclosed. Delivery of these prednisolone-related compounds to the back of the eye via topical ophthalmic administration is also disclosed.
Owner:ALLERGAN INC

Butylbenzene phthalein cyclodextrin or cyclodextrin derivative clathrate, its preparation method and application

InactiveCN1394880AGood water solubilityThe solution cannot be directly used in solid dosage formsCyclodextrin derivativeChemistry
The present invention relates to butylbenzene phthalein cyclodextrin or cyclodextrin derivative clathrate, its preparation method and application. The described butylbenzene phthalein is mixed-rotatory butylbenzene phthalein and levo-butylbenzene phthalein. In order to raise water solubility of butylbenzene phthalein and develop solid dosage form and liquid dosage form required for clinical application said invention adopts cyclodextrin or cyclodextrin derivative to include the butylbenzene phthalein. Said clatherate contains butylbenzene phthalein and cyclodextrin or cyclodextrin derivative, the mole ratio of both them is 1:1-10. The cyclodextrin or cyclodextrin derivative optimally selects hydroxypropyl-beta-cyclodextrin. Said clathrate can be used for preparing various dosage forms of injection, oral preparation, tablet, capsule and others.
Owner:CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1

Cyclodextrin sulfonates, guest inclusion complexes methods of making the same and related materials

This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.
Owner:EASTMAN CHEM CO

Composition used in scale-inhibition corrosion inhibitor, scale-inhibition corrosion inhibitor, and application thereof

The invention discloses a composition used in a scale-inhibition corrosion inhibitor, a scale-inhibition corrosion inhibitor, and an application thereof. The composition used in the scale-inhibition corrosion inhibitor comprises cyclodextrin and / or a cyclodextrin derivative, a carboxylic-acid-group-containing homopolymer, a sulfonic-acid-group-containing copolymer, and selectively hydroxycarboxylic acid with a weight ratio of 1:0.2-20:0.04-15:0.2-30:0-20. The scale-inhibition corrosion inhibitor provided by the invention is environment-friendly. According to the invention, the application of phosphorus-containing compound or non-renewable molybdate or tungstate is prevented, such that the scale-inhibition corrosion inhibitor is phosphorus-free and nitrogen-free. The scale-inhibition corrosion inhibitor has high tolerance to calcium and alkali, resistance to corrosion of high-concentration chloride ion and sulfate ion, and wide applicability to water quality. Therefore, technical condition is provided for operation of circulation water under high concentration multiple and for reducing sewage discharge. The scale-inhibition corrosion inhibitor provided by the invention has excellent scale inhibition and corrosion inhibition performances in circulation water system application. With the scale-inhibition corrosion inhibitor, a dose is low, scale-inhibition treatment process is simple and substantial effect is provided. The scale-inhibition corrosion inhibitor is suitable for popularization.
Owner:CHINA PETROLEUM & CHEM CORP +1

Nanoporous carbohydrate frameworks and the sequestration and detection of molecules using the same

Disclosed are cyclodextrin-based metal organic frameworks comprising a metal cation and cyclodextrin or a cyclodextrin derivative. These metal organic frameworks are permanently porous and capable of molecule storage.
Owner:NORTHWESTERN UNIV +1

Formulations Containing Clopidogrel and Sulfoalkyl Ether Cyclodextrin and Methods of Use

The present invention provides compositions containing clopidogrel, present as a free base or a pharmaceutically acceptable salt thereof, and sulfoalkyl ether cyclodextrin (SAE-CD). The compositions can be liquid, suspension or solid compositions. They can be adapted for oral, peroral or parenteral administration. The SAE-CD serves to aid in dissolution and stabilization of the clopidogrel in aqueous media. The stability of clopidogrel against hydrolytic degradation, thermal degradation, and photolytic degradation are improved. SAE-CD provides improved results over other cyclodextrin derivatives. The SAE-CD-containing composition of clopidogrel can be provided in liquid form, solid form or as a reconstitutable powder. Both ready-to-use and concentrated liquid compositions can be prepared. The liquid composition is optionally available as a clear solution. The compositions herein can be administered perorally or parenterally and provide substantial pharmacokinetic, pharmacodynamic and / or therapeutic advantages over a tablet composition administered perorally and excluding SAE-CD.
Owner:CYDEX PHARMACEUTICALS INC

Barrier material with nanosize metal particles

The incorporation of nanosized metal particles into cyclodextrin-containing material leads to a “reactive” barrier material having excellent barrier properties. Also, it has been found that the presence of nanosized metal or metal alloy particles in a barrier material such as thermoplastic material, wherein said material comprises cyclodextrin derivatives, may be advantageous in achieving excellent barrier properties. The barrier material of the present invention may provide improved barrier resistance to a variety of permeants and / or impurities. The diffusion of volatile substances through the barrier material may be prevented by adding compatible derivatized cyclodextrin and nanosized metal particles to the material used. Accordingly, the inventive material also is suitable for many applications including food-contact packaging, flexible packaging to dispose of adult and baby diapers, incontinent products, hospital and household waste and also for packaging pharmaceutical products, medical devices and dental materials.
Owner:VERDANT TECH LLC

Crystallization controllable thermoplastic polyurethane material and preparation method thereof

ActiveCN107141437AControllable crystallization propertiesLow shrinkageSelective laser sinteringCrystallinity
The invention discloses a crystallization controllable thermoplastic polyurethane material and a preparation method of the crystallization controllable thermoplastic polyurethane material. The thermoplastic polyurethane material comprises and is prepared from the following components: 1) a diisocyanate compound; 2) a hydroxyl and / or amido end capped macromolecular compound; 3) a diamine or diol cyclodextrin derivative; 4) a chain extender. The types and the use amounts of a main chain extender and an auxiliary chain extender in the chain extender are controlled, meanwhile, the cyclodextrin derivative is introduced, so that the crystallization characteristic of the thermoplastic polyurethane material is controlled, the controllable degree of crystallinity and the improved viscosity temperature sensitivity are obtained, and the shrinkage percentage of the material is also changed correspondingly. The obtained thermoplastic polyurethane material can be used in a rapid forming method in the fusing processing, like a fused deposition rapid forming method or a selective laser sintering method.
Owner:WANHUA CHEM GRP CO LTD

Fluorescent color conversion film, fluorescent color conversion filter using the same, and an organic light-emitting device equipped with this fluorescent color conversion filter

A fluorescent color conversion film has an organic fluorescent dye, which absorbs light obtained from a light-emitting element in the near ultraviolet to the visible range and emits a visible light of a different wavelength, and a matrix resin, which bears the organic fluorescent dye. The organic dye is an immobilized organic fluorescent dye enclosed by a cyclodextrin derivative represented by general formula (I),wherein n is an integer from 4 to 10, each of R1-R5 are selected independently from the group consisting of a hydrogen atom, a carboxyl group, a hydroxyl group, and a C1-C6 alkyl group. An organic light-emitting device equipped with this fluorescent color conversion film suppresses the decomposition and quenching of the fluorescent dye from attacks by radicals generated from the polymerization initiators in photolithography and / or growth radicals of reactive multifunctional monomers.
Owner:SHARP KK

Voriconazole injection and its preparing method

The present invention relates to a fuliconazole injection. Said injection includes the following components; (by wt%) fuliconazole 0.01-20%, cyclodextrin or cyclodextrin derivative 0%-60%, water-soluble excipient 0-75%, solubilizer 0%-20% and the rest is injection water. Its preparation method includes the following steps: mixing the above-mentioned raw materials, using active carbon to remove impurity and heat source, filtering, fine filtering, filling, sterilizing, checking and putting in storage.
Owner:南京都药医药科技有限公司

Pharmaceutical composition containing arctigenin and preparation method

A composition for medicine having arctigenin and a method for preparing the same, in particular the arctigenin is involved in a cyclodextrin derivative, which mixture ratio is in a range of 1g:3g-30g, and the composition can effectively increase solubility and bioavailability of the arctigenin.
Owner:海南盛科天然药物研究院有限公司

6-deoxy-sulfones cyclodextrin derivatives and preparation method thereof

ActiveCN101591402AEffective antagonistRestoration of neuromuscular conductionOrganic active ingredientsDrug compositionsSulfur containingThioether
The invention provides 6-deoxy-sulfones cyclodextrin derivatives, which have a structure in a formula (I). The preparation method comprises the following steps: taking 6-deoxy-thioether aminoacid cyclodextrin derivatives or 6-deoxy-thioether cyclodextrin derivatives as raw materials, and obtaining 6-deoxy-sulfoxide cyclodextrin derivatives through oxidation reaction 1; and furthering oxidizing to obtain the 6-deoxy-sulfones cyclodextrin derivatives, wherein the 6-deoxy-thioether aminoacid cyclodextrin derivatives are prepared by the following steps: performing halogenation on acetic acid containing R3 substituent to obtain double halides; performing condensation on the double halides and amino acid to obtain acid amides; adding a sulfur reagent to obtain a sulfur-containing compound; removing protecting groups to obtain a sulfhydryl compound; and performing condensation on the sulfhydryl compound and halogenated cyclodextrin. The compounds provided by the invention can be used for reversing the phenomenon of neuromuscular relaxation induced by human or animal muscular relaxants, have effects of reversing and antagonizing the muscular relaxation induced by the muscular relaxants, and can be applied to the preparation of medicaments for antagonizing the muscular relaxation.
Owner:HANGZHOU ADAMERCK PHARMLABS INC

Garlicin and garlic oil cyclodextrin derivatives inclusion compound and method for making same

The present invention aims to raise water solubility and stability of allicin and allium sativum oil, develop clinically required solid preparation form and liquid preparation form and make use of the treating effect of allicin and allium sativum oil. Cyclodextrin is used to include allicin and allium sativum oil and the clathrate contains allicin oil and cyclodextrin derivative in the molar ratio of 1 to 1-1000 or allium sativum and cyclodextrin derivative in the molar ratio of 1 to 8.6-8600. The cyclodextrin derivative is preferably propyl-beta- cyclodextrin. The clathrate may be used inpreparing injection, powder for injection, infusion fluid, tablet, capsule, microball, etc. and may be developed into various solid and liquid preparation forms for clinical application.
Owner:GENERAL HOSPITAL OF THE NORTHERN WAR ZONE OF THE CHINESE PEOPLES LIBERATION ARMY

Tobacco Product, Preparation and Uses Thereof

A smokeless oral tobacco product comprises a cyclodextrin or cyclodextrin derivative. Such a product can further comprise a flavourant complexed with the cyclodextrin or derivative thereof. Cyclodextrins or their derivative can be used in smokeless oral tobacco products to complex with molecules which arise or solubilize during use of the product and optionally to also release, e.g., flavour or aroma during use of the product.
Owner:BRITISH AMERICAN TOBACCO (INVESTMENTS) LTD

Skinniness hormone packing matter water solution and application thereof

InactiveCN101199855AUniform inclusionLow moisture requirementsOrganic active ingredientsSenses disorderWater solubleCyclodextrin derivative
The invention relates to a preparation of antibiotic and cortical hormone, in particular to an eye-used or ear-used preparation combining cortical-hormone inclusion compound and antibiotic. Cyclodextrin derivative is used to prepare insoluble cortical hormone into water-soluble inclusion compound, and then the inclusion compound solution, along with antibiotic is used to prepare pellucid medicinal dropping liquid or transparent gelatine solution preparation, for local eye or ear treatment. The preparation, which is based on cortical-hormone inclusion compound, has the advantage of stable liquid, high inclusion efficiency, simple preparation process, high yield and good adaptability. The invention can obtain the dropping liquid and gelatine solution prepared jointly by cortical-hormone inclusion compound and antibiotic.
Owner:TIANJIN PHARMA GROUP CORP

Mezloxicon liquid preparation using HPCD as solubilizing and stabilizing agent and its preparation method

A liquid preparation of meloxican is prepared from the meloxicam or its medical salt and water-soluble cyclodextrin derivative HP-beta-CD used as solubilizer and stabilizer, proportionally mixing, adding cosolvent, pH regulator and water for injection, heating and membrane filtering. It has long storage time at low temp.
Owner:SHENYANG PHARMA UNIVERSITY

Garlic oil cyclodextrin or cyclodextrin derivate inclusion compound and preparation method

The invention relates to a garlic oil cyclodextrin or cyclodextrin derivative inclusion compound, and a preparation method thereof. Garlic oil is an organic sulfide extracted from garlic and has the functions of resisting bacteria, diminishing inflammation, improving organism immunity, preventing and treating cardiovascular system diseases, and the like. Garlic oil has aroma and hot taste similar to fresh garlic, is integral in flavor, pure natural, safe and healthy, and is widely applied to salty food additives, health-care food, edible blend oil and the like, but as the garlic oil is unstable in properties, strong in volatility and acrimony and difficult to dissolve in water, the application of the garlic oil to food is greatly limited. The preparation method applies cyclodextrin and cyclodextrin derivatives to the inclusion of garlic oil so as to prepare the garlic oil cyclodextrin or cyclodextrin derivative inclusion compound, solves the problems that the garlic oil is low in water solubility, strong in acrimony and the like, and enables the garlic oil to be directly applied to food and health care products.
Owner:BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY

Medicine use of cyclodextrin derivs. and medicine composition thereof

A cyclodextrin derivative for preventing and treating cardiovascular and cerebrovascular diseases, diabetes, liver injury, diseases in respiratory system, rheumatic and rheumatoid diseases, dermatopathy and tumor is disclosed. It is an artificial analogue enzyme with the activity of glutathion peroxidase.
Owner:JILIN UNIV

Supermolecule corrosion inhibitor for copper and copper alloy and high-speed mixing preparation method thereof

The invention discloses a supermolecule corrosion inhibitor for copper and copper alloy and a high-speed mixing preparation method thereof, belonging to the technical field of metal corrosion and protection. The supermolecule corrosion inhibitor comprises the following components in parts by mass: 20-30 parts of a cyclodextrin derivative, 5-10 parts of an organic imidazole compound, 10-20 parts of an inducer and 40-600 parts of water, and is prepared by stirring at high speed. According to the supermolecule corrosion inhibitor for copper and copper alloy, the organic imidazole compound and cyclodextrin derivative are used for forming a subject-object supermolecule structure through weak interaction such as hydrophobic effect and hydrogen bond, so that the solubility and dispersibility of the organic imidazole compound in water are improved. The supermolecule corrosion inhibitor for copper and copper alloy has strong universality and good anti-corrosion effect, the use amount is less, when the chemical dosing concentration is 20-60mg / L, the corrosion rate of the copper and copper alloy can be controlled to be less than 0.005mm / a, effective components of the supermolecule corrosion inhibitor can be released uniformly, and the supermolecule corrosion inhibitor can work for a long period with chemical dosing once.
Owner:BEIJING UNIV OF CHEM TECH
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