97 results about "Cyclodextrin derivative" patented technology

The invention belongs to the technical field of semipermeable membrane preparation, and particularly relates to a preparation method of a nanofiltration membrane. The preparation method comprises the following steps: (1) cleaning the supporting layer for later use; the preparation method comprises the following steps: blending diamine, an amino beta-cyclodextrin derivative, an inorganic hybridizing agent, a zwitterionic compound and water to obtain a water phase for later use; blending aromatic acyl chloride, a cosolvent and an organic solvent to obtain an oil phase for later use; and (2) sequentially carrying out primary impregnation in a water phase, membrane scraping, secondary impregnation in an oil phase and heating curing on the supporting layer, and finally carrying out post-treatment to obtain the nanofiltration membrane. The nanofiltration membrane is prepared by introducing the amino beta-cyclodextrin derivative, the inorganic hybridization agent and other components into polyamide, so that the water flux of the polyamide nanofiltration membrane and the capability of effectively separating ions with different valence states are further improved.

The invention relates to a dihydroartemisinic acid inclusion compound as well as a preparation method and application thereof. The dihydroarteannuic acid clathrate compound comprises dihydroarteannuic acid and a cyclodextrin compound wrapping the dihydroarteannuic acid. The cyclodextrin compound comprises cyclodextrin and / or a cyclodextrin derivative. According to the invention, the inclusion effect of the cyclodextrin compound on the dihydroarteannuic acid is utilized, so that dihydroarteannuic acid molecules are embedded in the tubular structure of the cyclodextrin compound, and the water solubility of the dihydroarteannuic acid is greatly improved.

The invention discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by salicylic acid, amino acid and a cyclodextrin derivative through non-covalent bond interaction, the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, salicylic acid molecules are included in a cavity of the cross-linked beta-cyclodextrin polymer, and the cross-linked beta-cyclodextrin polymer is a cross-linked beta-cyclodextrin polymer. And meanwhile, guanidyl or carboxyl of an amino acid side chain interacts with hydroxyl outside the cross-linked beta-cyclodextrin polymer or an exposed part of an included salicylic acid molecule. According to the invention, a cross-linked beta-cyclodextrin polymer is used, arginine is introduced as a synergist, a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary clathrate compound is constructed, and through charge neutralization and hydrogen bond network synergistic effect, clathration efficiency is significantly improved, and water solubility of salicylic acid is improved.

The invention relates to the field of high polymer material modification, and discloses a low-toxicity nylon material modification composition and a preparation method and application thereof, and the composition comprises the following components by weight: 70-90% of bio-based polyamide; 2-10% of surface functionalized nano-chitosan, wherein a beta-cyclodextrin derivative is grafted on the surface of the surface functionalized nano-chitosan to adsorb harmful small molecules; the 3-15% of double-layer wall material natural polyphenol microcapsules are used for slowly releasing natural polyphenols with anti-oxidation and skin soothing effects; and 0.1-0.5% of an interface synergistic locking agent to enhance the stability of the functional components in the matrix. The preparation method comprises the following steps: mixing the components, and carrying out melt blending granulation through a double-screw extruder. The cytotoxicity of the nylon material is remarkably reduced, the nylon material is endowed with active skin-friendly characteristic and lasting functionality, and the nylon material is suitable for preparing long-term skin contact products such as watchbands and the like.

The invention provides a nicotine releasing agent for buccal cigarettes and a preparation method and application of the nicotine releasing agent, and belongs to the technical field of tobaccos. The nicotine releasing agent for the buccal cigarette comprises cyclodextrin nanometer sponge with a three-dimensional porous nanometer structure and nicotine salt embedded and / or adsorbed and loaded on the cyclodextrin nanometer sponge, and cyclodextrin / cyclodextrin derivatives and a covalent cross-linking agent are subjected to a cross-linking reaction to form the cyclodextrin nanometer sponge.

This invention relates to the field of separation membrane technology, and more specifically, to a highly selective PVA separation membrane, its preparation method, and its applications. The PVA separation membrane provided by this invention, modified with α-cyclodextrin and / or α-cyclodextrin derivatives, significantly improves the selectivity of the PVA separation membrane. It can be used to separate mixtures of organic matter and water, such as alcohol-water systems, and is suitable for the separation and preparation of high-purity products. The preparation method employed in this invention is simple and easy to operate, and does not introduce new impurities, making it applicable to the industrial production of high-purity products.

The present invention provides a novel composite polymer material with excellent mechanical properties, a method for producing the composite polymer material, and an optical material containing the composite polymer material. The composite polymer material of the present invention contains a crosslinked polymer formed by crosslinking a silicone-based polymer S having a polysiloxane backbone as a main chain with a polymer P having a backbone other than a polysiloxane backbone as a main chain, wherein host-guest interaction based on a host group and a guest group is formed between the silicone-based polymer S and the polymer P, and the host group is a monovalent group formed by removing one hydrogen atom or one hydroxy group from a cyclodextrin or a cyclodextrin derivative.

The utility model discloses a cyclodextrin derivative decolorizing device which comprises a box body, electric heating plates are installed on the inner wall of the box body at equal intervals, a decolorizing tank is rotatably connected to the interior of the box body, a stirring shaft is rotatably connected to the interior of the decolorizing tank, stirring blades are symmetrically and fixedly connected to the outer side of the stirring shaft, and a connecting frame is slidably connected to the interior of the box body. Air outlet plates are symmetrically and fixedly connected to the outer side of the connecting frame; the utility model relates to the technical field of decolorizing devices, and the cyclodextrin derivative decolorizing device is provided with the transmission shaft, the transmission gear, the outer gear ring, the decolorizing tank, the stirring shaft and the stirring blades, so that the function of fully mixing raw materials, a decolorizing agent and the like is realized, and the cyclodextrin derivative can be conveniently decolorized; by arranging an electric heating plate, an air outlet plate, a driving shaft, an eccentric wheel, a sliding plate, a spring and a connecting frame, the function of uniformly heating the decolorizing tank in the decolorizing process is realized, the heating efficiency is improved, and the decolorizing effect is better.

The utility model relates to the technical field of separation equipment, in particular to a cyclodextrin derivative solution concentration device which comprises a biological solution concentration mechanism, and the biological solution concentration mechanism comprises a solution inlet plate, a solution filter screen, a concentration device body, control equipment, a device base, fixing screws and a circulation pipeline. When the equipment is operated, a cyclodextrin derivative solution needing to be concentrated is put into the circulation pipeline through the solution inlet plate, an evaporation concentration method or a freeze drying method is selected to be used for concentration according to the property of the cyclodextrin derivative solution, and when the evaporation concentration method needs to be used, the steam door is pulled open; water resources used for producing steam are put into the steam production bin, the electric heating pipe is started to heat the water resources and generate steam, the steam enters the reaction plate through the steam pipeline to concentrate a cyclodextrin derivative solution, and the steam enters the steam circulating pipeline after concentration is completed for next round of concentration.

The present invention addresses the problem of providing a cured film-forming composition for forming a cured film for forming an alignment material which has excellent solvent resistance, can align polymerizable liquid crystals with high sensitivity, and has little liquid crystal rejection. [Solution] A composition for forming a cured film, an alignment material, and a phase difference material. The composition for forming a cured film contains (A) a compound having a photo-alignment group, (B) a polymer having a structural unit having an N-hydroxymethyl group or an N-alkoxymethyl group, and (C) a cyclodextrin derivative in which some or all of hydroxyl groups are modified.

This invention relates to the field of soil remediation technology, and discloses a soil remediation composition, a contaminated soil leaching agent, and a method for remediating contaminated soil. The composition comprises a modified cyclodextrin derivative and an anionic nonionic surfactant; the modified cyclodextrin derivative has the structure shown in formula (I), where R1 is selected from C8-C9. 22 The composition comprises alkyl groups; R3 and R4 are each independently selected from H, -PO3M2, -PO3HM, -SO3M, or -COOM, and at least one of R3 and R4 is not H; M is selected from any one of Li, Na, K, and NH4; each R2 is independently selected from hydrogen or a C1-C4 alkyl group; m is selected from any integer from 1 to 10, n is selected from any integer from 1 to 10, z is selected from any integer from 0 to 9, and the sum of m, n, and z is any integer from 5 to 11. This composition, as a leaching agent, can effectively remove benzene-based pollutants from soil, is environmentally friendly, and pollution-free.

The application discloses a microneedle, a microneedle patch and a preparation method and application thereof. The microneedle comprises drug-loaded microspheres and a matrix, the drug-loaded microspheres are distributed in the matrix, and the matrix comprises a matrix material and a thickening agent; wherein the matrix material comprises a beta-cyclodextrin derivative. The microneedle patch comprises the microneedle and a substrate, and the microneedle is distributed on the surface of the substrate. The microneedle has high mechanical strength and long-term stability, and the obtained microneedle patch can be applied to the fields of medicine and medical aesthetics.

This invention belongs to the field of semi-permeable membrane preparation technology, specifically relating to a method for preparing a nanofiltration membrane. The preparation method includes the following steps: (1) cleaning the support layer for later use; mixing diamine, aminoβ-cyclodextrin derivative, inorganic hybrid agent, zwitterionic compound and water to obtain an aqueous phase for later use; mixing aromatic acyl chloride, co-solvent and organic solvent to obtain an oil phase for later use; (2) sequentially impregnating the support layer in the aqueous phase once, scraping the membrane, impregnating it in the oil phase a second time, and heating and curing it, and finally performing post-treatment to obtain the nanofiltration membrane. This invention introduces aminoβ-cyclodextrin derivative, inorganic hybrid agent and other components into polyamide to prepare a nanofiltration membrane, further improving the water flux and the ability to effectively separate ions of different valence states of the polyamide nanofiltration membrane.

The invention discloses salicylic acid sustained-release microspheres prepared by a cyclodextrin inclusion technology and a preparation method of the salicylic acid sustained-release microspheres, and belongs to the technical field of pharmaceutical preparations. The method aims to solve the problems of poor solubility, low drug loading capacity and lack of sustained-release capability of traditional cyclodextrin inclusion salicylic acid. The core of the method is that two brand new functional compounds, namely quaternary ammonium salt hydroxypropyl beta cyclodextrin and nicotinamide poloxamer covalent conjugates, are firstly prepared; when the microspheres are prepared, the two compounds are dissolved in a mixed solvent of ethanol and water, then salicylic acid and nicotinamide are added, a supramolecular inclusion solution is formed through stirring, and finally a microsphere product is obtained through spray drying and screening. Wherein the affinity with the skin is enhanced by the cationic cyclodextrin derivative, the nicotinamide conjugate and salicylic acid form a stable compound through intermolecular interaction, and efficient inclusion and loading of salicylic acid are realized through synergism of the cationic cyclodextrin derivative and the nicotinamide conjugate. The dissolvability, the solution transparency and the storage stability of salicylic acid are remarkably improved, the microsphere wrapping amount is high, a good slow-release effect is achieved, and the salicylic acid microsphere is suitable for the field of skin external preparations.

The application discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by non-covalent bond interaction of salicylic acid, amino acid and cyclodextrin derivatives, wherein the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, wherein the salicylic acid molecules are included in the cavity of the cross-linked beta-cyclodextrin polymer, and meanwhile, the guanidino group or carboxyl group of the amino acid side chain interacts with the hydroxyl group outside the cross-linked beta-cyclodextrin polymer or the exposed part of the salicylic acid molecules after inclusion. The application uses the cross-linked beta-cyclodextrin polymer and introduces arginine as a synergist to construct a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary inclusion compound, and through charge neutralization and hydrogen bond network synergistic effect, the inclusion efficiency is significantly improved, and the water solubility of salicylic acid is improved.

The invention belongs to the technical field of high performance liquid chromatography, and particularly relates to a preparation method and application of chiral hybrid microspheres containing beta-cyclodextrin shells. Firstly, (3-mercaptopropyl) triethoxy silane and vinyl cyclodextrin are used as raw materials, and a beta-cyclodextrin derivative modified by triethoxy silane is generated in a mercapto-alkene click chemistry mode. And reacting the beta-cyclodextrin with tetraethyl silicate and solid silicon dioxide to obtain a core-shell hybrid microsphere containing a beta-cyclodextrin shell layer. The beta-cyclodextrin can be used as a chiral selective agent and has a chiral recognition function, so that the hybrid microsphere can be used as a chiral chromatographic stationary phase and is used for separation and analysis of chiral enantiomers, and compared with chiral hybrid microspheres containing beta-cyclodextrin shells in the prior art, the loading capacity and firmness degree of the beta-cyclodextrin on the surface of a matrix are improved; the chiral separation capability of the chiral hybrid microspheres is improved.

The application relates to the technical field of inclusion compounds, in particular to a coenzyme Q10-cyclodextrin inclusion compound and a preparation method and application thereof, which comprises the following steps: dissolving coenzyme Q10 in an alcohol aqueous solution to obtain a first solution; performing ultrasonic treatment on the first solution at 40 DEG C-45 DEG C to obtain a second solution; performing cooling treatment on the second solution to obtain a third solution; adding a cyclodextrin derivative solution into the third solution to mix, and obtaining a fourth solution of the coenzyme Q10-cyclodextrin inclusion compound; adding corn starch into the fourth solution, stirring and reacting, removing a solvent, and obtaining a coenzyme Q10-cyclodextrin derivative corn starch inclusion compound. The preparation method has the advantages of simple operation and high encapsulation rate, and the coenzyme Q10-cyclodextrin derivative corn starch inclusion compound has good long-term storage stability.

The invention discloses a multifunctional hydrogel which comprises polyethylene glycol diacrylate, methacrylated beta-cyclodextrin and a zwitterionic monomer, and the zwitterionic monomer is sulfobetaine methacrylate or [2-(methacryloyloxy) ethyl] dimethyl (3-sulfopropyl) ammonium salt; wherein the mass percentage of the polyethylene glycol diacrylate is 1-30%, the mass percentage of the zwitterionic monomer is 10-30%, and the mass percentage of the methacrylated beta-cyclodextrin is 1-5%. According to the invention, a polyethylene glycol diacrylate cross-linked skeleton is combined with a zwitterionic monomer to enhance hydrophilicity and ion complexing ability, so that a large-mesh structure is formed; and the beta-cyclodextrin derivative is selectively combined with the aromatic organic pollutants through the host-guest interaction. Through cooperation of multifunctional sites, dyes, drugs, metals and micro-plastics are removed at the same time. The multifunctional hydrogel disclosed by the invention has the advantages that the pollutant removal rate is increased, and the multifunctional hydrogel has reproducibility and can be applied to various water treatment processes.

To provide a water-resistant substrate excellent in water resistance.SOLUTION: A water-resistant substrate is formed by impregnating a fibrous core material with a cyclodextrin compound. The cyclodextrin compound is preferably a polymer containing cyclodextrin or a cyclodextrin derivative, or a non-polymeric cyclodextrin compound having a hydrophobic group. In the former case, the polymer is preferably a copolymer of a cyclodextrin derivative with a polymerizable group and an acrylic monomer. In the latter case, the non-polymeric cyclodextrin compound is preferably impregnated into the core material together with an acrylic polymer.SELECTED DRAWING: None

The invention relates to an antiseptic material, in particular as a wound dressing, containing a carrier material and at least one antiseptic together with a surfactant, wherein the carrier material is equipped with a cyclodextrin or cyclodextrin derivative that is loaded in the antiseptic or antiseptics.

The invention discloses an acoustic sensor, a preparation method thereof and a detection system, and the acoustic sensor comprises a substrate which is internally provided with an acoustic inlet hole penetrating through the substrate; the first functional layer is located on the substrate, a first cavity is formed between the first functional layer and the substrate, and the first cavity is communicated with the acoustic inlet hole; the second functional layer is located on the first functional layer, a capacitor cavity is formed between the second functional layer and the first functional layer, one of the first functional layer and the second functional layer is a vibrating diaphragm, and the other one is a backboard. According to the structure, the MEMS microphone is formed, the gas sensitive film is arranged on the bottom surface of the back plate, and the gas sensitive film comprises the porous organic framework material and the cyclodextrin derivative grafted in the pore channel of the porous organic framework material, so that automatic adsorption and desorption of target gas molecules are realized without external energy input in the whole process; therefore, automatic repeated detection of the target gas is realized.

The present invention relates to a cyclodextrin derivative of formula (I), wherein the cyclodextrin derivative has an average percentage of primary substitution (Rp) to total substitution with the substituted alkyl in the range of 15-99 %. The invention also relates to a composition comprising said cyclodextrin derivatives, a drug-cyclodextrin complex, use of a cyclodextrin derivative and a manufacturing method thereof.

The invention provides monodisperse cyclodextrin derived carbon nanospheres and a preparation method thereof, and relates to the field of materials. The preparation method of the monodisperse cyclodextrin-derived carbon nanospheres comprises the following steps: mixing cyclodextrin, a surfactant and water, and carrying out a hydrothermal carbonization reaction; after the hydrothermal carbonization reaction is finished, a mixture is cooled and centrifugally separated, electrolyte is added in the centrifugal separation process, then a solid product is washed, collected and dried, and the monodisperse cyclodextrin derived carbon nanospheres are obtained. According to the method, the carbon nanospheres with the monodisperse characteristic are prepared on the basis of the hydrothermal carbonization process, the whole process is simple, conditions are mild, the method is environmentally friendly, and the prepared material has wide application potential in the fields of energy storage, adsorbents, catalyst carriers and the like.

This invention belongs to the field of pharmaceutical formulations and relates to a compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection, its preparation method, and its application. By weight percentage, the compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection comprises 0.1-2.0% of a nitroimidazole compound, 0.05-3.0% of an isoxazoline compound, 0.1-1.5% of a gelling polymer, 1.0-8.0% of a complex solubilizing system, 0.1-3.0% of pharmaceutically acceptable excipients, and the balance being water. The complex solubilizing system includes polyvinylpyrrolidone and cyclodextrin derivatives. This invention effectively solves the problem of poor solubility of isoxazoline drugs through a complex solubilizing system, and the combination of the two drugs has a significant synergistic acaricidal effect. Combined with a gelling polymer, it can achieve in-situ gelation on the ocular surface, prolong retention, and sustained drug release, with low ocular irritation, providing a highly effective, long-lasting, and safe new local treatment option for Demodex mite-related eye diseases.

The invention discloses a quick-acting heart-saving freeze-dried orally disintegrating tablet and a preparation method thereof, and relates to the technical field of medicines, the quick-acting heart-saving freeze-dried orally disintegrating tablet is prepared from the following materials through freeze drying: a ligusticum wallichii extract, a borneol clathrate compound, a freeze-dried proppant, and an optional sweetening agent and / or thickening agent, the borneol clathrate compound is a clathrate compound prepared from cyclodextrin or a derivative thereof through a clathration technology. According to the freeze-dried orally disintegrating tablet and the preparation method thereof, the inclusion compound of the borneol and the cyclodextrin derivative is prepared firstly, then the inclusion compound and other raw and auxiliary materials are prepared into the freeze-dried orally disintegrating tablet according to a specific process, the stability of the borneol content in a final product can be effectively guaranteed, and cyclodextrin or the cyclodextrin derivative is selected from at least one of beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin and sulfobutyl-beta-cyclodextrin. Meanwhile, the absolute ethyl alcohol for dissolving the borneol is removed during preparation of the inclusion compound, a special freeze dryer is not needed, the safety problem of equipment operation is avoided, and the production cost is reduced.

1. Name of the product in this design: Graphical User Interface for Estimating the Physical Properties of Electronic Devices. 2. Purpose of this design: An electronic device. 3. The key design features of this product are its graphical user interface in electronic devices. 4. The image or photograph that best illustrates the design's key features: the front view. 5. Application of the graphical user interface: used for predicting and calculating the binding properties of novel cyclodextrin derivatives. 6. Human-computer interaction method of graphical user interface: The interface shown in the main view is the login interface; after clicking the Start Experience button in the middle of the main view, the interface changes to state 1, which shows the custom drawing page; after clicking the Substituent Performance Prediction button in the left navigation bar of state 1, the interface changes to state 2, which shows the performance prediction interface.

The invention discloses a preparation method and application of a liquid chromatography filler for chiral resolution of a fenugreek lactone derivative, glycidyl is used as a derivatization reagent for the first time, beta-cyclodextrin is continuously modified in the reaction process, so that the beta-cyclodextrin is modified, the adsorption capacity of the beta-cyclodextrin is changed, and the adsorption capacity of the beta-cyclodextrin is changed. According to the preparation method disclosed by the invention, the beta-cyclodextrin derivative bonded with glycidyl is bonded to the silica gel microspheres by using isocyanatopropyltriethoxysilane as a silane coupling agent, and the finally obtained (R)-OH-CSP or OH-CSP can be used for splitting the fenugreek lactone derivative enantiomer, and meanwhile, the separation degree is relatively high.

Disclosed herein are novel compounds of Formula (I), (Ia), (Ib), (Ic), (Id), (Ie) or (If), which are useful in the treatment of cholesterol-related diseases, including cardiovascular diseases.

The invention discloses polypeptide-cyclodextrin nanoparticles as well as a preparation method and application thereof, and relates to the technical field of preparation of inclusion polypeptide nanoparticles. The preparation method comprises the following steps: carrying out a cross-linking reaction on one or more of a polypeptide compound and cyclodextrin or a derivative thereof to complete inclusion, and carrying out compounding and homogenizing treatment to obtain the inclusion polypeptide-cyclodextrin nanoparticles. The polypeptide and / or the polypeptide analogue are clathrated by the cyclodextrin derivative and the azone, and the sulfobutyl ether-beta-cyclodextrin is selected as a framework for clathration of the polypeptide and the polypeptide analogue, so that compared with conventional beta-cyclodextrin, the polypeptide and the polypeptide analogue have the advantages of better water solubility, higher stability, higher safety and the like; when the polypeptide is combined with azone for use, the transdermal efficiency of polypeptide and analogue raw materials can be further improved, and the bioavailability of the raw materials is fundamentally improved. According to the polypeptide-cyclodextrin nanoparticles constructed by the invention, the embedding efficiency and the drug loading capacity of polypeptide are remarkably improved, the controlled release effect is realized, and the degradation of active ingredients is reduced.

Tuowei The present invention belongs to the field of cosmetic technology, and specifically relates to a mild and highly moisturizing amino acid cleanser and a preparation method thereof. The mild and highly moisturizing amino acid cleanser comprises the following raw material components in percentage by mass: 10-20% amino acid surfactant, 5-15% moisturizer, 2-6% cyclodextrin derivative, 0.5-2% pearlescent agent, 0.05-0.2% fragrance, 0.05-0.5% preservative, and the balance is water; the cyclodextrin derivative comprises one or two of hydroxypropyl cyclodextrin and fatty alcohol polyoxyethylene ether modified cyclodextrin. The present invention uses cyclodextrin derivatives in combination with polyhydroxy moisturizers to thicken and synergistically moisturize the amino acid surfactant, which can significantly improve the thickening ability, foaming performance and cleaning ability of the amino acid cleanser, and significantly improve the skin feel when used.