54 results about "Cyclodextrin derivative" patented technology

The invention provides a nicotine releasing agent for buccal cigarettes and a preparation method and application of the nicotine releasing agent, and belongs to the technical field of tobaccos. The nicotine releasing agent for the buccal cigarette comprises cyclodextrin nanometer sponge with a three-dimensional porous nanometer structure and nicotine salt embedded and / or adsorbed and loaded on the cyclodextrin nanometer sponge, and cyclodextrin / cyclodextrin derivatives and a covalent cross-linking agent are subjected to a cross-linking reaction to form the cyclodextrin nanometer sponge.

This invention relates to the field of separation membrane technology, and more specifically, to a highly selective PVA separation membrane, its preparation method, and its applications. The PVA separation membrane provided by this invention, modified with α-cyclodextrin and / or α-cyclodextrin derivatives, significantly improves the selectivity of the PVA separation membrane. It can be used to separate mixtures of organic matter and water, such as alcohol-water systems, and is suitable for the separation and preparation of high-purity products. The preparation method employed in this invention is simple and easy to operate, and does not introduce new impurities, making it applicable to the industrial production of high-purity products.

The present invention provides a novel composite polymer material with excellent mechanical properties, a method for producing the composite polymer material, and an optical material containing the composite polymer material. The composite polymer material of the present invention contains a crosslinked polymer formed by crosslinking a silicone-based polymer S having a polysiloxane backbone as a main chain with a polymer P having a backbone other than a polysiloxane backbone as a main chain, wherein host-guest interaction based on a host group and a guest group is formed between the silicone-based polymer S and the polymer P, and the host group is a monovalent group formed by removing one hydrogen atom or one hydroxy group from a cyclodextrin or a cyclodextrin derivative.

The present invention addresses the problem of providing a cured film-forming composition for forming a cured film for forming an alignment material which has excellent solvent resistance, can align polymerizable liquid crystals with high sensitivity, and has little liquid crystal rejection. [Solution] A composition for forming a cured film, an alignment material, and a phase difference material. The composition for forming a cured film contains (A) a compound having a photo-alignment group, (B) a polymer having a structural unit having an N-hydroxymethyl group or an N-alkoxymethyl group, and (C) a cyclodextrin derivative in which some or all of hydroxyl groups are modified.

The application discloses a microneedle, a microneedle patch and a preparation method and application thereof. The microneedle comprises drug-loaded microspheres and a matrix, the drug-loaded microspheres are distributed in the matrix, and the matrix comprises a matrix material and a thickening agent; wherein the matrix material comprises a beta-cyclodextrin derivative. The microneedle patch comprises the microneedle and a substrate, and the microneedle is distributed on the surface of the substrate. The microneedle has high mechanical strength and long-term stability, and the obtained microneedle patch can be applied to the fields of medicine and medical aesthetics.

This invention belongs to the field of semi-permeable membrane preparation technology, specifically relating to a method for preparing a nanofiltration membrane. The preparation method includes the following steps: (1) cleaning the support layer for later use; mixing diamine, aminoβ-cyclodextrin derivative, inorganic hybrid agent, zwitterionic compound and water to obtain an aqueous phase for later use; mixing aromatic acyl chloride, co-solvent and organic solvent to obtain an oil phase for later use; (2) sequentially impregnating the support layer in the aqueous phase once, scraping the membrane, impregnating it in the oil phase a second time, and heating and curing it, and finally performing post-treatment to obtain the nanofiltration membrane. This invention introduces aminoβ-cyclodextrin derivative, inorganic hybrid agent and other components into polyamide to prepare a nanofiltration membrane, further improving the water flux and the ability to effectively separate ions of different valence states of the polyamide nanofiltration membrane.

The invention discloses salicylic acid sustained-release microspheres prepared by a cyclodextrin inclusion technology and a preparation method of the salicylic acid sustained-release microspheres, and belongs to the technical field of pharmaceutical preparations. The method aims to solve the problems of poor solubility, low drug loading capacity and lack of sustained-release capability of traditional cyclodextrin inclusion salicylic acid. The core of the method is that two brand new functional compounds, namely quaternary ammonium salt hydroxypropyl beta cyclodextrin and nicotinamide poloxamer covalent conjugates, are firstly prepared; when the microspheres are prepared, the two compounds are dissolved in a mixed solvent of ethanol and water, then salicylic acid and nicotinamide are added, a supramolecular inclusion solution is formed through stirring, and finally a microsphere product is obtained through spray drying and screening. Wherein the affinity with the skin is enhanced by the cationic cyclodextrin derivative, the nicotinamide conjugate and salicylic acid form a stable compound through intermolecular interaction, and efficient inclusion and loading of salicylic acid are realized through synergism of the cationic cyclodextrin derivative and the nicotinamide conjugate. The dissolvability, the solution transparency and the storage stability of salicylic acid are remarkably improved, the microsphere wrapping amount is high, a good slow-release effect is achieved, and the salicylic acid microsphere is suitable for the field of skin external preparations.

The application discloses a salicylic acid-cyclodextrin-amino acid ternary inclusion compound and a preparation method thereof. The salicylic acid-cyclodextrin-amino acid ternary inclusion compound is formed by non-covalent bond interaction of salicylic acid, amino acid and cyclodextrin derivatives, wherein the cyclodextrin derivative is a cross-linked beta-cyclodextrin polymer, wherein the salicylic acid molecules are included in the cavity of the cross-linked beta-cyclodextrin polymer, and meanwhile, the guanidino group or carboxyl group of the amino acid side chain interacts with the hydroxyl group outside the cross-linked beta-cyclodextrin polymer or the exposed part of the salicylic acid molecules after inclusion. The application uses the cross-linked beta-cyclodextrin polymer and introduces arginine as a synergist to construct a salicylic acid-cross-linked beta-cyclodextrin polymer-arginine ternary inclusion compound, and through charge neutralization and hydrogen bond network synergistic effect, the inclusion efficiency is significantly improved, and the water solubility of salicylic acid is improved.

The invention belongs to the technical field of high performance liquid chromatography, and particularly relates to a preparation method and application of chiral hybrid microspheres containing beta-cyclodextrin shells. Firstly, (3-mercaptopropyl) triethoxy silane and vinyl cyclodextrin are used as raw materials, and a beta-cyclodextrin derivative modified by triethoxy silane is generated in a mercapto-alkene click chemistry mode. And reacting the beta-cyclodextrin with tetraethyl silicate and solid silicon dioxide to obtain a core-shell hybrid microsphere containing a beta-cyclodextrin shell layer. The beta-cyclodextrin can be used as a chiral selective agent and has a chiral recognition function, so that the hybrid microsphere can be used as a chiral chromatographic stationary phase and is used for separation and analysis of chiral enantiomers, and compared with chiral hybrid microspheres containing beta-cyclodextrin shells in the prior art, the loading capacity and firmness degree of the beta-cyclodextrin on the surface of a matrix are improved; the chiral separation capability of the chiral hybrid microspheres is improved.

The application relates to the technical field of inclusion compounds, in particular to a coenzyme Q10-cyclodextrin inclusion compound and a preparation method and application thereof, which comprises the following steps: dissolving coenzyme Q10 in an alcohol aqueous solution to obtain a first solution; performing ultrasonic treatment on the first solution at 40 DEG C-45 DEG C to obtain a second solution; performing cooling treatment on the second solution to obtain a third solution; adding a cyclodextrin derivative solution into the third solution to mix, and obtaining a fourth solution of the coenzyme Q10-cyclodextrin inclusion compound; adding corn starch into the fourth solution, stirring and reacting, removing a solvent, and obtaining a coenzyme Q10-cyclodextrin derivative corn starch inclusion compound. The preparation method has the advantages of simple operation and high encapsulation rate, and the coenzyme Q10-cyclodextrin derivative corn starch inclusion compound has good long-term storage stability.

The invention discloses a multifunctional hydrogel which comprises polyethylene glycol diacrylate, methacrylated beta-cyclodextrin and a zwitterionic monomer, and the zwitterionic monomer is sulfobetaine methacrylate or [2-(methacryloyloxy) ethyl] dimethyl (3-sulfopropyl) ammonium salt; wherein the mass percentage of the polyethylene glycol diacrylate is 1-30%, the mass percentage of the zwitterionic monomer is 10-30%, and the mass percentage of the methacrylated beta-cyclodextrin is 1-5%. According to the invention, a polyethylene glycol diacrylate cross-linked skeleton is combined with a zwitterionic monomer to enhance hydrophilicity and ion complexing ability, so that a large-mesh structure is formed; and the beta-cyclodextrin derivative is selectively combined with the aromatic organic pollutants through the host-guest interaction. Through cooperation of multifunctional sites, dyes, drugs, metals and micro-plastics are removed at the same time. The multifunctional hydrogel disclosed by the invention has the advantages that the pollutant removal rate is increased, and the multifunctional hydrogel has reproducibility and can be applied to various water treatment processes.

The invention discloses an acoustic sensor, a preparation method thereof and a detection system, and the acoustic sensor comprises a substrate which is internally provided with an acoustic inlet hole penetrating through the substrate; the first functional layer is located on the substrate, a first cavity is formed between the first functional layer and the substrate, and the first cavity is communicated with the acoustic inlet hole; the second functional layer is located on the first functional layer, a capacitor cavity is formed between the second functional layer and the first functional layer, one of the first functional layer and the second functional layer is a vibrating diaphragm, and the other one is a backboard. According to the structure, the MEMS microphone is formed, the gas sensitive film is arranged on the bottom surface of the back plate, and the gas sensitive film comprises the porous organic framework material and the cyclodextrin derivative grafted in the pore channel of the porous organic framework material, so that automatic adsorption and desorption of target gas molecules are realized without external energy input in the whole process; therefore, automatic repeated detection of the target gas is realized.

This invention belongs to the field of pharmaceutical formulations and relates to a compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection, its preparation method, and its application. By weight percentage, the compound ophthalmic in-situ gel composition for treating ocular Demodex mite infection comprises 0.1-2.0% of a nitroimidazole compound, 0.05-3.0% of an isoxazoline compound, 0.1-1.5% of a gelling polymer, 1.0-8.0% of a complex solubilizing system, 0.1-3.0% of pharmaceutically acceptable excipients, and the balance being water. The complex solubilizing system includes polyvinylpyrrolidone and cyclodextrin derivatives. This invention effectively solves the problem of poor solubility of isoxazoline drugs through a complex solubilizing system, and the combination of the two drugs has a significant synergistic acaricidal effect. Combined with a gelling polymer, it can achieve in-situ gelation on the ocular surface, prolong retention, and sustained drug release, with low ocular irritation, providing a highly effective, long-lasting, and safe new local treatment option for Demodex mite-related eye diseases.

The invention discloses a quick-acting heart-saving freeze-dried orally disintegrating tablet and a preparation method thereof, and relates to the technical field of medicines, the quick-acting heart-saving freeze-dried orally disintegrating tablet is prepared from the following materials through freeze drying: a ligusticum wallichii extract, a borneol clathrate compound, a freeze-dried proppant, and an optional sweetening agent and / or thickening agent, the borneol clathrate compound is a clathrate compound prepared from cyclodextrin or a derivative thereof through a clathration technology. According to the freeze-dried orally disintegrating tablet and the preparation method thereof, the inclusion compound of the borneol and the cyclodextrin derivative is prepared firstly, then the inclusion compound and other raw and auxiliary materials are prepared into the freeze-dried orally disintegrating tablet according to a specific process, the stability of the borneol content in a final product can be effectively guaranteed, and cyclodextrin or the cyclodextrin derivative is selected from at least one of beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin and sulfobutyl-beta-cyclodextrin. Meanwhile, the absolute ethyl alcohol for dissolving the borneol is removed during preparation of the inclusion compound, a special freeze dryer is not needed, the safety problem of equipment operation is avoided, and the production cost is reduced.

1. Name of the product in this design: Graphical User Interface for Estimating the Physical Properties of Electronic Devices. 2. Purpose of this design: An electronic device. 3. The key design features of this product are its graphical user interface in electronic devices. 4. The image or photograph that best illustrates the design's key features: the front view. 5. Application of the graphical user interface: used for predicting and calculating the binding properties of novel cyclodextrin derivatives. 6. Human-computer interaction method of graphical user interface: The interface shown in the main view is the login interface; after clicking the Start Experience button in the middle of the main view, the interface changes to state 1, which shows the custom drawing page; after clicking the Substituent Performance Prediction button in the left navigation bar of state 1, the interface changes to state 2, which shows the performance prediction interface.

The invention discloses a preparation method and application of a liquid chromatography filler for chiral resolution of a fenugreek lactone derivative, glycidyl is used as a derivatization reagent for the first time, beta-cyclodextrin is continuously modified in the reaction process, so that the beta-cyclodextrin is modified, the adsorption capacity of the beta-cyclodextrin is changed, and the adsorption capacity of the beta-cyclodextrin is changed. According to the preparation method disclosed by the invention, the beta-cyclodextrin derivative bonded with glycidyl is bonded to the silica gel microspheres by using isocyanatopropyltriethoxysilane as a silane coupling agent, and the finally obtained (R)-OH-CSP or OH-CSP can be used for splitting the fenugreek lactone derivative enantiomer, and meanwhile, the separation degree is relatively high.

Disclosed herein are novel compounds of Formula (I), (Ia), (Ib), (Ic), (Id), (Ie) or (If), which are useful in the treatment of cholesterol-related diseases, including cardiovascular diseases.

The application relates to the technical field of functional polymer materials, and discloses a preparation method of high-absorbability resin with ammonia and indole double-effect deodorization performance. + The method comprises the following steps: obtaining a sodium type zeolite by saturating treatment; obtaining a monomer system containing acrylic acid and an acrylic acid salt by partially neutralizing an acrylic acid system; adding an internal crosslinking agent, a dispersing agent, the sodium type zeolite and a first part of beta-cyclodextrin derivatives and performing free radical polymerization to obtain a gel-like polymer; crushing, drying, crushing and screening the gel-like polymer to obtain base resin particles; and spraying a surface crosslinking agent and a second part of beta-cyclodextrin derivatives on the surface of the base resin particles and performing solidification to obtain target resin. The high-absorbability resin prepared by the method has high absorbability and ammonia and indole double-effect deodorization performance.

The present invention relates to an oxidizing composite material comprising a solid, inorganic, porous support, all or part of whose pores contain cyclodextrins and / or cyclodextrin derivatives rendered oxidizing by ozone treatment. The present invention also relates to a method for preparing such a material and its uses.

Disclosed is a detergent composition, comprising the following reagent and reagent combination: a first reagent, i.e., a potassium salt or a sodium salt; and a second reagent combination, i.e., trichloroacetic acid, acetonitrile, cyclodextrin, or a cyclodextrin derivative. The detergent composition in the present disclosure can be used to remove a surfactant used in a protein extraction process.

The present invention relates to an oxidizing composite material comprising a solid, inorganic and porous support, all or some of the pores of which contain cyclodextrins and / or cyclodextrin derivatives rendered oxidizing by ozone treatment. The present invention also relates to process for preparing such a material and to the uses thereof.

The application belongs to the technical field of high performance liquid chromatography, and particularly relates to a preparation method and application of chiral hybrid microspheres containing a beta-cyclodextrin shell. Specifically, (3-mercapto propyl) triethoxysilane and vinyl cyclodextrin are used as raw materials, and a triethoxysilane modified beta-cyclodextrin derivative is generated through a mercapto-alkene click chemistry method. The beta-cyclodextrin shell containing core-shell hybrid microspheres are obtained by reacting with tetraethyl orthosilicate and solid silica. Since the beta-cyclodextrin can be used as a chiral selector and has a chiral recognition function, the hybrid microspheres can be used as a chiral chromatographic stationary phase for the separation and analysis of chiral enantiomers. Compared with the prior art, the beta-cyclodextrin shell containing chiral hybrid microspheres improve the loading and firmness of beta-cyclodextrin on the matrix surface, and enhance the chiral separation capacity of the chiral hybrid microspheres.

This invention belongs to the field of chemical synthesis and fiber preparation technology, and particularly relates to a composite modifier and its preparation method, as well as a urine-resistant nylon 6 fiber and its preparation method. This invention utilizes a triple synergistic mechanism of "amine hydrolysis inhibition - urate chelation - pigment adsorption" to block the chemical and physical causes of yellowing, fundamentally solving the problem of urine-resistant yellowing. Epichlorohydrin is used for crosslinking, and amino groups are introduced at the ends to form amino-terminated cyclodextrin derivatives. Urate chelation is achieved by grafting polyethylene glycol with sodium citrate, and nano-hydroxyapatite is introduced as an auxiliary component to reduce the generation of chromophores at the source. The fiber prepared by this invention maintains excellent mechanical properties while being formaldehyde-free and bisphenol A-free, fully complying with the safety standards for children's textiles. The innovative combination of in-situ polymerization and spray drying processes ensures uniform dispersion of functional components, solving the long-standing industry problem of agglomeration.

This application belongs to the technical field of biochar adsorption materials, specifically providing a biochar composite adsorption material for efficiently removing pollutants from water and its preparation method. The biochar composite adsorption material for efficiently removing pollutants from water comprises: a porous biochar matrix; ZnAl-LDH loaded on the porous biochar matrix; and a cyclodextrin derivative bound to the ZnAl-LDH and / or the porous biochar matrix, wherein the cyclodextrin derivative comprises a supramolecular complex of tannic acid and aminocyclodextrin; the tannic acid and aminocyclodextrin self-assemble to form the supramolecular complex through intermolecular hydrogen bonds and host-guest interactions. The adsorption material prepared in this application has the advantage of multiple adsorption of metal ions and organic pollutants.

Pharmaceutical compositions comprising a chemotherapeutic agent based on a B-substituted B- amino acid derivative are disclosed. The pharmaceutical compositions include a B-substituted B-amino acid derivative and a cyclodextrin derivative. The pharmaceutical compositions are useful for treating cancer. 20 24 26 46 62 14 N ov 2 02 4 2 0 2 4 2 6 4 6 6 2 1 4 N o v 2 0 2 4 A B S T R A C T c a n c e r .

The utility model relates to the technical field of cyclodextrin derivative production, and discloses a material quantitative dropwise adding device for cyclodextrin derivative production, which comprises a material storage barrel, a stirring mechanism is arranged at the top of the material storage barrel, a mixing mechanism is arranged on one side of the stirring mechanism, a support arm is fixedly connected to the outer wall of the material storage barrel, and the support arm is fixedly connected to the outer wall of the material storage barrel. The bottom of the supporting arm is fixedly connected with a peristaltic pump, and the left side of the peristaltic pump is fixedly connected with a water pumping pipe and a water conveying pipe. According to the quantitative material dropwise adding device for cyclodextrin derivative production, through the arranged stirring mechanism, when a gear is not engaged with a rack any more, a spring in a compressed state can push a turning frame to descend, and at the moment, a worm is in a continuous rotating state, so that the turning frame can reciprocate up and down; the purpose of turning over the cyclodextrin derivative material is achieved, the purpose of stirring and mixing the cyclodextrin derivative material is achieved, and the uniformity of dilution and mixing of the cyclodextrin derivative material is guaranteed.

The invention relates to injectable pharmaceutical compositions, methods of use and formulation, wherein the compositions comprise: one or more water soluble complexes, each complex comprising a cyclodextrin or a cyclodextrin derivative and a hydrophobic drug; at least one preservative; and at least one co-solvent. The compositions are effectively preserved in accordance with the European Pharmacopoeia 2011 Test for Efficacy of Antimicrobial Preservation, satisfying at least the B criteria as it applies to parenterals, and the United States Pharmacopeia 2011 Guidelines for Antimicrobial Effectiveness Testing, satisfying the criteria for Category 1 (injectable) products.

The invention discloses an automobile interior carpet and a preparation method thereof, and relates to the technical field of automobile interiors, the automobile interior carpet comprises a backing layer, the backing layer is prepared from a thermoplastic elastomer composition, and the thermoplastic elastomer composition comprises the following components in parts by weight: 20-50 parts of thermoplastic elastomer matrix resin; 10 to 30 parts of plasticizing oil; 0.5 to 10 parts of a functionalized star cyclodextrin modifier; 20-60 parts of an inorganic filler; the functionalized star cyclodextrin modifier has a core-shell structure, and takes beta-cyclodextrin or a beta-cyclodextrin derivative as a core and a grafted polyacrylate flexible polymer chain as a shell. By introducing the modifier with a core-shell structure, adsorbing high-temperature volatile matters by utilizing a cavity of the core structure, and dissipating vibration energy in cooperation with the movement of the flexible chain segment of the shell layer, the synergistic effect of low odor, low VOC emission and excellent damping performance is realized, the problem that environmental protection and sound insulation of a traditional carpet are difficult to consider at the same time is solved, and the driving and riding comfort is improved.

The present invention addresses the problem of providing a cured film-forming composition for forming a cured film for forming an alignment material which has excellent solvent resistance, can align polymerizable liquid crystals with high sensitivity, and has little liquid crystal rejection. [Solution] A composition for forming a cured film, an alignment material, and a phase difference material. The composition for forming a cured film contains (A) a compound having a photo-alignment group, (B) a polymer having a structural unit having an N-hydroxymethyl group or an N-alkoxymethyl group, and (C) a cyclodextrin derivative in which some or all of hydroxyl groups are modified.

The invention discloses a yarn dyeing method and yarn dyeing equipment. The yarn dyeing method is implemented in real-time dyeing equipment, and primary color yarns are continuously conveyed into the real-time dyeing equipment to be dyed in real time. The yarn dyeing method comprises the following steps: spraying and dyeing the primary color dyed yarn by using coating ink to obtain candidate dyed yarn; wherein the primary color yarn is the yarn which is treated by a pretreatment solution and is preheated, and / or the coating ink is the coating ink which is pretreated by a modifier before dyeing; performing post-processing operation on the basis of the candidate dyed yarns to obtain target dyed yarns; wherein the modifier comprises one or more of cationic starch and a cyclodextrin derivative; the pretreatment solution comprises a penetrating agent. The penetrating agent is used for pre-treating the yarn and pre-drying the yarn, so that the yarn dyeing effect is improved.