The invention provides a pharmaceutical composition containing active procyanidins and
prasugrel or the pharmacologically acceptable salt thereof. The procyanidins and the
prasugrel are used in a combined manner, a more
effective method for curing thrombotic diseases is found, after trail for many times, the
prasugrel and the procyanidins (an extract of
traditional Chinese medicine) are creatively and effectively combined together, the effect of applying the procyanidins to inhibit the
thrombosis in a combined manner is discovered unexpected in the process of applying the prasugrel to cure the thrombotic diseases, and not only the
anticoagulant effect of the prasugrel is free from the influence of the procyanidins, but also a good effect is achieved in the aspect of reducing the adverse reaction of bleeding after the use of the prasugrel and the procyanidins in a combined manner, therefore, the risk of bleeding is greatly reduced when the advantages of good
anticoagulant activity and fast effect of the prasugrel during the antiplatelet aggregation are fully exerted, the risk of bleeding of the prasugrel during the antiplatelet aggregation is effectively reduced and the adverse reaction of the prasugrel is greatly reduced.