Pharmaceutical composition containing prasugrel

A composition and drug technology, applied in the field of medicine, can solve the problems of reducing patient compliance, rebound of cardiovascular events, etc., and achieve the effects of reducing bleeding rate, enhancing anticoagulant activity, and inhibiting platelet aggregation.

Active Publication Date: 2009-10-14
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the drug induces an increased risk of bleeding, even if the bleeding is not severe, it will significantly reduce the patient's compliance. Reduced compliance or bleeding risk is important in antiplatelet agents, which may lead to rebound cardiovascular events

Method used

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  • Pharmaceutical composition containing prasugrel
  • Pharmaceutical composition containing prasugrel
  • Pharmaceutical composition containing prasugrel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 common tablet

[0015] Proanthocyanidins 200g

[0016] Prasugrel Maleate 10g

[0017] Microcrystalline Cellulose 250g

[0018] Lactose 40g

[0019] 10% starch slurry appropriate amount

[0020] Magnesium Stearate 4g

[0021] Preparation process: Weigh the prescribed amount of proanthocyanidins, prasugrel maleate, microcrystalline cellulose, and lactose and mix evenly. In addition, add an appropriate amount of 10% starch slurry to the mixed powder, mix evenly, make soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0022] Embodiment 2 common tablet

[0023] Catechin 50g

[0024] Prasugrel hydrochloride 5g

[0025] Starch 140g

[0026] Dextrin 50g

[0027] 50% ethanol appropriate amount

[0028] Magnesium Stearate 1g

[0029] Preparation process: Weigh the prescribed amount of catechin, prasugrel hydrochloride, starch, and dextrin and mix evenly. In addition, add an appropriate amount of 50% ethanol to the pre-mixed powder, mix evenly, make soft materials, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 3

[0030] Embodiment 3 Dispersible tablets

[0031] Epicatechin 500g

[0032] Prasugrel 5g

[0033] Croscarmellose Sodium 80g

[0034] Microcrystalline Cellulose 750g

[0035] Polyvinylpyrrolidone 55g

[0036] 5% PVP60% Alcohol Solution Appropriate

[0037] Micronized silica gel 20g

[0038] Preparation process: Weigh epicatechin and prasugrel according to the prescription, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60% ethanol solution It is used as binder, and micronized silica gel is used as flow aid. It is granulated in one step in a fluidized bed, and then compressed into tablets.

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PUM

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Abstract

The invention provides a pharmaceutical composition containing active procyanidins and prasugrel or the pharmacologically acceptable salt thereof. The procyanidins and the prasugrel are used in a combined manner, a more effective method for curing thrombotic diseases is found, after trail for many times, the prasugrel and the procyanidins (an extract of traditional Chinese medicine) are creatively and effectively combined together, the effect of applying the procyanidins to inhibit the thrombosis in a combined manner is discovered unexpected in the process of applying the prasugrel to cure the thrombotic diseases, and not only the anticoagulant effect of the prasugrel is free from the influence of the procyanidins, but also a good effect is achieved in the aspect of reducing the adverse reaction of bleeding after the use of the prasugrel and the procyanidins in a combined manner, therefore, the risk of bleeding is greatly reduced when the advantages of good anticoagulant activity and fast effect of the prasugrel during the antiplatelet aggregation are fully exerted, the risk of bleeding of the prasugrel during the antiplatelet aggregation is effectively reduced and the adverse reaction of the prasugrel is greatly reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition comprising proanthocyanidin and prasugrel or a pharmacologically acceptable salt thereof as active ingredients. Background technique [0002] Anthocyanin (anthocyanin) belongs to flavonoids in phenolic compounds, is a kind of water-soluble pigment, and is a kind of main coloring substance widely present in plants, which can change color with the acidity and alkalinity of cell fluid (cell fluid If it is acidic, it will be reddish, and if the cell fluid is alkaline, it will be blue), and it is mostly found in plants such as grapes, apples, sorghum and cherries, among which grapes (seeds and skins) are the most abundant. Anthocyanin is one of the main pigments that constitute the color of petals and fruits. It is composed of different amounts of catechin or epicatechin. Free anthocyanins are extremely rare under natural conditions. Proanthoc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4365A61K31/352A61P7/02
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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