The invention discloses a composition of traditional Chinese medicines and a western medicine for treating angiitis and a preparation method of the composition. The composition of the traditional Chinese medicines and the western medicine contains the following raw materials in parts by weight: radix salviae miltiorrhizae, rhizoma chuanxiong, radix paeoniae rubra, semen persicae, flos carthami, sanguis draxonis, earthworms, leeches, radix achyranthis bidentatae, liquorice, astragalus membranaceus, angelica sinensis, herba ephedrae, rhubarb, rhizoma cyperi, rhizoma sparganii, saxifraga stolonifera, cynanchum paniculatum, semen pharbitidis, litsea pungens and aspirin. The defect that gastrointestinal reactions such as nausea, throw-up, epigastric discomfort or ache can be caused as gastric mucosa is irritated by aspirin can be effectively avoided, gastrointestinal bleeding or anabrosis which is caused in long-term taking can be prevented, and thus the composition can be relatively well popularized and applied. As an improved mixing machine is adopted to mix the medicines, the case shaking prevention property and the stability can be greatly improved, the medicine preparation efficiency can be improved, and the medicine production cost can be reduced.