73 results about "Plaque area" patented technology

The invention belongs to the field of intersection of a computer technology and medical images, and in particular relates to a dividing method of plaque in the cross section direction of carotid artery blood vessel in an ultrasound image. The method specifically comprises the following steps of: selecting the current frame image; dividing to obtain profiles of internal and external membranes of the blood vessel; extracting the plaque and dividing the interested area; detecting an initial plaque external boundary: carrying out curve fitting on each column of pixel point gray value between the internal and external membrane profiles on a polar coordinate image obtained through conversion in the interested area, and detecting the pixel point with the minimum gray value and nearest to the external membrane profile as the initial plaque external boundary point; carrying out level set evolution to obtain the final plaque external boundary; and using the area between the final external boundary and the internal membrane profile as the plaque area. By adopting the dividing method of ultrasound carotid artery plaque, plaque can be accurately divided, the workload of doctors can be greatly reduced, and the plaque size and area calculated on the basis of the division result can help doctors analyze the lesion degree and treatment effect.

The invention relates to an automatic identifying method of artery plaque type based on an ultrasonic image in a blood vessel. The method comprises the following steps of: extracting two images of a plaque area and a plaque radial area as the classification feature with respect to the characteristics of plaque ultrasonic image in the artery blood vessel; extracting the image classification information via K-L conversion, mapping a plurality of features into a few comprehensive features, and reducing the space dimension of the features; and constructing a classifier suitable for the plaque image by using a support vector machine as the classification model, wherein the support vector machine classification method comprises a training stage and an identifying stage. The method improves the precision rate for identifying the plaque and provides an objectivity reference basis for clinically diagnosing the degree of blood vessels of coronary arteries.

The invention provides a land cover classification method which comprises the steps of (1) determining plaque areas with similar domestic remote sensing image characters and than carrying out reasonable image segmentation, (2) according to the different areas divided in the step (1), by using spectrum, texture and geometrical characteristics, calculating an image characteristic, (3) by using historical land use data and a ground object spectral library, combined with the image characteristic in the step (2), a ground object sample is obtained automatically, (4) with the ground object sample of the step (3) as an information entropy, various types of ground objects are extracted by using a decision tree and the boosting technology, (5) calculating various types of ground object plaque areas, carrying out plaque combination and elimination according to a set value, and finally obtaining a classification result. The problems of wrong land cover classification and multiple broken plaques are solved, thus the operation efficiency is improved by 50%, and the classification accuracy is raised to 90%.

The invention provides a carotid plaque identification method based on cross-modal prediction from CTA to MRA. The method comprises the following steps: a data collection step: paired carotid CTA andMRA image data are collected; plaque segmentation and model training: carotid artery lumens of CTA and MRA are positioned firstly, then carotid artery plaques are segmented, plaque area images of CTAand MRA are obtained, the plaque area images of CTA and MRA are sent to a pix2pix or cycle-GAN network to be trained, and a model obtained after preliminary training is obtained. According to the method, a complete and novel algorithm flow is designed, the carotid artery lumen and plaque on the CTA image are automatically segmented by using an improved deep learning Multiplan-net algorithm, and anoptimized adversarial generative network is designed on the basis to perform CTA data amplification, so that the segmentation precision is further improved.

The invention relates to a meat quality detection system. The system comprises an image acquisition module, an image processing module, a characteristic value extraction module, a spectral analysis module and a data fusion processing module, wherein the image acquisition module is used for acquiring an adipose tissue image of a meat sample; the image processing module is used for extracting a culture medium from the adipose tissue image; the characteristic value extraction module is used for acquiring a ratio of the total area of bacterial plaques in the culture medium to the area of the culture medium; the spectral analysis module is used for analyzing a near infrared spectrum of the sample so as to acquire structure composition data of the meat sample; and the data fusion processing module is used for carrying out fusion processing on the ratio acquired by the characteristic value extraction module and the structure composition data of the meat sample so as to obtain an actual output value. The culture medium is a fixed region which is detected in the adipose tissue image and is only provided with adipose tissues of the meat sample. The actual output value represents the quality of the meat sample. The invention also provides a meat quality detection method. The meat quality detection system and the meat quality detection method can rapidly and accurately detect the meat quality and have the advantages of simple structure and detection process.

The invention discloses a method for producing patterns and characters on a stainless steel plate, which comprises the following steps of: placing two stainless steel plates in a NaCL solution dissolving tank in parallel, leading one stainless steel plate to be a plaque substrate as a positive electrode and to be adhered with required font styles or patterns which are countermarked by a self-adhesive plastic film as a protective layer after the plaque substrate is performed with polishing treatment, having the other stainless steel plate used as a negative electrode, requiring the side with font styles of the substrate to face to the negative electrode, and leading the distance between the two stainless steel plates to be not more than 1cm; connecting the positive electrode and the negative electrode and communicating direct current of 10 to 15V; controlling the magnitude of current to galvanize the plaque area at 100mA per square centimeter; stopping electrifying when the mirror side without the font styles or patterns is corroded into a rough side; and removing the protective layer and washing the plaque with clear water. The invention is mainly used in stainless steel plaques, tablets, etc. The stainless steel plaques and tablets made according to the method have shining characters and patterns under shining light, and have strong contrast with the corroded rough side of the substrate so as to provide noble and luxurious feeling for people.

The invention relates to the technical field of medicine, and provides new application of macrophage beta-profilin-1, namely application of macrophage beta-profilin-1 to preparation of a drug for preventing or treating atherosclerosis. It is proved through experiments that in comparison with wild type mice, the serum total cholesterol content of macrophage beta-arrestin-1 specificity myelogenous knockout mice is remarkably increased, and it is found through oil red O dyeing that the aorta overall plaque area and the plaque area of aorta roots are obviously increased compared with those of the wild type mice. By changing the macrophage beta-arrestin-1 gene expression level through virus transfection, and it is found that macrophage phagocytosis lipid is increased by interfering beta-arrestin-1 expression and is decreased by overexpressing beta-arrestin-1. The results show that the beta-arrestin-1 gene has a protective effect on the severity degree and prognosis of atherosclerosis.

The invention relates to the field of natural medicines, and particularly relates to use of beta-elemene and derivatives thereof in preventing atherosclerosis, and in particular relates to an application in preparation of medicines for treating atherosclerosis. Test results show that beta-elemene and derivatives can remarkably reduce the atherosclerotic plaque area in the coronary artery of an animal model, and meanwhile has remarkable improving effect on two key links in development process of atherosclerosis: adhesion of leukocyte and endothelial cells and peroxidation of lipids. Expression of adherence factors closely related to atherosclerosis can be reduced, so that peroxidation damage of endothelial cells in vitro and in vivo caused by high fat and H2O2 is avoided.

The invention relates to an application of a compound (I), with the chemical name of 20-(S)-protopanoxadiol-3-[O-beta-D-glucopyranose (1->2)-beta-D-glucopyranose]-20-O-beta-D-glucopyranoside, in preparing a medicament for improving atherosclerosis. Experiment results show that, at the beginning of building an atherosclerosis model generated by high-fat feeding of ApoE gene knockout mice, by preventively administrating the compound (I), an aortic plaque area can be reduced, macrophages in blood are restrained from absorbing lipid, and the bubbling process of the macrophages is restrained so as to reverse and delay formation of atherosclerosis induced by hyperlipidemia. The compound (I) can be prepared into oral or injection formulations and can be compounded with other medicaments for preparing a compound preparation, and when the preparation is made, the preparation comprises the compound (I) and a carrier or an excipient which are pharmaceutically acceptable.

The invention provides an atherosclerotic plaque classifying system. The system comprises an angiography device which is used for acquiring a vascular ultrasound contrastographic image, a basic parameter acquisition device which is used for analyzing the vascular ultrasound contrastographic image to acquire the maximum plaque area A, an intraluminal time-intensity curve and an intra-plaque time-intensity curve, extracting the intraluminal contrast agent peak time TTP1, the peak intensity IMAX1 and the area under the curve AUC1 from the intraluminal time-intensity curve, and extracting the intra-plaque contrast agent peak time TTP2, the peak intensity IMAX2 and the area under the curve AUC2 from the intra-plaque time-intensity curve, a plaque quantitative parameter calculation device which is used for acquiring the enhancement intensity IMAX, the maximum enhancement density DMAX, the relative peak time delta TTP, the area under the curve delta AUC and the relative average transit time delta mTT, and a classification result output device which is used for classifying atherosclerotic plaques according to the plaque quantitative parameter.

The invention discloses application of Xyloketal B in preparing antiatherosclerotic medicaments. Experiments prove that: Xyloketal B has the effects of reducing the plaque area and regulating blood fat on atherosclerotic lesions, and can prevent and treat atherosclerosis by protecting vascular endothelium, regulating the blood fat level such as reducing low-density lipoprotein cholesterol (LDL-C) and raising the LDL-C, resisting oxidative stress in vivo and other action mechanisms. A novel application field of the Xyloketal B is developed when the Xyloketal B is applied to preparing the antiatherosclerotic medicaments, and the Xyloketal B is safe and non-toxic and has strong pharmacological action and good medicinal prospect.

The invention provides a leaf disease identification method and system. The method includes the following steps that: plaque detection is performed on a blade to be identified, each plaque region on the blade to be identified is obtained, the surface appearance feature words and color feature words of the same position in any plaque region form a word pair; the word pairs are converted into corresponding compound feature words in a compound feature dictionary one by one, and the composite feature histogram of the leaf to be identified is constructed according to the number of times of the appearance of the compound feature words on the blade to be identified; and the compound feature histogram is used as the input of a pre-obtained disease classifier, and the disease of the leaf is identified according to the output result of the disease classifier. With the leaf disease identification method and system of the invention adopted, a blade or disease plaque area is not required to be pre-segmented in an image, instead, the words in the compound feature vocabulary of the image are put into statistics, so that the type of the disease can be identified. The leaf disease identification method and system have the advantages of high recognition rate and high recognition speed.

The invention discloses a traditional Chinese medicine composition improving dementia and a preparation method and application thereof. The traditional Chinese medicine composition improving the dementia is prepared from a rhizoma anemarrhenae extract, a folium ginkgo extract, a rhizoma curcumae longae extract, soybean lecithin, a kirilow rhodiola root extract, a radix polygalae extract, a sharpleaf galangal fruit extract, a green tea extract, a grape seed extract, phosphatidylserine, Y-aminobutyric acid, euphausia superba oil powder and punicosides. The traditional Chinese medicine composition can obviously decrease the beta-AP plaque area inside the brain, forms and number of nerve cells around an injection region and in a more distant region can be obviously improved, and a protective effect on the neuronal toxicity caused by beta-AP is achieved. Meanwhile, according to the experiment, an objective basis is provided for further researching and developing the traditional Chinese medicine for treating the dementia by researching the reaction and action mechanism of a traditional Chinese medicine composition dementia animal model.

The invention provides a peotopanaxadiol ginsenoside derivative with a structure shown as formula I or a formula II and provides application of the peotopanaxadiol ginsenoside derivative to preparation of drugs for preventing and curing atherosclerosis. The peotopanaxadiol ginsenoside derivative has the advantages that the peotopanaxadiol ginsenoside derivative is low in cytotoxicity and capable of decreasing the percentage of the apoE- / -mouse atherosclerotic plaque area, reducing medium-low density lipoprotein cholesterol level in mouse serum effectively and raising high-density lipoprotein cholesterol level effectively; the peotopanaxadiol ginsenoside derivative is capable of reducing partial TNF-alpha level of apoE- / -mouse arteries, thereby having a good anti-inflammatory effect; the peotopanaxadiol ginsenoside derivative is capable of reducing RAW264.7 cell-derived foam cell forming degree under a dosage of 30 micron remarkably. The invention further provides a preparation method of the peotopanaxadiol ginsenoside derivative. The preparation method is simple and convenient to implement and high in yield.

The invention relates to a method for evaluating a plaque removing effect on the surface of a space cabin material based on image analysis, which comprises the following steps: firstly, the surface ofthe material before and after the plaque removing is shot by a camera on a plaque removing device respectively to obtain a plaque image before and after the plaque removing; and secondly; the highlight regions in plaque images were accurately obtained and labeled by a clustering method; the plaque image of the marked high-light area is subjected to high-light removing treatment; the feature vector is normalized as the data set of the neural network to train the model, which is used to identify and mark the plaque; the area of plaque region marked by plaque image is calculated; wherein the removal rate is the ratio of the area of labeled plaque in the image before and after plaque removal. As the plaque area in the image before and after the plaque removal can be effectively obtained, theplaque removal efficiency can be accurately obtained.

The invention discloses a function and application of an interferon regulatory factor 9 (IRF9) gene in atherosclerosis (AS), belonging to the field of gene functions and applications. According to the function and application disclosed by the invention, LDLR (Low Density Lipoprotein Receptor)- / - mice and IRF9- / -LDLR- / - mice are taken as experimental subjects, an atherosclerosis model is obtained by high fat induction, and AS model mouse plaque area determination and inclusion analysis are carried out; results show that compared with LDLR- / - mice, the aortal plaque area of the IRF9- / -LDLR- / - mice is significantly increased. The results indicate that the function of IRF9 gene in atherosclerosis is manifested by the action in inhibiting aortal plaque formation, especially inhibiting atherosclerosis. As for the function of the IRF9 gene, IRF9 gene can be used for preparing medicaments for treating atherosclerosis.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 1 (Mnk1) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk1<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk1 obviously reduces the plaque area of an aorta tree, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk1 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion of the atherosclerosis. Aiming at the function of the Mnk1, the Mnk1 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk1 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention discloses a function and application of an MAPK (mitogen-activated protein kinase) signal-integrating kinase 2 (Mnk2) in treatment of the atherosclerosis and belongs to the field of a function and application of a gene. According to the invention, an ApoE<- / -> mouse and an Mnk2<- / ->ApoE<- / -> mouse are used as experimental objects and an atherosclerosis module is obtained by high fat diet induction; the result shows that compared with the ApoE<- / -> mouse, the gene defect of the Mnk2 obviously reduces the plaque area of an aorta, reinforces stability of an aortic sinus plaque and obviously reduces the inflammatory response. The invention shows that the function of the Mnk2 in the atherosclerosis mainly represents promotion for forming of the aortic plaque and particularly promotion for the atherosclerosis. Aiming at the function of the Mnk2, the Mnk2 can be used as a drug target for screening a medicament for preventing, relieving and / or treating the atherosclerosis and an inhibitor of the Mnk2 can be used for preparing the medicament for preventing, relieving and / or treating the atherosclerosis.

The invention relates to an application of a Tibetan medicine namely epipremnum aureum flower in preparation of a medicine for treating atherosclerosis, and belongs to the technical field of traditional Chinese medicine. The invention shows that at the animal level, the epipremnum aureum flower alcohol extract can significantly reduce the atherosclerotic plaque area of mice, and the specific mechanism is shown as follows: on one hand, cholesterol absorption is inhibited by reducing the SR-BI expression level, and on the other hand, cholesterol metabolism is promoted to generate bile acid by increasing the CYP7A1 gene expression; and at the cellular level, the epipremnum aureum flower alcohol extract can significantly reduce cholesterol uptake of cells and reduce expression of a macrophagemarker CD36 to reduce cholesterol uptake of macrophages so as to reduce macrophage foaming. The invention provides scientific data and an idea basis for clinical treatment of atherosclerosis through the epipremnum aureum flower, and provides data support for a new method and an action target for clinically preventing and treating cardiovascular diseases.

The invention discloses an ENaC and an application of an inhibitor thereof in preventing, alleviating and / or treating atherosclerosis and belongs to the technical field of medicines. By taking a LDL- / -mouse and gamma-ENaC- / -LDLR- / - as experimental objects, a high fat diet-induced atherosclerosis model is obtained, and the result shows that compared with the LDLR- / - mouse, the plaque area of the aorta of the mouse without the ENaC gene or inhibiting the ENaC gene is reduced obviously. The ENaC plays roles of promoting plaque formation of aorta and promoting atherosclerosis. According to the functions of the ENaC, the invention provides the application of the ENaC as a medicine target in a medicine for preventing, alleviating and / or treating atherosclerosis and an application of the inhibitor of ENaC in preparing a medicine for preventing, alleviating and / or treating atherosclerosis. The invention provides a novel target and a medicine for preventing, alleviating and / or treating atherosclerosis, and has important meaning in illuminating the molecular mechanism of genesis and development processes of atherosclerosis and searching for the molecular target for atherosclerosis treatment.

The invention discloses a calcified plaque detection decision system based on an artificial intelligence algorithm. According to the system, an intravascular image is acquired based on an intravascular image or an intravascular radiography and intravascular image integrated system or an intravascular imaging-calcified plaque decision integrated system; if the intravascular image is an integrated image of OCT and IVUS, the OCT image and the IVUS image are collected at the same time, and the positions of the OCT image and the IVUS image in rotation and pull-back are consistent, wherein alignmentis conducted through an image processing algorithm; the collected OCT image and IVUS image are automatically detected and segmented to obtain a calcified plaque area; the related characteristics of the calcified plaque are detected and quantified; the related characteristics are displayed on a display terminal after two-dimensional and three-dimensional rendering; the calcified plaques are classified and decided, and an optimal decision scheme is automatically recommended; and a result after calcified plaque operation is evaluated, and stent intervention is performed after optimizing. According to the invention, automatic identification and segmentation quantification of calcified plaques in intravascular image detection are realized, and accurate data support is provided for doctors.

The invention discloses pharmaceutical application of a composition for treating atherosclerosis. The invention particularly relates to an application of a composition containing microbubbles and copper ions in preparation of a medicine for treating atherosclerosis. When the microbubble and copper ion composition disclosed by the invention is used for treating atherosclerosis, the plaque area is obviously reduced, but plaque fragmentation and shedding are not caused.

The invention belongs to the field of medicines, and relates to a novel fusion protein. The fusion protein is combined with CD47 molecules on the surfaces of deposited cells in atherosclerotic plaquesto block the transmission of signals to macrophages, relieve the inhibition of a phagocytic function of macrophages, promote the macrophages to phagocytize the deposited cells in the atheroscleroticplaques, and delay and reverse the progress of the atherosclerosis course. Animal experiments of atherosclerosis early-stage and middle-late-stage model mice prove that after the fusion protein is injected, the aorta total length, the aorta root and the plaque area at the aortic arch of an experimental mouse are remarkably reduced. The fusion protein can be used for delaying and reversing the progress of the disease course of an atherosclerosis model animal and reducing related acute cardiovascular events of the atherosclerosis model animal, and further can be used for preparing a new medicinefor clinically treating atherosclerosis.

The invention discloses application of geraniin in the preparation of drugs to prevent or treat atherosclerosis. Experiments verify that geraniin can diminish atherosclerotic plaque area and prevent or treat atherosclerosis by reducing lipids in atherosclerotic plaques and reducing macrophages in the atherosclerotic plaques. The provision of the application helps provide a drug with clear effect and composition and controllable quality for the prevention or treatment of atherosclerosis; geraniin is derived from natural plants; drugs made with geraniin as a main effective component are widely resourceful, has low toxic and side effects and are suitable for atherosclerotic patients to take often.

The invention discloses function and application of signal regulatory protein 1 (SHPS1) treating atherosclerosis, and belongs to the field of functions and application of genes. According to the technical scheme, an ApoE<- / -> mouse and a SHPS1<- / ->ApoE<- / -> mouse are taken as experiment objects, atherosclerotic models are obtained through high-fat diet induction, and results show that compared with the ApoE<- / -> mouse, SHPS1 gene defect leads to substantial reduction of the aorta plaque area, stability enhancement of aortic sinus plaque and mitigation of inflammation reaction. The results show that SHPS1 mainly has the effects of promoting formation of aorta plaque area and especially promoting atherosclerosis in the functions of atherosclerosis. Aiming at the above functions of SHPS1, SHPS1 can be used as a medicine target and is applied to screen medicines for preventing, alleviating and / or treating atherosclerosis, and an inhibitor of SHPS1 is applicable to prepare medicines for preventing, alleviating and / or treating atherosclerosis.

The invention belongs to the field of image classification detection, and provides a carotid artery ultrasound image plaque classification detection method and system. The method comprises the following steps: collecting carotid artery cross section video information and carotid artery longitudinal section video information; key continuous frame extraction is carried out on the carotid artery cross section video information and the carotid artery longitudinal section video information, and feature enhancement is carried out on the extracted key continuous frames; performing identity prediction on the carotid artery cross section image and the carotid artery longitudinal section image after feature enhancement, tracking images corresponding to identities, and performing pixel-level segmentation to realize association of identity information and segmentation results in a time domain; according to a segmentation result, traversing each column of mask pixels, determining coordinates through color difference marks, and determining the size, area and stenosis rate of plaques corresponding to identity information associated with the segmentation result; and determining the plaque type according to the plaque size, the plaque area and the stenosis rate so as to output early warning prompts of different degrees.

The invention discloses applications of an interferon regulatory factor 1 gene in treatment of atherosclerosis, belonging to the field of the functions and applications of a gene. An atherosclerosis model is obtained by taking ApoE- / -mice and IRF1- / -ApoE- / -mice as experimental objects through induction of high-fat diet, results show that the IRF1 gene defects markedly reduce the plaque area of the aorta, enhance the stability of aortic sinus plaque, and markedly lighten the inflammatory response compared with the ApoE- / -mice. The function of the IRF1 in the atherosclerosis is mainly reflected by the fact that the IRF1 achieves the effect of promoting the formation of the aortic plaque, especially the effect of promoting the atherosclerosis. Aiming to the functions of the IRF1, the IRF1 can be used as a drug target for screening drugs preventing, alleviating and / or treating atherosclerosis, and an inhibitor of the IRF1 can be used for preparing a drug for preventing, alleviating and / or treating atherosclerosis.

The invention discloses a method for treating diabetes and atherosclerosis. The method comprises the following steps of 1, preparing umbilical cord blood stem cells; 2, exciting autologous peripheralblood stem cells; 3, injecting umbilical cord blood cell factors to blood, and combining the umbilical cord blood stem cells and the autologous peripheral blood stem cells for treatment; 4, periodically paying follow-up visits to curers for artery atherosclerotic plaque area, blood glucose and triglyceride changes. Due to combination of the umbilical cord blood stem cells and the autologous peripheral blood stem cells for treatment, the artery atherosclerotic plaque is decreased which shows that treatment is effective; the recent effect for treating the diabetes is obvious, however, the lasting time is short, and the treatment effect needs to be consolidated and improved; the blood lipid level of the high lipid patient can be rapidly and obviously lowered, the lasting time is longer, and the treatment effect for patients is obvious; due to combination of the umbilical cord blood stem cells and the autologous peripheral blood stem cells for treatment of diabetes and atherosclerosis, theeffect of treating diabetes and atherosclerosis is better than that of other national and international products, and no side effect is caused.

The invention relates to the technical field of food nutrition, in particular to application of sea cucumber sterol sulfate in an anti-atherosclerosis product. The sea cucumber sterol sulfate is extracted and separated from sea cucumbers and subjected to microencapsulation, and experiments verify that the sea cucumber sterol sulfate and a microcapsule thereof have improvement functions on atherosclerosis. The sterol sulfate is prepared with the sea cucumbers as a raw material, experiments prove that the sea cucumber sterol sulfate can effectively reduce plaque areas of the atherosclerosis, that is, the sea cucumber sterol sulfate can remarkably inhibit the development of the atherosclerosis, indicating that the sea cucumber sterol sulfate can effectively prevent, improve or treat the atherosclerosis.

A method for distinguishing plaque and calculus is provided. The method is used in a device and includes the following steps: emitting, by a blue light-emitting diode, blue light to illuminate teeth in an oral cavity, wherein the blue light is used to generate autofluorescence of plaque and calculus on the teeth; sensing, by an image sensor, the autofluorescence of plaque and calculus; and distinguishing, by a processor, a plaque area and a calculus area on the teeth based on the autofluorescence.