34 results about "Pentadecanoic acid" patented technology

This application discloses a method of differentiating stable angina pectoris from acute coronary syndrome, including: obtaining a blood plasma sample from a patient; measuring a relative concentration of at least one metabolic biomarker in the blood plasma sample, wherein the at least one metabolic biomarker is selected from the group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine, and pentadecanoic acid; calculating a value according to the relative concentration of at least one metabolic biomarker; comparing the value with a predefined critical value, if the value is more than the predefined critical value, the patient has the acute coronary syndrome, otherwise, the patient has the stable angina pectoris. The method and a diagnostic kit thereof is capable of differential diagnosis of SA and ACS and it can improve the diagnostic convenience and promote the diagnostic standardization.

The invention discloses a metabolism marker group used for diagnosing and differentiating stable angina pectoris and acute coronary syndrome. The metabolism marker group comprises one or more selected from a group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine and pentadecanoic acid. When an individual metabolism marker is used for diagnosing and differentiating patients with stable angina pectoris and patients with acute coronary syndrome, an area under a ROC curve (AUC) is greater than 0.7, the individual metabolism marker has clinical diagnosis significance; when metabolism markers are combined and used for diagnosis, AUC further increases with increase of the number of the combined metabolism markers; and AUC reaches a highest value of 0.987 when all the six metabolism markers are combined, and sensitivity and specificity are 96.8% and 97.7% respectively under the condition of an optimal cutoff value. The metabolism marker group provided by the invention can accurately diagnose and differentiate stable angina pectoris and acute coronary syndrome and has high sensitivity and good specificity.

Disclosed are compositions and methods for producing a poultry egg that is rich in odd-chain fatty acid (OCFA), particularly pentadecanoic acid (C15:0) and heptadecanoic (C17:0) acid. Poultry feed can be mixed with a compound (e.g. biomass or oil extract) that is produced from microalgae cultured to comprise elevated levels of OCFA. The OCFA-enriched poultry feed comprises an elevated level of OCFA and it can be fed to poultry that are laying eggs. As the OCFA-enriched feed is incorporated by the poultry, the resulting eggs comprise yolks that are rich in OCFA. The OCFA rich eggs can be consumed by humans as a dietary source of OCFA, to improve health.

The invention relates to cyclocarya paliurus extract and the application of the cyclocarya paliurus extract. The cyclocarya paliurus extract at least comprises the following effective ingredients: 10-methoxy-nb-alpha-methyl corynantheol, n-nonyl nitrate, iso-butoxyamine, pentadecanoic acid, 4, 6, 10, 14-tetramethyl-methyl-ester, adipic acid, bis--(2-ethylhexyl) ester, 2-butyl, 1-octanol, octadecyl vinyl ether and erythro cis-4, 5-dimethyl-2-undecene. The weight percentage of the effective ingredients in the cyclocarya paliurus extract is 50% to 98%. The cyclocarya paliurus extract can significantly promote the secretion of insulin by islet beta cells so as to enhance glucose tolerance of mice and regulate blood sugar, and therefore the cyclocarya paliurus extract can be used for preparing drugs for preventing and treating diabetes, and the direction is pointed out for further developing and utilizing the medical value of cyclocarya paliurus.

The invention relates to a lipid composition comprising fatty acids mainly in the form of triacylglycerols, in which composition at least 50% of the fatty acids are 14-methyl pentadecanoic acids, and at least 8% of the fatty acids are 12-methyl tetradecanoic acids, the percentages being expressed by weight with respect to the total fatty acids of the composition.

The invention discloses a novel cationic surface active agent and a preparing method thereof, and particularly relates to indole quaternary ammonium of monodisperse pentadecyl tribrachia polyglycol ether and a preparing method. Starting from hydroxyl pentadecanoic acid, through a primary addition reaction of the hydroxyl pentadecanoic acid and tribrachia polyethylene glycol p-toluenesulfonate under the function of alkali, pentadecanoic acid tribrachia polyethylene glycol is obtained, the pentadecanoic acid tribrachia polyethylene glycol and indole quaternary ammonium amine are subjected to anaddition reaction to obtain quaternary ammonium of pentadecyl tribrachia polyglycol ether, and acidification is conducted to obtain an indole quaternary ammonium salt of pentadecyl tribrachia polyglycol ether. The method can be used for preparation of long-chain alkyl ether and the indole quaternary ammonium salt of the monodisperse tribrachia polyethylene glycol. According to the preparing method, the tribrachia polyethylene glycol p-toluenesulfonate with a single molecular weight is taken as a raw material to achieve efficient synthesis of the pentadecanoic acid tribrachia polyethylene glycol, in the synthesis process, carboxyl protective groups are not utilized, steps are simple, and the method is suitable for industrial production; compared with PEG aliphatic-series indole quaternary ammonium salts prepared in the prior art, the obtained product has obvious advantages.

Disclosed are peptides having biological and therapeutic activity. Particularly disclosed are lipidated di- or tri-peptides analogs of KPV or KdPT that exhibit antimicrobial activity. In particular, the peptides of this invention provide enhanced anti-microbial activity over the base tri-peptides, lysine-proline-valine and lysine-d-proline-tyrosine. The disclosed peptides have the general formula of C12-18 lipid-KXZ-NH2i wherein K is lysine; X is proline, d-proline, histidine or arginine; Z is optional and if present Z is valine, threonine, alanine or leucine; and the terminal COOH is NH2 amidated. The C12-18 lipid is preferably the lipid moiety of lauric acid (C12), myristic acid (C14), pentadecanoic acid (C15), palmitic acid (C16), or stearic acid (C18). The invention is further related to methods of using of these peptides to treat various insults, inflammations or bacterial infections affecting the skin and other related mucosal body surfaces such as the oral cavity.

The invention relates to dialkyl dimethyl quaternary ammonium salt, which has the following chemical structure as shown in the accompanying drawing. In the formula, R1 or R2 is identical or different C1 to C2 alkyls, identical or different C3 to C22 saturated or unsaturated strain chain alkyls and saturated or unsaturated branch chain alkyls, A<-> is methyl carbonate radical, bicarbonate radical, halogen ion, hydrogen sulfate radical, dihydrogen phosphate radical, nitrate radical, nitrite radical, perchlorate radical, permanganate radical, oxacid radical, acetate radical, malonate radical, lactate radical, butyrate radical, glutaconate radical, adipate radical, pimelate radical, azelate radical, quinate radical, undecandioate radical, dodecanoate radical, tridecanoic acid radical, tetradecanoic acid radical, pentadecanoic acid radical, palmitate radical, hexadecenoic acid radical, stearate radical or oleate radical. The dialkyl dimethyl quaternary ammonium salt has the advantages that no pollution is caused on the environment, the dialkyl dimethyl quaternary ammonium salt with the acid radical anions can be synthesized, and the surface activity higher than that of the traditional quaternary ammonium salt can be obtained.

The invention is a fatty acid metabolism developer beta-methyl-15-(4-fluorophenyl [18F]) -pentadecanoic acid as well as its synthesizing method, relating to a fluorin-labeled fatty acid cardiac muscle metabolism developer. The 18F-BMFPP is reformed by beta-methyl-phenyl-pentadecanoic acid in *I-BMIPP structure as mother substance, a compound designed and synthesized by ourselves. It uses omega bromo-undecoic acid as initial raw material to synthesize BMPPA through multiple step reaction, then begins with BMPPA to make nitrification, esterification, reducing, diazotization and diazonium decomposition to obtain label precursor NO2-BMPPA and nonradiative BMFPP. It makes NO2-BMPPA through nucleophilic displacement reaction to synthesize 18F-BMFPP. And it improves the iodinating method of synthesis of intermediate phenyl-dodecyl iodine and alpha-methyl- phenyltetadecyl iodine.

The invention discloses an aroma composition extracted from spring orchids and an extraction method thereof. The composition includes octadecatrienal, nerolidol, dibutyl phthalate, heptacosanol , Pentadecanoic acid, hexadecanoic acid (palmitic acid), oleic acid, linoleic acid and cyclohexadecane were extracted by leaching and filtering, reflux leaching, filtering, merging and separation, volatile separation, concentration and drying steps, and successfully The aroma substance has been extracted from the flowers of Chunlan, the most important thing is that the main aroma substance octadecatrienal has been found, and the extraction rate of the aroma substance of the present invention is also relatively high. Octatrienal and nerolidol are the main components of the fragrance, and their content is almost 30%. The composition of the present invention has met the basic requirements of natural fragrances, and can be used in fragrances, perfumes, fragrances, etc. according to existing methods. In fragrance body and bath products, this natural "orchid fragrance" can be applied in industry.

The invention discloses butylene glycol fatty acid ester. The butylene glycol fatty acid ester is prepared by esterifying 1,4-butylene glycol or 2,3-butylene glycol and fatty acids with the carbon atom number of 12-18 (including lauric acid, tridecanoic acid, myristic acid, pentadecanoic acid, palmitic acid, heptadecanoic acid and stearic acid); and the butylene glycol fatty acid ester provided by the invention can be used as the gel factor and can form organic gel with heat stability under low concentration (2g / L).

The invention discloses a novel cationic surfactant and a preparation method thereof, and particularly relates to indole quaternary ammonium of monodisperse pentadecyl triple-arm polyglycol ether anda preparation method thereof. The preparation method comprises the following steps: hydroxypentadecanoic acid and triple-arm polyethylene glycol p-toluenesulfonate are subjected to a primary additionreaction under the action of alkali to obtain pentadecanoic acid triple-arm polyethylene glycol; the pentadecanoic acid triple-arm polyethylene glycol and indole quaternary ammonium are subjected to an addition reaction to obtain quaternary ammonium of pentadecyl triple-arm polyglycol ether; and the quaternary ammonium of pentadecyl triple-arm polyglycol ether is acidified to obtain the indole quaternary ammonium salt of pentadecyl triple-arm polyglycol ether. The method can be used for preparing long-chain alkyl ether of monodisperse triple-arm polyethylene glycol and indole quaternary ammonium salt of the long-chain alkyl ether. According to the method, the pentadecanoic acid triple-arm polyethylene glycol is efficiently synthesized by taking the single-molecular-weight triple-arm polyethylene glycol p-toluenesulfonate as a raw material, a carboxyl protecting group is not used in the synthesis, the steps are simple and convenient, the method is suitable for industrial production, andthe obtained product has obvious advantages compared with the existing prepared PEGylated aliphatic indole quaternary ammonium salt.

The invention provides a method for preparing bacillus licheniformis. The method comprises the following steps of liquid state fermentation, solid fermentation, drying and detection of inoculated CGMCC No.2876 bacillus licheniformis. The bacillus licheniformis prepared by the method is accompanied by a plurality of other useful metabolites of organic acids, such as 3-methylbutyric acid, 2-methyl-butyric acid, phenylacetic acid, pentadecanoic acid, palmitic acid, linoleic acid and the like and digestive enzymes, such as amylase, protease and the like. A final product contains probiotics-bacillus licheniformis and prebiotics-metabolite, the gastroenteric function of animals can be obviously improved and the healthy growth of animals can be promoted due to the synthetic action of the two matters, and the effect is superior to that of a single viable organism. Meanwhile, the method is simple, low in cost and convenient in industrial implementation.

The invention discloses a soil microorganism prebiotic composition for improving plant system resistance and application thereof. The soil microorganism prebiotic composition is prepared from capric acid, dodecanoic acid, tridecanoic acid, pentadecanoic acid, palmitoleic acid, hexadecanoic acid, octadecanoic acid, arachidonic acid, isoleucine, leucine, methionine, proline, tryptophan, ornithine, alanine and aspartic acid. After application, the number of pseudomonas in soil can be increased by more than two orders of magnitudes, the plant system resistance is remarkably improved, and the morbidity is reduced. The formula product is suitable for herbaceous crops such as fruits and vegetables.

The invention discloses a novel cationic surfactant and a preparation method thereof, in particular indole quaternary ammonium monodisperse pentadecyl three-arm polyethylene glycol ether and a preparation method thereof. Starting from hydroxypentadecanoic acid, pentadecanoic acid three-arm polyethylene glycol was obtained through an addition reaction with three-arm polyethylene glycol p-toluenesulfonate under the action of a base. Pentadecanoic acid three-arm polyethylene glycol Addition reaction of ethylene glycol and indole quaternary ammonium amine to obtain quaternary ammonium of pentadecyl three-arm polyethylene glycol ether, and acidification to obtain indole quaternary ammonium salt of pentadecyl three-arm polyethylene glycol ether. The method can be used in the preparation of long-chain alkyl ether of monodisperse three-arm polyethylene glycol and its indole quaternary ammonium salt. The present invention realizes the high-efficiency synthesis of pentadecanoic acid three-arm polyethylene glycol by using single-molecular-weight three-arm polyethylene glycol p-toluenesulfonate as a raw material. No carboxyl protecting group is used in the synthesis, and the steps are simple and suitable for industrial production. The obtained product has obvious advantages over the existing PEGylated aliphatic indole quaternary ammonium salts.

The invention belongs to the technical field of plant active ingredient extraction, and particularly relates to an extraction method, a detection method and application of oak bark volatile oil. A steam distillation method is adopted for extraction; the chemical components, antioxidant activity and anticoagulant activity of the oak bark volatile oil are explored, and GC-MS and FT-IR are adopted for analyzing the chemical components of the oak bark volatile oil. 28 components are identified in the oak bark volatile oil and account for 96.98% of the total mass of the oak bark volatile oil. A functional group deduced from an FT-IR curve fitting result is verified through GC-MS analysis, and the FT-IR spectrum of the oak bark volatile oil is consistent with the FT-IR spectrum of an n-pentadecanoic acid functional group. Based on the outstanding antioxidant and anticoagulant activities of the oak bark volatile oil, a soft capsule dosage form with antioxidant and anticoagulant effects is developed, and a new economic value is provided for comprehensive development and utilization of plant resources.

This application discloses a method of differentiating stable angina pectoris from acute coronary syndrome, including: obtaining a blood plasma sample from a patient; measuring a relative concentration of at least one metabolic biomarker in the blood plasma sample, wherein the at least one metabolic biomarker is selected from the group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine, and pentadecanoic acid; calculating a value according to the relative concentration of at least one metabolic biomarker; comparing the value with a predefined critical value, if the value is more than the predefined critical value, the patient has the acute coronary syndrome, otherwise, the patient has the stable angina pectoris. The method and a diagnostic kit thereof is capable of differential diagnosis of SA and ACS and it can improve the diagnostic convenience and promote the diagnostic standardization.