66 results about "Soft Capsule Dosage Form" patented technology

The invention provides a facial make-up with excellent effect on moisturizing, whitening and nourishing and small irritation to skin. The facial make-up consists of make-up substrate and make-up active substances, wherein the make-up active substances comprise glycolic acid, kojic acid, arbutin, aloin, baicalin, paeoniflorin, glycyrrhizic acid, squalane, hyaluronic acid and chitin to be prepared into toner, facial cream, facial cleanser, facial mask, gel and external soft capsule preparations.

The present invention relates to a health-care food capable of regulating blood sugar and blood fat for preventing and curing diabetes. Its main component contains propolis, royal jelly, mulberry leaf and pueraria root, and its dosage form includes capsule preparation, tablet preparation, granule preparation and oral liquor, its optimized dosage form is soft capsule preparation. Besides, said invention also has the action of raising immunoregulatory compentence of human body. Said invention also provides its preparation method and its characteristics.

The invention relates to a Niuhuangshangqing soft capsule and a preparation method thereof, as well as a quality control method of capsule contents. The Niuhuangshangqing soft capsule comprises contents and capsule shell. The contents include an extent of Chinese medicinal materials in Niuhuangshangqing prescription and a dispersion medium with a weight ratio of 1:(1-2), wherein, the dispersion medium is vegetable oil. The soft capsule is prepared by extracting effective components from Chinese medicinal materials in Niuhuangshangqing prescription in accordance with the properties of the effective components by using different modern extraction techniques and making into soft capsule. The soft capsule has embedding and masking effects, and can prevent volatilization loss of oil components and oxygenation or photodecomposition of effective components. The soft capsule also has the advantages of rapid disintegration, uniform dispersion, high bioavailability, good stability of effective components, low liability of moisture absorption, good air tightness, direct intestinal absorption after disintegration, masking of unpleasant odors of effective components, convenience for administration and carrying, and so on.

A Chinese medicine in the form of softgel, capsule, particle, tablet, oral liquid, etc for treating irritable bowel syndrome is prepared from white atractylodes rhizome, white peony root, tangerine peel, ledebouriella root and plant oil. Its preparing process is also disclosed.

Disclosed is a compound tomatine preparation for female and its preparing process, wherein the preparation comprises tomatine, soybean isoflavones, vitamin E, anti-oxidant, capsule stabilizing agent and balancing deflocculating agent. The preparation can be made into the dosage forms of soft capsules, tablets or oral liquids.

The invention discloses a Yixingrui Brand soft capsule containing coenzyme Q10 which can improve immunity and fight against cancers, and a preparation method and application thereof. The preparation method comprises the following steps: using 45-55g of raw medicine containing coenzyme Q10 with content more than or equal to 99 percent as an effective ingredient, using 100-300g of perilla herb oil as solvent, preparing the effective ingredient and the solvent into contents at 40-50 DEG C, proportioning 200-300g of gelatin, 100-250g of glycerin, 250-400g of purified water, 0.8-1.2g of pigment and 1-1.2g of pulpy antholeucin to prepare capsule material, adopting sol to prepare the contents and pressing pellets, conducting processes such as drying, pellet picking and the like of a soft capsule preparation technology, and pressing the material medicine into 1000 Yixingrui Brand soft capsules at 50-55 DEG C through a soft capsule pressing technology. The invention is characterized in that the physical efficacy of the coenzyme Q10 is adopted, solvent, vitamin and minerals with collaborative function are screened and the raw medicine is pressed into pellets by adopting the matured Yixingrui Brand soft capsule preparation technology. According to stability tests, evaluative animal safety tests, hygienic tests and efficacy tests, the invention has the advantages of stable form and efficacy ingredients, no toxic and side effects, strong immunologic function, novel anticancer indication effect and promising application prospect.

The invention relates to a traditional Chinese medicine composition for improving immunity. The traditional Chinese medicine composition for improving immunity is a preparation prepared from the following raw materials in weight portion: 20 to 30 portions of sea buckthorn, 20 to 30 portions of yam, 18 to 27 portions of radix astragali, 15 to 25 portions of semen euryales, 7 to 15 portions of boxthorn and 5 to 15 portions of leek seed. The composition can be prepared into a soft capsule preparation form by raw material compositions through a routine preparation technology, is suitable for yang deficiency and qi weakness of spleen and kidney, deficient fatigue, frailness, qi shortness, asthenia, listlessness, lasting diarrhea, spermatorrhea, amnesia and other typical low immunity symptoms.

The invention discloses a VE (Vitamin E) coenzyme Q10 composition for assisting to reduce blood fat and boosting immunity and a preparation method of the composition. The VE coenzyme Q10 composition comprises the following components in parts by weight: 0.5-5 part(s) of coenzyme Q10, 0.7-21 part(s) of vitamin E and 25-300 parts of granulesten. The preparation method for the composition comprises the following steps of: adding the materials to matrix which is mixed and dissolved with soybean oil and beewax; stirring and dissolving the materials in the matrix at about 50 DEG C; putting the mixture to a colloid mill for grinding and circulating until the mixture is uniform; and obtaining soft capsule preparation by carrying out the processes such as pelleting, shaping, pill-washing, drying in the air, drying, picking and the like. According to the VE coenzyme Q10 composition provided by the invention, the bioavailability and stability of the coenzyme Q10 are greatly increased; and the dual effects of assisting to reduce blood fat and boosting immunity are achieved.

Seabuckthorn compound oil series health care products comprise the following components in percentage by weight: 10-60% of seabuckthorn berry oil, 10-40% of seabuckthorn seed oil, 5-30% of seabuckthorn fruit residue oil and 0.5-10% of seabuckthorn leaf oil, or the seabuckthorn compound oil series health care products are functional food prepared by adding seabuckthorn flavonoids to the seabuckthorn compound oil formed by proportionally mixing and blending the seabuckthorn berry oil, the seabuckthorn seed oil, the seabuckthorn residual oil and the seabuckthorn leaf oil, wherein the ratios of percentages by weight of the seabuckthorn compound oil and the seabuckthorn flavonoids is 80-99%:0.5-10%. The formulation of the seabuckthorn compound oil series health care products includes but is not limited to the soft capsules. The seabuckthorn products have complete bioactive components and simple technical composition, expand the applicable scope, improve the health care effect and are easy to realize industrial production.

The invention belongs to the technical field of medicines and particularly relates to a soft capsule containing desloratadine and a preparation method thereof. Content of the soft capsule is prepared by esloratadine, antioxygen, dispersion media and suspending agents according to certain proportion, safety and stability of the soft capsule are improved by means of the soft capsule mode, so that the soft capsule is fast in dissolving, high in bioavailability, accurate in dose and fast in effect, the preparation method is simple, and the soft capsule is easy to produce and wide in application prospect.

The invention herein relates to a pharmaceutical composition containing loratadine and derivatives thereof which is suitable for use in soft capsule dosage forms. A pharmaceutical composition according to the invention comprises loratadine and derivatives thereof in a pharmaceutically effective amount; and a solvent system comprising a mixture of medium chain fatty acids. The loratadine compositions exhibit good solubility and storage stability while maintaining bioavailability of the drug. The compositions also permit high concentrations of solubilized loratadine per total fill volume and thereby permit the use of smaller capsules to deliver the same dosage of drug.

The invention discloses a cinobufotoxin soft capsule and making method, which comprises the following steps: adapting the toad fur as raw material; utilizing the alcohol-extracting of water sediment method to condense the fur into concrete; adding fitful auxiliary even mixing material; making the particle; drying and disintegrating the toad fur extraction into fine powder; adding fitful auxiliary material to blend evenly; making the content of cinobufotoxin soft capsule. The invention improves the biological availability with good stability, which guarantees the production quality.

The present invention discloses propolis soft capsules and a preparation method thereof. The capsules include capsule shells and capsule contents, wherein the above-mentioned capsule shells are made of gelatin, glycerin and water with a mass ratio of 7: 20: 20; the above-mentioned capsule contents consist of purified propolis, rapeseed oil and beeswax with a mass ratio of 50: 85: 7. The preparation method comprises: (1) purifying the propolis; (2) preparing material liquid; (3) dissolving gelatin mixture; (4) pelleting the gelatin mixture to form gelatin pellets; (5) washing and drying the gelatin pellets; and (6) packaging the end products. The produced capsules are fully enclosed products and easier to swallow, and improved taste, smell and mouthfeel of the propolis are realized with the addition of the rapeseed oil. The capsules are disintegrated after being swallowed, and then can be absorbed directly and quickly by the intestinal tract without a dissolving process; in addition, the capsule packaging is not liable to break, and is safe and convenient to carry so that the capsules are suitable for home use, and also suitable for taking when a user is going on a vacation and a journey.

The invention discloses a health-care food composition. The health-care food composition is prepared by taking purple perilla seed oil and grape seed oil as raw materials and gelatin, glycerol and water as assisting materials, and the weight ratio of the purple perilla seed oil to the grape seed oil is (1-10):(1-5). A preparation method comprises the steps of uniformly mixing the purple perilla seed oil and the grape seed oil, uniformly mixing the gelatin, the glycerol and the water, using an automatic soft capsule pelletizer to pellet capsules, molding, washing, drying, and obtaining the soft capsule health-care food composition. The health-care food composition has a function of assisting in reducing blood fat.

The invention relates to a Chinese medicinal composition for loosening bowel and relieving constipation, which is prepared from the following raw materials in part by weight: 10 to 25 parts of desertliving cistanche, 10 to 20 parts of radishseed, 10 to 20 parts of cassia seed, and 10 to 25 parts of bighead atractylodes rhizome. The prescription of the Chinese medicament composition has the advantages of precise formula, obvious effect, wide source of raw material medicaments, and low cost. Due to simple formula, the medicament quality control is simple. The Chinese medicinal composition is prepared into a soft capsule preparation according to the characteristics of active ingredients thereof, the quantification is accurate, after the composition is disintegrated in vivo, the contents can be quickly absorbed in a liquid form by the body; and the soft capsule has smooth surface and good mouthfeel, and is easy to take. Through clinically primary pharmacodynamic validation, the composition has definite curative effect particularly on middle and old aged constipation patients, quick response, no toxic or side effect, safety, effectiveness and safe portability, and convenient . The clinical experiments prove that the Chinese medicinal composition has the effective rate of over 90 percent and has excellent application prospects and market prospects.

The disclosed soft capsule is prepared from rhubarb horsetails, goldthread root, baikal skullcap root and right amount of medicinal adjuvant, which form the content and coated into capsule shell of the soft capsule. The advantages of the capsule include convenient administration, quick action, high biological availability, and less side effects.

The invention relates to a Chinese medicinal composition for relaxing bowel. The composition is prepared from the following raw materials in part by weight: 10 to 25 parts of desertliving cistanche, 10 to 20 parts of radish seed, 10 to 20 parts of cassia seed and 10 to 25 parts of bighead atractylodes rhizome. The composition has the advantages of strict prescription, remarkable special effect, wide resource of raw materials and low cost. Because the prescription is simple, the quality control of the medicament is simple. The composition is prepared into the soft capsule formulation according to the characteristics of active ingredients and has accurate dosing; the contents can be very quickly absorbed by a human body in the form of liquid state after the capsules are disintegrated in vivo; and the soft capsules have the advantages of smooth surfaces, good mouthfeel and easy swallowing. The clinical primary pharmaceutical effect verifies that the composition has the advantages of definite therapeutic effect, rapid response, no toxic or side effect, safety, effectiveness, safe carrying and convenient eating for middle aged and elderly constipation patients. Clinical experiments verify that the effectiveness ratio reaches 100 percent and the composition has bright application prospect and market prospect.

The invention described herein relates to a pharmaceutical composition containing vinorelbine as an active ingredient which is suitable for encapsulation in soft capsules. The liquid oral pharmaceutical composition suitable for a liquid fill composition for a soft capsule dosage form comprises: vinorelbine or a pharmaceutically acceptable salt thereof; ethanol; water; glycerol; and polyethylene glycol. In a preferred embodiment, the tartrate salt form of vinorelbine is used in the composition. The invention also provides for a method of treating cancer comprising orally administering, to a patient in need of treatment thereof, a soft capsule comprising the pharmaceutical composition of the invention.

The present invention relates to one kind of Chinese medicine soft capsule for treating kidney deficiency and its preparation process. The Chinese medicine in the capsule is prepared with ten kinds of Chinese medicinal materials, including ginseng, desert cistanche, prepared rhizome of rehmannia, epimedium, wolfberry fruit, etc in certain weight proportion. The Chinese medicine soft capsule may capsulate the Chinese medicine extractum or the Chinese medicine extractum powder. The Chinese medicine soft capsule has the features of regulating Yin and Yang, no hormone content, protecting liver and kidney, high bioavailability, etc. It is used in treating various diseases caused by kidney deficiency, and has obvious curative effect.

The invention discloses a healthcare composition with a physical fatigue relieving function and a preparing method thereof. The healthcare composition contains ginseng extract, astragalus extract, herba epimedii extract, radix ophiopogonis extract, soybean oil and beewax. The invention further provides soft capsules containing the healthcare composition and a preparing method thereof. The healthcare composition aims at people feeling fatigue easily and is guided by traditional healthcare theory, scientific selection and reasonable compatibility are realized, ginseng, astragalus, herba epimedii and radix ophiopogonis extracts are used as raw materials to achieve qi tonifying, yang reinforcement, yin nourishing and liquid engendering in a 'warm but not dry, moist but not cold' mode, and exercise induced fatigue can be well relieved; the prepared soft capsules have high bioavailability and airtightness, dosage is accurate, bad flavor of medicine is effectively covered, and the soft capsules are convenient to carry, easy to take and suitable for people feeling fatigue easily.

The invention discloses a health food having functions of bone density increasing and joint protecting, and a preparation method thereof, and provides a design scheme of the health food having functions of bone density increasing and joint protecting and comprising glucosamine, a calcium agent and fish oil. The glucosamine is an important nutrition element in forming cartilage cells, and can increase density and flintiness of bone; the calcium agent can enhance bone absorption, increase bone density and promote fracture healing; and the fish oil contains abundant OMEGA-3 unsaturated fatty acid, and can improve osteoarthritis and bone swell. A combination of the three components has synergistic effects of bone absorption enhancing, bone density increasing, fracture healing promoting, osteoporosis delaying, joint protecting, osteoarthritis and joint protective film repairing, and is suitable for middle-aged and elderly people suffering from osteoporosis and accompanying osteoarthritis. The health food of the invention is made into the dosage form of soft capsule to maintain stable content and efficacy, and has the advantages of good mouthfeel, swallow easiness, safe portability; andthe health food of the invention is convenient for eating.

A soft capsule of cnidium lactone for treating cardiovascular and cerebrovascular diseases is prepared from the active cnidium lactone type components, dispersing medium, plasticizer, disintegrant, coloring agent, optical mask and others.

The invention discloses a medicinal and edible dual-purpose composition for preventing and treating vascular dementia and a preparation method thereof, belonging to the fields of food therapy and preparation of health products and traditional Chinese medicines. An optimal dosage form of a composition product is a soft capsule dosage form, and the medicinal and edible dual-purpose composition comprises the following components in parts by weight: 10-18 parts of a seabuckthorn seed procyanidine extract, 4-11 parts of a seabuckthorn flavone extract, 8-18 parts of a longstamen onion bulb extract and 63-72 parts of seabuckthorn seed oil. A preparation method of a soft capsule comprises the following steps: firstly preparing inclusions in the capsule into oil powder suspensions, and then preparing the oil powder suspensions into the soft capsule dosage form. The components of the medicinal and edible dual-purpose composition are all medicinal and edible dual-purpose varieties, are safe, and can be taken for a long time. The medicinal and edible dual-purpose composition disclosed by the invention can be used for effectively reducing the platelet aggregation rate and blood viscosity and increasing the cerebral blood flow, has extremely strong free radical removal and anti-oxidation effects, can be used for reducing the generation rate of MDA, repairing and protecting cranial nerve injury, and inhibiting hippocampal neuronal apoptosis, and plays roles in effectively preventing vascular dementia and treating vascular dementia.

A Chinese medicine in the form of softgel for treating gynopathy is prepared from 9 raw materials including berberine hydrochloride, menthol, flavescent sophora root, borneol, etc. Its preparing process is also disclosed.

A moonseed rhizome capsule features that its core is prepared from moonseed rhizome and medical auxiliary. Its preparing process is also disclosed.

The invention relates to a medicinal oral preparation containing anethol trithione, more specifically, the invention relates to a soft capsule for enhancing the beneficial effects of the anethol trithione.

A resveratrol self-microemulsion preparation is disclosed. The preparation includes glyceryl triacetate that is adopted as an oil phase, polyoxyethylene castor oil (Cremophor EL), polyoxyethylene hydrogenated castor oil (Cremophor RH40) and isopropanol. The mass ratio of the glyceryl triacetate, the Cremophor EL, the Cremophor RH40 and the isopropanol is 1:1-1.5:0.5-0.7:1.5-2.0. The preparation is prepared by fully mixing the glyceryl triacetate, the Cremophor EL, the Cremophor RH40 and the isopropanol under stirring in a water bath having a temperature of (37+ / -2) DEG C. The preparation can be prepared into microemulsion and soft capsules, or can be adopted as an adhesive and prepared into granules, tablets, micro-pills, and other dosage forms.

A soft capsule of lipitor salt with high stability and disintegrating speed is prepared from lipitor salt, auxiliary, and soft shell prepared from gelatin, glycerin, distilled water, ethylparaben, Fe2O3, microcrystalline cellulose and antioxidant. Its preparing process is also disclosed.

The invention relates to a soft capsule preparation for promoting blood circulation and relieving pain, its preparation method and forming process, wherein the preparation mainly comprises Chinese angelica root, native copper, notoginseng, frank incense and borneol. The invention discloses three processes for preparation which mainly comprises directly disintegrating part of the medicinal material, extracting different active ingredient, charging right amount of rationalized findings, grinding, stirring continuously, obtaining stock liquor, making soft capsule peel with gelatin, pressing the stock liquor and soft capsule peel into soft capsule.

This invention relates to macromolecular complexes useful in drug delivery systems, specifically tri-molecular complexes made between a water-soluble polymer and an acid-insoluble polymer in presence of a bridging molecule. In one aspect, the invention relates to a tri-molecular complex comprising gelatin, acrylic acid / methacrylic acid copolymers, and arginine for use in a soft capsule dosage form. In another aspect, the invention is directed to a tri-molecular complex a hydrophilic, film-forming, water-soluble polymer, a second water-soluble polymer, and a bridging molecule, wherein the second water-soluble polymer is less water-soluble than the hydrophilic, film-forming, water-soluble polymer.