7 results about "Citraconic acid" patented technology

The present application relates to the technical field of food packaging materials, and particularly relates to an oil-proof packaging material for food contact paper and a preparation process thereof. The oil-proof packaging material for food contact paper is prepared by the following steps: preparing a citraconic acid fermentation liquor, preparing methyl succinic acid by hydrogenation reaction of the citraconic acid, and preparing the oil-proof packaging material for food contact paper. The present application realizes the full-chain green preparation from straw to bio-based methyl succinic acid, and produces degradable polymer particles on the basis. The bio-based methyl succinic acid endows the oil-proof packaging material for food contact paper with the characteristics of renewability and biodegradability, helps to solve the problem of plastic pollution, and in terms of material performance, the introduction of bio-based monomers can optimize the polymer chain structure, improve the barrier effect of the film on oil, make the film thinner and tougher, and thus improve the oil-proof capacity.

The invention belongs to the field of biological medicines, and relates to application of an intestinal flora metabolite citraconic acid in prevention and treatment of colorectal cancer. The citraconic acid can significantly inhibit the proliferation of colorectal cancer cells, shows concentration dependence and time dependence, reduces the proportion of EdU positive red stained cells, inhibits the migration distance of the colorectal cancer cells and the number of migrated cells, inhibits the volume and weight of mouse tumors, and reduces tumor tissue necrosis and the number of pathological nuclear division cells. The expression of Ki67 in tumor tissues of mice is reduced.

The invention discloses a preparation method of citraconic acid, and relates to the technical field of preparation of citraconic acid. According to the invention, itaconic acid is used as a reaction raw material, water is used as a reaction solvent, a combination of nickel acetylacetonate and a tertiary amine compound is used as a catalyst, and citraconic acid is prepared through an isomerization reaction. The citraconic acid prepared by the preparation method disclosed by the invention is high in purity and high in yield, specifically, the purity of the citraconic acid prepared by the preparation method disclosed by the invention is 99.1%-99.5%, and the yield of the citraconic acid prepared by the preparation method is 80%-95%. The preparation method for preparing the citraconic acid is low in reaction temperature and low in production energy consumption, the citraconic acid can be prepared by adopting a one-pot end method, the operation is simple, the synthesis is simple and convenient, and a new reaction thought is provided for industrial large-scale production of the citraconic acid.

The invention discloses a pH-temperature dual-responsive core-shell structure microgel and a preparation method and application thereof, and the preparation method comprises the step of introducing citraconic acid or mesaconic acid into a core or a shell layer in a PNIPAM polymerization process to prepare the pH-temperature dual-responsive core-shell structure microgel. According to the method disclosed by the invention, dibasic acids (citraconic acid and mesaconic acid) which are isomeride to each other are respectively introduced into a core and a shell layer in a polymerization process, so that the core-shell PNIPAM microgel with pH and temperature dual responsiveness in the core and the shell layer is prepared, and the microgel has good stability, uniformity and swelling property; the material can be applied to the fields of biomedicine and the like as an encapsulating material with excellent performance.

The invention relates to application of citraconic acid in preparation of medicines for treating tumors. Specifically, it is found for the first time that citraconic acid or pharmaceutically acceptable salts thereof can maintain dryness of CD8 + T cells and inhibit T cell depletion so as to efficiently inhibit tumor growth, and citraconic acid can be used in combination with an immunodetection point inhibitor to generate a synergistic tumor treatment effect. Meanwhile, the downstream target ALOX5 inhibitor and the PDE1A inhibitor can maintain dryness of CD8 + T cells and inhibit depletion of the T cells.

The invention relates to the technical field of preparation of organic photoelectric materials, in particular to a preparation method of 1, 3-dimethyl-1, 2, 3, 4-cyclobutane tetracarboxylic dianhydride. The preparation method comprises the following steps: (1) carrying out addition reaction on dimethyl carbonate, a catalyst and dimethyl citraconate under the irradiation of a mercury lamp source to obtain an intermediate S1; (2) adding the intermediate S1 into an acidic solution, heating and carrying out hydrolysis reaction to obtain an intermediate S2; and (3) adding the intermediate S2 into acetic anhydride, heating and stirring, and carrying out dehydration ring closing reaction to obtain the finished product 1, 3-DMCBDA. According to the method, the defects in the prior art are overcome, the purity of the produced 1, 3-dimethyl-1, 2, 3, 4-cyclobutane tetracarboxylic dianhydride is improved, and the content of isomers and the content of metal impurities are greatly reduced.

The invention relates to the technical field of coal mine underground dustproof materials, in particular to a coal mine underground dust suppression material as well as a preparation method and a dustproof method thereof. According to the dust suppression material, iohexol, citraconic acid and arabinogalactan serve as main raw materials, the adding proportion of all the raw materials is adjusted in a targeted mode, covalent bond connecting molecules are constructed through step-by-step esterification reaction, the water content of the obtained material can reach 6% in the high-temperature environment of 40 DEG C for 16 h, the hardness of a curing layer reaches 81.82 HA, the dust suppression efficiency at the wind speed of 15 m / s reaches up to 89.25%, and the dust suppression effect is good. The remarkable effect of lasting dust suppression under the high-temperature severe condition is achieved, and the key problems that a high-temperature underground dust suppressant is short in service life and prone to failure are solved.