48 results about "Citraconic acid" patented technology

This invention provides methods and devices for spatially separating at least first and second components in a sample which in one exemplary embodiment comprises introducing the first and second components into a first microfluidic channel of a microfluidic device in a carrier fluid comprising a spacer electrolyte solution and stacking the first and second components by isotachophoresis between a leading electrolyte solution and a trailing electrolyte solution, wherein the spacer electrolyte solution comprises ions which have an intermediate mobility in an electric field between the mobility of the ions present in the leading and trailing electrolyte solutions and wherein the spacer electrolyte solution comprises at least one of the following spacer ions MOPS, MES, Nonanoic acid, D-Glucuronic acid, Acetylsalicyclic acid, 4-Ethoxybenzoic acid, Glutaric acid, 3-Phenylpropionic acid, Phenoxyacetic acid, Cysteine, hippuric acid, p-hydroxyphenylacetic acid, isopropylmalonic acid, itaconic acid, citraconic acid, 3,5-dimethylbenzoic acid, 2,3-dimethylbenzoic acid, p-hydroxycinnamic acid, and 5-br-2,4-dihydroxybenzoic acid, and wherein the first component comprises a DNA-antibody conjugate and the second component comprises a complex of the DNA-antibody conjugate and an analyte.

A hot melt adhesive composition comprising: (a) a functional copolymer obtained from copolymerization of ethylene and a comonomer selected from maleic anhydride, citraconic anhydride, itaconic anhydride, tetrahydrophthalic anhydride, maleic acid, citraconic acid, itaconic acid, fumaric acid, tetrahydrophthalic acid, the corresponding salts, monoesters and diesters of these acids, and mixtures of any of these, wherein the functional copolymer is present in an amount from about 5 to about 95 weight % of the combined total amount of (a) and (b); and (b) at least one ethylene copolymer obtained from copolymerization of ethylene with a polar monomer wherein said polar comonomer is present in the copolymer in an amount of from 8 to 40 weight %, wherein said ethylene copolymer is selected from the group consisting of ethylene/vinyl acetate copolymers, ethylene/alkyl (meth)acrylate copolymers and ethylene/alkyl (meth)acrylate/carbon monoxide terpolymers, in an amount from about 5 to about 95 weight % of the combined total amount of (a) and (b); wherein the composition has a melt index of 100 grams/10 minutes or higher. Articles comprising and process using the hot melt adhesive are also disclosed.

An object of the present invention is to provide a novel polychloroprene-based copolymer, a soapless polychloroprene-based latex, and a process for producing the same in a simple and convenient manner, which are intended to be used for the improvement in adhesiveness and water resistance of a conventional polychloroprene adhesive or the improvement in oil resistance and adhesiveness of a styrene-butadiene block copolymer.

The invention relates to a chloroprene-based block copolymer comprising a polymer (A) having a composition represented by the following formula (1) and a chloroprene-based polymer (B), the polymer (A) being linked to one terminal or both terminals of the chloroprene-based polymer (B), and the total amount of the 1,2-bond and the isomerized 1,2-bond in the chloroprene-based polymer (B) as determined by carbon-13 nuclear magnetic resonance spectrometry being 2.0 mol % or less; a soapless polychloroprene-based latex comprising an amphipathic chloroprene copolymer having a hydrophobic chloroprene-based polymer and a hydrophilic oligomer or polymer having an acidic functional group linked to the hydrophobic chloroprene-based polymer and 2 wt % or less of an emulsifying agent; and a process for producing the same:

wherein U represents hydrogen, a methyl group, a cyano group, or a substituted alkyl group; V represents a phenyl group, a substituted phenyl group, a carboxyl group, an alkoxycarbonyl group, a substituted alkoxycarbonyl group, an allyloxycarbonyl group, a substituted allyloxycarbonyl group, an acyloxy group, a substituted acyloxy group, an amido group, or a substituted amido group; X represents hydrogen, a methyl group, chlorine, or a cyano group; Y represents hydrogen, chlorine, or a methyl group; Q represents a polymerization residue of maleic anhydride, citraconic acid, maleic acid, fumalic acid, a maleate ester, or a fumalate ester; and k, n, and m each represents an integer of 0 or more.

A rubber composition comprises at least one rubber ingredient selected from natural rubber and synthetic rubbers, and a polymaleimide synthesized by reacting at least one of anhydrous maleic acid and anhydrous citraconic acid with methylene polyaniline.

The invention provides a method for preparing citraconic anhydride and a method for isomerizing/dehydrating itaconic acid. The method for preparing the citraconic anhydride comprises the following steps of: supplying the itaconic acid to serve as a reaction initiator; in the presence of a catalytic agent, and carrying out isomerizing/dehydrating reaction on the itaconic acid or a combination containing the itaconic acid to obtain the citraconic anhydride, wherein the catalytic agent contains heteropoly acid or salt of the heteropoly acid. The method for isomerizing/dehydrating itaconic acid comprises the following steps of: supplying the itaconic acid to serve as the reaction initiator; supplying the heteropoly acid or the salt of the heteropoly acid to form a mixture with the itaconic acid; and heating the mixture so as to carry out isomerizing/dehydrating reaction on the mixture, thereby obtaining the citraconic anhydride. According to the method, the itaconic acid can be converted into the citraconic anhydride product with high yield and application value under the preparation condition of the use or non-use of a dissolvant, and the industrial volume production is easily realized.

A method for producing anteiso fatty acid is provided. The method comprises culturing a cell comprising at least one exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes at least one of the following reactions: conversion of pyruvate to citramalate; conversion of citramalate to citraconate; conversion of citraconate to β-methyl-D-malate; conversion of β-methyl-D-malate to 2-oxobutanoate; or conversion of threonine to 2-oxobutanoate, under conditions allowing expression of the polynucleotide(s) and production of anteiso fatty acid. Optionally the cell further comprises at least one exogenous or overexpressed polynucleotide comprising a nucleic acid sequence encoding a polypeptide that catalyzes conversion of 2-oxobutanoate to 2-aceto-2-hydroxy-butyrate, conversion of 2-aceto-2-hydroxy-butyrate to 2,3-dihydroxy-3-methylvalerate, and/or conversion of 2,3-dihydroxy-3-methylvalerate to α-keto-3-methylvalerate. A cell that produces anteiso fatty acid and a method of using the cell to produce anteiso fatty acid also are provided.

The invention discloses a Parkinson's disease specific serum endogenous small molecule marker and application thereof. The marker contains 2-amino-3-(4-hydroxyl-3-methoxyphenyl) propionic acid, ferulic acid and citraconic acid, altrose, pentadecanoic acid, o-phosphoserine, 4, 6 beta-hydroxymorphine, L-thyroxine, 5[epsilon], 9[epsilon], 16[epsilon]-17-hydroxy peraluminum-19-acid, 8-(1,2,dyhydroxy-3-methylbutyl-3-ene-1-yl)-7-methoxy-2H-chromine-2-2-ketone,10-hydroxydecanoic acid, perfluoro caprylic acid, and Corchorifatty acid F. The Parkinson's disease specific serum endogenous small molecule marker provided by the invention has the characteristics of high accuracy and high sensitivity. The prediction offline prediction area AUC of some markers reaches 0.95 or above, the accuracy and sensitivity of the markers are high, and the markers can be directly used for Parkinson's disease indexes.

The invention discloses biomarker compositions, and provides biomarker compositions for diagnosing cervicitis and a cervical cancer. The biomarker compositions are characterized by at least comprising one or a combination of uridine-5'-monophosphate disodium, histamine, 3'-O-methyl-guanosine and phenyllactic acid. The biomarker composition for diagnosing the cervicitis is characterized by comprising one or a combination of uridine-5'-monophosphate disodium, L-cysteine, isocitric acid, uridine diphosphate glucose, adenosine monophosphate, inosine 5'-monophosphate, L-pipecolic acid, N-acetyl putrescine and saccharose. The biomarker composition for diagnosing the cervical cancer is characterized by comprising one or a combination of histamine, phenyllactic acid, citraconic acid, L-2-aminoadipic acid, 3'-O-methyl-guanosine, beta-D-glucosamine, glycerin and cholesterol sulfate.

A novel copolymer and a dispersant using the copolymer are provided. The copolymer is formed of a polyalkylene glycol diester body of itaconic acid, citraconic acid, or mesaconic acid and (meth)acrylic acid. It may further contain other copolymerizable monomer. The copolymer of this invention excels in dispersing property and water-reducing property and manifests a high flow magnitude. Thus, the cement composition using this copolymer enjoys excellent workability when it is put to use.

The invention discloses a preparation method of a metolachlor molecular imprinting sensor. The preparation method is characterized by comprising the following steps of adding the following componentsin percentage concentration by mass: 74-80% of ethanol, 6-10% of N-ethyl-2-aminomethyl pyrrolidone, 6-10% of citraconic acid, 2-4% of metolachlor, 0.5-1.5% of diisocyanate and 3-5% of ammonium persulfate, wherein the sum of the contents of the components is 100%; performing stirring and dissolving, introducing nitrogen to remove oxygen for 10 minutes, and in an oxygen-free atmosphere, carrying outa stirring reaction at 60 +/-2 DEG C for 10-12 hours, enabling the obtained product to be soaked in a mixed solution with ethanol and acetic acid at the volume ratio of 8:1 for 10 hours, performing washing for multiple times, and removing template molecules, and carrying out drying to obtain a metolachlor molecular imprinting polymer; and the sensor has high sensitivity and selectivity. The sensor has the advantages of being high in sensitivity, high in specificity, rapid in detection and capable of being repeatedly used.

The invention discloses an antibacterial HDPE plastic chair suitable for outdoor use. The plastic chair comprises the following components in parts by weight: 100 parts of high density polyethylene, 15-25 parts of polypropylene, 2-6 parts of an ethylene-vinyl acetate copolymer, 1-2 parts of carboxylated polypropylene, 1-2 parts of cedar oil, 0.5-1.2 parts of epoxidized soybean oil, 0.2-1 part of sodium stearate, 1-2 parts of magnesium oxide, 2-4 parts of a high-stability antibacterial agent, 1-2 parts of a compatilizer, 1-2 parts of an antioxidant and 1-2 parts of a light stabilizer; wherein the high-stability antibacterial agent is obtained by acidolysis of calcined attapulgite and combination with 8-hydroxyquinoline; the compatilizer is a graft of polypropylene and unsaturated acid or agraft of polypropylene and anhydride; the unsaturated acid is acrylic acid or methacrylic acid, and the anhydride is maleic anhydride, fumaric acid, itaconic acid, citraconic acid, citraconic anhydride or vinyl succinic anhydride. The invention further discloses a preparation method of the antibacterial HDPE plastic chair suitable for outdoor use.

The invention relates to an intelligent nano-medicament delivery system with pH responsiveness and a preparation method and application thereof. The delivery system comprises a nano-medicament carrier and a medicament encapsulated in the carrier, wherein the carrier is formed by a dendritic polymer and a molecular ligand connected to the carrier; the dendritic polymer is a polyamide-imide dendritic polymer or a polyamide-imide dendritic polymer containing cholate acid terminal group; and the molecular ligand is citraconic acid or 3, 4, 5, 6-tetrahydro benzoic acid. The medicament is an anti-tumor medicament or an induced differentiation medicament. The medicament delivery system is prepared by modifying a lower-generation polyamide-imide dendritic polymer, and the preparation process is simple. An experiment proves that the system plays a good cell delivery role on the anti-tumor medicament or a tumor differentiation medicament. The effect of the anti-tumor medicament can be effectively improved, the induced differentiation capability of an anti-differentiation medicament on cancer cells is improved, the toxic and side effect in an organism is small and the system can be used for treating cancers.

The disclosure provides a method for preparing the citraconic anhydride and a method for isomerizing/dehydrating itaconic acid. The method for preparing the citraconic anhydride includes the following steps: providing itaconic acid as a starting material; and subjecting the itaconic acid to an isomerization/dehydration reaction in the presence of a catalyst to obtain the citraconic anhydride, wherein the catalyst includes a heteropolyacid or heteropolyacid salt.

Disclosed is a method of making methacrylic acid, or a carboxylic derivative thereof, from itaconic acid, isomers, or precursors thereof. A starting material comprising an acid selected from the group consisting of itaconic acid, citraconic acid, mesaconic acid, citric acid, aconitic acid, isocitric acid and mixtures thereof, is subjected to contact with 0.1 eq. to 3.0 eq. of a base, at a temperature of 150° C. to 350° C., under the influence of a transition metal-containing heterogeneous catalyst. A better yield at lower temperatures is achieved.