7 results about "Pipecolic acid" patented technology

The present specification relates to a composition including a new amide-based compound derived from an amino acid structure such as valine, leucine, phenylalanine, proline, pipecolic acid, or the like, wherein the composition exhibits a skin anti-aging or skin reverse-aging effect by restoring the size and number of dendrites of aged melanin-producing cells to those of young cells. As a result, the composition may exhibit a skin brightening effect by inhibiting the amount of melanin produced in the melanin-producing cells.

Pipecolic acid-based surfactants and their use This invention deals with pipeolic acid-based surfactants and their uses, for example in laundry or dishwashing.

This specification relates to novel amide compounds derived from amino acid structures such as valine, leucine, phenylalanine, proline, or pipecolic acid, which have MMP-1, MMP-2, or MMP-9 inhibitory effects even in trace amounts, their isomers, pharmaceutically acceptable salts thereof, their hydrates, or solvates, and compositions containing the same.

This specification relates to compositions comprising novel amide compounds derived from amino acid structures such as valine, leucine, phenylalanine, proline, or pipecolic acid. [Solution] The composition can exert an immune-enhancing effect by activating the phagocytic activity of macrophages, which are important components of the human immune system and help eliminate pathogens.

The present invention addresses the problem of providing: a mutant L-pipecolic acid hydroxylase for producing cis-5-hydroxy-L-pipecolic acid in a highly productive and highly selective manner by hydrating L-pipecolic acid; and a novel method for industrially producing cis-5-hydroxy-L-pipecolic acid from L-pipecolic acid in a highly productive and low-cost manner. The present invention provides a mutant L-pipecolic acid hydroxylase that has an amino acid sequence in which a specific amino acid mutation is introduced in the amino acid sequence represented by SEQ ID NO: 2.

The present invention addresses the problem of providing a stable hydroxylase having high L-pipecolic acid hydroxylation activity and high stability by introducing a mutation into an L-pipecolic acid hydroxylase.　It has been found that the effects of improving the L-pipecolic acid hydroxylation activity and stability of a hydroxylase (McPH) when the hydroxylase is expressed in a host such as E. coli can be obtained by identifying an amino acid residue that can affect an improvement in the hydroxylation activity and stability of the hydroxylase, and introducing a mutation into the identified amino acid residue.

The present invention addresses the problem of providing a hydroxylase having high L-pipecolic acid hydroxylation activity for efficiently producing high-purity hydroxy-L-pipecolic acid at low cost and with high productivity.　It has been found that the effects of increasing the yield of a solubilizing enzyme when a hydroxylase (McPH) is expressed in cells, improving the L-pipecolic acid hydroxylation activity of the enzyme itself, and reducing the activity of converting L-proline into hydroxy-L-proline are obtained by identifying an amino acid residue capable of affecting an improvement in the hydroxylation activity of the hydroxylase, and introducing a mutation into the identified amino acid residue.