35 results about "Pipemidic acid" patented technology

Novel and optimized classes of pipemidic acid derivative compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes of compounds exhibit exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

The invention provides a pharmaceutical composition for treating colitis and its preparing process, wherein the medicinal composition is prepared from pseudostellaria root 25-35g, white atractylodes rhizome 10-15g, dried orange peel 5-9g, poria cocos wolf 12-15g, licorice root 3-8g, coix seed 25-35g, slices of aconite 8-12g, root of herbaceous peony 10-20g, coptis root 1-5g, prepared dark Japanese plum 8-12g, ledebouriella root 8-12g, kudzuvine root 8-12g, rifampicin 1-5g, pipemidic acid 4-8g and metronidazole 7-11g through steps of disintegrating, mixing, sieving, and making into various preparation, in particular capsules by the conventional preparing method.

The invention discloses a method for measuring pipemidic acid by using a resonance scattering spectrum. Pipemidic acid and tetraphenylboron sodium react in acetic acid-acetic acid buffer solution with the pH value being 3.6 to form ionic associate particles, wherein the particles generate a resonance scattering spectrum peak at the wavelength being 480nm, and the resonance scattering intensity is linearly related to the concentration of the pipemidic acid so as to provide a new method for measuring the content of the pipemidic acid by using the resonance scattering spectrum. In comparison with the conventional method, the method provided by the invention has the advantages of simple instrument, convenience in operation, rapidness, easily obtained reagent and high sensitivity.

The invention provides a rare-earth fluorescent coordination compound synthesized by using dioxane micromolecule as a second ligand and pipemidic acid (PPA) as a first ligand, and a preparation method thereof. Due to the existence of dioxane, the fluorescence of the rare-earth coordination compound is obviously enhanced, and the fluorescence lifetime of the rare-earth coordination compound is greatly influenced when the dioxane is used as the second ligand. The novel rare-earth coordination compound provides a new optional reagent for quinolone broad-spectrum antibacterial drugs, and the fluorescence enhanced phenomenon also provides a new method for detecting existence and content of micromolecule dioxane.

The invention discloses a broad spectrum specific molecularly imprinted polymer of quinolone medicine, a chemiluminescence kit using the broad spectrum specific molecularly imprinted polymer as a recognition element, a detection method and application. The molecularly imprinted polymer uses pipemidic acid as a pseudomolecular template. The synthesized broad spectrum specific molecularly imprintedpolymer can recognize eight kinds of quinolone medicine. The chemiluminescence kit prepared on the basis of the molecularly imprinted polymer can be used for performing multi-residue detection on eight kinds of quinolone medicine in meat tissues; the repeated utilization can be realized; the detection sensitivity is improved; the detection time is shortened; the detection cost is reduced.

The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic acid in the presence of 2-oxoglutaric acid and iron(II) ions to produce trans-4-hydroxy-L-pipecolic acid, and a method for producing 4-hydroxy amino acid, which method comprises reacting the pipecolic acid 4-hydroxylase protein, cells containing the protein, a treated product of the cells, and/or a culture liquid obtained by culturing the cells, with α-amino acid to produce 4-hydroxy amino acid:

• (A) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18;
• (B) a polypeptide comprising the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18 except that one or several amino acids are deleted, substituted, and/or added, and having pipecolic acid 4-hydroxylase activity; and
• (C) a polypeptide having an amino acid sequence that is not less than 80% identical to the amino acid sequence represented by SEQ ID NO:2, 4, 6, 8, 10, 12, 16, or 18, and having pipecolic acid 4-hydroxylase activity.

A novel method of producing high-purity hydroxy-L-pipecolic acids in an efficient and inexpensive manner while suppressing the production of hydroxy-L-proline is provided. The method includes allowing an L-pipecolic acid hydroxylase, a microorganism or cell having the ability to produce the enzyme, a processed product of the microorganism or cell, and/or a culture liquid comprising the enzyme and obtained by culturing the microorganism or cell, to act on L-pipecolic acid as a substrate in the presence of 2-oxoglutaric acid and ferrous ion, wherein the L-pipecolic acid hydroxylase has the properties:

• • (1) the enzyme can act on L-pipecolic acid in the presence of 2-oxoglutaric acid and ferrous ion to add a hydroxy group to the carbon atom at positions 3, 4, and/or 5 of L-pipecolic acid; and
  • (2) the enzyme has a catalytic efficiency (kcat/Km) with L-proline that is equal to or less than 7 times the catalytic efficiency (kcat/Km) with L-pipecolic acid.

The invention belongs to the technical field of novel environment-friendly materials, and discloses a preparation method of a molecularly imprinted material for efficiently adsorbing and removing fluoroquinolone antibiotics, which comprises the following steps: firstly, respectively taking pipemidic acid, zirconium tetrachloride and 2-aminoterephthalic acid as template molecules, metal salts and organic ligands; the preparation method comprises the following steps: synthesizing a molecularly imprinted polymer with NH2-UiO-66 as a substrate by using a solvothermal one-pot method; then, a proper solvent is selected to elute the template molecules, and the molecularly imprinted NH2-UiO-66 material is prepared. According to the invention, pipemidic acid is used as a virtual template molecule, the molecularly imprinted NH2-UiO-66 material with specific adsorption performance is provided, and the material has good adsorption performance on fluoroquinolone antibiotics, can realize selective adsorption removal, and has good application prospects. The problems that a traditional molecularly imprinted polymer is low in adsorption capacity and poor in specific recognition capacity in a polar environment are effectively solved, and the problem that the adsorption removal effect of a molecularly imprinted material is affected by leakage of template molecules is effectively solved by using the virtual template.

The invention discloses a new application of quinolone compounds as bactericides in prevention and treatment of bacterial diseases and citrus canker of crops. The quinolone compounds comprise floroxacin, enofloxacin, gatifloxacin, moxifloxacin hydrochloride, enrofloxacin, marbofloxacin, floxacin, mononorfloxacin mesylate, prulifloxacin, Balofloxacin, pazufloxacin mesylate, pipemidic acid, sparfloxacin, difloxacin hydrochloride, lomefloxacin hydrochloride, pefloxacin, tosufloxacin mesylate, Cinoxacin, galafloxacin, besifloxacin hydrochloride, ofloxacin, nalidixic acid, Clinafloxacin and Sitafloxacin. The quinolone compounds can be used for preventing and treating bacterial diseases caused by citrus canker pathogens, especially gatifloxacin, moxifloxacin hydrochloride, mononorfloxacin mesylate, sparfloxacin, tosufloxacin mesylate, clinafloxacin and sitafloxacin, has excellent bacteriostatic activity on citrus canker pathogens, and can be used for preventing and treating bacterial diseases of crops.

The invention provides a montmorillonite-containing composite adsorbing material. The montmorillonite-containing composite adsorbing material comprises montmorillonite and chitosan forming an intercalated structure with the montmorillonite, wherein the chitosan is loaded with a nanometer titanium dioxide-mesoporous carbon precipitate. The invention provides the montmorillonite-containing compositeadsorbing material prepared by a preparation method and application thereof. The montmorillonite-containing composite adsorbing material can be applied to treatment to PPCP pollutants such as chloramphenicol, penicillin, erythromycin, streptomycin, vancomycin, pipemidic acid, ibuprofen, diclofenac sodium in wastewater and is relatively good in treatment effect. The patented technology is funded by a key research project (15A610008) in a higher education institution and a doctoral research startup fund (201610009) in North China University of Water Resources and Hydropower.

The present invention provides a kaolin composite adsorption material, which comprises kaolin and chitosan, wherein the chitosan and the kaolin form an intercalation structure, the chitosan loads a core-shell structure photocatalyst, and the core-shell structure photocatalyst comprises a tin dioxide nanometer core and a porous carbon shell coated on the surface of the tin oxide nanometer core. Theinvention further provides the kaolin composite adsorption material prepared through the method, and applications thereof. According to the present invention, the kaolin composite adsorption materialcan be used for treating chloramphenicol, penicillin, erythromycin, streptomycin, vancomycin, pipemidic acid, ibuprofen, diclofenac sodium and other PPCPs contaminants in wastewater, and has good treatment effect. The technology of the present invention is funded by key scientific research projects of universities (15A610008) and PhD research initiation funds (201610009) of North China UniversityOf Water Resources And Electric Power.

The invention discloses a pharmaceutical compound preparation for treating acute gastritis. The compound preparation comprises the following components in parts by weight: 10 to 300 parts of propantheline bromide, 10 to 120 parts of pipemidic acid, and 10 to 1600 parts of drug carrier. Propantheline bromide and pipemidic acid are taken as the pharmaceutical components and mixed with the drug carrier to prepare the compound preparation. The compound preparation is convenient to take, is very safe, has a prominent effect, can greatly reduce complications, generates few sequelae, barely causes adverse reactions, and promotes the healing.

The invention discloses a pipecolinic acid preparation process based on reverse dropping and belongs to the technical field of medicines. By adopting the pipecolinic acid preparation process based onreverse dropping, S1-S2 and S3-S7 can be implemented simultaneously, so that the lasting time of the whole preparation process can be effectively shortened; meanwhile, by adopting a dropping mode in the preparation process, a conventional mode of dropping from top to bottom is changed into a mode of dropping from bottom to top, small water domes can be formed because of instantaneous impact resulted when a liquid to be dropped is fed into a reaction kettle, and are diffused outwards and upwards, liquid convection of the dropped liquid and a reactant can be enhanced because of the water domes,thus a good mixing effect is achieved, reactions can be accelerated to a certain extent, the preparation efficiency can be improved, and compared with the mode of dropping from top to bottom, the process is capable of effectively avoiding the phenomenon that the content of the reactant is changed to a certain extent as the liquid is splashed because of water impact and is adhered to an inner wall.

The invention belongs to the technical field of a catalyst and especially relates to a preparation method for a nanometer ozonation catalyst. The nanometer ozonation catalyst prepared according to the method provided by the invention is a nanometer Sn/Ti compound material which is formed in the manner of eutectic growth of SnO2 and TiO2 two metal oxides. According to the invention, the nanometer Sn/Ti bimetal compound material is adopted and a template agent is used as a structure guide, so that the metal crystal grows in a certain skeleton structure, and meanwhile, the material has a certain space structure and an excellent adsorbing property. The nanometer ozonation catalyst acquired according to the method provided by the invention is ultrahigh in active component content, high in pollutant removal rate, high in catalytic activity, less in active component loss, free from influence on the catalyst activity and obvious in catalytic effect in catalytic ozonation treatment for antibiotic wastewater, such as, chloramphenicol wastewater, penicillin wastewater, erythrocin wastewater, streptomycin wastewater, vancomycin wastewater and pipemidic acid wastewater.

The invention relates to a fast-acting Fuyankang powder preparation. Particularly, the fast-acting Fuyankang powder preparation is an external-application powder preparation for treating infective inflammations of external reproductive tracts of women. Many disadvantages in treatment of gynecologic inflammations, i.e., low healing speed and recrudescence are overcome. The powder preparation is prepared from rifampin, pipemidic acid, metronidazole, moroxydine, nystatin, cimetidine, dexamethasone and vitamin B12. The powder preparation has the actions of sterilizing and resisting viruses, rapidly diminishing inflammations, promoting tissue regeneration and restoring a wounded area. The fast-acting Fuyankang powder preparation is used for treating various inflammations, erosions and the likecaused by various bacteria, cocci, viruses, fungi and trichomonads of the external reproductive tracts of the women and is simple and convenient in method, simple in procedure, free of secondary wounds, free of sufferings, high in healing speed and difficult in recrudescence; general inflammations and level I erosions can be healed generally through medication once or twice; and complicated inflammations and level-II and level-III erosions caused by mixed type infections can be healed generally through medication in 3 to 5 times, the effective rate is 98% or more, the cure rate is 95% or more,the inflammation extinction speed is high, and the wounded area healing speed is high.

The invention belongs to the field of synthetic medical chemistry and particularly relates to chemical preparation and application of a trans-1,2-(1,4-diazulyl)ethene derivative. During chemical synthesis study of a framework with guaiazulene and piperidine as raw materials, the trans-1,2-(1,4-diazulyl)ethene derivative is found, in-vitro H1N1 influenza virus test results indicate that the compound has in-vitro antiviral activity superior to a positive drug ribavirin at the concentration level of 25 mM. In-vivo activity tests find that the compound can inhibit pneumonic symptoms, reduce lung virus titer and increase survival rate of mice and can significantly increase the survival rate of virus infected mice and reduce lung virus titer by gavage at the dosage of 5 mg/kg/day in particular.In conclusion, the compound has in-vivo activity equivalent to oseltamivir effect, so that the compound can be used for preparing antiviral drugs. A new way is opened up for deep research and development of novel antiviral drugs.

The invention discloses an osmanthus fragrans cultivation root protecting fertilizer and a preparation method thereof. The osmanthus fragrans cultivation root protecting fertilizer is prepared from, by weight, 28-40 parts of kieselguhr, 25-30 parts of plant ash, 12-28 parts of apricot kernel dregs, 30-35 parts of sesame dregs, 26-30 parts of astragalus sinicus straw, 4-12 parts of water moss, 4-8 parts of willow bark, 1-2 parts of glutamic acid, 1-3 parts of indolebutyric acid, 3-5 parts of glucose, 4-6 parts of sodium nitrate, 1-2 parts of cephalosporin C, 2-3 parts of nalidixic acid, 3-5 parts of pipemidic acid, 10-15 parts of carbon dregs and a proper amount of water. The fertilizer is prepared through the reasonable processing procedures of mixing, stirring and pelleting. Salicin is obtained after degradation of willow bark and can be used for disinfecting the growing environment around the roots of osmanthus fragrans in cooperation with cephalosporin C, nalidixic acid and pipemidic acid; meanwhile, the root protecting and rooting effects are achieved, and the cultivation survival rate can be increased.