6 results about "Isonicotinamide" patented technology

The invention discloses an acacetin and isonicotinamide eutectic, a preparation method, a composition and application thereof, and belongs to the technical field of medicines. Specifically, the invention discloses an eutectic substance formed by acacetin and isonicotinamide, and the molecular formula of the eutectic substance is (C16H12O5). (C6H6N2O), the invention relates to a preparation method of a cocrystal of acacetin and isonicotinamide. The acacetin and isonicotinamide eutectic is used as an active ingredient of a medicine and is applied to preparation of medicines for resisting oxidation, resisting inflammation, resisting viruses, resisting tumors, resisting rheumatism, easing pain, protecting the liver, regulating immunity, treating osteoporosis and treating cardiovascular and cerebrovascular diseases.

The invention belongs to the technical field of crystal form medicine molecules, and particularly relates to a rosmeltirol crystal form and a preparation method thereof. The invention provides two crystal forms of rosmeltirol, and the crystal forms of rosmeltirol-nicotinamide-methanol have characteristic peaks at least at the positions of 6.2 + / -0.2 degrees, 14.4 + / -0.2 degrees, 21.5 + / -0.2 degrees, 22.4 + / -0.2 degrees, 24.3 + / -0.2 degrees, 26.5 + / -0.2 degrees and 27.4 + / -0.2 degrees in an X-ray diffraction spectrum represented by 2 theta by using Cu-K alpha radiation; according to the crystal form, Cu-K alpha radiation is used, and an X-ray diffraction spectrum represented by 2 theta has characteristic peaks at least at the positions of 12.0 + / -0.2 degrees, 15.6 + / -0.2 degrees, 17.8 + / -0.2 degrees, 19.9 + / -0.2 degrees, 20.8 + / -0.2 degrees and 28.1 + / -0.2 degrees. The rosmeltirol crystal form is good in stability, almost free of hygroscopicity, high in solubility and high in medicinal value.

The application discloses a zinc(II)-calix[4]arene complex single crystal and a preparation method and application thereof, and belongs to the technical field of coordination chemistry and adsorbents, and provides a preparation method of the zinc(II)-calix[4]arene complex single crystal, which comprises the following steps: mixing a soluble zinc source, 5,11,17,23-tetra[(m-carboxylphenyl)azo]-25,26,27,28-tetrahydroxycalix[4]arene and N-(pyridin-4-yl)isonicotinamide in a solvent, and reacting to obtain the zinc(II)-calix[4]arene complex single crystal. The zinc(II)-calix[4]arene complex single crystal prepared by the application has rich amide functional groups in a three-dimensional framework structure, and has rich active adsorption sites, and has good UO2 2+ adsorption removal effect.

Provided in the present invention are a plurality of cocrystal forms of Resmetirom and isonicotinamide, a pharmaceutical composition containing the crystal forms, and the use of the crystal forms in the preparation of drugs for treating THR-β-mediated diseases.

The invention belongs to the technical field of aluminum foil formation, and discloses an amide-aluminum sulfate hydrated eutectic electrolyte for hydration treatment of a high-voltage electrode foil and application of the amide-aluminum sulfate hydrated eutectic electrolyte. The hydrated eutectic electrolyte is prepared by compounding aluminum sulfate and an amide compound (isonicotinamide, N-methyl nicotinamide or 2-pyrrolidone) according to a specific molar ratio, and the hydrated eutectic electrolyte is dissolved in high-purity water to form a stable eutectic system. Through the synergistic effect of the eutectic electrolyte, formation and densification of a hydration film (Al2O3.nH2O) on the surface of the aluminum foil are accelerated, and the technical problems that traditional hydration treatment is long in time (larger than or equal to 10 minutes), high in energy consumption, low in formation efficiency and multiple in oxidation film defect are solved. By applying the hydration treatment process, the hydration time can be shortened to 5-8 minutes, the formation efficiency is improved by 25-35%, the specific capacitance is improved by 1-5%, the leakage current is reduced by 15-25%, the energy consumption is reduced by 15-30%, the product quality and the production economy are remarkably improved, and the hydration treatment process is suitable for industrial production of the high-voltage electrode foil.