54 results about "Isonicotinamide" patented technology

The invention discloses a method for preparing cephalonium from 7-aminocephalosporanic acid at one step. The method comprises the following steps: (1) adding 7-aminocephalosporanic acid into water with the temperature of 0-10 DEG C; (2) regulating the pH value of the solution; (3) adding an organic solvent, tiophencacetyl chloride and ethyl acetate, and reacting for 1-3h while stirring at the temperature of 0-10 DEG C; (4) after the reaction is ended, standing for layering; (5) adding activated carbon into a water phase for decoloring, and carrying out suction filtration; (6) adjusting the pH value of the filtrate, then, adding isonicotinamide, and reacting at the temperature of 15-50 DEG C; (7) after the reaction is ended, growing the grain for over 1h; (8) filtering to obtain a crystal, and drying to obtain the cephalonium. The cephalonium is prepared at one step, and an intermediate is not needed to be separated and extracted in the reaction process, so that the method is simple and convenient in operation, simple in reaction step and high in yield; the 7-aminocephalosporanic acid is used as the raw material and is simple and easy to obtain and low in market price, so that the production cost is greatly reduced.

A cyanide-free lytic reagent composition and method for measuring the total hemoglobin concentration in a blood sample, for counting the number of leukocytes and for deferential counting of leukocyte subpopulations are described. The cyanide-free lytic reagent composition comprises a quaternary ammonium salt or a pyridinium salt to lyse erythrocytes and release hemoglobin, and an organic ligand selected from the group consisting of triazole and its derivatives, tetrazole and its derivatives, alkaline metal salts of oxonic acid, melamine, aniline-2-sulfonic acid, quinaldic acid, 2-amino-1,3,4-thiadiazole, triazine and its derivatives, urazole, DL-pipecolinic acid, isonicotinamide, anthranilonitrile, 6-aza-2-thiothymine, 3-(2-thienyl)acrylic acid, benzoic acid and alkali metal and ammonium salts of benzoic acid, and pyrazine and its derivatives to form a stable chromogen with hemoglobin, and a salt to adjust conductivity of the reagent for impedance measurement. The reagent composition is mixed with a blood sample without pre-dilution and the UV absorption of the sample mixture is measured at the predetermined absorption wavelength. Counting the number of leukocytes and differential counting of leukocyte subpopulations are accomplished simultaneously on an automated cell counter utilizing DC impedance measurement.

The invention relates to a co-crystal of nifedipine and isonicotinamide, its preparation method and application. The co-crystal of nifedipine and isonicotinamide was comprehensively characterized by means of X-ray single crystal diffraction analysis, X-ray powder diffraction analysis, thermogravimetric analysis, differential scanning calorimetry analysis, and infrared spectroscopy, and it was found that the Compared with nifedipine, the co-crystal has the advantage of higher light stability. The preparation method of the co-crystal of nifedipine and isonicotinamide is simple, easy to control and good in reproducibility, and stable co-crystal of nifedipine and isonicotinamide can be obtained.

The invention discloses a 5-isonicotinamide-pyridyl-isophthalic acid porous copper complex, as well as a preparation method and application thereof. The porous copper complex comprises a (3,6) dual-node three-dimensional topology lattice structure; the chemical formula of the porous copper complex is [Cu(L)].DMAc.H2O, wherein L is 5-isonicotinamide-pyridyl-isophthalic acid radical ion. The preparation method comprises the following steps: solvent thermal reaction between 5-isonicotinamide-pyridyl-isophthalic acid and nantokite, washing, and drying to obtain the novel porous copper complex of which the structure is stable. The preparation method is simple in process, convenient to operate and high in productivity. The 5-isonicotinamide-pyridyl-isophthalic acid porous copper complex obtained according to the method can catalyze the Knovevenagel condensation reaction between benzaldehyde and malononitrile, is high in catalysis selectivity and catalytic activity, and can be effectively recycled and used repeatedly.

The invention discloses a co-crystal of kaempferol and isonicotinamide, a preparation method, a composition and an application thereof. Specifically, the present invention discloses a new kaempferol and isonicotinamide co-crystal with kaempferol (such as formula a) as the active ingredient of medicine and isonicotinamide (such as formula b) as the eutectic ligand; kaempferol The preparation method of the co-crystal with isonicotinamide; the application of the co-crystal of kaempferol and isonicotinamide as active ingredients in the preparation of anti-cancer, anti-cancer, anti-inflammatory, anti-oxidation, antibacterial or antiviral drugs.

The present invention provides a corrective method for converting cyano-group pyridines compound to niacinamide compound. In particular, the invention relates to the preparation of the niacinamide compound and the isonicotinamide compound, it is used for preparing anti-TB medicine-retozide, and an intermediate of vitamin B12. The invention also relates to catalyst preparing method by niacinamide and isonicotinamide.

The present invention discloses an isonicotinamide derivative represented by a formula (I) and a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and A are defined in the specification. The present invention further discloses a preparation method of the compounds, a drug composition containing the compound, and applications of the compounds in treatment of mammal, especially human overproliferation diseases and in preparation of drugs for treatment of mammal, especially human overproliferation diseases. The formula (I) is defined in the specification.

The present invention relates to an improved process for conversion of cyanopyridines to nicotinamides. More particularly the present invention relates to preparation of nicotinamides and isonicotinamides which finds its usage in the preparation of anti-TB drug i.e. isoniazid and as an intermediate of vitamin B12. The present invention also relates to a process for a catalyst useful for the preparation of nicotinamide and isonicotinamide.