27 results about "Isonicotinic acid" patented technology

The application belongs to the field of catalyst and its preparation technology, and particularly relates to a three-dimensional network structure barium complex catalyst and a preparation method and application thereof.The three-dimensional network structure barium complex catalyst is a monoclinic crystal.The preparation method of the three-dimensional network structure barium complex catalyst comprises the following steps: mixing 3-(3-carboxyphenyl)-isonicotinic acid, a barium source and an alkali auxiliary agent in a solvent, heating and reacting, filtering, and standing the filtrate to obtain the three-dimensional network structure barium complex catalyst.The preparation method of the three-dimensional network structure barium complex catalyst has the characteristics of low cost, low toxicity, high selectivity, good stability and green environmental protection when the prepared catalyst with a crystal structure is applied to the preparation of N-(1-phenyl-3-phenylprop-2-yn-1-yl)piperidine.

This invention provides a chemical mechanical polishing (CMP) slurry and its application. The CMP slurry comprises: a catalyst, a stabilizer, an oxidant, a pH adjuster, abrasive particles, a corrosion inhibitor, and water. The corrosion inhibitor is a nitrogen-containing heterocyclic carboxylic acid compound, wherein the nitrogen-containing heterocyclic carboxylic acid compound includes at least one selected from nicotinic acid, isonicotinic acid, pyridinecarboxylic acid, imidazocarboxylic acid, pyrazolecarboxylic acid, 3-pyridineacetic acid, 3-pyridinepropionic acid, 3-methyl-2-pyridinecarboxylic acid, and L-piperidine acid. The CMP slurry provided by this invention can simultaneously polish tungsten and silicon oxide, and can also control the polishing rate of silicon oxide while inhibiting tungsten corrosion, thus making it suitable for different application scenarios. In addition, the CMP slurry has good stability and can maintain its performance even after long-term standing.

The application discloses a nickel-based metal organic framework and a preparation method and detection application thereof. The nickel-based metal organic framework is formed by coordination of 2,6-bis(1H-pyrazol-1-yl) isonicotinic acid (H2BPIA) and nickel ions Ni(II). The H2BPIA and NiCl2·6H2O are prepared by a hydrothermal / solvothermal method in a water-acetonitrile mixed solvent, and the obtained nickel-based metal organic framework has high thermal stability and can be used for detection of marbofloxacin and has the advantages of high selectivity, strong anti-environmental interference capability and fast response speed.

The invention discloses a wide-temperature-range electrolyte and application thereof, and belongs to the technical field of supercapacitors. The wide-temperature-range electrolyte comprises the following components in percentage by mass: 12.5%-15% of lithium salt, 0.3%-1% of [2, 2 '-dinaphthalene]-7-yl trifluoromethanesulfonate, 0.5%-1.5% of a sulfur additive, 0.5%-1% of a lithium salt additive and the balance of an organic solvent, by taking the total volume of the organic solvent as 100%, the volume ratio of the 2-bromo-5-fluoroisonicotinic acid methyl ester to the total volume of the ethylene carbonate and the propylene carbonate to the diethyl carbonate to the ethyl methyl carbonate is (5-10): (10-15): (10-20): (50-65). Experiments prove that by adding the methyl 2-bromo-5-fluoroisonicotinate and the functional [2, 2 '-dinaphthalene]-7-yl trifluoromethanesulfonate into the electrolyte, the high and low temperature discharge performance, especially the low temperature performance, of the supercapacitor can be remarkably improved, and the highest discharge capacity retention rate at-20 DEG C is 84.5%. Therefore, the wide-temperature-range electrolyte prepared by the method can solve the problem that a traditional supercapacitor electrolyte is difficult to consider high and low temperature performance at the same time.

A high-performance benzoxazine composite material and its preparation method are disclosed, relating to the design and manufacturing of flame-retardant benzoxazine composite materials. The composite material comprises a benzoxazine-based phase change material and a silane-crosslinked melamine-isonicotinic acid supramolecular aerogel (Si-MA / IA) encapsulating the benzoxazine-based phase change material. The benzoxazine-based phase change material is prepared by a Mannich reaction of phenolic compounds, octadecylamine, and paraformaldehyde. The Si-MA / IA is prepared by a crosslinking reaction of melamine (MA), isonicotinic acid (IA), and silica sol precursor, followed by freeze-drying. This invention prepares benzoxazine-based phase change materials (BZ-PCMs) through a Mannich reaction and encapsulates them in a silane-crosslinked melamine-isonicotinic acid supramolecular aerogel (Si-MA / IA). This composite material can form a stable char layer at high temperatures to prevent leakage, exhibits excellent synergistic flame-retardant effects, meets the requirements of sustainable development, and has broad application prospects.

The present invention provides a preparation method of tozasertib, which relates to the technical field of medicine. The preparation method provided by the present invention comprises the following steps: (1) reacting methyl 2-cyanoisonicotinate with hydrazine hydrate, and crystallizing to obtain intermediate TPS-1; (2) reacting 4-cyanopyridine with a base, and then reacting completely with TPS-1, followed by filtration, washing and drying to obtain TPS-2a; (3) subjecting TPS-2a to a cyclization reaction with a reaction solvent, and after the reaction is complete, mixing with a crystallization solvent to obtain the product TPS. The product obtained by this process has a relatively high yield, with the highest total yield being about 62%, high purity, with a purity greater than 99.9%; the preparation method is simple, under the conditions of this preparation method, the raw materials react quickly, and at the same time, time-consuming operations such as extraction and concentration are avoided, and the product can be directly obtained by filtration after the reaction, with a short production cycle; the reaction conditions are easy to realize industrial operation.

The invention relates to the technical field of organic synthesis catalysts, and discloses an isononanoic acid catalyst as well as a preparation method and application thereof. The isononanoic acid catalyst comprises a carrier and an active component loaded on the carrier, the carrier is nitrogen-doped activated carbon; the active components comprise a first active component Au and a second active component; and the second active component is selected from one or more than two of Fe, Co and Ni. The isononanoic acid catalyst is higher in catalytic activity, not prone to inactivation and lower in catalyst cost, and meanwhile the preparation method of the isononanoic acid catalyst is mild in reaction condition and environmentally friendly in process; the isononanoic acid is prepared from isononyl alcohol by adopting the isononanoic acid catalyst, the participation of hydrogen peroxide is not needed, the whole process is safe and efficient, the isononanoic acid catalyst is easy to separate from a product, the post-treatment method is simple, the prepared isononanoic acid is higher in purity, and meanwhile, the isononanoic acid catalyst has higher isononanoic acid selectivity and isononyl alcohol conversion rate.

The invention relates to a method for repairing lattice defects in a porous coordination polymer and application of the method in ethylene / ethane separation, and belongs to the technical field of coordination chemical materials. According to the invention, a porous crystal with connector defects is successfully repaired through a directional repair strategy, so that a complete frame structure is obtained. Lattice linker defects caused by steric hindrance of an adjacent carboxylic acid group of isonicotinic acid INA in NTU-70D are successfully repaired by installing additional INA along a specific direction under the assistance of formic acid. In-situ infrared analysis shows that the repaired NTU-70P has more contactable OINA sites in a regular and smooth nano channel, so that the C2H6 adsorption capacity and the C2H6 / C2H4 selectivity of the repaired NTU-70P are remarkably improved, and meanwhile, the repaired NTU-70P shows the capability of efficiently producing high-purity C2H4 (as high as 46.4 mLg <-1 >) from a mixture containing C2H6.

The invention discloses a nickel-based metal organic framework as well as a preparation method and detection application thereof. The nickel-based metal organic framework is formed by coordination of 2, 6-bis (1H-pyrazole-1-yl) isonicotinic acid (H2BPIA) and nickel ions Ni (II), the H2BPIA and NiCl2. 6H2O are prepared in a water-acetonitrile mixed solvent through a hydrothermal / solvothermal method, and the obtained nickel-based metal organic framework is high in thermal stability, can be used for marbofloxacin detection, and can be applied to detection of marbofloxacin. The method has the advantages of high selectivity, high environmental interference resistance and high response speed.

The invention relates to the technical field of perovskite batteries, in particular to a passivation solution for a perovskite film layer interface, a passivation layer, a preparation method of the passivation layer and a battery. The invention provides a passivation solution for a perovskite film interface, the passivation solution comprises a passivator and a solvent, and the passivator comprises a nicotinic acid compound and / or an isonicotinic acid compound. The passivation solution acts on a perovskite film layer interface and can passivate perovskite defects, lone electron pairs of C = O on carboxyl interact with under-coordinated Pb < 2 + >, non-radiative recombination loss can be reduced, defect ion migration is inhibited, meanwhile, the passivation effect is improved through cooperation with different substituted functional groups on pyridine, the quality of a perovskite film layer is improved, and the perovskite film layer is prepared. The ultraviolet light stability of the cell is improved, and the photoelectric conversion efficiency is improved.

This invention discloses a dual-site heterovalent metal MOF material for NO adsorption, its preparation method, and its application, belonging to the field of gas adsorption materials. The chemical formula of this material is [Cu]. Ⅰ (Cu Ⅱ )4(2-TPY)2(IA ‑ )3(NO3 ‑ )2I ‑ O 2‑ ]·(NO3 ‑ The material was prepared by a solvothermal method using the reaction of bis(terpyridine), isonicotinic acid, and cuprous iodide. This material possesses a three-dimensional structure and Cu... Ⅰ / Cu Ⅱ The bimetallic active sites exhibit excellent thermal stability, high specific surface area, and highly selective adsorption capacity for NO. This invention solves the problems of low NO adsorption capacity and poor selectivity of traditional adsorbents in complex flue gas, and can efficiently achieve NO / CO separation. It is suitable for the deep removal and resource utilization of NO in industrial waste gas, and has good cycle stability and application prospects.

The present invention belongs to the technical field of preparation and application of copper ion coordination compounds, and specifically provides a divalent copper ion coordination polymer and a preparation method and application thereof. The present invention uses 1,2-ethylenediamine, isonicotinic acid, and triphenyl phosphite as raw materials to synthesize N,N'-bis(4-pyridinecarboxamide)-1,2-ethane, and then uses it as a ligand to construct a divalent copper ion coordination polymer by a hydrothermal method. The coordination polymer is a triclinic system with a molecular formula of C 21 H 17 CuN2O5 can not only inhibit the activation process of urease apoprotein, but also fill the active pocket of urease well, occupy the active position of urease hydrolysis of urea, and interact with the active site of urease, thereby causing irreversible inhibition of urease activity and achieving the effect of inhibiting urease activity.

The invention belongs to the technical field of preparation of pyridine derivatives, and particularly relates to a method for preparing 4-pyridinemethanol, wherein an acidic aqueous solution is used as a reaction medium, ethyl isonicotinate is used as a raw material, and an electrolytic reaction is carried out at a constant current under normal temperature and pressure to prepare 4-pyridinemethanol. The preparation method of the invention can be carried out at normal temperature and pressure, while avoiding the use of a reducing agent, a transition metal catalyst and an organic solvent, the preparation process is green and environmentally friendly, the obtained 4-pyridinemethanol has a high yield, a strong atom economy, and has a strong market application prospect.

The invention relates to the technical field of chemical synthesis, in particular to a synthetic method of isoniazide, which comprises the following steps: carrying out cyanation reaction on 4-bromopyridine and K4Fe (CN) 6 under the catalytic action of a catalyst Pd / Fe3O4NPs to generate 4-cyanopyridine; 4-cyanopyridine is subjected to a hydrolysis reaction under the alkaline condition to generate isonicotinic acid; isonicotinic acid and hydrazine hydrate are subjected to an amidation reaction under the action of a condensing agent to generate isoniazide. The synthesis method of isoniazide has the advantages of simple operation, good repeatability and cost saving.

The invention provides an organic-inorganic hybrid material with X-ray scintillation performance as well as a preparation method and application of the organic-inorganic hybrid material. The preparation method of the organic-inorganic hybrid material comprises the following steps: fully mixing uranium salt, boric acid (H3BO3), isonicotinic acid and deionized water (H2O), carrying out a heating reaction, and washing and drying a solid product to obtain the organic-inorganic hybrid material with the X-ray scintillation performance. The synthesis method of the material is simple and convenient, mild in reaction condition, low in cost and high in yield. The material provided by the invention can effectively absorb high-energy X-rays and convert the X-rays into visible light, and has the properties of high light output, stable material, strong ray retardation capability and the like. The organic-inorganic hybrid material combines the advantages of organic and inorganic materials, such as structural diversity, tunability and good processability, and provides a new thought for the development of novel scintillation materials.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing 4-acetylpyridine from isonicotinic acid, which comprises the following steps: carrying out esterification reaction on isonicotinic acid and ethanol as raw materials to obtain ethyl isonicotinate, carrying out Claisen ester condensation reaction on ethyl isonicotinate and ethyl acetate to obtain ethyl 3-oxo-3-(4-pyridyl) propionate, and carrying out condensation reaction on ethyl 3-oxo-3-(4-pyridyl) propionate to obtain 4-acetylpyridine. And then carrying out hydrolysis decarboxylation to obtain a target product 4-acetylpyridine. The method for preparing the 4-acetylpyridine is high in yield, easy to amplify and simple and convenient to operate, the product quality is good, and the method has good industrial application value.

The invention relates to a preparation method of topiromilast and an intermediate I and an intermediate II thereof, isonicotinic acid and N-oxidized 4-cyanopyridine are used as starting materials, and the topiromilast is prepared through hydrazinolysis, condensation cyclization and cyanidation. The isonicotinic acid and the N-oxidized 4-cyanopyridine which are selected as starting raw materials are low in price and commercially available; by buckling and then cyaniding, reaction sites of a substrate are few, so that byproducts after cyaniding are few. The preparation method provided by the invention has the advantages of low production cost, high yield, high purity and less three wastes, and is suitable for industrial production of topiromilast.

The present invention discloses a method for preparing isonicotinic acid ester with high conversion rate, which comprises the following steps: (1) Under nitrogen protection, isonicotinic acid, polyhydric alcohol and solid organic acid catalyst are added into a reactor; (2) The reactor is heated to 110-180 °C and reacted for 4-6 hours, and the generated water is separated by a water separator during the reaction process; (3) After the reaction is completed, the product is filtered, neutralized, and distilled under reduced pressure to obtain the isonicotinic acid ester. The water separator contains a water-carrying agent; the solid organic acid catalyst comprises a strongly acidic cation exchange resin and a metal chloride; the strongly acidic cation exchange resin has the structure shown in the following formula A. The method for preparing isonicotinic acid ester with high conversion rate provided by the present invention has high conversion rate and yield, less pollution and simple process flow.

The invention relates to the technical field of organic synthesis, in particular to a 2-(styryl) tetrahydrofuran compound and a preparation method thereof, and the structure of the compound is shown as a general formula (I). The method comprises the following steps: under the protection of an inert atmosphere, reacting tetrahydrofuran, aryl alkyne as shown in a general formula Ar-C = CH, methyl isonicotinate, pinacol borate and alkyl N-hydroxyphthalimide ether under a heating condition, and separating and purifying after the reaction is completed, so as to obtain the compound as shown in the general formula (I). A pyridine-boron free radical is used as a catalyst to induce alkyl N-hydroxyphthalimide ether to be reduced to generate an oxygen free radical, the oxygen free radical is used as an HAT reagent to grab H, then activation of a C-H bond is achieved, and then the two components are coupled to obtain a target product. The method does not need metal participation, the reaction condition is mild, and the substrate range is wide; the method can be used as an ideal alternative way for synthesizing the 2-(styryl) tetrahydrofuran compound.

To provide an oral composition that contains an azulene compound while effectively inhibiting color change thereof.SOLUTION: An oral composition comprising the following components (A) and (B): (A) one or two or more azulene compounds selected from azulene, azulene sulfonic acid and a salt thereof, and guaiazulene; and (B) one or two or more nicotinic acid compounds selected from nicotinic acid, isonicotinic acid, chloronicotinic acid, and salts thereof.SELECTED DRAWING: None

The present application relates to a kind of favipiravir co-crystal and its preparation method, belong to the field of pharmaceutical chemistry.The favipiravir co-crystal includes favipiravir-isonicotinic acid co-crystal, favipiravir-urea co-crystal or favipiravir-orthoaminobenzoic acid co-crystal, the favipiravir co-crystal has good solubility and stability.

The invention discloses an aqueous zinc ion battery electrolyte, an application of isonicotinic acid in an electrolyte additive and a performance prediction method, the electrolyte comprises a water-soluble zinc salt, deionized water and a neutralization additive, the additive comprises isonicotinic acid, N and carboxyl sites in isonicotinic acid can form a strong hydrogen bond effect with protons in the electrolyte, so that the performance of the electrolyte is improved. Interface proton transmission is hindered, and a solvation structure and a bulk phase hydrogen bond of zinc ions do not need to be regulated and controlled, so that an HER process and side reactions derived from the HER process are inhibited; when the electrolyte containing the additive is applied, the extremely ideal cycle life of a Zn / / Zn symmetric battery can be realized at 1mA / cm < 2 > at 1mAh / cm < 2 >, and the extremely high and stable coulombic efficiency of a Zn / / Cu battery can be obtained in thousand times of cycle processes.

The invention discloses a method for liquid-phase stripping of a MoSe2 nanosheet based on a pyridine ionic liquid aqueous solution, which comprises the following steps: placing a blocky material MoSe2 in the pyridine ionic liquid aqueous solution to carry out probe ultrasonic liquid-phase stripping, and carrying out centrifugal washing and drying treatment on dispersion liquid to obtain the MoSe2 nanosheet. Wherein the pyridine ionic liquid is 1-dodecyl pyridine isonicotinic acid [C12py] [C6H5NO2], 1-tetradecyl pyridine isonicotinic acid [C14py] [C6H5NO2] or 1-hexadecyl pyridine isonicotinic acid [C16py] [C6H5NO2]. The invention also discloses a preparation method of the pyridine ionic liquid. According to the method, the operation process is simple, the few-layer MoSe2 nanosheets can be efficiently prepared on a large scale at low cost, the yield of the MoSe2 nanosheets subjected to liquid phase stripping under the optimal condition reaches 37%, and the proportion of the nanosheets with the thickness smaller than 2 nm reaches 80%.

The invention belongs to the technical field of catalysts and preparation thereof, and particularly relates to a barium complex catalyst of a three-dimensional network structure as well as a preparation method and application thereof. According to the barium complex catalyst with the three-dimensional network structure, the barium complex catalyst with the three-dimensional network structure is a monoclinic system. The preparation method of the barium complex catalyst with the three-dimensional network structure comprises the following steps: in a solvent, mixing 3-(3-carboxyphenyl)-isonicotinic acid, a barium source and an alkali auxiliary agent, heating to react, filtering, and standing filtrate to obtain the barium complex catalyst with the three-dimensional network structure. According to the preparation method of the barium complex catalyst with the three-dimensional network structure, provided by the invention, the prepared catalyst has a crystal structure, is applied to preparation of N-(1-phenyl-3-phenylpropyl-2-alkyne-1-yl) piperidine, and has the characteristics of low cost, low toxicity, high selectivity, good stability and environmental protection.

Derivatives of polymethinium salts of the general formula I, where both terminal heteroaromatic groups of the methinium chain are identical or different and are benzothiazole, naphthothiazole, benzimidazole, naphthoimidazole, benzooxazole, naphthooxazole, benzoselenazole, naphthoselenazole, quinoline, benzoquinoline, indole or benzoindole, the particular structure of which is characterized by the groups A, B, X, Y, with one or more R groups on both terminal heteroaromatic groups of the methinium salt, where R is H, C1 to C12 alkyl, glycol chains with 1 to 8 glycol (OCH2CH2) repeating units terminating with an O—C1 to C12 alkyl substituent or OH group, alkyl C1 to C8 sulfonic acids or their corresponding lithium, sodium or potassium salts, allyl, propargyl, phenyl, benzyl, pyridyl, halogen, CH2OR′, OR′, CHF2, CF3, OCF, OCOR′, CN, CHO, COOR′, CONHR′, CONR′2, CONHOR′, CONHNHR′, CONHNR′2, N3, NO2, SR′, SCN, NHR′, NR′2, NHCOR′, NHCONHR′, NHCONR′2, NHCSNHR′, NHCSNR′2, NHSO2NHR′, NHSO2NR′2, NHCOOR′, N(COOR′)2, B(OR′)2, SO3R′, SO2NHR′, SO2NR′2, SO2R′, where R′ is H, alkyl C1 to C12, phenyl, p-tolyl, benzyl, allyl, propargyl, CF3; CH═CH—CH═CH (i.e. a fused benzene nucleus), where X is O, S, Se, CR′2, NR′, CH═CH, where R′ has the above meaning; where A is alkyl C1 to C12, benzyl, allyl, propargyl, a glycol chain with a number of 1 to 8 glycolic (CH2CH2O) repeating units terminating with the substituent R′, (CH2)jCOR′, (CH2)jCOOR′, (CH2)jSO3R′, (CH2)jSO3H, (CH2)jCONHR′, (CH2)jCONR′2, where j is in the range of 1 to 12 and R′ has the above meaning; where B is phenyl, pyridyl, pyrazinyl, quinolyl, quinoxalyl, furanyl, thienyl, benzoxazolyl, benzothiazolyl, which may be further substituted by one or more of the same or different substituents R, where R has the above meaning, where in the case of doubly charged salts the group B is formed by pyridyl or quinolyl quaternized on its nitrogen atom by A, where A is as defined above, where Y is acetate, acetylacetate, adipate, ascorbate, benzoate, besylate, borate, bromide, butanoate, citrate, deoxycholate, dihydrogen phosphate, phenylacetate, fluoride, phosphate, fumarate, gallate, glutarate, hexafluorophosphate, hippurate, hydrogen sulfate, chloride, perchlorate, cholate, isocyanate, isonicotinate, iodide, caprylate, cyanate, lactate, laurate, lithocholate, malate, maleate, malonate, mandelate, mesylate, monohydrogen phosphate, formate, myristate, napsylate, nicotinate, nitrate, nonafluorobutylsulfonate, oleate, oxalate, oxopropanoate, palmitate, picrate, pimelate, propionate, rhodanide, salicylate, sebacate, cinnamate, stearate, suberate, succinate, sulfate, tetrafluoroborate, tosylate, triflate, trifluoroacetate, trichloroacetate, carbonate, valerate, tartrate, and salts of natural amino acids, for the use as an inhibitor of dihydroorotate dehydrogenase.

The invention belongs to the technical field of lithium-sulfur battery materials, and particularly relates to a method for preparing a lithium-sulfur battery based on a cubic alkane tetranuclear copper iodine cluster metal organic framework modified diaphragm coating, and the method comprises the following steps: weighing isonicotinic acid powder, dissolving the isonicotinic acid powder in N, N-dimethylformamide, and after the isonicotinic acid powder is fully dissolved, dropwise adding a proper amount of triethylamine into a solution to obtain a solution A; dissolving cuprous iodide and zinc salt powder in an ethanol solution to obtain a solution B; slowly dropwise adding the solution A into the heated and stirred solution B; putting the solution into a drying oven to react, cooling, washing and drying to obtain a cubic alkane tetranuclear copper iodine cluster metal organic framework crystal material; the prepared crystalline material is ground into slurry, and the slurry is coated on a PP diaphragm for assembling a lithium-sulfur battery. The cubic alkane tetranuclear copper iodine cluster metal organic framework synthesized by solvothermal self-assembly of CuI, Zn < 2 + > and INA ligands is applied to the diaphragm material of the lithium-sulfur battery; the lithium-sulfur battery prepared by the method can efficiently adsorb lithium ions, is beneficial to rapid transmission of the lithium ions, improves the cycle performance of the lithium-sulfur battery, and has the initial capacity of 710.6 mAh.g <-1 > under the current density of 0.1 C.