30 results about "Barbituric acid" patented technology

The invention belongs to the technical field of methyl red azo dye purification, and discloses a methyl red azo dye adsorbent with good adsorption performance on a methyl red azo dye adsorbent, and a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing a first precursor solution and a second precursor solution; the first precursor solution contains melamine, and the second precursor solution contains cyanuric acid and / or barbituric acid; (2) sequentially adding the first precursor solution and the second precursor solution into biomass carbon powder to form a reaction solution; enabling the supermolecule aggregate to grow in situ and coat the surface of the biomass carbon powder under a stirring condition to form a solid-liquid mixture; removing the solvent in the solid-liquid mixture, and drying to obtain a supramolecular composite precursor; (3) carrying out pressure molding on a mixture of the supramolecular composite precursor, silicate clay mineral and nickel salt to obtain a green body; and (4) carrying out heat treatment on the green body to obtain the methyl red azo dye adsorbent.

The invention relates to the technical field of medicine synthesis, and particularly provides a preparation method of Mavaktai. The method comprises the following steps: carrying out nucleophilic substitution reaction on barbituric acid and 2-chloropropane or 2-hydroxypropane to obtain 1-isopropyl barbituric acid; the preparation method comprises the following steps: reacting 1-isopropyl barbituric acid with a chlorination reagent to prepare 6-chloro-3-isopropyl pyrimidine-2, 4 (1H, 3H)-diketone; the preparation method comprises the following steps: carrying out nucleophilic substitution reaction on 6-chloro-3-isopropylpyrimidine-2, 4 (1H, 3H)-diketone and S-1-phenylethylamine under the condition of base catalysis, so as to prepare a crude product of the macavaktai. According to the method, the process operation is simplified, and the cost is reduced.

The invention relates to the technical field of pigment synthesis, in particular to a production process of pigment yellow 139, which comprises the following steps: 1) adding water into barbituric acid, fully dissolving at the temperature of 30-70 DEG C, adjusting the pH value to be less than or equal to 1.8 to form a supersaturated solution, keeping the temperature unchanged, adding 1, 3-diimino isoindoline solid or a mixed solution of the 1, 3-diimino isoindoline solid and the water for multiple times, and reacting the barbituric acid with the 1, 3-diimino isoindoline solid to obtain a mixture; the molar ratio of the 2, 3-diimino isoindoline to the 2, 3-diimino isoindoline is (2.5-4.5): 1, keeping the pH value of the system to be less than 7 in the adding process, and then keeping the temperature at 40-70 DEG 2) crude product separation: after the heat preservation reaction is finished, keeping the temperature of the mixed solution in the step 1) at 50 DEG C or above, and carrying out hot filtration to separate a pigment crude product; 3) pigmentation: adding water into the pigment crude product, preserving heat at 105-130 DEG C for pigmentation within 4-10 hours to obtain a pigment yellow 139 product; and 4) carrying out heating reduced pressure distillation treatment on the filtrate obtained by hot filtration separation in the step 2) to obtain a barbituric acid aqueous solution and ammonia water. The raw material utilization rate is improved.

The invention discloses a polypropylene material which comprises the following components in parts by weight: 68-97 parts of polypropylene; 0.04 to 1.6 parts of polyethyleneimine; 0.05 to 0.6 part of barbituric acid or a derivative thereof; 0-12 parts of a toughening agent; and 0-35 parts of an inorganic filler. By introducing a specific content of polyethyleneimine and barbituric acid or a derivative thereof into the polypropylene material, the volatilization of aldehyde organic matters can be effectively inhibited, and the low glossiness of the polypropylene material can be effectively reduced.

The application discloses a multifunctional high-absorption chrome tanning auxiliary agent containing a barbituric acid structure, and the auxiliary agent is a polycarboxylic acid compound containing a barbituric acid structure. The application discloses a preparation method of the high-absorption chrome tanning auxiliary agent, which comprises four reaction steps, namely, C-alkylation reaction, cyclization reaction, N-alkylation reaction and hydrolysis reaction. The high-absorption chrome tanning auxiliary agent contains 2-3 ketone carbonyl groups and 2-4 carboxyl groups, wherein the ortho ketone carbonyl group and the carboxyl group can be cyclized with arginine in collagen protein, collagen modification is realized, carboxyl groups are introduced, the number of side chain carboxyl groups of collagen is increased, the coordination sites of chromium are increased, the absorption of trivalent chromium can be significantly improved, the concentration of trivalent chromium in chrome tanning wastewater is reduced, the high-absorption chrome tanning target is realized, and clean production of the leather-making industry is promoted. The application provides a new idea for the design and preparation of the high-absorption chrome tanning auxiliary agent.

The invention discloses a preparation method of a light conversion film, which comprises the following steps: step 1, mixing a light conversion material with a solvent to obtain a light conversion material solution with solid content of 5-20 mg / ml, the light conversion material being a barbituric acid organic compound with an aromatic amine structure unit; 2, arranging the light conversion material solution on the film main body through a patterning process; and 3, heating the product obtained in the step 2 to obtain the light conversion film. The solvent is at least one of methylbenzene, chlorobenzene, dimethyl sulfoxide, tetrahydrofuran, chloroform and butyl benzoate. The film main body is prepared from one or more of polyvinyl chloride, polyethylene, polypropylene and ethylene-vinyl acetate copolymer. According to the invention, the patterned light conversion film is formed on the film main body by the light conversion material through a printing / coating method; the light conversion film can make full use of solar energy resources with the wave band of 510 nm to 550 nm, and is suitable for being popularized and applied to crop growth.

The invention discloses a multifunctional copper-based composite catalytic material and a preparation method and application thereof, urea, boric acid and barbituric acid are respectively used as a nitrogen source, a boron source and a carbon source, phthalocyanine is used as a complexing agent, Cu (NO3) 2.6 H2O is used as a metal source, and the multifunctional copper-based composite material with an interspersed two-dimensional nanosheet structure is obtained through heating, stirring, drying, grinding, calcining and the like. The preparation method is simple in synthesis process, high-dispersion Cu metal is modified and loaded on the carbon carrier by constructing a strong covalent coordination effect between a central metal single atom and surrounding coordination atoms and utilizing a Cu-N chemical bond bonding effect, and regulation and optimization of an electronic structure and steric hindrance of the catalyst are realized. The obtained catalytic material can efficiently show high catalytic activity in H2S high-valued reaction catalysis, is not prone to inactivation due to sulfur poisoning, can be recycled, is wide in substrate applicability and large in industrial application prospect, and has important significance.

The application discloses an oil oxidation type time-temperature indicator, which comprises a sealed container which is partially or wholly transparent, vegetable oil and a thio-barbituric acid color developing agent which are packaged in the sealed container. The application mixes the vegetable oil and the thio-barbituric acid color developing agent to prepare an oxidation indicator, and the oxidation degree of food containing the same vegetable oil can be indicated by using the color developing reaction of the vegetable oil oxidation product and the thio-barbituric acid color developing agent, and the color change is irreversible. The oxidation indicator is packaged in the sealed container which is partially or wholly transparent, so that the oil oxidation indicator with small volume, convenient use and direct indication is prepared. The problem that the color change of the existing time-temperature indicator for food containing vegetable oil is not obvious or reversible is solved.

The invention relates to the field of analysis and detection, in particular to a fluorescent probe as well as a preparation method and application thereof. The fluorescent probe provided by the invention is prepared by carrying out condensation reaction on barbituric acid and 2-hydroxy-1-naphthaldehyde in a polar solvent, a carbon-carbon double bond formed by condensation of barbituric acid and 2-hydroxy-1-naphthaldehyde is used as a key pi bridge in a molecule, and a chromophore with a strong intramolecular charge transfer effect is jointly constructed; the fluorescent dye shows cyan appearance and strong green fluorescence in an aqueous solution. After specific reaction with hypochlorite, a conjugated skeleton and an ICT process of the whole molecule are destroyed, so that the color of a solution is changed from cyan to colorless, fluorescence is remarkably quenched, and'off-on 'type detection is realized. The probe has the advantages of quick response, high sensitivity and good selectivity, can be applied to qualitative and quantitative detection of hypochlorite in environmental water quality and biological samples, and supports test paper portable detection.

The application belongs to the technical field of small-molecule organic fluorescent probes, and discloses an imino stilbene fluorescent probe for detecting hydrazine hydrate as well as a preparation method and application of the probe. The probe selects imino stilbene with strong power supply characteristics as a fluorophore, barbituric acid as an acceptor and N2H4 as a recognition part. The probe has excellent rapid response capability and high selectivity, and the fluorescence is quenched from pink after being combined with N2H4. Compared with other fluorescent probes, the application has AIE characteristics, and the fluorescence signal is more stable. Through development of a portable N2H4 recognition test strip, a powerful tool is provided for on-site rapid detection, and the application has broad application prospects. The fluorescent probe has high selectivity and rapid response, and brings significant benefits in the fields of biological imaging, drug screening, environmental monitoring and food safety. The application not only improves the accuracy and efficiency of research, but also helps to solve real-world problems such as environmental protection, drug development and food safety.

This invention relates to a highly sensitive polarity and ONOO ‑ The dual-response fluorescent probe and its preparation method include the following steps: (1) adding 1,3-dicyclohexylbarbituric acid to acetic anhydride, and then adding boron trifluoride diethyl ether to react and obtain an intermediate product; (2) adding 7-(diethylamino)coumarin-3-carboxaldehyde, the intermediate product and piperidine to a first organic solvent, and after heating and reflux, extraction, filtration and recrystallization, obtaining the fluorescent dye LD-YB; (3) preparing the metal-organic framework material UiO with hafnium tetrachloride and organic ligands; (4) adding LD-YB and UiO to a second organic solvent, and reacting to obtain polar and ONOO. ‑ Dual-response fluorescent probe. This invention obtains polar and ONOO fluorescent probes by loading LD-YB onto UiO. ‑ The dual-response fluorescent probe improves detection accuracy and has good hydrophilicity.

The application belongs to the field of electrochemical synthesis, and discloses a method for preparing indane compounds under electrochemical conditions. The method uses inexpensive nickel as a catalyst to realize the cycloaddition reaction of 1,6-diynyl and alkyne under electrolytic conditions at room temperature, and rapidly and efficiently synthesizes indane compounds. The method can be applied to the cycloaddition reaction of 1,6-diynyl derived from the barbituric acid, a sedative and hypnotic, and 2,6-dichloro-5-fluoronicotinic acid ethyl ester, a medical intermediate, and synthesizes indane compounds containing a pharmacologically active fragment. The method has green and mild reaction conditions, does not need heating and uses a noble metal catalyst, has low reaction cost, and has good application value.

The application belongs to the technical field of methyl red azo dye purification, and discloses a methyl red azo dye adsorbent with good adsorption performance on methyl red azo dye, and a preparation method and application thereof. The preparation method comprises the following steps: (1) preparing a first precursor solution and a second precursor solution; the first precursor solution contains melamine, and the second precursor solution contains cyanuric acid and / or barbituric acid; (2) sequentially adding the first precursor solution and the second precursor solution into biomass carbon powder to form a reaction liquid; under stirring, in-situ growth of a supramolecular aggregate is realized and the supramolecular aggregate is coated on the surface of the biomass carbon powder to form a solid-liquid mixture; the solvent in the solid-liquid mixture is removed, and the supramolecular composite precursor is obtained through drying; (3) pressure forming a mixture of the supramolecular composite precursor, a silicate clay mineral and a nickel salt into a green body; and (4) performing heat treatment on the green body to obtain the methyl red azo dye adsorbent.

The invention discloses a preparation method of a vitamin B2 diastereoisomer, which comprises the following steps: adding absolute ethyl alcohol into a high-pressure reaction kettle, adding 3, 4-dimethylaniline, D-arabinose and palladium carbon in a stirring state, introducing hydrogen, heating for reaction, and filtering while hot; cooling, crystallizing and filtering the filtrate, collecting a filter cake, dissolving the filter cake with a hydrochloric acid aqueous solution, adding aniline diazonium salt in a stirring state, after the reaction is completed, adding sodium acetate for crystallizing and filtering, and adding the filter cake into a mixed solution of a solvent A and barbituric acid for reflux reaction; cooling to room temperature and filtering to obtain a vitamin B2 diastereoisomer crude product; adding inorganic acid B into the crude wet filter cake for dissolving, adding into hot water, filtering while hot, and drying the diastereoisomer of the vitamin B2. The whole process steps are simple and easy to operate, all the raw materials required for preparation are common and easily available raw material substances, and meanwhile, the vitamin B2 diastereoisomer prepared by the whole preparation process is relatively high in purity, so that the whole preparation efficiency and quality are ensured.

The invention discloses a barbituric acid-tetraphenyl ethylene derivative as well as a preparation method and application thereof, and particularly provides a compound 6 shown in the specification. The molecules have good self-assembly performance, a supramolecular polymer is assembled through non-covalent interaction of hydrogen bonds and pi-pi accumulation, the aggregation-induced emission effect is achieved in a low-polarity solution, the molecules can be used for designing a dynamic covalent chemical system regulated and controlled by a solvent, detection of environmental changes can be achieved to a certain extent, and the application prospect is wide. And a theoretical basis is provided for construction of intelligent new materials. .

The invention discloses a spiro pyrazolone compound, a preparation method and application, and belongs to the technical field of preparation and application of compounds. Specifically, a barbital diazo compound and a pyrazolone diazo compound are taken as reactants, a transition metal catalyst, an organic ligand and an organic solvent are added, a cross-coupling / spiro-cyclization cascade reaction is carried out under a heating reaction condition, and a target product is generated. The preparation method is mild in reaction condition, high in reaction speed, simple in post-treatment and good in substrate universality. According to the method, the spiro pyrazolone compound with antitumor activity can be obtained with high chemical yield and high chemical / regioselectivity, and an efficient and simple organic synthesis method and technology are provided for research and development of candidate drugs.

The application provides a continuous flow synthesis method of a Bose factor derivative, which comprises flowing reaction of D-glucose and dimethyl barbituric acid under alkaline conditions in a micro-channel reactor to synthesize 2,4(1H,3H)-pyrimidine dione-5-D-glucopyranosyl-6-hydroxy-1,3-dimethyl sodium salt, and flowing reaction of the reaction product with an oxidizing agent in another micro-channel reactor to obtain the Bose factor derivative (2ξ,3ξ)-3,7-dehydrated-N-methyl-D-glucosinamide. The continuous synthesis method of the Bose factor derivative has the advantages of short reaction time, simple operation, high automation degree, cheap and easily obtained reagent, high purity of the obtained product, and few impurities. Meanwhile, the preparation method has the advantages of high safety, large production capacity, high yield, reduced environmental pollution, and good application prospect.

The invention provides a dapinustat solvate and a preparation method thereof, and belongs to the technical field of anti-anemia preparations taking barbituric acid compounds as active substances. The dapinustat solvate is a dapinustat hydrate or a dapinustat DMSO (dimethylsulfoxide) compound, has the characteristics of high purity, difficulty in moisture absorption, good stability and good fluidity, improves the solubility of a conventional dapinustat crystal form, improves the bioavailability of the dapinustat crystal form, is simple in preparation process and low in cost, is suitable for preparation application, and can realize industrial stable production.

The invention discloses a two-stage method industrial continuous production process of a pigment yellow 139 condensation section, relates to the technical field of chemical engineering, and solves the problems that the existing production process is complicated, produced waste gas is inconvenient to recycle, the environment is easily polluted, the safety influence is relatively great, and the product supply is severely insufficient. Dropwise adding part of the phthalocyanine solution and the barbituric acid solution into the R1 reactor at the same time, starting nitrogen at the bottom of the R1 reactor, and generating ammonia gas through gas stripping discharge reaction of the nitrogen; a second reaction stage: extracting the reaction liquid 1 from the reactor R1, continuously dropwise adding the reaction liquid 1 into the reactor R2, dropwise adding a dilute sulphuric acid solution and the remaining phthalocyanine solution, and controlling the dropwise adding speed of the dilute sulphuric acid solution to keep the pH value of the system acidic; and extracting the reaction liquid 2 in the R2 reactor, and treating to obtain the pigment yellow 139. The use amount of sulfuric acid is reduced by 30-60%, and the equipment corrosion risk and the equipment investment are reduced.

The invention discloses a method for decomposing a lithium compound. The method for decomposing the lithium compound includes decomposing the lithium compound by an organic matter. The organic matter is obtained by reacting a nucleophilic compound with a compound containing at least one ethylene unsaturated group. The nucleophilic compound comprises a barbital compound, thiobarbituric acid, cyanuric acid, trithiocyanuric acid or a pyrimidine compound. The compound containing at least one ethylene unsaturated group comprises acrylic epoxy resin, a maleimide compound or a pyrimidine compound. The lithium compound includes lithium carbonate, lithium hydroxide, or a combination thereof. According to the method for decomposing the lithium compound, the reaction temperature is low (for example, 60 DEG C to 150 DEG C), the reaction time is short (for example, 3 hours to 15 hours), and therefore the lithium compound can be decomposed under mild conditions, and the decomposition efficiency is improved.

The application provides a spiro-barbituric acid-epoxyhexane compound and a synthesis method and application thereof. A structural formula of the compound is as follows: wherein, a group R 2 is C 1‑6 alkyl, C 1‑6 alkoxy, hydrogen, halogen, halogenated C 1‑6 alkyl, nitro or naphthyl, a group R 3 is C 1‑6 alkyl, C 1‑6 alkoxy, hydrogen, halogen or naphthyl; and a group R 4 is C 1‑6 alkyl or benzyl. The application further provides a synthesis method of the compound, which comprises using an alkenyl barbituric acid compound and a 1,2-substituted allyl carbonate compound as raw materials, and under the action of a palladium catalyst, a chiral ligand and a base, asymmetric cycloaddition reaction is generated to synthesize a series of spiro-barbituric acid-epoxyhexane compounds. The synthesis method has the advantages of mild reaction condition, simple operation, wide applicable range of substrates, high yield and good stereoselectivity. It is tested that the compound has certain antitumor activity. The application provides an application of the compound in preparation of an antitumor drug.

The invention provides a continuous flow synthesis method of a bose derivative, which comprises the following steps: carrying out flow reaction on D-glucose and dimethyl barbituric acid in a micro-channel reactor under an alkaline condition to synthesize 2, 4 (1H, 3H)-pyrimidinedione-5-D-glucopyranosyl-6-hydroxyl-1, 3-dimethyl sodium salt, and carrying out continuous flow reaction on the 2, 4 (1H, 3H)-pyrimidinedione-5-D-glucopyranosyl-6-hydroxyl-1, 3-dimethyl sodium salt to obtain the bose derivative. Then the reaction product and an oxidizing agent are subjected to a flow reaction in another micro-channel reactor, and the boine derivative (2xi, 3xi)-3, 7-anhydro-N-methyl-D-glucose caprylamide is obtained; the continuous synthesis method of the bose derivative, provided by the invention, has the advantages of short reaction time, simplicity and convenience in operation, high automation degree, cheap and easily available reagents, high purity of the obtained product and few impurities. Meanwhile, the preparation method is high in safety, large in productivity, high in yield and capable of reducing environmental pollution and has a good application prospect.

The invention provides barbituric acid modified coumarin derivatives as well as a synthesis method and application thereof, and relates to the field of coumarin derivatives. The synthesis method of the barbituric acid modified coumarin derivative comprises the following steps: primary reaction and secondary reaction. According to the barbituric acid modified coumarin derivative, the fluorescence analysis accuracy and sensitivity of the barbituric acid modified coumarin derivative as a fluorescent dye can be effectively improved, the Stokes shift is increased, the problems of low signal-to-noise ratio and self-quenching caused by crosstalk among fluorescent substances, dye excitation and emission spectrums are effectively avoided, and the luminescence property stability is improved; the invention also expands and provides a fluorescent probe which is sensitive to polarity and can carry out lipid droplet labeling imaging on the coumarin derivative.

The present application belongs to the technical field of heterocyclic compounds, and particularly relates to a method for preparing 5-ethyl-5-isopentyl malonyl urea by acidifying and crystallizing 5-ethyl-5-isopentyl barbituric acid sodium. Cycloalkane and alicyclic ketone mixed solvents are added to 5-ethyl-5-isopentyl barbituric acid sodium filtrate, hydrochloric acid is added dropwise for acidification and crystallization, centrifugation, ethyl acetate elution, and drying, so as to obtain 5-ethyl-5-isopentyl malonyl urea. The present application adds cycloalkane and alicyclic ketone mixed solvents to 5-ethyl-5-isopentyl barbituric acid sodium filtrate, and controls the pH value of the system to 2.2-2.8 by using hydrochloric acid for acidification and crystallization, so that the crystallization effect is greatly improved. The present application creatively improves the existing acidification and crystallization system, adds cycloalkane and alicyclic ketone to the ethanol aqueous solution, reduces the polarity of the system, controls the pH value of the system, and successfully reduces the twice crystallization process in the prior art to once.

The application provides a viscosity and SO2 dual-response fluorescent probe, a preparation method and application thereof, and belongs to the technical field of organic small-molecule fluorescent probes.The fluorescent probe of the application takes barbituric acid and derivatives as an electron donor (Donor, D), and 3-quinoline formaldehyde iodonium salt as an electron acceptor (Acceptor, A) to construct a fluorescent molecular probe with a D-2A pi system based on Knoevenagel condensation reaction.The probe realizes high selectivity to viscosity by using a twisted intramolecular charge transfer effect; after a 1,4-Michael addition reaction occurs between the 4-position of the quinoline iodonium salt and SO2, the quinoline iodonium salt is converted from an electron acceptor to an electron donor, thereby causing a fluorescence signal change to achieve the purpose of detecting SO2, and the viscosity response signal and the SO2 response signal do not cross.The fluorescent probe of the application has the advantages of high sensitivity, low interference and low toxicity, and can be used for detecting viscosity and SO2 in actual samples such as saccharides, lake water and food viscous agents, and has a wide application prospect in the field of biomolecule detection and actual samples.

The invention discloses an up-conversion luminescent nanoprobe, a preparation method and application thereof, and a portable 5-hydroxymethylfurfural detection device, and relates to the technical field of analytical chemistry, the up-conversion luminescent nanoprobe comprises UCNPs, p-toluidine and barbituric acid; the p-toluidine-barbituric acid composite system is used as a recognition unit of the 5-HMF, the UCNPs are used as a near-infrared energy donor, green UCL of the UCNPs is selectively quenched through an inner filter effect in the presence of the 5-HMF, red UCL is kept stable, background-free fluorescence, high-sensitivity and visual detection of the 5-HMF can be achieved, and the application prospect is wide. The method has a wide application prospect in the field of on-site rapid detection of 5-HMF in food.

The invention discloses a spiro barbital compound, a preparation method and application, and belongs to the technical field of preparation and application of compounds. Specifically, a barbital diazo compound and pyrazolone exocyclic olefin are used as reactants, a transition metal catalyst and an organic ligand are added, under the heating reaction condition, a three-molecule metal carbene mediated metathesis / spirocyclization cascade reaction is carried out, and the novel spiro barbital compound with antitumor activity is prepared. The preparation method has the characteristics of high chemical yield, high chemical / regioselectivity, mild reaction conditions, high universality of reaction substrates and the like. The spiro barbital compound obtained by the organic synthesis technology has obvious drug-likeness structural characteristics, and has important medicinal research and development values.

The application discloses a barbituric acid macrocycle compound and a preparation method and application thereof. The structural formula of the barbituric acid macrocycle compound is shown as formula I, formula II, formula III or formula IV. The barbituric acid macrocycle compound and an assembly thereof can be used for separating organic small molecules. When the barbituric acid macrocycle compound is applied, the barbituric acid macrocycle compound or the assembly thereof is filled as a filler in a filter column, and the separation of the organic small molecules is realized through a column chromatography method. In the application, inexpensive and readily available raw materials are selected, starting from several inexpensive and readily available reagents such as substituted malonyl chloride, substituted ketone compounds, 1,3-dibenzyl bromide and substituted barbituric acid. Through simple nucleophilic substitution reaction and dehydration condensation reaction, the barbituric acid macrocycle compound with multiple substitutions can be quickly prepared, and can be applied to the separation of dyes, and has good practicability and application prospect.

The application discloses a preparation method of super-drawing carbon fibers, the carbon fibers and application, and relates to the technical field of inorganic materials. The method comprises the following steps: preparing a spinning solution with 10-40wt% of polyacrylonitrile; adding 2,4,6-triaminopyrimidine and barbituric acid into the spinning solution, and the total amount of the two accounts for 1-20wt% of the polyacrylonitrile, to obtain a spinning stock solution; after dry spraying and preforming the spinning stock solution, the spinning stock solution is put into a coagulation bath solution at 0-10 DEG C, and low-temperature coagulation bath treatment is carried out at a drawing ratio of 1-10, to obtain nascent fibers; the nascent fibers are made into original fibers, and the original fibers are made into carbon fibers through pre-oxidation and carbonization processes. The addition of the supramolecular gel promoter enables the spinning stock solution to be quickly gelled in the coagulation bath, and then high-drawing can be applied to the nascent fibers. The carbon fibers prepared through the super-drawing gel spinning technology have perfect graphite structures, good orientation and reduced defects, and the fiber strength is improved.

The present invention discloses the use of 1,3-dicyclohexylbarbituric acid combined with dexamethasone in the preparation of a drug for treating leukemia. Experimental testing shows that 1,3-dicyclohexylbarbituric acid can increase the sensitivity of leukemia to dexamethasone. In vitro testing using the glucocorticoid-resistant acute T lymphocytic leukemia cell line Jurkat reveals that 1,3-dicyclohexylbarbituric acid and dexamethasone have a significant synergistic effect on Jurkat cells, and 1,3-dicyclohexylbarbituric acid can enhance the sensitivity of Jurkat cells to dexamethasone in a concentration- and time-dependent manner. The combination of 1,3-dicyclohexylbarbituric acid and dexamethasone can induce G1 arrest in Jurkat cells and regulate GR / BIM and JAK2 / STAT3 signal transduction to activate the caspase cascade reaction, thereby inducing Jurkat cell apoptosis. The 1,3-dicyclohexylbarbituric acid of the present invention has the potential to become a dexamethasone sensitizer, and also provides a research basis for the development of drugs to overcome glucocorticoid resistance.