An imino stilbene fluorescent probe for detecting hydrazine hydrate, a preparation method and application thereof

By designing an iminostilbene-derived fluorescent probe, the problems of aggregation quenching and long response time of fluorescent probes in the detection of hydrazine hydrate were solved, achieving highly selective detection with long emission wavelength and fast response, which is suitable for bioimaging, drug screening, environmental monitoring and food safety.

CN118388456BActive Publication Date: 2025-12-05TIANJIN UNIV
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Patent Information

Application Number
CN202410548428.3
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-05-06
Publication Date
2025-12-05
Estimated Expiration
2044-05-06

AI Technical Summary

Technical Problem

Existing fluorescent probes for the detection of hydrazine hydrate suffer from drawbacks such as aggregation-induced quenching (ACQ), long response time, short emission wavelength, and small Stokes shift, resulting in large detection errors and limiting their application in environmental monitoring.

Method used

An iminostilbene-derived fluorescent probe with a D-π-A structure was designed. Using iminostilbene as the fluorophore and barbituric acid as the acceptor, a probe molecule with AIE properties was formed by linking them through a benzene ring for the detection of hydrazine hydrate.

Benefits of technology

It achieves long emission wavelength, fast response and high selectivity detection of hydrazine hydrate, overcomes the aggregation quenching effect of traditional probes, and improves the accuracy and efficiency of detection.

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Abstract

The application belongs to the technical field of small-molecule organic fluorescent probes, and discloses an imino stilbene fluorescent probe for detecting hydrazine hydrate as well as a preparation method and application of the probe. The probe selects imino stilbene with strong power supply characteristics as a fluorophore, barbituric acid as an acceptor and N2H4 as a recognition part. The probe has excellent rapid response capability and high selectivity, and the fluorescence is quenched from pink after being combined with N2H4. Compared with other fluorescent probes, the application has AIE characteristics, and the fluorescence signal is more stable. Through development of a portable N2H4 recognition test strip, a powerful tool is provided for on-site rapid detection, and the application has broad application prospects. The fluorescent probe has high selectivity and rapid response, and brings significant benefits in the fields of biological imaging, drug screening, environmental monitoring and food safety. The application not only improves the accuracy and efficiency of research, but also helps to solve real-world problems such as environmental protection, drug development and food safety.
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