11 results about "Indane" patented technology

This invention relates to the field of pharmaceutical intermediates, and in particular to a method for synthesizing chiral indane. The method uses indane as a raw material, synthesizes an oxime, then an enamine, and subsequently synthesizes the trans-chiral indane via an asymmetric hydrogenation reaction using a ruthenium chiral bisphosphine catalyst, achieving high yield and high stereoselectivity. The advantages of this invention are: in the asymmetric hydrogenation reaction of the enamine, the trans-chiral indane is obtained with a content greater than 97%, an ee of 95%, and a yield greater than 90%; the catalyst is readily available; the operation is simple; the raw materials are readily available; there is minimal pollution from waste; and energy consumption is low, making it suitable for industrial production.

The invention provides a method for obtaining high-purity naphthalene by extracting and removing sulfurindene. The method comprises the following steps: step 1, mixing industrial naphthalene and a solvent according to a preset proportion to obtain a solid-liquid mixture; 2, grinding the solid-liquid mixture to obtain naphthalene powder slurry; and 3, carrying out solid-liquid separation on the naphthalene powder slurry to obtain purified naphthalene powder. Compared with an extraction method for purifying the naphthalene, the method has the advantages that the naphthalene does not need to be dissolved at a relatively high temperature during extraction, so that the dissolving and recrystallization processes are omitted; meanwhile, the temperature is generally 60-80 DEG C when the naphthalene is dissolved by the solvent, and then the temperature is reduced to room temperature for cooling crystallization. The naphthalene does not need to be dissolved, so that the solvent does not need to be heated, and the energy consumption caused by heating the solvent is reduced. Compared with a distributed crystallization method for purifying naphthalene, the method has the advantages that the frequency of distributed crystallization is remarkably reduced, and the energy consumption is reduced.

The application belongs to the technical field of proton exchange membrane fuel cells, and discloses an imidazole high-temperature proton exchange membrane with a twisted structure and a preparation method thereof. One of 1-methyl-1H imidazole-2-formaldehyde, 1-ethyl-1H imidazole-2-formaldehyde, 1-propyl-1H imidazole-2-formaldehyde, 1-butyl-1H imidazole-2-formaldehyde, tetramethyl tetrahydro-spirobi[indane]-diol, trifluoroacetic acid and trifluoromethane sulfonic acid is used as catalysis, and a copolymer is synthesized by polycondensation, so that a full-carbon skeleton aromatic polymer with a spiro twisted microporous structure is obtained, and a copolymer membrane material is obtained. The copolymer membrane material is doped with phosphoric acid. The application has low preparation cost, mild reaction condition, compact or dense structure of the membrane material, transparency, uniformity and density, and good electric conductivity and mechanical properties.

The application belongs to the field of electrochemical synthesis, and discloses a method for preparing indane compounds under electrochemical conditions. The method uses inexpensive nickel as a catalyst to realize the cycloaddition reaction of 1,6-diynyl and alkyne under electrolytic conditions at room temperature, and rapidly and efficiently synthesizes indane compounds. The method can be applied to the cycloaddition reaction of 1,6-diynyl derived from the barbituric acid, a sedative and hypnotic, and 2,6-dichloro-5-fluoronicotinic acid ethyl ester, a medical intermediate, and synthesizes indane compounds containing a pharmacologically active fragment. The method has green and mild reaction conditions, does not need heating and uses a noble metal catalyst, has low reaction cost, and has good application value.

The invention relates to the field of organic synthesis, relates to a method for splitting trans-2, 6-dimethyl-1-indene amine, and in particular relates to a method for obtaining (1R, 2S)-2, 6-dimethyl-1-indene amine by splitting trans-2, 6-dimethyl-1-indene amine by utilizing a chiral inulin compound. The method comprises the following steps: reacting a chiral inulin compound with trans-2, 6-dimethyl-1-indene amine under a heating condition to generate salt, cooling and crystallizing, and hydrolyzing the obtained solid under an alkaline condition to obtain (1R, 2S)-2, 6-dimethyl-1-indene amine. The chiral chrysanthemic acid compound is adopted as a resolving agent, a traditional amino acid derivative resolving agent is replaced, good durability and stability are achieved, and by optimizing resolving conditions and technological parameters, a universal solvent which is widely applied in the market, low in price and easy to obtain serves as a solvent system, and the resolution efficiency is improved. The resolution with high yield (greater than 97%) and high optical purity (ee value greater than 98%) is realized.

The compounds represented by formula (I) or (II) are provided herein, or a pharmaceutically acceptable salt, or a prodrug or bioisostere thereof; where R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, R2a', R2b', R2c', R3', R4', R5', R6a', R6b', Y, Y', and the subscripts mn are defined herein.

The invention relates to a racemization method of trans-chiral indene amine, belonging to the field of organic synthesis. The method comprises the following steps: adding chiral indene amine and a phase transfer catalyst into a solvent, adding an oxidant, carrying out an oxidation reaction for 14-16 hours, washing and desolventizing an oil layer to obtain an intermediate imine chloride, and carrying out catalytic hydrogenation to obtain racemic trans-indene amine. The invention aims to realize racemization and cyclic utilization of ineffective body chiral indene amine through oxidation and reductive hydrogenation of low-drug-effect or ineffective trans-chiral indene amine so as to achieve the purposes of saving raw materials, reducing resource waste and saving indene amine production cost.

The invention relates to the technical field of chemical production, and discloses an industrial impurity removal method for recycling indane and application. In order to solve the problem that a pentamethylindane solution recovered from galaxolide rectification contains impurities and affects the subsequent reaction, the method comprises the following steps: firstly, adding anhydrous aluminum trichloride into the recovered solution, and reacting at a set temperature according to a specific mass ratio; after reaction, preserving heat, adding water for washing, layering and taking an oil phase; adding alkali liquor with specific concentration and proportion into the oil phase to neutralize, and layering to remove the water phase, so as to obtain purified pentamethylindane. The method has the advantages of high impurity removal efficiency, effective recovery of the reaction activity of pentamethylindane, simple process, easy industrialization, mild conditions, efficient recovery and purification of pentamethylindane in galaxolide production, and improvement of the utilization rate and economy of production materials.

The invention relates to the technical field of chemical production, and discloses a synthetic method and equipment of indane alcohol. The method comprises the following steps: adding pentamethylindane and aluminum trichloride into a reaction kettle to form an initial mixture, and simultaneously preparing a mixed solution of chlorobenzene and epoxypropane; dropwise adding the mixed solution into the initial mixture under continuous stirring, performing continuous circulating cooling through an external circulating heat exchange system formed by a tubular heat exchanger in the dropwise adding process, and controlling the reaction temperature to be within a preset low-temperature range; after dropwise adding, preserving heat and stirring, and then quenching, separating, washing and performing reduced pressure distillation to obtain a product. According to the Friedel-Crafts alkylation reaction device and method, through the integrated tubular heat exchange and automatic temperature control strategy, the problems that Friedel-Crafts alkylation reaction releases heat violently and the temperature is prone to being out of control are effectively solved, stable control over the reaction process is achieved, the reaction yield and product selectivity are remarkably improved, the production period is shortened, energy consumption is reduced, and the device and method have good industrial application prospects and are suitable for industrial production. And a foundation is provided for the development of a continuous reaction process.

The application discloses a molecular fluorescent probe for detecting Hg 2+ , and a preparation method and application thereof, and has a structural formula: the preparation method comprises the following steps: firstly, reacting phenoxazine with 1-bromoethane to obtain compound A; then, generating compound B under the action of DMF and POCl3; and finally, reacting with 1,3-indane diketone to obtain the molecular fluorescent probe. The molecular fluorescent probe has the advantages of simple structure, convenient synthesis, easily obtained raw materials, low cost, high selectivity and high sensitivity, and has important practical application values for detecting samples containing Hg 2+ in the environment.