25 results about "Phosphoramide" patented technology

The invention discloses a chiral alpha-amino acid with a C3 symmetric structure and a preparation method and application thereof, the chiral alpha-amino acid with the C3 symmetric structure provided by the invention is used as an ion pair catalyst, and the structure of the chiral alpha-amino acid with the C3 symmetric structure is more stable than that of other ion pair catalysts due to the C3 symmetric structure; and meanwhile, the chiral phosphamide compound is successfully constructed with relatively high yield (70-80%) and enantioselectivity (80-95%), so that the chiral phosphamide compound has excellent catalytic performance, and the problem that the chiral phosphamide compound is difficult to construct by a traditional ion pair catalyst is solved.

The invention provides a preparation method of a phosphoramidite compound. The preparation method comprises the following steps: (1) mixing a nitrogen-containing compound and an acid-binding agent with a first solvent to obtain a first mixed solution; mixing phosphorus trichloride with a second solvent to obtain a second mixed solution; mixing aromatic diphenol with a third solvent to obtain a third mixed solution; (2) pumping the first mixed solution and the second mixed solution obtained in the step (1) into a first micro-mixer, and then enabling the first mixed solution and the second mixed solution to enter a first micro-channel reactor for reaction to obtain a reaction solution containing monochlorophosphoramidite; (3) enabling the reaction solution containing the monochlorophosphoramidite obtained in the step (2) and the third mixed solution obtained in the step (1) to enter a second micro-mixer, and then enabling the mixture to enter a second micro-channel reactor for reaction to obtain a phosphoramidite compound; the acid-binding agent is a polyether tertiary amine compound. The preparation method is short in reaction time and high in product yield.

The invention belongs to the field of organic small molecule synthesis, and particularly relates to a synthesis method of a biphosphamide compound, the structural formula of the biphosphamide compound is shown in the specification, and the synthesis method comprises the following steps: by taking N, N-dimethylformamide (DMF) as a reaction solvent, under the action of an oxidizing agent and acid, carrying out a reaction on the reaction solvent to obtain the biphosphamide compound. And carrying out a free radical mediated deoxidation double phosphating reaction with an equivalent amount of phosphine oxide compound to obtain the bisphosphamide compound. Wherein Ar is aryl, A is a straight chain or a 5-7-membered ring, R is hydrogen, alkyl or aryl, and R'is alkyl or aryl. According to the method, equivalent oxime and phosphine oxide compounds are taken as reactants, under the action of cheap protonic acid and oxidizing agent, the synthesis of the deoxidized double phosphating product biphosphamide compound can be economically and efficiently realized, and the method is good in substrate universality, mild in reaction condition, simple in process, safe and easy to operate.

The present invention concerns optimized microbubbles, in particular lipid microbubbles, which can be used in the prevention and treatment of diseases or for marking.The invention relates in particular to a lipid microbubble, comprising at least one cationic compound selected from lipophosphoramidates, histidylated polyethylenimines, and any mixture thereof. The microbubble preferably further comprises at least one agent selected from a therapeutic agent, a targeting agent, a marking agent, and any combination thereof.The invention also relates to a method for producing this microbubble.The present invention also relates to a composition, in particular a pharmaceutical composition, and a kit, comprising at least one of these microbubbles. The present invention also relates to the use of these microbubbles, composition, kit, as a medicament or as a marking agent.

The invention discloses a synthesis process of chiral UNA phosphoramidite, phosphoryl chloride and phosphoramidite and application of the chiral UNA phosphoramidite, phosphoryl chloride and phosphoramidite in oligonucleotides, and particularly designs preparation and synthesis of (2S)-UNA monomer phosphoramidite, phosphoryl chloride and phosphoramidite. And the method can also be used for solid-phase synthesized oligonucleotides in the conventional 3-to-5 direction, and the influence of introduction of monomers with different chirality to design sites on the structure, the biological activity and the like is researched.

The invention relates to the technical field of chemical synthesis, and discloses a phosphorus-boron-nitrogen multi-element synergistic flame retardant based on aminobiphenyl and a preparation method thereof.The preparation method comprises the steps that 2, 4-dinitrophenol is dissolved in a reaction solvent containing aniline, a reaction is conducted in the hydrogen atmosphere under the action of a catalyst, and 2-aminobiphenyl is obtained; the preparation method comprises the following steps: dissolving 2-aminobiphenyl in an organic solvent to form a reaction base solution, adding a phosphoryl chloride compound into the reaction base solution, and condensing to obtain a phosphamide product; and dissolving the phosphamide product in an organic solvent system, adding a boron compound, and reacting to obtain the flame retardant. The flame retardant takes aminobiphenyl as a framework, and a phosphorus-containing unit and a boron-containing unit are introduced to the framework, so that molecules contain flame-retardant elements of phosphorus, boron and nitrogen, the synergistic effect of gas-phase flame retardance and condensed-phase charring is realized, the limit oxygen index and the vertical combustion performance are improved under the condition of relatively low addition amount, and the peak heat release rate and the smoke density are reduced; and after being subjected to damp-heat aging, the flame-retardant plastic still has a relatively high flame-retardant property retention rate.

The invention relates to continuous reaction equipment of N-n-butyl thiophosphoric triamide and a preparation method of the N-n-butyl thiophosphoric triamide. The invention discloses a continuous preparation method of N-n-butyl thiophosphoric triamide and reaction equipment, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: uniformly mixing thiophosphoryl chloride serving as an initial raw material with a solvent in a batching kettle to prepare a thiophosphoryl chloride solution; the method comprises the following steps: respectively adding a thiophosphoryl chloride solution, n-butylamine and inert gas into a micro-channel reactor through a flow pump to carry out substitution reaction, and separating hydrogen chloride gas and an N-n-butyl dichlorothiophosphoramide solution through a gas-liquid separator; then adding the N-n-butyl dichlorophosphoramide thiophosphate solution and liquid ammonia into a tubular reactor through a flow pump to obtain an N-n-butyl thiophosphoric triamide solution; and finally, extracting, washing, concentrating an organic phase, crystallizing, separating and drying to obtain the high-purity N-n-butyl thiophosphoric triamide. The method is safe, efficient, simple and convenient to operate, good in reaction selectivity, high in yield, low in pollutant emission, low in production cost and suitable for industrial production.

This invention relates to the field of flame retardant preparation technology, and more particularly to a method for preparing an environmentally friendly and highly efficient flame-retardant polyolefin cable sheath material. The invention uses compounds containing primary amino and amide bonds and compounds containing phenyl and phosphoryl chloride groups as raw materials. The reaction is carried out at room temperature for 0.5-1 h, then heated to 45 °C for 3-4 h, and then to 65 °C for 5-6 h. Through a condensation reaction, a phosphoramide macromolecular flame retardant containing phenyl and amide bonds is obtained, with a yield as high as 80.5-95.6%. This flame retardant is added to polyolefin cable sheath material at a mass ratio of 25%, then compounded and extruded to obtain a halogen-free flame-retardant polyolefin cable sheath material. The flame retardant molecule prepared by this invention simultaneously contains phosphorus and nitrogen flame-retardant elements and amide bonds forming a char skeleton. During combustion, it can exert a phosphorus-nitrogen synergistic flame-retardant effect and promote the catalytic char formation of the matrix, which can significantly reduce the heat and toxic gas release of polyolefin cable sheath material during combustion, thereby providing protection for the lives of people in fire scenes.

The invention discloses a preparation method of a phosphoric acid amide modified carbon nitride material for treating uranium-containing wastewater. The method comprises the following steps: 1, calcining dicyandiamide at high temperature, cooling and grinding to obtain blocky carbon nitride; 2, thermally stripping the blocky carbon nitride, and performing thermal treatment under ammonia gas to obtain flaky carbon nitride with amino on the edge; 3, carrying out gas-solid phase reaction on the flaky carbon nitride and sodium hypophosphite, and then carrying out annealing treatment to obtain a phosphoric acid amide modified carbon nitride material; a phosphoric acid amide group is introduced into a framework of the material to form an intramolecular dipole structure; the material is used as a photocatalyst to be added into uranium-containing wastewater for photocatalytic reaction. The functional photocatalyst with strong intramolecular polarity is constructed by accurately introducing a phosphoric acid amide group into a carbon nitride skeleton, has strong adsorption and efficient photocatalytic reduction capabilities on uranyl ions, and can efficiently and stably treat hexavalent uranium in uranium-containing wastewater into tetravalent uranium in an open water system without a sacrificial agent; the method is suitable for uranium-containing wastewater field.

This invention discloses a high-temperature resistant nylon resin and its synthesis method. The high-temperature resistant nylon resin is synthesized from the following raw materials: 1,5-pentanediamine, terephthalic acid, glutaric acid, phosphoramide salt, toluene diisocyanate, organic copper chrome black, acrylate copolymer, and a high-temperature antioxidant. This high-temperature resistant nylon resin possesses excellent mechanical properties, flame retardant properties, and laser direct forming properties, and can be widely used in communication fields requiring flame retardancy and laser direct forming capabilities.

The invention relates to the technical field of polyurethane, and discloses a water-based polyurethane fireproof coating and a preparation method thereof, pentaerythritol diphosphate diphosphoryl chloride, 4-methoxy-L-phenylalanine, pyridine hydrochloride and the like are used as reactants to prepare a novel carboxyl-containing water-based flame-retardant chain extender, and the water-based flame-retardant chain extender is used as a fire retardant. And carrying out polymerization reaction with dihydric alcohol and diisocyanate monomer to obtain the waterborne polyurethane fireproof coating. The polyurethane water-based emulsion is good in dispersity, high in emulsion stability and excellent in hardness; meanwhile, a nitrogen-phosphorus flame-retardant structure of the bis-spirophosphamide is grafted into a polyurethane molecular chain, so that the combustion limit oxygen index of the polyurethane film material is remarkably improved and reaches 27.9-29.6%, and the UL-94 grade reaches V-0.

Provided are a hydration method for a lyophilized cyclophosphamide composition and a composition and preparation prepared thereby. The hydration method comprises: (a) providing an aqueous solution comprising cyclophosphamide and an optional pharmaceutically acceptable excipient; (b) freeze-drying the solution to obtain a lyophilized composition; and (c) hydrating the lyophilized composition by using liquid water to obtain the product.

This invention discloses a high-temperature resistant polyamide resin and its synthesis method. The high-temperature resistant polyamide resin is synthesized from the following raw materials: 1,5-pentanediamine, terephthalic acid, glutaric acid, phosphoramide salt, 2,2'-(1,3-phenylene)-dioxazoline, organic carbon nanotubes, benzoic acid, and a high-temperature resistant antioxidant. This high-temperature resistant polyamide resin possesses excellent mechanical properties, flame retardant properties, and electromagnetic shielding properties, and can be widely used in communication devices requiring flame retardancy and electromagnetic shielding.

This invention discloses a magnetic wicking wire and its preparation method, belonging to the field of magnetic composite material technology. The magnetic wicking wire comprises the following raw materials in parts by weight: 10-20 parts of modified styrene-based thermoplastic elastomer; 80-85 parts of modified magnetic powder; 0.5-1 parts of antioxidant; and 0.5-1 parts of lubricant. The modified styrene-based thermoplastic elastomer is a naphthenic oil-toughened styrene-based thermoplastic elastomer. The modified magnetic powder is hyperbranched polyphosphoramide-coated isotropic samarium iron nitrogen magnetic powder. This invention uses isotropic samarium iron nitrogen magnetic powder, fundamentally eliminating the orientation step required in traditional processes. Magnetization is performed simultaneously during extrusion, and a high-performance, high-elasticity magnetic wicking wire can be obtained after winding without secondary magnetization, simplifying the process.

The invention discloses a trifluoromethyl-containing phosphamide compound and an electrochemical synthesis method thereof, and belongs to the field of organic synthesis, and the structural formula of the trifluoromethyl-containing phosphamide compound is shown in the specification; wherein R is cyclopropyl, methyl, n-butyl, phenyl, p-tolyl, m-methylphenyl, p-methoxyphenyl, p-isopropyl phenyl, p-tert-butylphenyl, p-fluorophenyl, p-chlorphenyl, p-bromophenyl, p-ethoxycarbonyl phenyl, benzyl, o-methylbenzyl, m-methylbenzyl, p-methylbenzyl, p-methoxybenzyl, p-isopropyl benzyl, p-tert-butylbenzyl, p-fluorobenzyl, p-chlorophenyl, p-bromophenyl, p-ethoxycarbonyl phenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, the compound is one of p-chlorobenzyl, p-bromobenzyl, p-chlorobenzyl, p-bromobenzyl and pyridine-3-yl. According to the invention, the preparation of the trifluoromethyl-containing phosphamide compound is realized under mild conditions without additional chemical oxidants.

This invention relates to the field of polyurethane technology and discloses a waterborne polyurethane fire-retardant coating and its preparation method. A novel carboxyl-containing waterborne flame-retardant chain extender is prepared using pentaerythritol diphosphate bisphosphonate chloride, 4-methoxy-L-phenylalanine, and pyridine hydrochloride as reactants. This chain extender is then polymerized with diol and diisocyanate monomers to obtain the waterborne polyurethane fire-retardant coating. The waterborne polyurethane emulsion exhibits good dispersibility, high emulsion stability, and excellent hardness. Furthermore, the nitrogen-phosphorus flame-retardant structure of bisspirocyclic phosphoramide is grafted into the polyurethane molecular chain, significantly improving the limiting oxygen index of the polyurethane film material to 27.9-29.6%, achieving a UL-94 rating of V-0.

The invention discloses a novel alkaline hydrogen bond-assisted chiral bicyclic guanidine ion pair catalyst and its preparation and application, the present invention carries out certain structural transformation to traditional PN ion pair catalyst, without destroying the original structural basis, adds the structure of hydrogen bond, makes this novel H PN in various asymmetric catalytic reactions can play the dual role of hydrogen bond and ion pair catalysis, successfully constructs chiral phosphoramide compounds with higher yield (70% 80%) and enantioselectivity (80% 90%), solves the problem that traditional ion pair catalyst is difficult to construct chiral phosphoramide compounds. With phosphoryl chloride or secondary phosphorus oxide as substrate, various primary amine secondary amines as nucleophilic reagent, using 4% 10% catalyst of the present invention, successfully obtains phosphoramide with high yield (60% 80%) and high enantioselectivity (70% 90%).

The invention discloses a nano-ceramic coating for renovating a galvanized guardrail steel plate coating and a preparation method of the nano-ceramic coating, and belongs to the technical field of coatings. The nano ceramic coating for renovating the galvanized guardrail steel plate coating comprises the following raw material components in parts by mass: 20-30 parts of an epoxy resin base material, 4-6 parts of an epoxy diluent, 30-45 parts of a titanium-containing filler, 0.5-1 part of a dispersing agent, 0.5-1 part of a defoaming agent, 0.5-1 part of an accelerant, 5-10 parts of a solvent, 8-10 parts of an amine curing agent and 1-3 parts of carbon disulfide. The titanium-containing filler is obtained by carrying out in-situ hydrolysis on titanium tetrachloride on the surface of hexagonal boron nitride; the amine curing agent comprises 4, 5-dimethyl-1, 2-phenylenediamine, a phosphamide curing agent, modified polyamide and modified fatty amine; the accelerant comprises any one or more of bis (triphenylphosphine) ammonium chloride, phenol, salicylic acid and tri-(dimethylaminomethyl) phenol; the solvent is any one or more of methyl ethyl ketone, xylene, butanol, methyl isobutyl ketone and methylbenzene.

The invention provides a non-distillative process for manufacturing amphetamine and substituted amphetamines, comprising obtaining a highly pure phosphoramidate compound, converting the highly pure phosphoramidate compound to an amphetamine sulfate compound, concentrating the amphetamine sulfate compound in isopropanol, and then salting out the amphetamine compound directly to obtain an amphetamine salt, the amphetamine salt selected from amphetamine saccharate, amphetamine sulfate, amphetamine aspartate, alkyl-amphetamine saccharate, alkyl-amphetamine sulfate, alkyl-amphetamine aspartate, aryl-amphetamine saccharate, aryl-amphetamine sulfate, aryl-amphetamine aspartate, and mixtures thereof.

The invention provides an electrolyte additive and application thereof, and belongs to the technical field of sodium ion battery manufacturing. According to the invention, an additive a thiophosphoramide compound with a specific structure and a conventional additive are combined as an electrolyte additive; s and N atoms are introduced into a phosphate framework by the additive a thiophosphoramide compound, an inorganic interfacial film rich in Na2S, Na3N and Na3P is generated in the formation stage, the solid electrolyte interfacial film contains more inorganic components and less organic components, has higher high temperature resistance, improves the safety performance of the battery, and is used cooperatively with a conventional additive, so that the battery has a good application prospect. A more uniform and compact SEI film with smaller impedance is formed, so that the safety performance of the battery is further improved, and the obtained sodium ion battery has good flame retardant property and safety performance.

The invention relates to the technical field of power batteries, in particular to a wide-temperature-range non-aqueous electrolyte, a lithium ion battery, a battery module, a battery pack and a power utilization device. The non-aqueous electrolyte comprises a lithium salt, a solvent and a functional additive, and the functional additive comprises an ammonium nitrate salt compound as shown in a formula I and a phosphamide compound as shown in a formula II. The two additives both contain an element N, can mutually promote decomposition and jointly form a compact and uniform interface layer with excellent thermal stability, and have excellent ionic conductivity at low temperature and are not easy to decompose and crack at high temperature.

Provided are a hydration method for a lyophilized cyclophosphamide composition and a composition and preparation prepared thereby. The hydration method comprises: (a) providing an aqueous solution comprising cyclophosphamide and an optional pharmaceutically acceptable excipient; (b) freeze-drying the solution to obtain a lyophilized composition; and (c) hydrating the lyophilized composition by using liquid water to obtain the product.

The invention relates to the field of medicinal chemistry, in particular to a synthesis process of a 2-TBS adenosine phosphoramidite monomer. Comprising the following steps: S1, carrying out silylation protection on 2 ', 3' and 5 'hydroxyl groups of adenosine to obtain a compound A; s2, reacting the compound A with benzoyl chloride to obtain a compound B; s3, carrying out selective deprotection on the compound B and a hydrogen fluoride-pyridine complex to obtain a compound C; s4, reacting the compound C with 4, 4 '-dimethoxytriphenylmethyl chloride to obtain a compound D; and S5, carrying out phosphorylation reaction on the compound D and a phosphorus reagent to obtain a compound E. According to the method, the problems that the total yield of the 2-TBS adenosine phosphoramidite monomer is low, and the stability and the purity of an intermediate product are poor are effectively solved, through a high-selectivity reaction system, the synthesized target product has high selectivity, the yield and the purity are improved, and the separation and purification steps are simplified by stabilizing groups of the intermediate product.

The invention relates to the technical field of chemical raw material medicine manufacturing, in particular to a phosphonamide compound with a pentavalent phosphorus chiral center and a one-pot synthesis method of the phosphonamide compound. The structural formula of the compound is shown as (V). The synthesis method comprises the following steps: by taking chiral bicyclic imidazole as a catalyst, carrying out enantioselective amino substitution reaction on a phosphonic dichloride raw material (I) and a secondary amine reactant (II) to obtain a chiral aminophosphoryl chloride intermediate (III), and carrying out stereospecific nucleophilic substitution on the chiral aminophosphoryl chloride intermediate (III) and a nucleophilic reagent (IV) to obtain a chiral phosphoramide product (V). By adopting the method, the substrate adaptability is wide, the enantioselectivity is excellent, the product derivatization is strong, and a universal platform is provided for efficient synthesis of phosphorus chiral bioactive molecules.

The application discloses a kind of nano porcelain coating for galvanized guardrail steel plate coating renovation and a preparation method thereof, and belongs to the technical field of coating.The nano porcelain coating for galvanized guardrail steel plate coating renovation of the application comprises, by mass fraction, 20-30 mass parts of epoxy resin base material, 4-6 mass parts of epoxy diluent, 30-45 mass parts of titanium-containing filler, 0.5-1 mass part of dispersant, 0.5-1 mass part of defoaming agent, 0.5-1 mass part of accelerator, 5-10 mass parts of solvent, 8-10 mass parts of amine curing agent and 1-3 mass parts of carbon disulfide.The titanium-containing filler is obtained by in-situ hydrolysis of titanium tetrachloride on the surface of hexagonal boron nitride.The amine curing agent comprises 4,5-dimethyl-1,2-phenylenediamine, phosphoramide curing agent, modified polyamide and modified aliphatic amine.The accelerator comprises any one or several of bis(triphenylphosphine)ammonium chloride, phenol, salicylic acid and tris(dimethylaminomethyl)phenol.The solvent is any one or several of methyl ethyl ketone, dimethylbenzene, butanol, methyl isobutyl ketone and toluene.