40 results about "Phosphoramide" patented technology

The invention relates to the field of fertilizers, in particular to a method for preparing an organic fertilizer by anaerobic fermentation of tylosin dregs, which comprises the following steps: (1) electron beam irradiation treatment; (2) adding the mushroom dreg powder into an ethanol solution, and treating with a coupling agent KH-550 to obtain aminated mushroom dregs; (3) preparing to obtain phosphorylated hydroxypropyl methyl cellulose; (4) mixing the aminated mushroom dregs and the phosphorylated hydroxypropyl methyl cellulose in an organic solvent for reaction to obtain phosphorylated hydroxypropyl methyl cellulose composite active mushroom dregs; and (5) composting to finally obtain the organic fertilizer. According to the organic fertilizer and the preparation method thereof, the tylosin mushroom dregs are subjected to modification treatment, anaerobic fermentation treatment and aerobic fermentation treatment, so that the content of antibiotic tylosin in the finally prepared organic fertilizer is greatly reduced, the industrial requirements can be met, the content of organic matters in soil can be increased, the soil structure can be improved, and the soil fertility can be improved; the plant growth is facilitated.

The invention belongs to the field of electrochemistry, and discloses a self-growing solid electrolyte interface in an electrolysis process and application of the self-growing solid electrolyte interface in aniline production. The method comprises the following steps: dissolving nitrobenzene, 2-piperidone, lithium bromide and tris (N, N-tetramethylene) phosphamide in an organic solvent to obtain an electrolyte, and placing the electrolyte in a single-chamber electrolytic tank provided with an anode and a cathode for electrolysis, so that a solid electrolyte interface automatically grows on the cathode along with electrolysis and generates electrocatalytic activity. According to the method, hydrogen is not used, so that the risks of combustion and explosion are avoided; the device can be coupled with clean energy power generation, and is environment-friendly and sustainable; the device is simple, the size of the device is obviously reduced, and an exchange membrane does not need to be used for separating a cavity; a catalyst does not need to be loaded on an electrode, and the cost and technical difficulty of synthesizing and loading the catalyst are avoided; the price is low and operation is easy; the problems of inactivation and shedding of the catalyst do not need to be considered, and the long-term stability is good.

The invention discloses an alkyl phenolic resin for improving the bonding performance of a GLR rubber adhesive and a preparation method thereof, and relates to the technical field of phenolic resin preparation, the alkyl phenolic resin comprises the following raw materials by weight: 60-70 parts of modified resin, 15-20 parts of modified EPDM, 2-4 parts of carbon fiber, 5-7 parts of naphthenic oil, and 0.8-1.0 part of an anti-aging agent. The modified resin is obtained by carrying out reaction grafting on methyl 3-dodecylthio-propionate, 5-amino-2-hydroxycycloheptyl-2, 4, 6-triene-1-ketone, punicic acid and the like, and then blending with alkyl phenolic resin. The modified EPDM is obtained by grafting a functional monomer and EPDM, wherein the functional monomer contains imidazole, amino, piperazine, phosphamide, hydroxyl and terminal carbon-carbon double bonds. The prepared alkyl phenolic resin has good corrosion resistance, toughness, antibacterial property, adhesion, oil resistance and flame retardance, and is worthy of popularization and application.

The invention discloses a chiral alpha-amino acid with a C3 symmetric structure and a preparation method and application thereof, the chiral alpha-amino acid with the C3 symmetric structure provided by the invention is used as an ion pair catalyst, and the structure of the chiral alpha-amino acid with the C3 symmetric structure is more stable than that of other ion pair catalysts due to the C3 symmetric structure; and meanwhile, the chiral phosphamide compound is successfully constructed with relatively high yield (70-80%) and enantioselectivity (80-95%), so that the chiral phosphamide compound has excellent catalytic performance, and the problem that the chiral phosphamide compound is difficult to construct by a traditional ion pair catalyst is solved.

The invention provides a preparation method of a phosphoramidite compound. The preparation method comprises the following steps: (1) mixing a nitrogen-containing compound and an acid-binding agent with a first solvent to obtain a first mixed solution; mixing phosphorus trichloride with a second solvent to obtain a second mixed solution; mixing aromatic diphenol with a third solvent to obtain a third mixed solution; (2) pumping the first mixed solution and the second mixed solution obtained in the step (1) into a first micro-mixer, and then enabling the first mixed solution and the second mixed solution to enter a first micro-channel reactor for reaction to obtain a reaction solution containing monochlorophosphoramidite; (3) enabling the reaction solution containing the monochlorophosphoramidite obtained in the step (2) and the third mixed solution obtained in the step (1) to enter a second micro-mixer, and then enabling the mixture to enter a second micro-channel reactor for reaction to obtain a phosphoramidite compound; the acid-binding agent is a polyether tertiary amine compound. The preparation method is short in reaction time and high in product yield.

The invention belongs to the field of organic small molecule synthesis, and particularly relates to a synthesis method of a biphosphamide compound, the structural formula of the biphosphamide compound is shown in the specification, and the synthesis method comprises the following steps: by taking N, N-dimethylformamide (DMF) as a reaction solvent, under the action of an oxidizing agent and acid, carrying out a reaction on the reaction solvent to obtain the biphosphamide compound. And carrying out a free radical mediated deoxidation double phosphating reaction with an equivalent amount of phosphine oxide compound to obtain the bisphosphamide compound. Wherein Ar is aryl, A is a straight chain or a 5-7-membered ring, R is hydrogen, alkyl or aryl, and R'is alkyl or aryl. According to the method, equivalent oxime and phosphine oxide compounds are taken as reactants, under the action of cheap protonic acid and oxidizing agent, the synthesis of the deoxidized double phosphating product biphosphamide compound can be economically and efficiently realized, and the method is good in substrate universality, mild in reaction condition, simple in process, safe and easy to operate.

The present invention concerns optimized microbubbles, in particular lipid microbubbles, which can be used in the prevention and treatment of diseases or for marking.The invention relates in particular to a lipid microbubble, comprising at least one cationic compound selected from lipophosphoramidates, histidylated polyethylenimines, and any mixture thereof. The microbubble preferably further comprises at least one agent selected from a therapeutic agent, a targeting agent, a marking agent, and any combination thereof.The invention also relates to a method for producing this microbubble.The present invention also relates to a composition, in particular a pharmaceutical composition, and a kit, comprising at least one of these microbubbles. The present invention also relates to the use of these microbubbles, composition, kit, as a medicament or as a marking agent.

The present invention relates to the technical field of UV-curable coatings, and discloses a high-temperature resistant chitosan-modified polyurethane UV-curable coating and a preparation method thereof. Using dipropylene glycol diacrylate and the like as reactive diluents, benzoin dimethyl ether and the like as photoinitiators, and using the alkenyl group of acryloyl chloride grafted chitosan as a crosslinking site, an ultraviolet curing crosslinking reaction occurs with the terminal alkenyl group of the alkenyl naphthalenediamine phosphoryl mercapto-modified polyurethane prepolymer, so that the polyurethane crosslinking system contains a rigid naphthalene ring, improving the chemical stability and dimensional stability of the polyurethane crosslinking network, which is beneficial to improving the hardness, impact resistance and tensile properties of the photocured paint film. At the same time, the polyurethane contains phosphorus amide and sulfur flame retardant elements, forming an intumescent flame retardant system with the naphthalene ring with a high carbon content and chitosan, which can increase the thermal decomposition temperature and char formation of the paint film, and enhance the high-temperature resistance and flame retardant properties of the paint film.

The invention discloses a synthesis process of chiral UNA phosphoramidite, phosphoryl chloride and phosphoramidite and application of the chiral UNA phosphoramidite, phosphoryl chloride and phosphoramidite in oligonucleotides, and particularly designs preparation and synthesis of (2S)-UNA monomer phosphoramidite, phosphoryl chloride and phosphoramidite. And the method can also be used for solid-phase synthesized oligonucleotides in the conventional 3-to-5 direction, and the influence of introduction of monomers with different chirality to design sites on the structure, the biological activity and the like is researched.

The invention relates to the technical field of phosphoramidite, and discloses (S)-GNA-U phosphoramidite and a preparation method thereof. The method comprises the following steps: putting dichloromethane, diisopropyl ammonium salt tetrazole, (S)-DMT-glycidol-urracil and bis (diisopropyl amino) (2-cyanoethoxy) phosphine which are prepared in advance into a reaction flask, and carrying out a stirring reaction for a preset time; after the stirring reaction, performing HPLC central control reaction to determine that the reaction is complete; washing the reaction liquid for multiple times, removing a water phase and retaining an organic phase; and filtering, concentrating and crystallizing the washed organic phase to obtain the (S)-GNA-U phosphoramidite. The method is simple to operate, low in cost, high in conversion rate and beneficial to large-scale production.

The invention relates to the technical field of chemical synthesis, and discloses a phosphorus-boron-nitrogen multi-element synergistic flame retardant based on aminobiphenyl and a preparation method thereof.The preparation method comprises the steps that 2, 4-dinitrophenol is dissolved in a reaction solvent containing aniline, a reaction is conducted in the hydrogen atmosphere under the action of a catalyst, and 2-aminobiphenyl is obtained; the preparation method comprises the following steps: dissolving 2-aminobiphenyl in an organic solvent to form a reaction base solution, adding a phosphoryl chloride compound into the reaction base solution, and condensing to obtain a phosphamide product; and dissolving the phosphamide product in an organic solvent system, adding a boron compound, and reacting to obtain the flame retardant. The flame retardant takes aminobiphenyl as a framework, and a phosphorus-containing unit and a boron-containing unit are introduced to the framework, so that molecules contain flame-retardant elements of phosphorus, boron and nitrogen, the synergistic effect of gas-phase flame retardance and condensed-phase charring is realized, the limit oxygen index and the vertical combustion performance are improved under the condition of relatively low addition amount, and the peak heat release rate and the smoke density are reduced; and after being subjected to damp-heat aging, the flame-retardant plastic still has a relatively high flame-retardant property retention rate.

The invention relates to continuous reaction equipment of N-n-butyl thiophosphoric triamide and a preparation method of the N-n-butyl thiophosphoric triamide. The invention discloses a continuous preparation method of N-n-butyl thiophosphoric triamide and reaction equipment, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: uniformly mixing thiophosphoryl chloride serving as an initial raw material with a solvent in a batching kettle to prepare a thiophosphoryl chloride solution; the method comprises the following steps: respectively adding a thiophosphoryl chloride solution, n-butylamine and inert gas into a micro-channel reactor through a flow pump to carry out substitution reaction, and separating hydrogen chloride gas and an N-n-butyl dichlorothiophosphoramide solution through a gas-liquid separator; then adding the N-n-butyl dichlorophosphoramide thiophosphate solution and liquid ammonia into a tubular reactor through a flow pump to obtain an N-n-butyl thiophosphoric triamide solution; and finally, extracting, washing, concentrating an organic phase, crystallizing, separating and drying to obtain the high-purity N-n-butyl thiophosphoric triamide. The method is safe, efficient, simple and convenient to operate, good in reaction selectivity, high in yield, low in pollutant emission, low in production cost and suitable for industrial production.

This invention relates to the field of flame retardant preparation technology, and more particularly to a method for preparing an environmentally friendly and highly efficient flame-retardant polyolefin cable sheath material. The invention uses compounds containing primary amino and amide bonds and compounds containing phenyl and phosphoryl chloride groups as raw materials. The reaction is carried out at room temperature for 0.5-1 h, then heated to 45 °C for 3-4 h, and then to 65 °C for 5-6 h. Through a condensation reaction, a phosphoramide macromolecular flame retardant containing phenyl and amide bonds is obtained, with a yield as high as 80.5-95.6%. This flame retardant is added to polyolefin cable sheath material at a mass ratio of 25%, then compounded and extruded to obtain a halogen-free flame-retardant polyolefin cable sheath material. The flame retardant molecule prepared by this invention simultaneously contains phosphorus and nitrogen flame-retardant elements and amide bonds forming a char skeleton. During combustion, it can exert a phosphorus-nitrogen synergistic flame-retardant effect and promote the catalytic char formation of the matrix, which can significantly reduce the heat and toxic gas release of polyolefin cable sheath material during combustion, thereby providing protection for the lives of people in fire scenes.

The invention discloses a preparation method of SNA phosphoramidite, an intermediate of the SNA phosphoramidite and a preparation method of the intermediate. Specifically disclosed is a preparation method of a compound as shown in a formula 3, which comprises the following steps: in an organic solvent, carrying out a reduction reaction on a compound as shown in a formula 2 in the presence of a reducing agent to obtain the compound as shown in the formula 3, the reducing agent is NaBH4 and / or LiBH4; when the reducing agent is NaBH4, the reduction reaction is carried out in the presence of calcium chloride and / or lithium chloride. According to the preparation method of the compound as shown in the formula 3, racemization is completely avoided in the reaction process, and the product completely keeps the chirality of raw materials. The compound shown in the formula 3 can be directly used for preparing L-serinol with single chirality and high ee value, and can be further used for preparing an SNA phosphoramidite monomer containing four basic groups. # imgabs0 #

The invention discloses a preparation method of a phosphoric acid amide modified carbon nitride material for treating uranium-containing wastewater. The method comprises the following steps: 1, calcining dicyandiamide at high temperature, cooling and grinding to obtain blocky carbon nitride; 2, thermally stripping the blocky carbon nitride, and performing thermal treatment under ammonia gas to obtain flaky carbon nitride with amino on the edge; 3, carrying out gas-solid phase reaction on the flaky carbon nitride and sodium hypophosphite, and then carrying out annealing treatment to obtain a phosphoric acid amide modified carbon nitride material; a phosphoric acid amide group is introduced into a framework of the material to form an intramolecular dipole structure; the material is used as a photocatalyst to be added into uranium-containing wastewater for photocatalytic reaction. The functional photocatalyst with strong intramolecular polarity is constructed by accurately introducing a phosphoric acid amide group into a carbon nitride skeleton, has strong adsorption and efficient photocatalytic reduction capabilities on uranyl ions, and can efficiently and stably treat hexavalent uranium in uranium-containing wastewater into tetravalent uranium in an open water system without a sacrificial agent; the method is suitable for uranium-containing wastewater field.

This invention discloses a high-temperature resistant nylon resin and its synthesis method. The high-temperature resistant nylon resin is synthesized from the following raw materials: 1,5-pentanediamine, terephthalic acid, glutaric acid, phosphoramide salt, toluene diisocyanate, organic copper chrome black, acrylate copolymer, and a high-temperature antioxidant. This high-temperature resistant nylon resin possesses excellent mechanical properties, flame retardant properties, and laser direct forming properties, and can be widely used in communication fields requiring flame retardancy and laser direct forming capabilities.

A semi-active phosphoramide ligand and its preparation method, through catalytic amount of Ru3(CO) 12 for C–H activation of diaryl monophosphine and isocyanate, a modular strategy for constructing phosphoramide ligands in an ideal and economical way, thereby providing a series of phosphoramide ligands to promote transition metal-catalyzed reactions to obtain high reactivity and high regioselectivity.

The invention provides a tripterygium wilfordii diagnosis and treatment prodrug, a precursor compound as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. According to the tripterygium wilfordii diagnosis and treatment prodrug, hemicyanine fluorescent dye is coupled with a neuroinflammation treatment drug, i.e., cellatrol, and diphenyl phosphinamide is introduced as a response switch, so that the tripterygium wilfordii diagnosis and treatment prodrug can detect ONOO <-> in a neuroinflammation microenvironment and realize targeted release of the cellatrol. The tripterygium wilfordii prodrug for diagnosis and treatment can effectively consume ONOO <-> and realize near-infrared fluorescence imaging in ischemic brain injury, the bioavailability of cellatrol is improved, and the toxicity of the drug is reduced, so that synchronous imaging and treatment are realized. Prodrug with structure as shown in general formula I: # imgabs0 #

The invention provides application of Yupingfeng granular polysaccharide, and particularly relates to application of the Yupingfeng granular polysaccharide in preparation of a medicine for preventing damage caused by cyclophosphamide. The Yupingfeng granule polysaccharide disclosed by the invention is used as an active ingredient of a medicine, can relieve chemotherapy injury caused by cyclophosphamide, such as weight loss, spleen injury and thymus injury, and can also play a role in relieving and even reversing the abnormal number of leukocytes.

The invention discloses a flame retardant oligomer containing ferrocene-cyano polyphosphamide as well as a preparation method and application of the flame retardant oligomer, the flame retardant oligomer containing ferrocene-cyano polyphosphamide is prepared by taking p-cyanophenyl dichlorophosphate, an aromatic diamine compound and 1, 1 '-ferrocene dicarbonyl chloride as raw materials, and the invention discloses a preparation method of the flame retardant oligomer containing the ferrocene-cyano polyphosphamide and the application of the flame retardant oligomer containing the ferrocene-cyano polyphosphamide. The invention relates to a synthetic method of 1, 1 '-ferrocene dicarbonyl chloride and p-cyanophenyl dichlorophosphate. The flame retardant oligomer containing ferrocene-cyano polyphosphamide disclosed by the invention not only has an excellent flame retardant effect, but also shows an excellent smoke suppression effect in a combustion process. The flame retardant oligomer containing ferrocene-cyano polyphosphamide can effectively improve the compatibility between the flame retardant and a high polymer material matrix, prevents the flame retardant from being separated out from the matrix, and improves the weather resistance and mechanical properties of the flame-retardant high polymer material. The polymeric monomolecular flame retardant disclosed by the invention is single in component, halogen-free, environment-friendly, simple in synthesis process, mild in condition and suitable for industrial production and use.

The invention relates to the technical field of polyurethane, and discloses a water-based polyurethane fireproof coating and a preparation method thereof, pentaerythritol diphosphate diphosphoryl chloride, 4-methoxy-L-phenylalanine, pyridine hydrochloride and the like are used as reactants to prepare a novel carboxyl-containing water-based flame-retardant chain extender, and the water-based flame-retardant chain extender is used as a fire retardant. And carrying out polymerization reaction with dihydric alcohol and diisocyanate monomer to obtain the waterborne polyurethane fireproof coating. The polyurethane water-based emulsion is good in dispersity, high in emulsion stability and excellent in hardness; meanwhile, a nitrogen-phosphorus flame-retardant structure of the bis-spirophosphamide is grafted into a polyurethane molecular chain, so that the combustion limit oxygen index of the polyurethane film material is remarkably improved and reaches 27.9-29.6%, and the UL-94 grade reaches V-0.

Provided are a hydration method for a lyophilized cyclophosphamide composition and a composition and preparation prepared thereby. The hydration method comprises: (a) providing an aqueous solution comprising cyclophosphamide and an optional pharmaceutically acceptable excipient; (b) freeze-drying the solution to obtain a lyophilized composition; and (c) hydrating the lyophilized composition by using liquid water to obtain the product.

This invention discloses a high-temperature resistant polyamide resin and its synthesis method. The high-temperature resistant polyamide resin is synthesized from the following raw materials: 1,5-pentanediamine, terephthalic acid, glutaric acid, phosphoramide salt, 2,2'-(1,3-phenylene)-dioxazoline, organic carbon nanotubes, benzoic acid, and a high-temperature resistant antioxidant. This high-temperature resistant polyamide resin possesses excellent mechanical properties, flame retardant properties, and electromagnetic shielding properties, and can be widely used in communication devices requiring flame retardancy and electromagnetic shielding.

This invention discloses a magnetic wicking wire and its preparation method, belonging to the field of magnetic composite material technology. The magnetic wicking wire comprises the following raw materials in parts by weight: 10-20 parts of modified styrene-based thermoplastic elastomer; 80-85 parts of modified magnetic powder; 0.5-1 parts of antioxidant; and 0.5-1 parts of lubricant. The modified styrene-based thermoplastic elastomer is a naphthenic oil-toughened styrene-based thermoplastic elastomer. The modified magnetic powder is hyperbranched polyphosphoramide-coated isotropic samarium iron nitrogen magnetic powder. This invention uses isotropic samarium iron nitrogen magnetic powder, fundamentally eliminating the orientation step required in traditional processes. Magnetization is performed simultaneously during extrusion, and a high-performance, high-elasticity magnetic wicking wire can be obtained after winding without secondary magnetization, simplifying the process.

The invention belongs to the field of pesticide chemicals, and in particular to a kind of synthetic method of acephate. Phosphorus oxychloride and methanol generate methyl dichlorophosphate through substitution reaction, methyl dichlorophosphate and ammonia generate methylphosphoramide chloride through acylation reaction, methylphosphoramide chloride and methyl mercaptan obtain methylamidophos through substitution reaction, and methylamidophos and acetic anhydride generate acephate through acylation reaction. Using phosphorus oxychloride as raw material, by multiple substitution reactions and one-step acylation reaction, target product can be obtained, avoiding the reaction of phosphorus trichloride and sulfur under high temperature conditions and the isomerization reaction of O, O-dimethylthiophosphoramide, and the use of caustic alkali. Meanwhile, the product appearance properties prepared by the inventive method are good.

The invention discloses phosphoramidite and a preparation method and application thereof.The phosphoramidite has high stability and can catalyze a hydroformylation reaction of a raw material olefin under milder reaction conditions to obtain a high aldehyde forming rate, so that the phosphoramidite can be recycled for a longer time and more times in the hydroformylation reaction, and the yield of the olefin is increased. Therefore, the production cost is remarkably reduced, and the method is particularly suitable for the hydroformylation reaction of the raw material olefin, such as dicyclopentadiene, with low or no requirement on the normal / isomer ratio. Meanwhile, the phosphoramidite ligand is simple in preparation process and high in yield, and the cost of the phosphoramidite ligand can be reduced in large-scale production due to no participation of oxygen, so that the total cost of the hydroformylation reaction is further reduced.

The invention discloses a trifluoromethyl-containing phosphamide compound and an electrochemical synthesis method thereof, and belongs to the field of organic synthesis, and the structural formula of the trifluoromethyl-containing phosphamide compound is shown in the specification; wherein R is cyclopropyl, methyl, n-butyl, phenyl, p-tolyl, m-methylphenyl, p-methoxyphenyl, p-isopropyl phenyl, p-tert-butylphenyl, p-fluorophenyl, p-chlorphenyl, p-bromophenyl, p-ethoxycarbonyl phenyl, benzyl, o-methylbenzyl, m-methylbenzyl, p-methylbenzyl, p-methoxybenzyl, p-isopropyl benzyl, p-tert-butylbenzyl, p-fluorobenzyl, p-chlorophenyl, p-bromophenyl, p-ethoxycarbonyl phenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, p-chlorophenyl, the compound is one of p-chlorobenzyl, p-bromobenzyl, p-chlorobenzyl, p-bromobenzyl and pyridine-3-yl. According to the invention, the preparation of the trifluoromethyl-containing phosphamide compound is realized under mild conditions without additional chemical oxidants.

This invention relates to the field of polyurethane technology and discloses a waterborne polyurethane fire-retardant coating and its preparation method. A novel carboxyl-containing waterborne flame-retardant chain extender is prepared using pentaerythritol diphosphate bisphosphonate chloride, 4-methoxy-L-phenylalanine, and pyridine hydrochloride as reactants. This chain extender is then polymerized with diol and diisocyanate monomers to obtain the waterborne polyurethane fire-retardant coating. The waterborne polyurethane emulsion exhibits good dispersibility, high emulsion stability, and excellent hardness. Furthermore, the nitrogen-phosphorus flame-retardant structure of bisspirocyclic phosphoramide is grafted into the polyurethane molecular chain, significantly improving the limiting oxygen index of the polyurethane film material to 27.9-29.6%, achieving a UL-94 rating of V-0.

The invention discloses a novel alkaline hydrogen bond-assisted chiral bicyclic guanidine ion pair catalyst and its preparation and application, the present invention carries out certain structural transformation to traditional PN ion pair catalyst, without destroying the original structural basis, adds the structure of hydrogen bond, makes this novel H PN in various asymmetric catalytic reactions can play the dual role of hydrogen bond and ion pair catalysis, successfully constructs chiral phosphoramide compounds with higher yield (70% 80%) and enantioselectivity (80% 90%), solves the problem that traditional ion pair catalyst is difficult to construct chiral phosphoramide compounds. With phosphoryl chloride or secondary phosphorus oxide as substrate, various primary amine secondary amines as nucleophilic reagent, using 4% 10% catalyst of the present invention, successfully obtains phosphoramide with high yield (60% 80%) and high enantioselectivity (70% 90%).

The present invention relates to the technical field of anti-cancer drugs, and particularly to a preparation method, product and application of cyclophosphamide sodium alginate nanospheres. The preparation method of the cyclophosphamide sodium alginate nanospheres of the present invention comprises the following steps: dissolving cyclophosphamide in an ε-polylysine aqueous solution to obtain a cyclophosphamide solution; dissolving an amphiphilic alginate in water to obtain an amphiphilic alginate aqueous solution; mixing the cyclophosphamide solution with the amphiphilic alginate aqueous solution to obtain a self-assembly system, and performing self-assembly to obtain the cyclophosphamide sodium alginate nanospheres. The present invention provides a preparation method of cyclophosphamide sodium alginate nanospheres. By encapsulating cyclophosphamide with an amphiphilic alginate and preparing it into a nanosphere drug, the sustained release of the cyclophosphamide drug can be achieved, the decomposition half-life of the drug can be prolonged, the drug utilization rate can be improved, and the drug dosage can be reduced.