A continuous flow method for the synthesis of a boscalid derivative
By employing a continuous flow synthesis method using a microchannel reactor, the problems of explosion risk and low yield in the synthesis of Bosein derivatives have been solved, achieving safe and efficient preparation of Bosein derivatives with improved yield and better environmental friendliness.
Patent Information
- Application Number
- CN202510742107.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-05
- Publication Date
- 2026-04-28
- Estimated Expiration
- 2045-06-05
AI Technical Summary
Existing synthesis processes for Bosein derivatives pose an explosion risk and have low yields, making it difficult to meet safety and environmental protection requirements.
A continuous flow synthesis method using a microchannel reactor was employed to synthesize 2,4(1H,3H)-pyrimidinidone-5-D-glucopyranosyl-6-hydroxy-1,3-dimethyl sodium salt under alkaline conditions via a two-step reaction. This salt was then reacted with an oxidant in another microchannel reactor to yield (2ξ,3ξ)-3,7-dehydro-N-methyl-D-glucosinolate. Subsequent alkalization, esterification protection, and lactone formation steps yielded a series of Bosein derivatives.
A safe and efficient synthesis of Bosein derivatives was achieved, increasing the yield from 61.7% to 78%, simplifying the operation process, reducing environmental pollution, and improving product purity and yield.