63 results about "Thioglycollic acid" patented technology

The invention relates to a dual-emission ratio-type quantum dot fluorescence probe for visual detection of aspirin, a preparation method and an application thereof and belongs to the technical field of preparation of material and detection of content of medicines. The preparation method of the probe includes following steps: preparing a precursor NaHTe solution from sodium borohydride, tellurium powder and water under an ultrasonic environment; adding the precursor to an aqueous solution of CdCl2.2.5H2O in the presence of thioglycollic acid; carrying out a reflux reaction with a nitrogen protecting condition to obtain required green fluorescence quantum dot and red fluorescence quantum dot; by means of a sol-gel method, wrapping the red fluorescence quantum dot with silicon spheres with amino group being connected; dispersing a green fluorescence quantum dot solution and the red fluorescence quantum dot wrapped with the silicon spheres in an MES buffer solution with addition of an EDC/NHS solution; and carrying out a reaction at room temperature in a dark place to obtain the dual-emission ratio-type quantum dot fluorescence probe. The dual-emission ratio-type quantum dot fluorescence probe is used in detection of the content of the aspirin through fluorescence quantitation and visualized analysis. The quantum dot fluorescence probe is quite good in optical performance and stability and has a capability of visualizedly detecting the aspirin.

The invention provides a method for preparing polyvinyl chloride with high polymerization degree. A mixed monomer, a dispersing agent, an initiator, soft water, a pH regulator and a composite chain extender are added into a polymerization kettle for suspension copolymerization reaction. The method is characterized in that the composite chain extender is a complex system formed by a chain extender and a chain transfer agent, wherein the chain extender can be one or more than one of diallyl fumarate, diallyl isophthalate and diallyl maleate, and the chain transfer agent can be one or more than one of lauryl mercaptan, mercaptoethanol, carbon terabromide, trichlorethylene, and thioglycollic acid alpha-ethyl hexaester; and the weight ratio of the chain extender to the chain transfer agent is between 2.8 to 1 and 3.2 to 1, and the total addition amount is between 0.08 and 0.15 percent. The complex system of the chain extender and the chain transfer agent can shorten the reaction time, solve the problem of the hardly-controllable polymerization temperature, improve the workability of products, and increase the mechanical property of the products.

A chemical preparation method for a CdTe quantum dot fluorescent probe for detecting a trace amount of paraquat comprises the step of modifying thioglycollic acid on the surface of the CdTe quantum dot fluorescent probe emitting a red emission spectrum band so as to enable the CdTe quantum dot fluorescent probe is provided with carboxyl functional groups on the surface. The preparation process comprises the following two specific steps: firstly, preparing a NaHTe solution; then, synthesizing CdTe quantum dots of which the surfaces are modified with thioglycollic acid, and adjusting the pH value to be 10-12 with KOH, so as to obtain the CdTe quantum dot fluorescent probe. According to the invention, carboxyl with negative charge on the surfaces of the CdTe quantum dots and target paraquat molecules with positive charge have the electrostatic interaction through the positive charge and negative charge, when the CdTe quantum dots and the paraquat approach to each other in space, the red spectrum band emitted by the CdTe quantum dot fluorescent probe can be absorbed by green target analyte paraquat modules through the fluorescence resonance energy transfer principle, and the detection of a trace amount of paraquat can be implemented through the utilization of the variation of the CdTe quantum dot fluorescence intensity.

The invention discloses a flaky titanium dioxide/bismuth oxybromide composite photocatalyst and a preparation method thereof. The composite photocatalyst is a heterogeneous composite material formed by depositing bismuth oxybromide on a titanium dioxide nanometer sheet. The preparation method comprises the following steps: dispersing the titanium dioxide nanometer sheet, thioglycollic acid, potassium bromide in deionized water in an ultrasonic manner, uniformly mixing to obtain a solution, and dissolving bismuth nitrate in ethylene glycol to obtain a solution; mixing the two solutions obtained in the former step to obtain a milky emulsion, stirring, leaving the emulsion to stand, and performing centrifugal separation and washing to obtain the composite photocatalyst. In the preparation process, through adjusting ratio of titanium dioxide to bismuth oxybromide, composite structures in different particle diameters can be obtained. The composite photocatalyst is simple in preparation technology; particularly, through thioglycollic acid, bismuth oxybromide can be uniformly distributed on the titanium dioxide (TiO2) sheet; the composite photocatalyst shows a more excellent photocatalytic activity compared with that of the titanium dioxide nanometer sheet under visible light, and has the potential practical application prospect of photocatalytic degration of organic pollutants through solar power light in the processing technology.

The invention provides a quantum dot fluorescent aspirin imprinted sensor and its preparation method and use and belongs to the technical field of material preparation and drug content detection. The preparation method comprises the following steps of preparing a precursor NaHTe solution from sodium borohydride, tellurium powder and water in an ultrasonic environment, injecting the precursor NaHTe solution into a CdCl2.2.5H2O solution fed with nitrogen for oxygen removal, having a pH value of 10.5-11.5 and containing thioglycollic acid (TGA), carrying out backflow reaction processes in a nitrogen protective atmosphere at a temperature of 100-110 DEG C to obtain quantum dots having different sizes according to different backflow time periods, and synthesizing a fluorescent molecule imprinted polymer from the CdTe quantum dots as fluorescent carriers, aspirin as a template molecule, (3-aminopropyl)triethoxysilane (APTES) as a functional monomer and tetraethyl orthosilicate (TEOS) as a cross-linking agent by a sol-gel method, wherein the fluorescent molecule imprinted polymer can be used for optical detection of aspirin. The fluorescent molecule imprinted polymer has good optical and pH stability and has an aspirin selective-identification function.

This invention discloses manufacture of water-soluble ZnSe/ZnS core/shell quantum dots by photodegradation together with program-controlled microwave radiation method. The method comprises the steps of: mixing zinc salt or zinc oxide with water-soluble thioglycollic acid in water phase, adding sodium selenium sulfite or potassium selenium sulfite formed by reaction of sodium sulfite or potassium sulfite with selenium powders, reacting to obtain ZnSe precursor solution, placing the solution in a glass tube for microwave radiation, controlling the microwave radiation by program to obtain ZnSe quantum dots, performing photodegradation to obtain water-soluble ZnSe/Zns core/shell quantum dots with a high fluorescence quantum efficiency. The method is completely operated in water phase, thus has such advantages as easy operation and low toxicity. The quantum dots manufactured have such advantages as high fluorescence quantum efficiency, high stability and good water solubility, and can be used as fluorescent labels and indicators for biological inspection and analysis.

The invention provides a method for preparing a slow-release polycarboxylic acid water reducing agent by using a molecular assembly technology. The method comprises the following two steps: 1. carrying out polymerization: preparing raw materials into a water solution, dropwisely adding the solution into water at 50-100 DEG C, and reacting at constant temperature to obtain an assembly precursor, wherein the fuel is prepared from 80-130 parts of macromonomer A, 10-40 parts of micromonomer B, 0.5-3.5 parts of thioglycollic acid and 0.5-3.5 parts of ammonium persulfate; and 2. adding 0.5-5 parts of assembly agent to the assembly precursor at 50-70 DEG C, and adding 5-25 parts of 40% sodium hydroxide while stirring, thereby obtaining the slow-release polycarboxylic acid water reducing agent. The macromonomer A is polyethylene glycol allyl ether (XPEG) or methoxypolyethylene glycol (MPEG); the micromonomer B is one of esters and amides of acrylic acid, methacrylic acid, acrylic acid and methacrylic acid; and the assembly agent is selected from one of ethylene diamine, propylene diamine and the like as well as alkyl derivatives thereof. The slow-release polycarboxylic acid water reducing agent has excellent adaptability for the fluctuations of the raw material quality of concrete.

The invention relates to an application of an isoalantolactone derivative and a salt thereof in the preparation of medicines for treating lung fibration, and provides an isoalantolactone derivative represented by formula (I). An acid for forming the salt is an inorganic acid or an organic acid, the inorganic acid is selected from hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, carbonic acid, boric acid, seleninic acid, phosphomolybdic acid, phosphorous acid and sulfurous acid, and the organic acid is selected from citric acid, maleic acid, D-malic acid, L-malic acid, DL-malic acid, L-lactic acid, D-lactic acid, DL-lactic acid, oxalic acid, methanesulfonic acid, pentanoic acid, oleic acid, lauric acid, p-methyl benzenesulfonic acid, 1-naphthalenesulfonic acid, 2-naphthalenesulfonic acid, phthalic acid, tartaric acid, propane diacid, succinic acid, fumaric acid, glycollic acid, thioglycollic acid, glycine, sarcosine, sulfonic acid, nicotinic acid, methylpyridine acid, isonicotinic acid, benzoic acid and substituted benzoic acid.

A method for preparing water soluble quantum of CbTe / CbS core / shell type includes mixing Cb salt with water soluble thioglycollic acid in water phase, injecting Te ¿C sodium hydride to obtain CbTe forebody solution, filling said solution into glass tube specially being used in microwave radiation, carrying out program ¿C controlled microwave radiation on forebody solution in said tube to prepare CbTe quantum point, obtaining water soluble CbTe / CbS core / shell quantum point with high fluorescent quantum efficiency by making light degradation on CbTe quantum point.

The invention discloses silica gel with an ionic liquid and mercaptan loaded on the surface as well as a preparation method and an application. The preparation method comprises the steps as follows: 1-(3-ethoxy silane propyl)-4, 5-dihydroimidazole is taken as a silane coupling agent, N-propyl-4, 5-dihydroimidazole is grafted on the surface of acidized silica gel and further reacts with 3-chlorine-1, 2-propylene glycol to obtain a 1-(2', 3'-dyhydroxylpropyl)-imidazole chloride ionic liquid loaded on the surface of silica gel; and under the catalytic action of p-toluenesulfonic acid, the 1-(2', 3'-dyhydroxylpropyl)-imidazole chloride ionic liquid loaded on the surface of silica gel further has an esterification reaction with thioglycollic acid to obtain ionic liquid functionalized mercaptan loaded on the surface of the silica gel. The ionic liquid functionalized mercaptan loaded on the surface of the silica gel is added into a cigarette filter stick for rolling cigarettes; and flue gas analysis shows that ionic liquid functionalized mercaptan loaded on the surface of the silica gel is added into the filter stick, so that 10%-30% of Cd, 10%-25% of Cr and 5%-20% of Pb of mainstream smoke of cigarettes can be effectively reduced, and besides, 10%-30% of tar of cigarettes further can be reduced.

The invention relates to a ZnxCd1-xTe fluorescent nano-bar and an aqueous phase synthesis method thereof. The ZnxCd1-xTe fluorescent nano-bar is bar-shaped under transmission electron microscopy(TEM), and has the length of 20 to 300nm and the diameter of 10 to 80nm, wherein x is more than 0 and less than 1; and the nano-bar is mainly applied in the fields of biology, medical science and optoelectronic devices, for example, the nano-bar is used as a fluorescent probe in fluorometry, and the optical characteristics of the nano-bar are obviously higher than those of organic dyestuffs. The invention also provides an aqueous phase synthesis method for the ZnxCd1-xTe fluorescent nano-bar. In the method, dual stabilizers of thioglycollic acid and L-cysteine are introduced into aqueous solution containing inorganic salts of Zn and Cd, and the bar-shaped alloy-type ZnxCd1-xTe fluorescent nano-crystal is synthesized in the aqueous phase for the first time by regulating parameters related to the reaction.

The invention discloses a nano-sphere with elements of silicon, cobalt and the like as well as a synergetic ammonium polyphosphate flame resistant polypropylene material thereof. The nano-sphere with elements of silicon, cobalt and the like takes vinyl trimethoxy silane as a monomer to prepare a vinyl silicone resin nano-sphere under an alkaline condition; by clicking a chemical method, thioglycollic acid is connected on the vinyl silicone resin nano-sphere; cobalt acetate reacts with the thioglycollic acid on the surface of the vinyl silicone resin nano-sphere to prepare the nano-sphere with elements of silicon, cobalt and the like. The synergetic ammonium polyphosphate flame resistant polypropylene material of the nano-sphere with elements of silicon, cobalt and the like is prepared by mixing polypropylene particles, ammonium polyphosphate, pentaerythritol and the nano-sphere with elements of silicon, cobalt and the like in a mass percentage of (60-80):(16-25):(3):(2-11) at a high speed, extruding through a twin screw extruder, cooling and pelletizing. The flame resistant polypropylene material is simple in formula, high in flame resistant efficiency, good in thermal stability, capable of generating a stable compact carbon layer during burning, free of molten drops and low in smoke amount.

The invention discloses a glycolic acid producing method through microbe, which comprises the following steps: (1) culturing ethylformic corynebacterium to produce nitrile hydration enzyme; (2) utilizing nitrile hydration enzyme as catalyst to produce low-density amide thioglycollic acid solution through hydroxyl acetonitrile hydration reaction; (3) evaporating low-density amide thioglycollic acid solution through drawing stickle to remove amide through ion exchange column to prepare high-density thioglycollic acid solution; (4) crystallizing and drying high-density thioglycollic acid solution at low temperature to prepare high-purity glycolic acid.

An analysis method for detecting lipase activity based on gold nanocluster fluorescence enhancement is disclosed. According to a detection mechanism, thioglycollic acid generated by a lipase hydrolysis substrate that is methyl thioglycolate can stabilize gold nanocluster and can make up surface defects of the gold nanocluster, thus enhancing fluorescence. Lipase activity is detected through fluorescence intensity increase of the god nanocluster at 570 nm. The method is simple, rapid and sensitive, and the lowest limit of detection is 0.37 [mu]g/mL. Compared with the prior art, the method is advantageous in that the method is simple and rapid to operate and low in cost, and does not require special instruments or devices.

The invention relates to a simple preparation method for synthesizing a CdTe quantum dot fluorescence probe at a normal temperature and an application of the CdTe quantum dot fluorescence probe, and belongs to the technical field of material preparation and medicine content detection. The method comprises the following steps: firstly, respectively preparing cadmium chloride (CdCl2), sodium tellurite (Na2TeO3) and thioglycollic acid (TGA) into aqueous solutions with certain concentrations; then, sequentially adding the CdCl2, water, the TGA, the Na2TeO3, sodium borohydride (NaBH4) and hydrazine hydrate (N2H4.H2O) into a conical flask one by one; and standing for certain time at the normal temperature so as to obtain a CdTeQDs aqueous solution which is used for optical detection of norfloxacin lactate. The TGA-modified CdTeQDs prepared by utilizing the method has the good optical property and has the ability of detecting the norfloxacin lactate content.

The invention discloses a high performance polycarboxylate water reducing agent which is prepared from the following materials in parts by weight: isobutenol polyoxyethylene ether, isopentenol polyethylene ether, alkylphenol ethoxylates, methyl allyl polyethenoxy, halogenated fatty acid, sucrose ester, sodium allylsulfonate, sodium persulfate, maleic anhydride, tartaric acid, cinnamic acid, sodiumhydroxide, thioglycollic acid, triethanolamine and thiourea; the high performance polycarboxylate water reducing agent has the advantages of reducing concrete slump loss and improving concrete fluidity.

A photoelectrochemical immunosensor for detecting a dairy product allergen beta-lactoglobulin (beta-LG) is constructed, an Ag2S sensitized spindle-shaped BiVO4/BiOBr heterojunction is fixed on the surface of an ITO (indium tin oxide) electrode by using an antibody for specifically recognizing allergen beta-LG to be used as an excellent photoactive substrate, so that the photocurrent response and the sensitivity are effectively improved. Thioglycollic acid TGA is used as a connecting agent to fix the beta-LG antibody, photocurrent signals of antigens with different concentrations are detected through specific binding between the antigens and the antibody, and the quantitative test of the beta-LG is completed. Under the optimal experiment conditions, the PEC immunosensor is good in stability, wide in linear range, high in sensitivity and good in reproducibility, and can be used for detecting actual samples. The label-free immunosensor has very strong capability of specially identifying beta-LG, is not influenced by other proteins in milk, and does not need pretreatment. Meanwhile, the developed immunosensor provides a promising PEC detection platform and a reference thought for detection of other proteins in milk.

The invention provides a thermo-sensitive western blot sensing microsphere based on a quantum dot and a preparation method of same and belongs to the technical field of material science and bio-separation engineering. The method includes the steps of: 1) with a functional protein molecule as a template molecule, combining the functional protein molecule with CdTe quantum dots, which are co-modified with glutathione-thioglycollic acid (GSH-TGA), through electrostatic charge effect by means of amino groups and carboxyl groups, which are rich in the functional protein molecule; 2) in a non-oxygenenvironment, initiating polymerization by means of potassium persulfate (KPS), wherein thermo-sensitive isopropyl acrylamide (NIPAM) is used as a functional monomer and N,N-methylene bisacrylamide (MBA) is used as a crosslinker, so that through the free radical polymerization, the thermo-sensitive western blot sensing microsphere based on the quantum dot is produced. Through mechanism of electrontransfer between the functional protein and the quantum dot, fluorescent sensing of the microspheres to the template protein is achieved, and the synthesized western blot microspheres has performances such as thermo-sensitive response, fluorescent detection, etc.

The invention discloses a composite absorbing material for removing germanium ions from a natural water body, and a preparation method of the composite absorbing material, and belongs to the field of material preparation. The preparation method comprises the steps of heating agarose powder in a buffer solution to prepare an agarose gel solution, cooling and solidifying to obtain agarose gel, adding thioglycollic acid and tetrahydrofuran for mixing, adding a drop of concentrated sulfuric acid and then agarose gel for stirring and backflow, cooling to a room temperature, conducting suction filtration, washing with deionized water to be neutral, washing with a little alcohol, drying and then obtaining the adsorbing material with a sulfydryl load surface and good selective adsorption performance on the germanium ions. The preparation method has the characteristics of innovation, novelty and uniqueness, and the prepared material has a good absorbing effect on the germanium ions in the water.

The invention discloses a synthesis method and application of cadmium telluride quantum dots, and relates to the technical field of quantum dot synthesis, and the technical key point is that the synthesis method comprises the following steps: S1, preparing a potassium hydrogen telluride solution; s2, synthesizing cadmium telluride quantum dots CdTeQDs: taking a 250 mL three-necked bottle, sequentially adding 1 mL of a CdCl2 solution with the concentration of 0.1 mol.L <-1 >, 180 mL of deionized water and thioglycollic acid (TGA), fully mixing, adjusting the pH value of the solution in the three-necked bottle to 8.6-10.2 by using 1.0 mol.L <-1 > NaOH, introducing nitrogen to remove oxygen for 30 minutes, rapidly adding 0.125-0.750 mL of a newly prepared potassium hydrogen telluride solution into the three-necked bottle, and heating and refluxing at the temperature of 100 DEG C for 3.0-5.5 hours to prepare a cadmium telluride quantum dot CdTeQDs solution. By optimizing and improving synthesis conditions such as the addition amount of synthesis raw materials and synthesis heating reflux time, the synthesized cadmium telluride quantum dots are good in stability and high in fluorescence quantum yield; meanwhile, the synthesized cadmium telluride quantum dots are high in detection sensitivity when being used for detecting the copper ions in the water body.

The invention discloses a high-temperature-resistant and hot-corrosion-resistant coating hole sealing agent, and belongs to the technical field of hole sealing agents. According to the coating hole sealing agent, basalt is subjected to acid treatment, then the basalt is oxidized, the activity of the basalt is improved with surface active substances, the bonding degree between the basalt and othermacromolecular substances is enhanced by using organic silicon, gas is generated to dissipate heat in the heating process, a boehmite component is longitudinally formed in a gap through a hydrothermalmethod for nano-scale filling, high temperature resistance is improved, hot corrosion resistance is improved, and the packing of coating pores is completed; thioglycollic acid is utilized to react with active centers or active groups such as Lewis acid on the surface of vermiculite, when the reaction is carried out at high temperature, surface tension among particles is obviously reduced, and a good hole sealing effect can be formed; and magnesium and aluminum metal salts are used as raw materials, hydrotalcite-like components with good adsorbability are prepared through the hydrothermal method, chelation is generated through complexing, and the hot corrosion resistance is improved. According to the coating hole sealing agent, the problem that an existing common coating hole sealing agentis poor in high temperature resistance and hot corrosion resistance is solved.